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High CTSL2 expression predicts poor prognosis in patients with lung adenocarcinoma.

Aging (Albany NY) 2021 Sep 23;13(undefined). Epub 2021 Sep 23.

Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun 130021, China.

Cathepsin like 2 (CTSL2) is a lysosomal cysteine protease, and may be associated with tumor metastasis. However, CTSL2 has not been reported as a biomarker in lung adenocarcinoma (LUAD). In this study, bioinformatics analysis using data from The Cancer Genome Atlas was performed. Read More

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September 2021

Clinical and radiographic performance of indirect foraminal decompression with anterior retroperitoneal lumbar approach for interbody fusion (ALIF).

Clin Neurol Neurosurg 2021 Sep 16;209:106946. Epub 2021 Sep 16.

IRCCS Istituto Ortopedico Galeazzi, Milan, Italy. Electronic address:

Study Design: Retrospective study BACKGROUND: Indirect decompression with ALIF allows the restoration of the disk and foraminal height with limited soft tissue damage. However, it does not offer a direct view of the neural structure and a direct intraoperative assessment of the results of the decompression is not possible. For this reason, ALIF is often accompanied by posterior, direct decompression. Read More

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September 2021

Biomonitoring of 89 POPs in blood serum samples of Czech city policemen.

Environ Pollut 2021 Sep 10;291:118140. Epub 2021 Sep 10.

University of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology, Department of Food Analysis and Nutrition, Technicka 3, 166 28, Prague 6, Czech Republic. Electronic address:

In this biomonitoring study, we evaluated the concentrations of 8 polychlorinated biphenyls (PCBs), 11 organochlorinated pesticides (OCPs), 33 brominated flame retardants (BFRs), 7 novel brominated and chlorinated flame retardants (novel FRs) and 30 per- and polyfluoroalkylated substances (PFAS) in human serum samples (n = 274). A total of 89 persistent organic pollutants (POPs) were measured in blood serum samples of city policemen living in three large cities and their adjacent areas (Ostrava, Prague, and Ceske Budejovice) in the Czech Republic. All samples were collected during the year 2019 in two sampling periods (spring and autumn). Read More

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September 2021

Identifying profiles of brain structure and associations with current and future psychopathology in youth.

Dev Cogn Neurosci 2021 Sep 14;51:101013. Epub 2021 Sep 14.

Temple University, Department of Psychology, 1701 N 13th St, Philadelphia, PA 19122, USA.

Brain structure is often studied as a marker of youth psychopathology by examining associations between volume or thickness of individual regions and specific diagnoses. However, these univariate approaches do not address whether the effect of a particular region may depend on the structure of other regions. Here, we identified subgroups of individuals with distinct profiles of brain structure and examined how these profiles were associated with concurrent and future youth psychopathology. Read More

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September 2021

Questioning the dichotomy: A Latent profile analysis of ecological management practices in Swedish agriculture.

J Environ Manage 2021 Sep 20;300:113770. Epub 2021 Sep 20.

Department of Economics, Agrifood Economic Centre, Swedish University of Agricultural Sciences, Box 7013, 750 07, Uppsala, Sweden. Electronic address:

Currently, farmers who are not certified according to organic certification schemes are considered to be conventional farmers. Discussions in the farming sector reveal a view that the current organic classification system is too narrow and does not account for the full heterogeneity of the ecological practices that are prevalent in the agricultural sector. The failure to recognise practices within conventional farming, such as low-input farming or conservation agriculture, may therefore undermine efforts to adopt ecological practices. Read More

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September 2021

Changes in cerebral arterial pulsatility and hippocampal volume: a transcranial doppler ultrasonography study.

Neurobiol Aging 2021 Aug 27;108:110-121. Epub 2021 Aug 27.

Wayne State University, Institute of Gerontology, Detroit, Michigan; Wayne State University, Department of Psychology, Detroit, Michigan; Max Planck Institute for Human Development, Berlin-Dahlem, Germany.

The physiological mechanisms of age-related cognitive decline remain unclear, in no small part due to the lack of longitudinal studies. Extant longitudinal studies focused on gross neuroanatomy and diffusion properties of the brain. We present herein a longitudinal analysis of changes in arterial pulsatility - a proxy for arterial stiffness - in two major cerebral arteries, middle cerebral and vertebral. Read More

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Deep learning analysis and age prediction from shoeprints.

Forensic Sci Int 2021 Aug 30;327:110987. Epub 2021 Aug 30.

Department of Electrical Engineering and Computer Science, Bond Life Sciences Center, University of Missouri, Columbia, MO, United States. Electronic address:

Human gaits are the patterns of limb movements which involve both the upper and lower body parts. These patterns in terms of step rate, gait speed, stance widening, stride, and bipedal forces are influenced by different factors including environmental (such as social, cultural, and behavioral traits) and physical changes (such as age and health status). These factors are reflected on the imprinted shoeprints generated with body forces, which in turn can be used to predict age, a problem not systematically addressed using any computational approach. Read More

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Longitudinal prognostication in retroperitoneal sarcoma survivors: Development and external validation of two dynamic nomograms.

Eur J Cancer 2021 Sep 20;157:291-300. Epub 2021 Sep 20.

Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address:

Purpose: The aim of this study was to create and validate dynamic nomograms to predict overall survival (OS) and disease-free survival (DFS) at different time points during follow-up in patients who had undergone resection of primary retroperitoneal sarcoma (RPS).

Methods: Patients with primary RPS operated upon between 2002 and 2017 at four and six referral centres comprised the development and external validation cohorts, respectively. Landmark analysis and multivariable Cox models were used to develop dynamic nomograms. Read More

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September 2021

Maxillary sinusitis as a respiratory health indicator: a bioarchaeological investigation into medieval central Italy.

Int J Paleopathol 2021 Sep 20;35:40-48. Epub 2021 Sep 20.

Division of Paleopathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 57, 56126, Pisa, Italy. Electronic address:

Objective: This study aims to assess chronic maxillary sinusitis in an osteoarchaeological sample from the medieval rural site of Pieve di Pava (central Italy), to investigate triggers responsible for sinus inflammation, and to compare prevalence rates with coeval European rural sites.

Materials: The analysis focused on 145 10-12-century adults with at least one preserved maxillary sinus.

Methods: Sinusitis-related lesions were observed macroscopically and microscopically. Read More

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September 2021

Is image guidance essential for external ventricular drain insertion?

World Neurosurg 2021 Sep 20. Epub 2021 Sep 20.

Department of Neurosurgery, Queen Elizabeth Hospital Birmingham, Mindlesohn Way, Birmingham, B15 2TH.

Background: This study aimed to compare the EVD placement accuracy and complication rates, between neuronavigation-guided, ultrasound-guided and free-hand techniques in our single centre cohort, and through an additional meta-analysis of the currently available literature.

Methods: A retrospective review of patients who underwent EVD insertion from January 2016 to April 2019 was conducted. Information regarding demographics, indication, Evan's index, use of image guidance, accuracy of catheter tip placement and procedural complications were extracted from electronic records and imaging systems. Read More

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September 2021

Sleep trajectories from early adolescence to emerging adulthood: Evidence from a nine-year population-based study.

J Adolesc 2021 Sep 20;92:177-188. Epub 2021 Sep 20.

National Sun Yat-sen University, Taiwan.

Introduction: Adolescence to emerging adulthood is a developmental period when individuals experience substantial biological changes and social transitions. In East Asian societies, this period is also marked by high pressure around college entrance exams. However, little is known about how young people's sleep changes over time, or how it is impacted by social institutions in the cultural context. Read More

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September 2021

Comparison of the clinical features in open and closed format intensive care units: A systematic review and meta-analysis.

Anaesth Crit Care Pain Med 2021 Sep 20:100950. Epub 2021 Sep 20.

Biotechnology Research Centre, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Applied biomedical Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Importance: The difference in clinical outcomes between closed and open designs of intensive care units (ICUs) is still an open question.

Objective: We conducted a systematic review and meta-analysis to compare total mortality, hospital and ICU length of stay (LOS) and mortality as primary outcomes, and severity of illness based on physiological variables, organ failure assessment, age, duration of mechanical ventilation and ventilator-associated pneumonia frequency as secondary outcomes in closed and open ICUs.

Evidence Review: Medline, PubMed, Scopus, Web of Science, Cochrane database, Iran-doc and Elm-net according to the MeSH terms were searched from 1988 to October 2019. Read More

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September 2021

The ALPACA study: (In)Appropriate LAMA Prescribing in Asthma: a Cohort Analysis.

Pulm Pharmacol Ther 2021 Sep 20:102074. Epub 2021 Sep 20.

Department of Medical Informatics, Erasmus Medical Centre, Rotterdam, Netherlands; Department of Bioanalysis, Ghent University, Ghent, Belgium.

Introduction: Since long-acting muscarinic antagonists (LAMA) are only indicated as add-on therapy in subjects with moderate-to-severe asthma, there are concerns whether LAMA monotherapy is associated with worse asthma control.

Aim: To study the prevalence of LAMA monotherapy and its potential association with severe asthma exacerbations (SAE) in patients with asthma.

Methods: A cohort study (2007-2017) in the IPCI primary care database, in asthma patients aged 6-50, using LAMA during follow-up. Read More

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September 2021

Innovative Bayesian EMAX model with a mixture of normal distributions for dose-response in clinical trials.

Contemp Clin Trials 2021 Sep 20:106571. Epub 2021 Sep 20.

Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS 66160, United States of America. Electronic address:

When a dose-response relationship is monotonic, the EMAX model has been shown to provide a good empirical fit for designing and analyzing dose-response data across a wide range of pharmaceutical studies. However, the EMAX model has never been applied to a finite mixture distribution. Motivated by a proposal investigating DHA dose effect on preterm birth (PTB, <37 weeks gestation) rate, we developed an innovative Bayesian EMAX mixture model incorporating the three normal components finite mixture model into the EMAX framework. Read More

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September 2021

Comparison of the predictive value of ten risk scores for outcomes of atrial fibrillation patients undergoing radiofrequency pulmonary vein isolation.

Int J Cardiol 2021 Sep 20. Epub 2021 Sep 20.

Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands. Electronic address:

Background: A significant number of patients experience recurrent atrial fibrillation (AF) after ablation. Various risk scores have been described that may predict outcomes after AF ablation. In this study, we aimed to compare ten previously described risk scores with regard to their predictive value for post-ablation AF recurrence and procedural complications. Read More

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September 2021

Non-alcoholic fatty liver disease and risk of fatal and non-fatal cardiovascular events: an updated systematic review and meta-analysis.

Lancet Gastroenterol Hepatol 2021 Sep 20. Epub 2021 Sep 20.

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy. Electronic address:

Background: Studies have reported a significant association between non-alcoholic fatty liver disease (NAFLD) and increased incidence of cardiovascular disease (CVD). However, the magnitude of the risk and whether this risk changes with the severity of NAFLD remains uncertain. We performed a meta-analysis of observational studies to quantify the magnitude of the association between NAFLD and risk of incident CVD events. Read More

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September 2021

Outcomes of newly diagnosed acute myeloid leukemia with myelodysplasia related changes and elderly acute myeloid leukemia following decitabine therapy in combination with priming regimen.

Hematology 2021 Dec;26(1):751-757

Department of Hematology, Ningbo First Hospital, Ningbo, Zhejiang, People's Republic of China.

Objectives: This study investigates efficacy of decitabine and priming regimen in treating newly diagnosed acute myeloid leukemia with myelodysplasia related changes (AML-MRC) and elderly AML.

Methods: Totally 69 newly diagnosed AML-MRC and elderly AML treated with decitabine and priming regimen were enrolled. The effects of clinical characteristics, gene mutations and karyotype on remission rate and overall survival were investigated, as well as the effects of allogeneic hematopoietic stem cell transplantation on survival after remission. Read More

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December 2021

Association analysis of B7-H3 and B7-H4 gene single nucleotide polymorphisms in susceptibility to ankylosing spondylitis in eastern Chinese Han population.

Int J Immunogenet 2021 Sep 23. Epub 2021 Sep 23.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.

This study was conducted to describe the association between the genetic variation of the recently identified immune checkpoint molecules B7-H3 and B7-H4, and the susceptibility to ankylosing spondylitis (AS). Two single nucleotide polymorphisms (SNPs) of B7-H3 gene and three SNPs of B7-H4 gene were genotyped in 649 AS patients and 646 age- and sex-matched healthy controls. Allele, genotype frequencies and different inheritance models were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs), and the demographic and clinical parameters of patients were recorded. Read More

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September 2021

Clinical outcomes of patients with and without HIV hospitalized with COVID-19 in England during the early stages of the pandemic: a matched retrospective multi-centre analysis (RECEDE-C19 study).

HIV Med 2021 Sep 23. Epub 2021 Sep 23.

Institute for Global Health, UCL, London, UK.

Background: The contribution of HIV to COVID-19 outcomes in hospitalized inpatients remains unclear. We conducted a multi-centre, retrospective matched cohort study of SARS-CoV-2 PCR-positive hospital inpatients analysed by HIV status.

Methods: HIV-negative patients were matched to people living with HIV (PLWH) admitted from 1 February 2020 to 31 May 2020 up to a 3:1 ratio by the following: hospital site, SARS-CoV-2 test date ± 7 days, age ± 5 years, gender, and index of multiple deprivation decile ± 1. Read More

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September 2021

Reproducibility of Longitudinal Changes in Cortical Thickness Determined by Surface-Based Morphometry Between Non-Accelerated and Accelerated MR Imaging.

J Magn Reson Imaging 2021 Sep 23. Epub 2021 Sep 23.

Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

Background: Scan acceleration such as parallel imaging reduces scan time, but shorter scan time may reduce the signal-to-noise ratio and affect image quality. The reproducibility of longitudinal changes in the brain structure between non-accelerated and accelerated imaging by surface-based analysis is unclear.

Purpose: To determine the reproducibility of longitudinal changes in cortical thickness, measured by surface-based morphometry, between non-accelerated and accelerated structural T -weighted imaging in the healthy elderly and those with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Read More

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September 2021

Resting echocardiographic predictors for true-severe aortic stenosis in patients with low-gradient severe aortic stenosis: A dobutamine stress echocardiography study.

Echocardiography 2021 Sep 23. Epub 2021 Sep 23.

Department of Cardiology, New Tokyo Hospital, Chiba, Japan.

Objective: Dobutamine stress echocardiography (DSE) is not always feasible in patients with low-gradient severe aortic stenosis (LG-SAS), and there are limited data available on the resting echocardiographic predictors for true-severe aortic stenosis (TSAS). This study investigated resting echocardiographic predictors for TSAS.

Methods: Clinical data of 106 LG-SAS patients who underwent DSE were retrospectively analyzed. Read More

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September 2021

School-based physical activity programs for promoting physical activity and fitness in children and adolescents aged 6 to 18.

Cochrane Database Syst Rev 2021 Sep 23;9:CD007651. Epub 2021 Sep 23.

School of Nursing, McMaster University, Hamilton, Canada.

Background: Physical activity among children and adolescents is associated with lower adiposity, improved cardio-metabolic health, and improved fitness. Worldwide, fewer than 30% of children and adolescents meet global physical activity recommendations of at least 60 minutes of moderate to vigorous physical activity per day. Schools may be ideal sites for interventions given that children and adolescents in most parts of the world spend a substantial amount of time in transit to and from school or attending school. Read More

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September 2021

Twenty-four hour blood pressure profile in idiopathic REM sleep behaviour disorder.

Sleep 2021 Sep 23. Epub 2021 Sep 23.

Unit of Sleep Medicine and Epilepsy, IRCCS Mondino Foundation, Pavia, Italy.

Study Objectives: To determine whether autonomic dysfunction in idiopathic REM sleep behaviour disorder (iRBD) affects circadian blood pressure (BP) profile.

Methods: 21 iRBD (mean age 68.8±6. Read More

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September 2021

Comparison of HAS-BLED and ORBIT Bleeding Risk Scores in AF Patients treated with NOACs: A Report from the ESC-EHRA EORP-AF General Long-Term Registry.

Eur Heart J Qual Care Clin Outcomes 2021 Sep 23. Epub 2021 Sep 23.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom.

Introduction: Bleeding risk assessment is recommended in guidelines for the management of atrial fibrillation (AF). HAS-BLED score was proposed prior to non-vitamin K antagonist oral anticoagulants (NOACs) and has been suggested that the ORBIT score may be superior in predicting bleeds in NOAC users. We aimed to compare the HAS-BLED and ORBIT scores in contemporary AF patients treated with NOACs. Read More

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September 2021

Choroidal features in flat irregular pigment epithelial detachment associated with Chronic central serous chorioretinopathy: Avascular versus vascularized.

PLoS One 2021 23;16(9):e0257763. Epub 2021 Sep 23.

Retina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: To investigate the differences in the choroidal biomarkers between two forms of flat irregular pigment epithelial detachment (FIPED): avascular (aFIPED) and vascularized (vFIPED) in eyes with chronic central serous chorioretinopathy (CSC).

Materials And Methods: Enhanced depth imaging optical coherence tomography (EDI-OCT) was done in eyes with FIPED correlated to chronic CSC, fellow eyes, and also in healthy eyes from gender- and age-matched subjects. Eyes with FIPED were classified into two subgroups based on optical coherence tomography angiography (OCTA) findings: vFIPED and aFIPED. Read More

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September 2021

Repurposing FIB-4 index as a predictor of mortality in patients with hematological malignancies and COVID-19.

PLoS One 2021 23;16(9):e0257775. Epub 2021 Sep 23.

COVID-19 Mitigation Research Team, Department of Pulmonology, Dharmais National Cancer Center, Jakarta, Indonesia.

Background: In this study, we aimed to investigate whether FIB-4 index is useful in predicting mortality in patients with concurrent hematological malignancies and COVID-19. We also aimed to determine the optimal cut-off point for the prediction.

Methods: This is a single-center retrospective cohort study conducted in Dharmais National Cancer Hospital, Indonesia. Read More

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September 2021

Risk factors for inadvertent intraoperative hypothermia in patients undergoing laparoscopic surgery: A prospective cohort study.

PLoS One 2021 23;16(9):e0257816. Epub 2021 Sep 23.

Department of Anesthesiology, Ningde Municipal Hospital of Ningde Normal University, Ningde, China.

Background: Inadvertent intraoperative hypothermia is frequent during open surgeries; however, few studies on hypothermia during laparoscopic abdominal surgery have been reported. We aimed to investigate the incidence and risk factors for hypothermia in patients undergoing laparoscopic abdominal surgery.

Methods: This single-center prospective cohort observational study involved patients undergoing laparoscopic surgery between October 2018 and June 2019. Read More

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September 2021

A prospective population-based multicentre study on the impact of maternal body mass index on adverse pregnancy outcomes: Focus on normal weight.

PLoS One 2021 23;16(9):e0257722. Epub 2021 Sep 23.

Department of Obstetrics and Gynaecology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Maternal body mass index (BMI) below or above the reference interval (18.5-24.9 kg/m2) is associated with adverse pregnancy outcomes. Read More

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September 2021

A simpler screening tool for sarcopenia in surgical patients.

PLoS One 2021 23;16(9):e0257672. Epub 2021 Sep 23.

Integrated Perioperative Geriatric Excellent Research Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Sarcopenia is defined as decreased skeletal muscle mass and muscle functions (strength and physical performance). Muscle mass is measured by specific methods, such as bioelectrical impedance analysis and dual-energy X-ray absorptiometry. However, the devices used for these methods are costly and are usually not portable. Read More

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September 2021

Advanced radiotherapy technique in hepatocellular carcinoma with portal vein thrombosis: Feasibility and clinical outcomes.

PLoS One 2021 23;16(9):e0257556. Epub 2021 Sep 23.

Faculty of Medicine, Division of Radiation Oncology, Department of Radiology, Chulalongkorn University, Bangkok, Thailand.

Background: In Thailand, individuals with hepatocellular carcinoma (HCC) who develop portal vein tumor thrombosis (PVTT) have a restricted treatment option because to the extent of the disease, poor underlying liver function, and non-coverage of immuno/targeted therapy. Radiotherapy (RT) plays an increasingly important function in these patients. To investigate the feasibility, efficacy, and adverse event rates, we performed a retrospective analysis of patients with HCC with PVTT who underwent 3-dimensional conformal radiation (3DCRT), intensity-modulated radiation (IMRT), volumetric-modulated radiotherapy (VMAT), and stereotactic body radiotherapy (SBRT) in a single-institution. Read More

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September 2021