9,352,335 results match your criteria analysis

Relationship between dry eye symptoms and quality of life: associations and mediation analysis.

Br J Ophthalmol 2022 Aug 8. Epub 2022 Aug 8.

Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore

Purpose: (1) To determine the independent association of dry eye symptoms with health-related quality of life (HRQoL) in the Singapore population and (2) to further investigate which factors mediate this association.

Methods: In this cross-sectional study, 7707 participants were included. The presence of dry eye symptoms was defined as experiencing at least one out of the six symptoms either 'often' or 'all the time'. Read More

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Use of Ketamine or Xylazine to Provide Balanced Anesthesia with Isoflurane in C57BL/6J Mice.

J Am Assoc Lab Anim Sci 2022 Aug 8. Epub 2022 Aug 8.

University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, Pennsylvania.

Balanced anesthesia—the use of a combination of drugs to achieve a desired anesthetic plane—offers many benefits, including smoother induction and recovery and fewer adverse effects than occur with individual drugs. Although premedication prior to inhalant anesthesia is routine in other species, mice are commonly induced with gas anesthesia alone. The hypothesis of this study was that premedication with ketamine or xylazine would safely reduce the stress of isoflurane induction and lower the minimum alveolar concentration (MAC) of isoflurane. Read More

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The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization.

Life Sci Alliance 2022 Dec 8;5(12). Epub 2022 Aug 8.

Departamento de Biología, Centro FONDAP de Regulación del Genoma, Facultad de Ciencias, Universidad de Chile, Santiago, Chile

Actin filament polymerization can be branched or linear, which depends on the associated regulatory proteins. Competition for actin monomers occurs between proteins that induce branched or linear actin polymerization. Cell specialization requires the regulation of actin filaments to allow the formation of cell type-specific structures, like cuticular hairs in , formed by linear actin filaments. Read More

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December 2022

Dissecting the histological features of lupus nephritis highlights new common patterns of injury in class III/IV.

Ann Rheum Dis 2022 Aug 8. Epub 2022 Aug 8.

Pathology, Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.

Objective: The International Society of Nephrology/Renal Pathology Society classification is the gold standard for the characterisation of lupus nephritis (LN) on renal biopsy, with therapeutic repercussions. Its recent revision simplified the current class subdivisions, eliminating the S/G forms of class IV, although data on a possible pathogenetic/clinical value of this subdivision are still contradictory.

Methods: 353 renal biopsies from Belimumab International Study in LN were assessed through central pathology review. Read More

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Complex genome assembly based on long-read sequencing.

Brief Bioinform 2022 Aug 6. Epub 2022 Aug 6.

College of Information and Computer Engineering, Northeast Forestry University, Harbin, 150040, China.

High-quality genome chromosome-scale sequences provide an important basis for genomics downstream analysis, especially the construction of haplotype-resolved and complete genomes, which plays a key role in genome annotation, mutation detection, evolutionary analysis, gene function research, comparative genomics and other aspects. However, genome-wide short-read sequencing is difficult to produce a complete genome in the face of a complex genome with high duplication and multiple heterozygosity. The emergence of long-read sequencing technology has greatly improved the integrity of complex genome assembly. Read More

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Community-based interventions to prevent stroke in low-income and middle-income countries: a protocol for a systematic review and meta-analysis.

BMJ Open 2022 Aug 8;12(8):e063181. Epub 2022 Aug 8.

Health Systems and Population Studies Division, ICDDRB, Dhaka, Bangladesh

Introduction: Stroke is the second leading cause of death and morbidity across the globe. In low-income and middle-income countries (LMICs), it has become an overwhelming burden over the past few decades. This burden is escalating at a much greater pace compared with that of high-income countries. Read More

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Navigating the river(s) of systems change: a multi-methods, qualitative evaluation exploring the implementation of a systems approach to physical activity in Gloucestershire, England.

BMJ Open 2022 Aug 8;12(8):e063638. Epub 2022 Aug 8.

Centre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK.

Objectives: Systems approaches aim to change the environments in which people live, through cross-sectoral working, by harnessing the complexity of the problem. This paper sought to identify: (1) the strategies which support the implementation of We Can Move (WCM), (2) the barriers to implementation, (3) key contextual factors that influence implementation and (4) impacts associated with WCM.

Design: A multi-methods evaluation of WCM was completed between April 2019 and April 2021. Read More

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Precription Digita Thraputic for atients with nsomnia ( a protocol for a pragmatic randomised controlled trial.

BMJ Open 2022 Aug 8;12(8):e062041. Epub 2022 Aug 8.

Center for Outcomes Research and Evaluation, Yale-New Haven Health, New Haven, Connecticut, USA.

Introduction: Cognitive behavioural therapy for insomnia (CBT-I) is effective at treating chronic insomnia, yet in-person CBT-I can often be challenging to access. Prior studies have used technology to bridge barriers but have been unable to extensively assess the impact of the digital therapeutic on real-world patient experience and multidimensional outcomes. Among patients with insomnia, our aim is to determine the impact of a prescription digital therapeutic (PDT) (PEAR-003b, FDA-authorised as Somryst; herein called PDT) that provides mobile-delivered CBT-I on patient-reported outcomes (PROs) and healthcare utilisation. Read More

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Educational inequalities in adult mortality: a systematic review and meta-analysis of the Asia Pacific region.

BMJ Open 2022 Aug 8;12(8):e059042. Epub 2022 Aug 8.

Centre for Global Health Inequalities Research, Department of Sociology and Political Science, Norwegian University of Science and Technology, Trondheim, Norway.

Objectives: In this study, we aim to analyse the relationship between educational attainment and all-cause mortality of adults in the high-income Asia Pacific region.

Design: This study is a comprehensive systematic review and meta-analysis with no language restrictions on searches. Included articles were assessed for study quality and risk of bias using the Joanna Briggs Institute critical appraisal checklists. Read More

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Type 2 diabetes and hypertension in Vietnam: a systematic review and meta-analysis of studies between 2000 and 2020.

BMJ Open 2022 Aug 8;12(8):e052725. Epub 2022 Aug 8.

Institute for Social Science Research, The University of Queensland, Brisbane, Queensland, Australia.

Objectives: The objective of this study was to determine the level of type 2 diabetes (T2DM) and hypertension (HTN) in Vietnam and to assess the trend and recommend the future direction of prevention research efforts.

Design: We searched scientific literature, databases including PubMed, EMBASE, CINHAL and Google Scholar; grey literature and reference lists for primary research published, nation database websites between 1 January 2000 and 30 September 2020. We adapted the modified Newcastle Ottawa Scale for assessing the quality of the study, as recommended by the Cochrane Collaboration. Read More

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Clinical presentation in EMS patients with acute chest pain in relation to sex, age and medical history: prospective cohort study.

BMJ Open 2022 Aug 8;12(8):e054622. Epub 2022 Aug 8.

Institute of Health and Care Sciences, University of Gothenburg, Goteborg, Sweden.

Objective: To assess symptom presentation related to age, sex and previous medical history in patients with chest pain.

Design: Prospective observational cohort study.

Setting: Two-centre study in a Swedish county emergency medical service (EMS) organisation. Read More

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PREPARE trial: a protocol for a multicentre randomised trial of frailty-focused preoperative exercise to decrease postoperative complication rates and disability scores.

BMJ Open 2022 Aug 8;12(8):e064165. Epub 2022 Aug 8.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Introduction: Frailty is a strong predictor of adverse postoperative outcomes. Prehabilitation may improve outcomes after surgery for older people with frailty by addressing physical and physiologic deficits. The objective of this trial is to evaluate the efficacy of home-based multimodal prehabilitation in decreasing patient-reported disability and postoperative complications in older people with frailty having major surgery. Read More

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Reporting and transparent research practices in sports medicine and orthopaedic clinical trials: a meta-research study.

BMJ Open 2022 Aug 8;12(8):e059347. Epub 2022 Aug 8.

BIH QUEST Center for Responsible Research, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany

Objectives: Transparent reporting of clinical trials is essential to assess the risk of bias and translate research findings into clinical practice. While existing studies have shown that deficiencies are common, detailed empirical and field-specific data are scarce. Therefore, this study aimed to examine current clinical trial reporting and transparent research practices in sports medicine and orthopaedics. Read More

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Use of a penicillin allergy clinical decision rule to enable direct oral penicillin provocation: an international multicentre randomised control trial in an adult population (PALACE): study protocol.

BMJ Open 2022 Aug 8;12(8):e063784. Epub 2022 Aug 8.

Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.

Introduction: Penicillin allergies are highly prevalent in the healthcare setting and associated with the prescription of second-line inferior antibiotics. More than 85% of all penicillin allergy labels can be removed by skin testing and 96%-99% of low-risk penicillin allergy labels can be removed by direct oral challenge. An internally and externally validated clinical assessment tool for penicillin allergy, PEN-FAST, can identify a low-risk penicillin allergy without the need for skin testing; a score of less than 3 has a negative predictive value of 96. Read More

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Long-term outcomes following antenatal exposure to low-dose aspirin: study protocol for the 4-year follow-up of the APRIL randomised controlled trial.

BMJ Open 2022 Aug 8;12(8):e060632. Epub 2022 Aug 8.

Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Obstetrics and Gynaecology, De Boelelaan 1117, Amsterdam, The Netherlands.

Introduction: The use of low-dose aspirin by pregnant women to prevent preterm pre-eclampsia is gradually increasing. The administration of aspirin during pregnancy improves perinatal outcome, which could translate into improved child outcome in the long term. However, antenatal exposure to aspirin could have adverse effects on child development that may manifest later in life. Read More

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Experiences of patients with multimorbidity with primary care and the association with patient activation: a cross-sectional study in Germany.

BMJ Open 2022 Aug 8;12(8):e059100. Epub 2022 Aug 8.

Department of General Practice and Health Services Research, University Hospital Heidelberg, Heidelberg, Germany.

Objectives: This study aimed to explore the association between patient activation and patients' experience of care among an elderly multimorbid population in Germany.

Design: Cross-sectional study.

Setting: Primary care practices in two German settings. Read More

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Percentage of Age-Predicted Cardiorespiratory Fitness May Be a Stronger Risk Indicator for Incident Type 2 Diabetes Than Absolute Levels of Cardiorespiratory Fitness.

J Cardiopulm Rehabil Prev 2022 Aug 4. Epub 2022 Aug 4.

National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, Bristol, and Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Learning & Research Building (Level 1), Southmead Hospital, Bristol, England (Dr Kunutsor); Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, England (Drs Kunutsor and Seidu); Leon H. Charney Division of Cardiology, New York University Langone Health, New York (Dr Khan); Department of Medicine, Central Finland Health Care District Hospital District, Jyväskylä, Finland District, Jyväskylä, and Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, and Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, Finland (Dr Laukkanen).

Purpose: There are inverse and independent associations between cardiorespiratory fitness (CRF) and several adverse cardiometabolic outcomes. The percentage of age-predicted CRF (%age-predicted CRF) is comparable to absolute CRF as a risk indicator for some of these outcomes, but the association between %age-predicted CRF and risk of type 2 diabetes (T2D) has not been previously investigated. We aimed to assess the association between %age-predicted CRF and T2D in a prospective cohort study. Read More

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Safety, tolerability and efficacy of agonist anti-CD27 antibody (varlilumab) administered in combination with anti-PD-1 (nivolumab) in advanced solid tumors.

J Immunother Cancer 2022 Aug;10(8)

R & D, Celldex Therapeutics Inc, Hampton, New Jersey, USA.

Background: Phase 1/2 dose-escalation and expansion study evaluating varlilumab, a fully human agonist anti-CD27 mAb, with nivolumab in anti-PD-1/L1 naïve, refractory solid tumors.

Methods: Phase 1 evaluated the safety of varlilumab (0.1-10 mg/kg) with nivolumab (3 mg/kg) administered once every 2 weeks. Read More

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Untargeted metabolomics analysis reveals improved phenolic profile in whole wheat bread with yerba mate and the effects of the bread-making process.

Food Res Int 2022 Sep 8;159:111635. Epub 2022 Jul 8.

Department of Food Science and Technology, Federal University of Santa Catarina, Rodovia Admar Gonzaga 1346, 88034-000, Florianópolis, SC, Brazil. Electronic address:

Untargeted metabolomics analysis was applied to evaluate the phenolic profile of whole wheat bread with yerba mate (YM) during the bread-making process (flour, dough and bread). The free, bound and total phenolic contents of the samples evaluated by the Folin-Ciocalteu method showed the highest values for the flour, dough and bread samples prepared with 4.5% YM in fine and medium particle sizes (flour 181. Read More

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September 2022

Modelling and experimental analysis of rice drying in new fluidized bed assisted hybrid infrared-microwave dryer.

Food Res Int 2022 Sep 5;159:111617. Epub 2022 Jul 5.

Scientific member of Rice Research Institute of Iran, Mazandaran branch, Agricultural Research, Education and Extension Organization (AREEO), Iran.

This study aimed to investigate how infrared (1000-2000 W) and microwave power (100-900 W), air velocity (1-5 m/s) and temperature (40-80 °C) affected the specific energy consumption, the moisture removal rate, and the product's quality (whiteness index, head rice yield, water uptake ratio, and elongation ratio) in hybrid dryer. Rising temperature, velocity and microwave power and lower temperatures resulted in improving head rice yield of paddy samples. The experiments proved that the new hybrid system significantly increased the moisture removal rate (from 100 to 700%), head rice yield (from 5 to 40 %) and decreased the specific energy consumption (from 10 to 80%) compared to the single fluidized bed dryer. Read More

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September 2022

How cereal flours, starters, enzymes, and process parameters affect the in vitro digestibility of sourdough bread.

Food Res Int 2022 Sep 2;159:111614. Epub 2022 Jul 2.

Department of Environmental Biology, "Sapienza" University of Rome, 00185 Rome, Italy.

Digestibility of leavened baked goods relies on multiple factors: starch bioavailability and protein hydrolysis during food processing and digestion, presence of antinutritional factors, and satiety and gastrointestinal symptoms after intake. Several studies highlighted that bread digestibility might be positively affected by long-time sourdough fermentation. Nevertheless, most research is focused on single factors and their effect on digestibility, excluding the potential complementary effects of more than one factor. Read More

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September 2022

Integration of multiplatform metabolomics and multivariate analysis for geographical origin discrimination of Panax ginseng.

Food Res Int 2022 Sep 1;159:111610. Epub 2022 Jul 1.

Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong 27709, Republic of Korea. Electronic address:

As the health food industry grows, the market for ginseng also expands globally. Korean ginseng (Panax ginseng C. A. Read More

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September 2022

Major lipophilic pigments in Atlantic seaweeds as valuable food ingredients: Analysis and assessment of quantification methods.

Food Res Int 2022 Sep 8;159:111609. Epub 2022 Jul 8.

IRTA-Food Safety and Functionality Programme. Finca Camps i Armet s/n, 17121 Monells, Girona, Spain. Electronic address:

Current trends towards the use of ingredients from natural origin in food, cosmetic and pharmaceutical industry, place macroalgae as a good reservoir of novel compounds. Among them, lipophilic major pigments such as chlorophylls and fucoxanthin, are of great interest because of their multiple applications as bioactive compounds and dyes. In this work, a mid-polarity medium was used to extract pigments from twenty-four species from North coast of Spain, including brown (Phaeophyceae) and red macroalgae (Rhodophyta). Read More

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September 2022

Changes of bacterial microbiota and volatile flavor compounds in ewe milk during dielectric barrier discharge cold plasma processing.

Food Res Int 2022 Sep 3;159:111607. Epub 2022 Jul 3.

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China. Electronic address:

Dielectric barrier discharge cold plasma (DBD-CP) processing can be considered as a potential alternative to conventional pasteurization in ewe milk, which has previously been shown. However, residual microorganisms in ewe milk during DBD-CP processing have not yet been evaluated. This study investigated the microbiota present in ewe milk that was cold plasma-treated. Read More

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September 2022

Transcriptome analysis revealed the role of capsular polysaccharides in desiccation tolerance of foodborne Staphylococcus aureus.

Food Res Int 2022 Sep 30;159:111602. Epub 2022 Jun 30.

School of Life Sciences, Anhui Agricultural University, Hefei, Anhui 230036, China; Food Procession Research Institude, Anhui Agricultural University, Hefei, Anhui 230036, China. Electronic address:

Staphylococcus aureus (S. aureus) is a momentous factor affecting food safety. It can survive under long-term desiccation stress and contaminate foods that have intermediate to low water activities. Read More

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September 2022

Identification, structure, and caseinolytic properties of milk-clotting proteases from Moringa oleifera flowers.

Food Res Int 2022 Sep 30;159:111598. Epub 2022 Jun 30.

College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, Yunnan, China; Yunnan Engineering Technology Research Center for Processing of Livestock Products, Kunming 650201, Yunnan, China. Electronic address:

The protein extract of Moringa oleifera flowers is reported to have milk-clotting activity (MCA), but information regarding its protease is unclear. In this study, two milk-clotting proteases (MoFP 12 and MoFP 13) with molecular weights of 42.304 kDa and 31. Read More

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September 2022

Flavor of fava bean (Vicia faba L.) ingredients: Effect of processing and application conditions on odor-perception and headspace volatile chemistry.

Food Res Int 2022 Sep 28;159:111582. Epub 2022 Jun 28.

Université Paris-Saclay, INRAE, AgroParisTech, UMR SayFood, Massy, France.

Application of plant-based sources for food, e.g. fava bean, is challenged by consumer acceptance. Read More

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September 2022

The impact of indigenous Saccharomyces cerevisiae and Schizosaccharomyces japonicus on typicality of crystal grape (Niagara) wine.

Food Res Int 2022 Sep 27;159:111580. Epub 2022 Jun 27.

Province Key Laboratory of Fermentation Engineering and Biopharmacy, School of Liquor and Food Engineering, Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Guizhou University, Guiyang 550025, China. Electronic address:

Schizosaccharomyces japonicus have been found as dominant yeast species coexisting with Saccharomyces cerevisiae during late stages of spontaneous fermentation of local grapes in Guizhou, China. Therefore, this study further investigated the impacts of the two indigenous yeast species on typicality of crystal grape (Niagara) wine. Five indigenous and one commercial S. Read More

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September 2022

Effects of modernized fermentation on the microbial community succession and ethyl lactate metabolism in Chinese baijiu fermentation.

Food Res Int 2022 Sep 25;159:111566. Epub 2022 Jun 25.

Department of Agriculture, Forestry and Food Engineering, Yibin University, Yibin, Sichuan 644000, China. Electronic address:

Modernized mechanization and intelligent transformation are the trends of Chinese baijiu industry development. However, these changes affect the operational environment, which lead to the decreased metabolism of esters during baijiu fermentation, especially for ethyl lactate. Ethyl lactate is an important flavor compound in most types of baijiu, which is mainly produced by esterification of lactic acid and ethanol. Read More

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September 2022

Dynamic succession of microbial community in Nongxiangxing daqu and microbial roles involved in flavor formation.

Food Res Int 2022 Sep 24;159:111559. Epub 2022 Jun 24.

College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China; Key Laboratory of Leather Chemistry and Engineering, Ministry of Education, Sichuan University, Chengdu 610065, China. Electronic address:

Daqu, the fermentation starter of Chinese baijiu, is produced by barley and/or peas during open fermentation using natural inoculation. However, the succession of microbial communities and their roles during daqu manufacture remain unclear, which are closely related to the flavor and quality of baijiu. In this study, the dynamics of physicochemical properties, microbial communities, and volatile compounds were investigated at both fermentation (FM) and storage (ST) stages during the manufacture of Nongxiangxing daqu. Read More

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September 2022