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Quantifying effects of reverse linear perspective as a visual cue on vehicle and platoon crash risk variations in car-following using path analysis.

Accid Anal Prev 2021 Jun 12;159:106215. Epub 2021 Jun 12.

School of Civil Engineering and Architecture, Wuhan Institute of Technology, Wuhan, 430205, China. Electronic address:

Road markings are prevalent in practice as perceptual countermeasures to crashes, and a great deal of them have been used for speed reduction. However, there is rare seen any equivalent measures especially for distance control. More importantly, the visual perceptual mechanism of road markings on driving behaviors and crash risk is still blur. Read More

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Personality disorders as predictors of intimate partner violence: A meta-analysis.

Clin Psychol Rev 2021 May 28;88:102047. Epub 2021 May 28.

Purdue University, United States of America.

Despite years of research demonstrating a relation between personality pathology and intimate partner violence (IPV), no meta-analysis has been published examining how well, or poorly, all ten personality disorders (PDs) predict IPV perpetration or victimization, nor has any meta-analysis examined these relations across types of IPV. Therefore, the present study was undertaken to synthesize existing research on the effects of all ten PDs, as well as psychopathy and global PD symptoms, on physical, psychological, and sexual IPV perpetration and victimization. An initial search in PsycINFO, PubMed, and Sociological Abstracts yielded 3988 results. Read More

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Maternal gestational mercury exposure in relation to cord blood T cell alterations and placental gene expression signatures.

Environ Res 2021 Jun 12:111385. Epub 2021 Jun 12.

Department of Epidemiology, Geisel School of Medicine and the Children's Environmental Health and Disease Prevention Research Center at Dartmouth; Hanover, NH, USA.

The immunotoxic impacts of mercury during early life is poorly understood. We investigated the associations between gestational mercury exposure and frequency of cord blood T cells as well as placental gene expression. Frequency of natural Treg cells was positively associated with prenatal and postpartum mercury toenail concentrations. Read More

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Assessing the Viability of American Horseshoe Crab () Embryos in Salt Marsh and Sandy Beach Habitats.

Biol Bull 2021 Jun 26;240(3):145-156. Epub 2021 Apr 26.

AbstractFor animal embryos that develop externally, the physio-chemical environment can substantially affect offspring viability. In the case of the American horseshoe crab (), sediment conditions along estuarine shorelines influence development rates and embryonic viability. Sandy beach habitats are considered to have optimal conditions for horseshoe crab embryonic development; however, spawning is often observed outside of these optimal habitats, in areas such as salt marshes, where reduced oxygen availability is thought to decrease the viability of eggs laid in these sediments. Read More

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An autopsy case of corticobasal syndrome with pure diffuse Lewy Body Disease.

Neurocase 2021 Jun 15:1-7. Epub 2021 Jun 15.

Department of Neurology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan.

Corticobasal syndrome (CBS) is associated with diverse pathological substrates such as tau, prion protein, transactive response and, rarely, alpha synuclein. We report the case of a54-year-old man, who presented with asymmetric levodopa-poor-responsive parkinsonism, frontal lobe signs and behavioral changes. He was diagnosed with CBS, and postmortem analyses revealed Lewy body disease Braak stage VI without comorbid pathologies. Read More

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Effect of vitamin D supplementation on benign paroxysmal positional vertigo recurrence: A meta-analysis.

Sci Prog 2021 Apr-Jun;104(2):368504211024569

Department of Neurosurgery, The First Hospital of Lanzhou University, Lanzhou, China.

Benign paroxysmal positional vertigo is characterized by recurrence, which exposes patients to repeated vertigo attacks. Vitamin D deficiency has been found to be a risk factor in benign paroxysmal positional vertigo, although effect of its elimination on recurrence reduction remains unknown. To determine the effect of vitamin D supplementation in preventing recurrence of benign paroxysmal positional vertigo patients with vitamin D deficiency using a meta-analysis study. Read More

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Beliefs About Morphine in Palliative Care: Results From an Ecuadorian Sample.

J Palliat Care 2021 Jun 15:8258597211026398. Epub 2021 Jun 15.

School of Psychology, Universidad de Las Américas, Quito, Ecuador.

Background: Previous research unambiguously establishes the importance of knowledge and education about opioids and pain management in medical care. This article aimed at describing the perception of the general public on the uses and the risks of morphine in palliative care in an Ecuadorian sample, where training and access to those services is limited.

Methods: We used an online recruited sample of 257 participants for this cross-sectional descriptive study. Read More

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Sleep timing and consistency are associated with the standardised test performance of Icelandic adolescents.

J Sleep Res 2021 Jun 14:e13422. Epub 2021 Jun 14.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.

Sleep has been shown to affect cognitive function in laboratory studies; however, its association to the academic performance of adolescents has largely been demonstrated using self-reported measures. Studies with objective measures of both sleep and academic performance are limited. The aim of the present study was to determine whether the free-living sleep quantity, quality, and timing of 15-year-old adolescents measured with wrist actiography are associated with their scores on national standardised examinations as an objective measure of academic achievement. Read More

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Rhizosphere Bacterial Networks, but Not Diversity, Are Impacted by Pea-Wheat Intercropping.

Front Microbiol 2021 28;12:674556. Epub 2021 May 28.

Agroécologie, AgroSup Dijon, INRAE, Université de Bourgogne - Université de Bourgogne Franche-Comté, Dijon, France.

Plant-plant associations, notably cereal-legume intercropping, have been proposed in agroecology to better value resources and thus reduce the use of chemical inputs in agriculture. Wheat-pea intercropping allows to decreasing the use of nitrogen fertilization through ecological processes such as niche complementarity and facilitation. Rhizosphere microbial communities may account for these processes, since they play a major role in biogeochemical cycles and impact plant nutrition. Read More

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Investigating the drivers of the spatio-temporal heterogeneity in COVID-19 hospital incidence-Belgium as a study case.

Int J Health Geogr 2021 06 14;20(1):29. Epub 2021 Jun 14.

Spatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, 50 av. FD Roosevelt, 1050, CP160/12, Bruxelles, Belgium.

Background: The COVID-19 pandemic is affecting nations globally, but with an impact exhibiting significant spatial and temporal variation at the sub-national level. Identifying and disentangling the drivers of resulting hospitalisation incidence at the local scale is key to predict, mitigate and manage epidemic surges, but also to develop targeted measures. However, this type of analysis is often not possible because of the lack of spatially-explicit health data and spatial uncertainties associated with infection. Read More

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Open-circuit-voltage shift of over 0.5 V in organic photovoltaic cells induced by a minor structural difference in alkyl substituents.

Chem Sci 2020 Jan 13;11(7):1825-1831. Epub 2020 Jan 13.

Division of Materials Science, Nara Institute of Science and Technology (NAIST) 8916-5 Takayama-cho Ikoma Nara 630-0192 Japan

The recent surge in the efficiency of organic photovoltaic devices (OPVs) largely hinges on the reduction of energy loss () that leads to improvements in open-circuit voltage (). However, there are still many unclarified factors regarding the relationship between the molecular structure and , hampering the establishment of widely applicable, effective principles for the design of active-layer materials. In this contribution, we examine the origin of the large shifts induced by minor structural differences in end-alkyl substituents on a series of anthracene-based p-type compounds. Read More

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January 2020

Effects of coastal acidification on North Atlantic bivalves: interpreting laboratory responses in the context of populations.

Mar Ecol Prog Ser 2020 Jan;633:89-104

School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, NY 11794.

Experimental exposure of early life stage bivalves has documented negative effects of elevated CO on survival and growth, but the population consequences of these effects are unknown. Following standard practices from population viability analysis and wildlife risk assessment, we substituted laboratory-derived stress-response relationships into baseline population models of and . The models were constructed using inverse demographic analyses with time series of size-structured field data in NY, USA, whereas the stress-response relationships were developed using data from a series of previously published laboratory studies. Read More

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January 2020

Intravitreal anti-VEGF use in France: a cross-sectional and longitudinal Nationwide observational study.

Acta Ophthalmol 2021 Jun 14. Epub 2021 Jun 14.

EPI-PHARE (French National Agency for Medicines and Health Products Safety (ANSM) and French National Health Insurance (CNAM)), Saint-Denis, France.

Purpose: To describe the sociodemographic, medical and management characteristics of patients using intravitreal (IVT) anti-vascular endothelial growth factors (VEGF) in France.

Methods: An observational study was conducted in patients treated with IVT ranibizumab or aflibercept, aged 18 years or older using the French National Health Insurance Databases covering 99% of the French population. Patients currently treated in 2018 were included in a cross-sectional approach to describe treatment history over the previous 6 years. Read More

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Neural and biomechanical tradeoffs associated with human-exoskeleton interactions.

Appl Ergon 2021 Jun 11;96:103494. Epub 2021 Jun 11.

Department of Integrated Systems Engineering, The Ohio State University, Columbus, OH, 43210, USA; Spine Research Institute, The Ohio State University, Columbus, OH, 43210, USA.

Industrial passive low-back exoskeletons have gained recent attention as ergonomic interventions to manual handling tasks. This research utilized a two-armed experimental approach (single vs dual-task paradigms) to quantify neural and biomechanical tradeoffs associated with short-term human-exoskeleton interaction (HEI) during asymmetrical lifting in twelve healthy adults balanced by gender. A dynamic, electromyography-assisted spine model was employed that indicated statistical, but marginal, biomechanical benefits of the tested exoskeleton, which diminished with the introduction of the cognitive dual-task. Read More

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Chemical interaction between 10-methacryloyloxydecyl dihydrogen phosphate and methacryloxypropyltrimethoxysilane in one-bottle dental primer and its effect on dentine bonding.

J Mech Behav Biomed Mater 2021 Jun 1;121:104610. Epub 2021 Jun 1.

Jiangsu Key Laboratory of Oral Diseases, Department of Prosthodontics, Affiliated Hospital of Stomatology, Nanjing Medical University, Jiangsu Province Key Laboratory of Oral Diseases, Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing, PR China.

In the present study, we investigated the chemical interaction between 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) and methacryloxypropyltrimethoxysilane (gamma-MPS) in one-bottle primer solutions and its effect on dentine bonding performance. Solutions containing 10 wt% 10-MDP and/or gamma-MPS at 0, 1, 5, 10, or 15 wt% were prepared, providing 10 experimental groups (labeled MDP/MPSxx or MPSxx, where MDP indicates the presence of 10 wt% MDP and xx is the wt% of gamma-MPS in the solution). Phosphoric-acid-etched dentine blocks were prepared from human molars and conditioned in the solutions before being used to build resin-dentine-bonded specimens, which were subsequently subjected to microtensile bond strength (μTBS) testing after 24-h or six-months water storage. Read More

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Abnormality of subcortical volume and resting functional connectivity in adolescents with early-onset and prodromal schizophrenia.

J Psychiatr Res 2021 Jun 4;140:282-288. Epub 2021 Jun 4.

Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China; Department of Mental Health, Shanxi Medical University, Taiyuan, China. Electronic address:

Objective: Studies have found that there may be qualitative changes in brain structure and function in adolescents with early-onset schizophrenia (EOS) and prodromal schizophrenia (PDS). However, the abnormal brain structure and function of adolescents with EOS and PDS have received little attention, and their underlying neural mechanisms are still unknown.

Methods: In this study, structural and resting-state functional magnetic resonance imaging (fMRI) were used to compare the subcortical volume and functional connectivity (FC) among EOS, PDS, and a control group. Read More

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Effective connectivity in brain networks estimated using EEG signals is altered in children with ADHD.

Comput Biol Med 2021 Jun 1;134:104515. Epub 2021 Jun 1.

Institute of Bioengineering, Center for Neuroprosthetics, Center for Biomedical Imaging, EPFL, Lausanne, Switzerland; Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland.

This study presents a methodology developed for estimating effective connectivity in brain networks (BNs) using multichannel scalp EEG recordings. The methodology uses transfer entropy as an information transfer measure to detect pair-wise directed information transfer between EEG signals within δ, θ, α, β and γ-bands. The developed methodology is then used to study the properties of directed BNs in children with attention-deficit hyperactivity disorder (ADHD) and compare them with that of the healthy controls using both statistical and receiver operating characteristic (ROC) analyses. Read More

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Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.

Am J Clin Dermatol 2021 Jun 14. Epub 2021 Jun 14.

Department of Dermatology and Allergology, Paracelsus Medical University, Salzburg, Austria.

Ten percent of all women have pigmented vulvar lesions. Fortunately, most of these are benign but 1% of all melanomas in women affect the vulva. While the mortality rate of cutaneous melanoma has dropped by 7% annually during the last 5 years, the prognosis of vulvar melanoma remains dismal: the 5-year overall survival rate is 47% compared with 92% for cutaneous melanoma. Read More

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Morphological mechanism allowing a parasitic leech, Ozobranchus jantseanus (Rhynchobdellida: Ozobranchidae), to survive in ultra-low temperatures.

Biol Open 2021 Jun 14. Epub 2021 Jun 14.

Provincial Key Lab of the Conservation and Exploitation Research of Biological Resources in Anhui, Life Science College of Anhui Normal University, Wuhu, Anhui, 241000, PRC.

Ozobranchus jantseanus is the largest metazoan known to survive in liquid nitrogen without pretreatment to date, however, the mechanism underlying this tolerance remains unclear. In this study, the first analyses of histological and morphological changes in normal, frozen, and dehydrated states were performed. Adults survived after direct placement in liquid nitrogen for 96 h, with a survival rate of approximately 86. Read More

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Who Is ? Genetic Structure of Populations and Critical Synthesis of the Current Knowledge.

Front Vet Sci 2021 28;8:650546. Epub 2021 May 28.

Norwegian Veterinary Institute, Ås, Norway.

Despite the economic and animal welfare importance of the Poultry Red Mite , its genetic structure has been studied in a scattered way so far. The prophylaxis and control of such a globally distributed ectoparasite can be significantly improved by understanding its genetic population structure (composition in species and intraspecific variants). The present study aims to establish a rigorous framework for characterizing the neutral genetic structure of based on a literature review combined with an integrative analysis of the data available in GenBank on population-level nucleotide sequence diversity supplemented by a new dataset. Read More

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Aortic Valve Sclerosis as an Important Predictor of Long-Term Mortality in Patients With Carotid Atheromatous Plaque Requiring Carotid Endarterectomy.

Front Cardiovasc Med 2021 28;8:653991. Epub 2021 May 28.

Unità per lo Studio delle Patologie Aortiche, Valvolari e Coronariche, Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.

A strong association between aortic valve sclerosis (AVSc), the earliest manifestation of calcific aortic valve disease, and atherosclerosis exists. The aim of the study was to evaluate the predictive capabilities of AVSc on long-term all-cause mortality, in patients requiring carotid endarterectomy (CEA). 806 consecutive CEA patients were enrolled. Read More

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Transcriptome and N6-Methyladenosine RNA Methylome Analyses in Aortic Dissection and Normal Human Aorta.

Front Cardiovasc Med 2021 28;8:627380. Epub 2021 May 28.

Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

To investigate the N6-methyladenosine (m6A) modification and the expressions of the m6A regulatory genes in the acute aortic dissection (AD). MeRIP-seq and RNA-seq experiments of aortic media tissue samples obtained from AD ( = 4) and Controls ( = 4) were conducted. m6A methylation quantification was used to measure the total mRNA m6A level. Read More

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Pandemics and Income Inequality: What Do the Data Tell for the Globalization Era?

Front Public Health 2021 28;9:674729. Epub 2021 May 28.

HeXie Management Research Centre, Xi'an Jiaotong-Liverpool University, Suzhou, China.

This paper empirically investigates the effects of pandemics uncertainty on income inequality We consider a new measure of pandemics uncertainty, the World Pandemic Discussion Index (WPDI), and the post-tax (net) Gini coefficient We focus on the panel data of 141 countries from 1996 to 2020. The results from the Feasible General Least Squares estimations indicate that the WPDI is negatively related to income inequality in 107 non-OECD countries. However, the WPDI is positively associated with income inequality in 34 OECD economies. Read More

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Screening of Chorioamnionitis Using Volatile Organic Compound Detection in Exhaled Breath: A Pre-clinical Proof of Concept Study.

Front Pediatr 2021 26;9:617906. Epub 2021 May 26.

Department of Pediatrics, Maastricht University Medical Center+, Maastricht, Netherlands.

Chorioamnionitis is a major risk factor for preterm birth and an independent risk factor for postnatal morbidity for which currently successful therapies are lacking. Emerging evidence indicates that the timing and duration of intra-amniotic infections are crucial determinants for the stage of developmental injury at birth. Insight into the dynamical changes of organ injury after the onset of chorioamnionitis revealed novel therapeutic windows of opportunity. Read More

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Community concern and government response: Identifying socio-economic and demographic predictors of oil and gas complaints and drinking water impairments in Pennsylvania.

Energy Res Soc Sci 2021 Jun 24;76. Epub 2021 Apr 24.

Department of Environmental Health Sciences, Yale School of Public Health, 60 College Street, New Haven CT, 06510, United States.

Oil and gas development has led to environmental hazards and community concerns, particularly in relation to water supply issues. Filing complaints with state agencies enables citizens to register concerns and seek investigations. We evaluated associations between county-level socio-economic and demographic factors, oil and gas drilling, and three outcomes in Pennsylvania between 2004-2016: number of oil and gas complaints filed, and both the number and proportion of state investigations of water supply complaints yielding a confirmed water supply impairment (i. Read More

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The economic burden of COVID-19 in the United States: Estimates and projections under an infection-based herd immunity approach.

J Econ Ageing 2021 May 29:100328. Epub 2021 May 29.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Objectives: To assess the economic burden of COVID-19 that would arise absent behavioral or policy responses under the herd immunity approach in the United States and compare it to total burden that also accounts for estimates of the value of lives lost.

Methods: We use the trajectories of age-specific human and physical capital in the production process to calculate output changes based on a human capital-augmented production function. We also calculate the total burden that results when including the value of lives lost as calculated from mortality rates of COVID-19 and estimates for the value of a statistical life in the United States based on studies assessing individual's willingness to avoid risks. Read More

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Using measured resting metabolic rate to derive calorie prescriptions in a behavioral weight loss program.

Obes Sci Pract 2021 Jun 9;7(3):335-338. Epub 2021 Mar 9.

Department of Health Behavior and Policy Virginia Commonwealth University School of Medicine Richmond Virginia USA.

Objective: Within behavioral weight loss (BWL) programs, using measured resting metabolic rate (RMR) is a more accurate-yet costlier-alternative to the standard method of assigning calorie prescriptions using baseline weight. This investigation aimed to assess differences between calorie goals prescribed using each method including demographic predictors and associations with weight loss.

Methods: This is an ancillary study to a trial comparing approaches to motivational enhancement in a 6-months BWL program designed for emerging adults age 18-25 ( = 308). Read More

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Genome-Wide Association Studies Reveal Susceptibility Loci for Noninfectious Claw Lesions in Holstein Dairy Cattle.

Front Genet 2021 28;12:657375. Epub 2021 May 28.

Animal Science Department, University of California, Davis, Davis, CA, United States.

Sole ulcers (SUs) and white line disease (WLD) are two common noninfectious claw lesions (NICL) that arise due to a compromised horn production and are frequent causes of lameness in dairy cattle, imposing welfare and profitability concerns. Low to moderate heritability estimates of SU and WLD susceptibility indicate that genetic selection could reduce their prevalence. To identify the susceptibility loci for SU, WLD, SU and/or WLD, and any type of noninfectious claw lesion, genome-wide association studies (GWAS) were performed using generalized linear mixed model (GLMM) regression, chunk-based association testing (CBAT), and a random forest (RF) approach. Read More

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Cannabis Use and Car Crashes: A Review.

Front Psychiatry 2021 28;12:643315. Epub 2021 May 28.

Clinic and Polyclinic for Psychiatry and Psychotherapy, Clinic of the Ludwig-Maximilian-University Munich, Munich, Germany.

In this review, state-of-the-art evidence on the relationship between cannabis use, traffic crash risks, and driving safety were analyzed. Systematic reviews, meta-analyses, and other relevant papers published within the last decade were systematically searched and synthesized. Findings show that meta-analyses and culpability studies consistently indicate a slightly but significantly increased risk of crashes after acute cannabis use. Read More

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