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Surgical outcomes of different approaches in robotic assisted thyroidectomy for thyroid cancer: A systematic review and Bayesian network meta-analysis.

Int J Surg 2021 Apr 14:105941. Epub 2021 Apr 14.

Center of Thyroid & Parathyroid Surgery, West China Hospital, Sichuan University, PR China. Electronic address:

Background: The aim of the study was to assess the feasibility, safety, and potential benefits of four approaches of robotic assisted thyroidectomy (RT). The approaches mentioned above are also compared with traditional open thyroidectomy (OPEN).

Materials And Methods: Medline, Embase, Cochrane library (CENTRAL) and Web of Science databases were searched up to 13 Dec, 2019. Read More

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Right ventricular lead location and outcomes among patients with cardiac resynchronization therapy: A meta-analysis.

Prog Cardiovasc Dis 2021 Apr 14. Epub 2021 Apr 14.

Division of Cardiology, Duke University Medical Center, Durham, NC 27710, United States of America; Duke Clinical Research Institute, Durham, NC 27710, United States of America.

Background: Cardiac resynchronization therapy (CRT) has been demonstrated to improve heart failure (HF) symptoms, reverse LV remodeling, and reduce mortality and HF hospitalization (HFH) in patients with a reduced left ventricular (LV) ejection fraction (LVEF). Prior studies examining outcomes based on right ventricular (RV) lead position among CRT patients have provided mixed results. We performed a systematic review and meta-analysis of randomized controlled trials and prospective observational studies comparing RV apical (RVA) and non-apical (RVNA) lead position in CRT. Read More

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Combined Anterolateral and Anterior Cruciate Ligament Reconstruction Improves Pivot Shift Compared to Isolated Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Arthroscopy 2021 Apr 14. Epub 2021 Apr 14.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA.

Purpose: The purpose of the current study was to perform a systematic review and meta-analysis of the literature on anterolateral ligament (ALL) reconstruction as it related to techniques, biomechanical properties, and clinical outcomes.

Methods: PubMed, OVID/Medline, and Embase were queried in July 2020. Data pertaining to (1)techniques, (2)biomechanical properties, and (3)clinical outcomes of ALL reconstruction were recorded. Read More

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Preradiosurgery embolization in reducing the postoperative hemorrhage rate for patients with cerebral arteriovenous malformations: a systematic review and meta-analysis.

Neurosurg Rev 2021 Apr 17. Epub 2021 Apr 17.

Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, East Lake District, 330006, Nanchang, Jiangxi, People's Republic of China.

Few studies have examined the postoperative hemorrhage rate of cerebral arteriovenous malformations (AVMs) treated by embolization prior to stereotactic radiosurgery. The objective of this analysis was to compare the postoperative hemorrhage rate between AVMs treated with and those treated without preradiosurgery embolization. A systematic search of the PubMed and Embase databases was performed with no restriction on the publication period. Read More

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Effects of Gocovri (Amantadine) Extended Release Capsules on Non-Motor Symptoms in Patients with Parkinson's Disease and Dyskinesia.

Neurol Ther 2021 Apr 17. Epub 2021 Apr 17.

Adamas Pharmaceuticals, Inc., Emeryville, CA, USA.

Introduction: Gocovri (amantadine) extended release capsules are approved for treatment of dyskinesia and as a levodopa adjunct for OFF episodes in patients with Parkinson's disease (PD). We report treatment-related effects on non-motor symptoms (NMS) assessed as secondary outcomes in two trials using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part I.

Methods: EASE LID and EASE LID 3 enrolled levodopa-treated patients with PD and ≥ 1 h/day ON time with troublesome dyskinesia. Read More

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Factors Associated with HIV and Vulnerability Contexts for Women in Brazil.

Arch Sex Behav 2021 Apr 16. Epub 2021 Apr 16.

Department of Collective Health, School of Nursing, Federal University of Rio Grande do Sul, 90620-110, Porto Alegre, Brazil.

The purpose of this study was to identify factors associated with HIV and vulnerability contexts for women in Porto Alegre, Brazil. The participants were 1326 women recruited by complex sampling design, divided into two groups: 640 women with HIV (WLH) and 686 women who did not have HIV (WNLH). Gross and weighted statistical analyses were performed. Read More

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Relationship between diversional stoma and mortality rate in Fournier's gangrene: a systematic review and meta-analysis.

Langenbecks Arch Surg 2021 Apr 16. Epub 2021 Apr 16.

University of New South Wales, Sydney, Australia.

Purpose: Fournier's gangrene (FG) is a rare potentially lethal necrotising infection of the perineum. While the gold standard management is early and aggressive surgical debridement, the evidence in the literature is unclear as to the role and outcomes of diversional stoma.

Methods: A systematic review was conducted to identify studies investigating the relationship between stoma formation and FG. Read More

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The short-term impact of combining pain neuroscience education with exercise for chronic musculoskeletal pain: a systematic review and meta-analysis.

Pain 2021 Apr 9. Epub 2021 Apr 9.

ANU Medical School, Australian National University, Canberra, Australian Capital Territory, Australia. School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia Centre for Pain IMPACT, Neuroscience Research Australia, Sydney, Australia Trauma and Orthopaedic Research Unit, Canberra Hospital, Canberra, Australian Capital Territory, Australia. Discipline of Physiotherapy, Faculty of Health, University of Canberra, Canberra, Australian Capital Territory, Australia. Brain Stimulation and Rehabilitation (BrainStAR) Lab, Western Sydney University, NSW 2560, Australia Discipline of Sport and Exercise, Faculty of Health, University of Canberra, ACT 2617, Australia Research School of Biology, Australian National University, ACT 2600, Australia.

Abstract: Exercise and pain neuroscience education (PNE) have both been used as standalone treatments for chronic musculoskeletal pain. The evidence supporting PNE as an adjunct to exercise therapy is growing but remains unclear. The aim of this systematic review and meta-analysis was to evaluate the effect of combining PNE and exercise for patients with chronic musculoskeletal pain, when compared to exercise alone. Read More

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Can synthetic data be a proxy for real clinical trial data? A validation study.

BMJ Open 2021 Apr 16;11(4):e043497. Epub 2021 Apr 16.

Electronic Health Information Laboratory, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada

Objectives: There are increasing requirements to make research data, especially clinical trial data, more broadly available for secondary analyses. However, data availability remains a challenge due to complex privacy requirements. This challenge can potentially be addressed using synthetic data. Read More

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Histological evaluation of inferior alveolar nerve injury after osteotomy of mandibular buccal cortex using piezoelectric versus conventional rotary devices: a split-mouth randomised study in rabbits.

Br J Oral Maxillofac Surg 2020 Aug 29. Epub 2020 Aug 29.

Department of Biostatistics and Epidemiology, Hamadan University of Medical Sciences, Hamadan, Iran.

Up until now, only a limited number of evidence-based studies with different results has evaluated traumatic nerve injury after maxillofacial surgery using piezoelectric devices versus rotary instruments. The present experiment was performed to evaluate damage to the inferior alveolar nerve (IAN), histologically, after osteotomy of the buccal cortex of the mandible using piezoelectric devices versus surgical handpieces. Forty rabbits underwent bilateral osteotomy of the mandibular buccal cortex. Read More

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Decreased circulatory levels of Vitamin D in Vitiligo: a meta-analysis.

An Bras Dermatol 2021 Mar 24. Epub 2021 Mar 24.

Department of Biochemistry, All India Institute of Medical Sciences, Bibinagar, India.

Background: The serum Vitamin D status in patients with vitiligo is ambiguous when compared to controls. A systematic review and updated meta-analysis were conducted to evaluate the association between Vitamin D and vitiligo.

Methods: Relevant studies were identified by searching PubMed and other databases. Read More

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The differences in health-related quality of life between younger and older adults and its associated factors in patients with type 2 diabetes mellitus in Indonesia.

Health Qual Life Outcomes 2021 Apr 16;19(1):124. Epub 2021 Apr 16.

Department of Nursing, Universitas Jenderal Soedirman, Purwokerto, Indonesia.

Background: It is well known that diabetes mellitus (DM) affects health-related quality of life (HRQOL) in both younger (aged 18-64 years) and older adults (aged ≥ 65 years). However, to date, no study has compared HRQOL and its predictors between younger and older adults with DM in Indonesia. Such a comparison is important because the results can guide nurses and clinicians to establish evidence-based educational programs that are specific and suitable for patients. Read More

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Shock and awe or incentive-compatible harm reduction? Graphic health warnings on tobacco packages.

Harm Reduct J 2021 Apr 16;18(1):43. Epub 2021 Apr 16.

School of Pharmacy, Memorial University of Newfoundland, St. John's, Canada.

Background: Graphic Health Warnings (GHWs) on cigarette packages were first introduced in Canada in 2001 and will become mandatory in the US as of January 2022. While previous studies have evaluated the impacts of GHWs, the data used in these studies have several shortcomings. The objective of this paper was to investigate the likely impact of such warnings in the US based upon the experience of Canada using hitherto unexplored monthly cigarette sales data, and to explore if alternative approaches involving risk-reduced products might be more successful in reducing smoking. Read More

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Effect of robotic-assisted gait training on objective biomechanical measures of gait in persons post-stroke: a systematic review and meta-analysis.

J Neuroeng Rehabil 2021 Apr 16;18(1):64. Epub 2021 Apr 16.

Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.

Background: Robotic-Assisted Gait Training (RAGT) may enable high-intensive and task-specific gait training post-stroke. The effect of RAGT on gait movement patterns has however not been comprehensively reviewed. The purpose of this review was to summarize the evidence for potentially superior effects of RAGT on biomechanical measures of gait post-stroke when compared with non-robotic gait training alone. Read More

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Efficacy and safety of fremanezumab in patients with migraine and inadequate response to prior preventive treatment: subgroup analyses by country of a randomized, placebo-controlled trial.

J Headache Pain 2021 Apr 16;22(1):26. Epub 2021 Apr 16.

Department of Neurology, Charité Universitätsmedizin, Charitépl. 1, 10117, Berlin, Germany.

Background: The FOCUS study evaluated the efficacy of migraine preventive medications across different countries within the same patient population, particularly for patients with difficult-to-treat migraine. These prespecified subgroup analyses evaluated efficacy by country in the FOCUS study of fremanezumab in adults with episodic migraine or chronic migraine and documented inadequate response to 2 to 4 migraine preventive medication classes.

Methods: Overall, 838 participants were enrolled in the FOCUS study, a randomized, double-blind, placebo-controlled, parallel-group, phase 3b study performed at 104 sites. Read More

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Socio-economic differences in smoking among adolescents in a school-based smoking intervention: The X:IT II study.

Scand J Public Health 2021 Apr 16:14034948211007683. Epub 2021 Apr 16.

Steno Diabetes Centre, Denmark.

Socio-economic inequalities in health behaviour may be influenced by health interventions. We examined whether the X:IT II intervention, aiming at preventing smoking in adolescence, was equally effective among students from different occupational social classes (OSC). We used data from the multi-component school-based smoking preventive intervention X:IT II, targeting 13- to 15-year-olds in Denmark. Read More

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Non-alcoholic fatty liver disease and clinical outcomes in patients with COVID-19: A comprehensive systematic review and meta-analysis.

Diabetes Metab Syndr 2021 Mar 31;15(3):813-822. Epub 2021 Mar 31.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. Electronic address:

Background: Non-alcoholic fatty liver disease (NAFLD) patients represent a vulnerable population that may be susceptible to more severe COVID-19. Moreover, not only the underlying NAFLD may influence the progression of COVID-19, but the COVID-19 may affect the clinical course of NAFLD as well. However, comprehensive evidence on clinical outcomes in patients with NAFLD is not well characterized. Read More

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Long-acting injectable versus oral antipsychotics for the maintenance treatment of schizophrenia: a systematic review and comparative meta-analysis of randomised, cohort, and pre-post studies.

Lancet Psychiatry 2021 Apr 6. Epub 2021 Apr 6.

Department of Psychiatry, The Zucker Hillside Hospital, Northwell Health, New York, NY, USA; Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA; The Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, NY, USA; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.

Background: Evidence of comparative benefits of long-acting injectable antipsychotics (LAIs) versus oral antipsychotics for schizophrenia has been inconsistent across study designs. The aim of this study was to evaluate the comparative benefits of LAIs versus oral antipsychotics in three study designs to inform clinical decision making.

Methods: We did a comprehensive systematic review and meta-analysis comparing LAIs versus oral antipsychotics for schizophrenia covering three study designs: randomised controlled trials (RCTs), cohort studies, and pre-post studies. Read More

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Reward-related Decision-making Deficits in Internet Gaming Disorder: A Systematic Review and Meta-analysis.

Addiction 2021 Apr 16. Epub 2021 Apr 16.

Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

Aims: To estimate the aggregated effect sizes of reward-related decision-making deficits in internet gaming disorder (IGD) and to explore potential moderators on the variability of effect sizes across studies.

Design: Review of peer-reviewed studies comparing reward-related decision-making performance between IGD and control participants identified via PubMed, Web of Science, and ProQuest databases. Random-effects modeling was conducted using Hedge's g as the effect size (ES). Read More

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Gateway to Global Aging Data: Resources for Cross-National Comparisons of Family, Social Environment, and Healthy Aging.

J Gerontol B Psychol Sci Soc Sci 2021 Apr 16. Epub 2021 Apr 16.

Center for Economic and Social Research, University of Southern California, Los Angeles, CA.

Objectives: The Gateway to Global Aging Data (Gateway; g2aging.org) is a data and information platform developed to facilitate cross-country analyses on aging, especially those using the international family of Health and Retirement studies. We provide a brief introduction to the Gateway to Global Aging Data, discussing its potential for cross-national comparisons of family, social environment, and healthy aging. Read More

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The processing of intimately familiar and unfamiliar voices: Specific neural responses of speaker recognition and identification.

PLoS One 2021 16;16(4):e0250214. Epub 2021 Apr 16.

Laboratoire de Recherche en Neurosciences et Électrophysiologie Cognitive, Hôpital Rivière-des-Prairies, Montréal, QC, Canada.

Research has repeatedly shown that familiar and unfamiliar voices elicit different neural responses. But it has also been suggested that different neural correlates associate with the feeling of having heard a voice and knowing who the voice represents. The terminology used to designate these varying responses remains vague, creating a degree of confusion in the literature. Read More

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Effects of Incretin-based Therapy on High-sensitivity C-reactive Protein in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Rev Invest Clin 2020 Oct 21;73(5). Epub 2020 Oct 21.

Department of Endocrinology, Taizhou People's Hospital, Taizhou, Jiangsu, China.

Background: Recently, studies had shown that incretin-based therapies could reduce the levels of pro-inflammatory markers. The data on the effects of incretin-based therapies on serum high-sensitivity C-reactive protein (hs-CRP) in type 2 diabetes (T2DM) were inconsistent.

Objective: The objective of the study was to assess the effects of incretin-based therapies on hs- CRP in patients with T2DM by meta-analysis. Read More

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October 2020

Association of Sedation, Coma, and In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019-Related Acute Respiratory Distress Syndrome: A Retrospective Cohort Study.

Crit Care Med 2021 Apr 5. Epub 2021 Apr 5.

1 Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. 2 Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. 3 Department of Medicine, Division of Pulmonary and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. 4Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada. 5 Department of Anesthesiology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY.

Objectives: In patients with coronavirus disease 2019-associated acute respiratory distress syndrome, sedatives and opioids are commonly administered which may lead to increased vulnerability to neurologic dysfunction. We tested the hypothesis that patients with coronavirus disease 2019-associated acute respiratory distress syndrome are at higher risk of in-hospital mortality due to prolonged coma compared with other patients with acute respiratory distress syndrome matched for disease severity.

Design: Propensity-matched cohort study. Read More

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Effects of estimated glomerular filtration rate and diabetes mellitus on the effect of insulin for treating hyperkalemia during anesthesia.

J Anesth 2021 Apr 16. Epub 2021 Apr 16.

Department of Anesthesiology and Pain Medicine, Hallym University School of Medicine, Chuncheon Sacred Heart Hospital, 77 Sakju-ro, Chuncheon, 24253, South Korea.

Purpose: We analyzed the effectiveness of insulin for treating hyperkalemia (≥ 5 mEq/L) during anesthesia and the effects of the estimated glomerular filtration rate (eGFR) and diabetes mellitus (DM) on the insulin treatment.

Methods: Patients 18 years of age and older who received intravenous insulin lispro for hyperkalemia under general anesthesia between January 2010 and March 2020 were enrolled. We performed three propensity score matching analyses according to eGFR stages (eGFR ≥ 60 vs. Read More

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Loving-Kindness Meditation vs Cognitive Processing Therapy for Posttraumatic Stress Disorder Among Veterans: A Randomized Clinical Trial.

JAMA Netw Open 2021 Apr 1;4(4):e216604. Epub 2021 Apr 1.

Center of Excellence in Substance Addiction Treatment and Education, VA Puget Sound Health Care System, Seattle, Washington.

Importance: Additional options are needed for treatment of posttraumatic stress disorder (PTSD) among veterans.

Objective: To determine whether group loving-kindness meditation is noninferior to group cognitive processing therapy for treatment of PTSD.

Design, Setting, And Participants: This randomized clinical noninferiority trial assessed PTSD and depression at baseline, posttreatment, and 3- and 6-month follow-up. Read More

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Higher Serum Uric Acid Levels Are Associated With an Increased Risk of Vision-Threatening Diabetic Retinopathy in Type 2 Diabetes Patients.

Invest Ophthalmol Vis Sci 2021 Apr;62(4):23

Department of Endocrinology and Metabolism, Shanghai 10th People's Hospital, Tongji University, Shanghai, China.

Purpose: To investigate the association between serum uric acid (SUA) levels and vision-threatening diabetic retinopathy (VTDR) in patients with type 2 diabetes.

Methods: This cross-sectional study evaluated 3481 patients with type 2 diabetes from four communities in China between 2016 and 2019. VTDR was defined as severe nonproliferative, proliferative diabetic retinopathy, or clinically significant macular edema evaluated by fundus photography and optical coherence tomography. Read More

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Effect of parental and ART treatment characteristics on perinatal outcomes.

Hum Reprod 2021 Apr 16. Epub 2021 Apr 16.

Department of Obstetrics and Gynaecology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

Study Question: Do parental characteristics and treatment with ART affect perinatal outcomes in singleton pregnancies?

Summary Answer: Both parental and ART treatment characteristics affect perinatal outcomes in singleton pregnancies.

What Is Known Already: Previous studies have shown that singleton pregnancies resulting from ART are at risk of preterm birth. ART children are lighter at birth after correction for duration of gestation and at increased risk of congenital abnormalities compared to naturally conceived children. Read More

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A neurogenetic analysis of female autism.

Brain 2021 Apr 16. Epub 2021 Apr 16.

Department of Pediatrics, Yale School of Medicine, New Haven, CT 06510, USA.

Females versus males are less frequently diagnosed with autism spectrum disorder (ASD), and while understanding sex differences is critical to delineating the systems biology of the condition, female ASD is understudied. We integrated functional MRI and genetic data in a sex-balanced sample of ASD and typically developing youth (8-17 years old) to characterize female-specific pathways of ASD risk. Our primary objectives were to: (i) characterize female ASD (n = 45) brain response to human motion, relative to matched typically developing female youth (n = 45); and (ii) evaluate whether genetic data could provide further insight into the potential relevance of these brain functional differences. Read More

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Identification and Validation of a Tumor Microenvironment-Related Gene Signature for Prognostic Prediction in Advanced-Stage Non-Small-Cell Lung Cancer.

Biomed Res Int 2021 30;2021:8864436. Epub 2021 Mar 30.

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.

The development of immunotherapy has greatly changed the advanced-stage non-small-cell lung cancer (NSCLC) treatment landscape. The complexity and heterogeneity of tumor microenvironment (TME) lead to discrepant immunotherapy effects among patients at the same pathologic stages. This study is aimed at exploring potential biomarkers of immunotherapy and accurately predicting the prognosis for advanced NSCLC patients. Read More

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