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An automatic sleep disorder detection model based on EEG cross-frequency coupling and Random Forest model.

J Neural Eng 2021 Apr 13. Epub 2021 Apr 13.

Research and Innovation Development, Brussels, Belgium, Intrasoft International S.A., Place du Champ de Mars 5/10 1050 Brussels, BRUSSELS, 1050, BELGIUM.

Sleep disorders are medical disorders of a subject's sleep architecture and based on their severity, they can interfere with mental, emotional and physical functioning. The most common ones are insomnia, narcolepsy, sleep apnea, bruxism, etc. There is an increased risk of developing sleep disorders in elderly like insomnia, periodic leg movements, rapid eye movement (REM) behaviour disorders, sleep disorder breathing, etc. Read More

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The Lanata trichome mutation increases stomatal conductance and reduces leaf temperature in tomato.

J Plant Physiol 2021 Apr 6;260:153413. Epub 2021 Apr 6.

Departamento de Biologia Vegetal, Universidade Federal de Viçosa, CEP 36570-900, Viçosa, MG, Brazil. Electronic address:

Trichomes are epidermal structures with a large variety of ecological functions and economic applications. Glandular trichomes produce a rich repertoire of secondary metabolites, whereas non-glandular trichomes create a physical barrier on the epidermis: both operate in tandem against biotic and abiotic stressors. A deeper understanding of trichome development and function would enable the breeding of more resilient crops. Read More

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Health promotion in emerging collectivist communities: a study of dietary acculturation in the South Sudanese community in Logan City, Australia.

Health Promot J Austr 2021 Apr 13. Epub 2021 Apr 13.

Metro South Health, Access & Capacity-building Team, Eight Miles Plains, Queensland, Australia.

Issue Addressed: Understanding dietary acculturation within collectivist communities is required to develop and tailor appropriate health promotion strategies to prevent diet-related chronic diseases. This research explores the journey of the South Sudanese community living in Logan City, Australia in establishing new norms around food choices and practices over time.

Methods: Three semi-structured group interviews and a final community forum of women (n=20) from the South Sudanese community were conducted. Read More

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Human telomerase RNA component (hTERC) gene expression and chromosome 7 ploidy correlate positively with histological grade of cervical intraepithelial neoplasia.

Cytopathology 2021 Apr 13. Epub 2021 Apr 13.

Department of Pathology, University College of Medical Sciences & Guru Teg Bahadur Hospital, University of Delhi, Delhi, India.

Objective: Cervical cancer screening by primary human papilloma virus detection and cytology is fraught with low specificity and variable sensitivity, respectively. Cytology-histology correlation remains modest. Biomarkers associated with early genetic events in cervical squamous carcinogenesis and detectable in cytology material are likely to be relevant. Read More

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Length of stay in the ward following a preeclamptic pregnancy.

J Hum Hypertens 2021 Apr 12. Epub 2021 Apr 12.

Department of Obstetrics & Gynaecology, The University of Auckland, Auckland, New Zealand.

To date, data on postpartum management of preeclampsia including the optimal time for discharge are limited. The aims of this study were to investigate the appropriate time for discharge after delivery, and factors that could affect the time for discharge. Data on 210 preeclamptic women including the severity or time of onset and days in the ward after delivery were collected and analysed. Read More

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Timing and Outcome of Endovascular Repair for Uncomplicated Type B Aortic Dissection.

Eur J Vasc Endovasc Surg 2021 Apr 9. Epub 2021 Apr 9.

Department of Cardiology, Vascular Centre, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People's Republic of China. Electronic address:

Objective: This study aimed to determine the effect of intervention timing, from symptom onset to thoracic endovascular aortic repair (TEVAR), on early and late outcomes in high risk patients with uncomplicated type B aortic dissection (uTBAD).

Methods: The study retrospectively evaluated 267 uTBAD patients with high risk radiographic features who underwent pre-emptive TEVAR during the acute and subacute periods. Demographics, comorbidities, pre-operative imaging features, peri-procedural details, and follow up outcomes were analysed. Read More

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Evaluation of the performance of a novel sputum processing ReaSLR methodology for culture of sputum samples in solid and liquid media in comparison with modified Petroff's method.

Indian J Tuberc 2021 Apr 22;68(2):255-260. Epub 2020 Sep 22.

Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, India. Electronic address:

Background: Early case detection by sputum smear microscopy is a crucial step in the control of pulmonary tuberculosis in high burden countries. Due to low sensitivity of this rapid and cost effective method, culture of Mycobacterium tuberculosis (MTB) is considered as the gold standard. Modified Petroff's method using 2%-4% sodium hydroxide (NaOH) and N-acetyl- l-cysteine (NALC) to digest and at the same time to decontaminate the specimen is widely used in developing countries prior to culture. Read More

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Barriers to a healthy postpartum lifestyle and the possibilities of an information technology-based intervention: A qualitative study.

Midwifery 2021 Apr 3;98:102994. Epub 2021 Apr 3.

Centre for Innovative Medical Technology, Odense University Hospital, Odense, Denmark; Department of Endocrinology, Odense University Hospital, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark; Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark. Electronic address:

Background: Being overweight or obese is associated with higher risk of adverse maternal and fetal outcomes, including gestational diabetes and childhood obesity. Many women exceed the gestational weight gain recommendations. Thus, it is important to focus on the women's lifestyle between their pregnancies to lower the risk of weight retention before the next pregnancy as well as in a life course perspective. Read More

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Identification of conserved Mycoplasma agalactiae surface antigens by immunoproteomics.

Vet Immunol Immunopathol 2021 Apr 7;236:110239. Epub 2021 Apr 7.

Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Italy; Mediterranean Center for Disease Control (MCDC), Università degli studi di Sassari, Italy. Electronic address:

Contagious agalactia represents one of the most relevant infectious diseases of dairy sheep, with Mycoplasma agalactiae being the primary etiological agent. The early, sensitive, and specific identification of infected animals, as well as the development of efficient prophylactic tools, remain challenging. Here, we present a comprehensive characterization of M. Read More

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Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial.

Lancet Respir Med 2021 Apr 9. Epub 2021 Apr 9.

Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; National Institute for Health Research (NIHR), Oxford Biomedical Research Centre, Oxford, UK. Electronic address:

Background: Multiple early reports of patients admitted to hospital with COVID-19 showed that patients with chronic respiratory disease were significantly under-represented in these cohorts. We hypothesised that the widespread use of inhaled glucocorticoids among these patients was responsible for this finding, and tested if inhaled glucocorticoids would be an effective treatment for early COVID-19.

Methods: We performed an open-label, parallel-group, phase 2, randomised controlled trial (Steroids in COVID-19; STOIC) of inhaled budesonide, compared with usual care, in adults within 7 days of the onset of mild COVID-19 symptoms. Read More

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Cognitive decline heralds onset of symptomatic inherited prion disease.

Brain 2021 Apr;144(3):989-998

Department of Neuropsychology, NHNN, University College London Hospitals NHS Foundation Trust, London, UK.

The clinical effectiveness of any disease-modifying treatment for prion disease, as for other neurodegenerative disorders, will depend on early treatment before damage to neural tissue is irrevocable. Thus, there is a need to identify markers that predict disease onset in healthy at-risk individuals. Whilst imaging and neurophysiological biomarkers have shown limited use in this regard, we recently reported progressive neurophysiological changes in individuals with the inherited prion disease mutation P102L. Read More

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Predicting failure before it happens: A 5-year, 1042 participant prospective study.

Med Teach 2021 Apr 12:1-5. Epub 2021 Apr 12.

Aston Medical School, Aston University, Birmingham, UK.

Purpose Of The Article: Students who fail assessments are at risk of negative consequences, including emotional distress and cessation of studies. Identifying students at risk of failure before they experience difficulties may considerably improve their outcomes.

Methods: Using a prospective design, we collected simple measures of engagement (formative assessment scores, compliance with routine administrative tasks, and attendance) over the first 6 weeks of Year 1. Read More

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Exploring the potential of rapid evaporative ionization mass spectrometry (Intelligent Knife) for point-of-care testing in aortic surgery.

Eur J Cardiothorac Surg 2021 Apr 11. Epub 2021 Apr 11.

Liverpool Centre for Cardiovascular Science, Liverpool, UK.

Objectives: Many intraoperative decisions regarding the extent of thoracic aortic surgery are subjective and are based on the appearance of the aorta, perceived surgical risks and likelihood of early recurrent disease. Our objective in this work was to carry out a cross-sectional study to demonstrate that rapid evaporative ionization mass spectrometry (REIMS) of electrosurgical aerosol is able to empirically discriminate ex vivo aneurysmal human thoracic aorta from normal aorta, thus providing supportive evidence for the development of the technique as a point-of-care test guiding intraoperative surgical decision-making.

Methods: Human aortic tissue was obtained from patients undergoing surgery for thoracic aortic aneurysms (n = 44). Read More

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Characteristics, management and outcomes of atypical haemolytic uraemic syndrome in kidney transplant patients: a retrospective national study.

Clin Kidney J 2021 Apr 13;14(4):1173-1180. Epub 2020 Aug 13.

RedInRen 16/009, RTYC ISCIII, Madrid, Spain.

Background: Kidney transplantation (KTx) is a strong trigger for the development of either recurrent or atypical haemolytic uraemic syndrome (aHUS). According to previous studies, eculizumab (ECU) is effective for prophylaxis and for treatment of recurrence.

Methods: We evaluated the experiences of Spanish patients with recurrent and aHUS associated with KTx, treated or not treated with ECU. Read More

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Comparative study on anticancer drug access times between FDA, EMA and the French temporary authorisation for use program over 13 years.

Eur J Cancer 2021 Apr 7;149:82-90. Epub 2021 Apr 7.

ANSM Agence Nationale de Sécurité des Médicaments Direction Onco-hématologie et Thérapie Cellulaire, 147 Boulevard Anatole France, Saint-Denis, France; Avec Groupe Hospitalier Mutualiste de Grenoble - Institut Daniel Hollard, 8, Rue Docteur Calmette, 38028 Grenoble cedex 1, France. Electronic address:

Introduction: The cancer incidence continues to rise worldwide. Medical innovation has a major impact on patient survival, but within drug development, it can take more than 10 years to obtain marketing authorisation (MA). The time required for access to therapeutic innovation remains critical, so France has developed a specific expanded access program named ATU, which allows the administration of drugs before the European Medicines Agency (EMA) approval. Read More

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Visceral malperfusion after Frozen Elephant Trunk in chronic aortic dissection: post-operative predictors and outcomes.

Int J Cardiol 2021 Apr 7. Epub 2021 Apr 7.

Cardiac Surgery Division, IRCCS Azienda Ospedaliero-Universitaria di Bologna - S. Orsola Policlinic, University of Bologna, Bologna, Italy.

Background: The aims of this study were to analyse the incidence of visceral malperfusion syndrome (MPS) following Frozen Elephant trunk operations in patients affected by chronic aortic dissection and the associated risk factors.

Methods: Between January 2007 and February 2019, 165 patients underwent surgery with FET for chronic aortic dissection. Post-operative computer tomography angiogram parameters (diameters, early post-operative false lumen enhancement and involving of aortic branches by the dissection) were collected and analysed to evaluate their impact on the occurrence of visceral malperfusion. Read More

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Egg nutritional modulation with amino acids improved performance in zebrafish larvae.

PLoS One 2021 9;16(4):e0248356. Epub 2021 Apr 9.

Aquaculture Research Group, Centro de Ciências do Mar do Algarve (CCMAR), Faro, Portugal.

New and more efficient methods to sustainably intensify Aquaculture production are essential to attain the seafood demand for direct human consumption in the near future. Nutrition has been identified as one strategy of early exposure that might affect animal early development and later phenotype. This strategy may have positive consequences in the modulation of fish digestive physiology, which will correlate with higher performance outputs. Read More

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Classification and analysis of outcome predictors in non-critically ill COVID-19 patients.

Intern Med J 2021 Apr 9. Epub 2021 Apr 9.

Department of Medicine, University of Udine, Udine, Italy.

Background: Early detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients who could develop a severe form of COVID-19 must be considered of great importance to carry out adequate care and optimise the use of limited resources.

Aims: To use several machine learning classification models to analyse a series of non-critically ill COVID-19 patients admitted to a general medicine ward to verify if any clinical variables recorded could predict the clinical outcome.

Methods: We retrospectively analysed non-critically ill patients with COVID-19 admitted to the general ward of the hospital in Pordenone from 1 March 2020 to 30 April 2020. Read More

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Blood donation in times of crisis: Early insight into the impact of COVID-19 on blood donors and their motivation to donate across European countries.

Vox Sang 2021 Apr 9. Epub 2021 Apr 9.

Hamburg Center for Health Economics, University of Hamburg, Hamburg, Germany.

Background: In this survey, we aimed to provide early insight into the impact of COVID-19 on blood donors and their motivation to donate during the crisis.

Study Design And Methods: We asked representative samples in 7 European countries (Denmark, France, Germany, Italy, Portugal, the Netherlands and the UK) about their blood donation activity and motivation to donate using an online survey. We analysed donor turnout during the COVID-19 period descriptively and using logistic regression. Read More

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Caesarean delivery and early childhood caries: Estimation with marginal structural models in Brazilian pre-schoolers.

Community Dent Oral Epidemiol 2021 Apr 8. Epub 2021 Apr 8.

Postgraduate Program in Dentistry, Federal University of Maranhão, São Luís, Brazil.

Objective: This study analysed the association between caesarean section and early childhood caries (ECC), estimating the effects using regression and causal inference models.

Methods: This was a historical cohort study of 697 mother-child dyads, conducted in São Luís, Brazil. The caesarean section was the exposure, and the severity of ECC (dmft) was the outcome. Read More

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Development and Validation of a Clinical Symptom-based Scoring System for Diagnostic Evaluation of COVID-19 Patients Presenting to Outpatient Department in a Pandemic Situation.

Cureus 2021 Mar 3;13(3):e13681. Epub 2021 Mar 3.

Medicine, All India Institute of Medical Sciences, New Delhi, IND.

Background Preventive strategies in the form of early identification and isolation of patients are the cornerstones in the control of COVID-19 pandemic. We have conducted this study to develop a clinical symptom-based scoring system (CSBSS) for the diagnostic evaluation of COVID-19.  Methods In this study, 378 patients presenting to screening outpatient clinic with clinical suspicion of COVID-19 were evaluated for various clinical symptoms. Read More

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How do colorectal cancer patients rate their GP: a mixed methods study.

BMC Fam Pract 2021 Apr 8;22(1):67. Epub 2021 Apr 8.

Medical Research Centre, University of Waikato, Hamilton, New Zealand.

Background: New Zealand (NZ) has a high incidence of colorectal cancer (CRC) and low rates of early diagnosis. With screening not yet nationwide, the majority of CRC is diagnosed through general practice. A good patient-general practitioner (GP) relationship can facilitate prompt diagnosis, but when there is a breakdown in this relationship, delays can occur. Read More

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Early commercial experience with a newly designed balloon-expandable transcatheter heart valve: 30-day outcomes and implications of preprocedural computed tomography.

Interact Cardiovasc Thorac Surg 2021 Apr;32(3):426-432

Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Hamburg, Germany.

Objectives: We herein report a single-centre experience with the SAPIEN 3 Ultra balloon-expandable transcatheter aortic valve implantation (TAVI) system.

Methods: Between March 2019 and January 2020, a total of 79 consecutive patients received transfemoral TAVI using the SAPIEN 3 Ultra device. Data were retrospectively analysed according to updated Valve Academic Research Consortium-2 definitions. Read More

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