J Formos Med Assoc 2021 Apr 6. Epub 2021 Apr 6.
Department of Internal Medicine, Cathay General Hospital, Taipei, 10630, Taiwan; Department of Medical Research, Cathay General Hospital, Taipei, 10630, Taiwan; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei, 24205, Taiwan. Electronic address:
Systemic lupus erythematosus (SLE) is a complex, heterogeneous, systemic autoimmune disease involving a wide array of aberrant innate and adaptive immune responses. The immune microenvironment of SLE promotes the metabolic reprogramming of immune cells, leading to immune dyshomeostasis and triggering autoimmune inflammation. Different immune subsets switch from a resting state to a highly metabolic active state by alternating the redox-sensitive signaling pathway and the involved metabolic intermediates to amplify the inflammatory response, which is critical in SLE pathogenesis. Read More