17,647 results match your criteria amount target


Toward Selective Oxidation of Contaminants in Aqueous Systems.

Environ Sci Technol 2021 Oct 20. Epub 2021 Oct 20.

Research Center for Environmental Nanotechnology (ReCENT), School of Environment and State Key Laboratory of Pollution Control and Resources Reuse, Nanjing University, Nanjing 210023, China.

The presence of diverse pollutants in water has been threating human health and aquatic ecosystems on a global scale. For more than a century, chemical oxidation using strongly oxidizing species was one of the most effective technologies to destruct pollutants and to ensure a safe and clean water supply. However, the removal of increasing amount of pollutants with higher structural complexity, especially the emerging micropollutants with trace concentrations in the complicated water matrix, requires excessive dosage of oxidant and/or energy input, resulting in a low cost-effectiveness and possible secondary pollution. Read More

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October 2021

The impact of immune checkpoint inhibitors on cost and quality of life in the initial treatment of patients with advanced or metastatic NSCLC.

Authors:
Kelly Procailo

Am J Manag Care 2021 10;27(18 Suppl):S333-S339

Oncology Medical Drug Management and Customer Initiatives, Blue Cross Blue Shield of Michigan, Detroit, MI. Email:

Immune checkpoint inhibitors (ICIs) represent a significant benefit for the initial treatment of patients with advanced or metastatic non-small cell lung cancer (NSCLC). Beyond clinical benefit of increased overall survival, it represents a class of medications with a favorable adverse effect profile compared with chemotherapy. Drugs that target programmed cell death protein 1 (PD-1) receptor and its ligand PD-L1 are ICIs that work by taking the brakes off the immune system and promote T-cell-mediated cancer cell destruction. Read More

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October 2021

Evaluation of energy intake compared to indirect calorimetry requirements in critically ill patients with acute brain injury.

JPEN J Parenter Enteral Nutr 2021 Oct 19. Epub 2021 Oct 19.

Department of Pharmacy - The Ohio State University Wexner Medical Center.

Background: Nutrition support in critically ill patients with acute brain injury is vitally important due to known hypermetabolism. We aimed to describe caloric and protein intake within the first 72 hours in a broad neurocritical care population, and compare caloric intake to the indirect calorimetry (IC) resting energy expenditure (REE) target.

Methods: IC data, daily caloric and protein intake were collected through chart review over the first 7 days of hospital admission. Read More

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October 2021

Clinical outcome of the patients with femoropopliteal artery disease after endovascular therapy: focused on drug-coated-balloon-related distal embolism detected by laser doppler flowmetry.

Cardiovasc Interv Ther 2021 Oct 19. Epub 2021 Oct 19.

Department of Cardiology, Rakuwakai Marutamachi Hospital, Kyoto, Japan.

Several trials have shown that paclitaxel drug-coated balloons (DCBs) significantly reduce restenosis rates. However, some reports have shown distal embolisms occurring after DCBs. No study has analyzed the clinical outcomes of patients with DCB-induced distal embolism. Read More

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October 2021

Convergence of forepaw somatosensory and motor cortical projections in the striatum, claustrum, thalamus, and pontine nuclei of cats.

Brain Struct Funct 2021 Oct 19. Epub 2021 Oct 19.

Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA.

The basal ganglia and pontocerebellar systems regulate somesthetic-guided motor behaviors and receive prominent inputs from sensorimotor cortex. In addition, the claustrum and thalamus are forebrain subcortical structures that have connections with somatosensory and motor cortices. Our previous studies in rats have shown that primary and secondary somatosensory cortex (S1 and S2) send overlapping projections to the neostriatum and pontine nuclei, whereas, overlap of primary motor cortex (M1) and S1 was much weaker. Read More

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October 2021

Examining Theoretical Factors That Influence Teachers' Intentions to Implement Inclusive Physical Education.

Res Q Exerc Sport 2021 Oct 18:1-14. Epub 2021 Oct 18.

York University.

: The purpose of the current study was to apply the Theoretical Domains Framework (TDF) and Capability, Opportunity, Motivation, and Behavior model (COM-B) to examine theoretical predictors of teachers' intentions to implement inclusive physical education. : Ontario primary and secondary teachers (n = 383) completed an online questionnaire which assessed potential factors associated with intentions toward implementation of inclusive physical education. : The final statistical model explained 72% of variance in intentions to implement inclusive physical education with the following theoretical domains identified as significant (<. Read More

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October 2021

Biomarkers in Acute Myeloid Leukemia: Leveraging Next Generation Sequencing Data for Optimal Therapeutic Strategies.

Front Oncol 2021 30;11:748250. Epub 2021 Sep 30.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Next generation sequencing (NGS) is routinely used for mutation profiling of acute myeloid leukemia. The extensive application of NGS in hematologic malignancies, and its significant association with the outcomes in multiple large cohorts constituted a proof of concept that AML phenotype is driven by underlying mutational signature and is amenable for targeted therapies. These findings urged incorporation of molecular results into the latest World Health Organization (WHO) sub-classification and integration into risk-stratification and treatment guidelines by the European Leukemia Net. Read More

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September 2021

TRAIL receptors are expressed in both malignant and stromal cells in pancreatic ductal adenocarcinoma.

Am J Cancer Res 2021 15;11(9):4500-4514. Epub 2021 Sep 15.

Division of Oncology, Laboratory of Cellular Therapy, Department of Medical and Surgical Sciences of Children & Adults, University of Modena and Reggio Emilia Modena 41124, Italy.

This study assesses the expression of all TNF-related apoptosis-inducing ligand (TRAIL) receptors in pancreatic ductal adenocarcinoma (PDAC) tumor tissue. We aimed to include TRAIL receptor expression as an inclusion parameter in a future clinical study using a TRAIL-based therapy approach for PDAC patients. Considering the emerging influence of PDAC desmoplastic stroma on the efficacy of anti-PDAC therapies, this analysis was extended to tumor stromal cells. Read More

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September 2021

Deep Learning Algorithms Correctly Classify Varieties Using Digital Images.

Front Plant Sci 2021 29;12:738685. Epub 2021 Sep 29.

Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.

Efficient and accurate methods of analysis are needed for the huge amount of biological data that have accumulated in various research fields, including genomics, phenomics, and genetics. Artificial intelligence (AI)-based analysis is one promising method to manipulate biological data. To this end, various algorithms have been developed and applied in fields such as disease diagnosis, species classification, and object prediction. Read More

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September 2021

Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis.

Biochem Biophys Res Commun 2021 Oct 11;581:81-88. Epub 2021 Oct 11.

Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Electronic address:

Background: Pulmonary fibrosis (PF) has attracted more and more attention due to its irreversibility and high mortality rate. Currently, there is no effective treatment option is available to reverse the disease. Caspase recruitment domain-containing membrane-associated guanylate kinase protein (CARMA3) has been recognized as a proinflammatory molecule involved in many lung diseases, such as Allergic airway inflammation and lung cancer. Read More

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October 2021

Bi-Functional Fe O /Au/CoFe-LDH Sandwich-Structured Electrocatalyst for Asymmetrical Electrolyzer with Low Operation Voltage.

Small 2021 Oct 15:e2103307. Epub 2021 Oct 15.

School of Materials Science and Engineering, China University of Petroleum (East China), Qingdao, 266580, China.

The reduction of the overall electrolysis potential to produce hydrogen is a critical target for fabricating applicable hydrogen evolution cells. Sandwich-structured Fe O /Au/CoFe-LDH is synthesized via a spontaneous galvanic displacement reaction. A series of structural characterizations indicate the successful synthesis of sandwich-structured Fe O /Au/CoFe-LDH electrocatalyst. Read More

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October 2021

[Sexual health information on social media: a systematic scoping review].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2021 Oct 14. Epub 2021 Oct 14.

Institut für Medien und Kommunikationswissenschaft, Technische Universität Ilmenau, Ehrenbergstraße 29, 98693, Ilmenau, Deutschland.

Background: Information on sexual and reproductive health is increasingly disseminated via social media and reaches a large audience.

Research Aim: Against this background, the aim of this paper is to systematically summarize the international state of research on sexual health information on social media for the first time with a scoping review. Seven research questions were explored, relating to the amount (F1), methods (F2: content analysis, F3: quality analysis), and results (F4: providers, F5: target groups, F6: topics, F7: quality of information) of previous studies. Read More

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October 2021

Neutrophil-derived heparin binding protein triggers vascular leakage and synergizes with myeloperoxidase at the early stage of severe burns (With video).

Burns Trauma 2021 17;9:tkab030. Epub 2021 Sep 17.

Department of Burns and Plastic Surgery, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, Jiangsu Province, China.

Background: Burn shock caused by vascular leakage is one of the main causes of high mortality in severe burn injury. However, the pathophysiological mechanism of vascular leakage is still unclear. The purpose of this study was to explore the molecular mechanism of vascular leakage in the early stage of severe burn and provide a new target for the treatment of severe burns. Read More

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September 2021

The S100A10-AnxA2 complex is associated with the exocytosis of hepatitis B virus in intrauterine infection.

Lab Invest 2021 Oct 13. Epub 2021 Oct 13.

The Women's Hospital, Zhejiang University School of Medicine, No. 1 Xueshi Road, Shangcheng District, Hangzhou, Zhejiang, 310001, China.

Mother-to-child transmission (MTCT) is the major cause of chronic infection of hepatitis B virus (HBV) in patients. However, whether and how HBV crosses the placenta to cause infection in utero remains unclear. In this study, we investigate the mechanism as to how the HBV virions pass through layers of the trophoblast. Read More

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October 2021

On site production of [F]PSMA-1007 using different [F]fluoride activities: practical, technical and economical impact.

EJNMMI Radiopharm Chem 2021 Oct 13;6(1):36. Epub 2021 Oct 13.

Nuclear Medicine Division, Istituto Nazionale Tumori - IRCCS Fondazione G. Pascale, Naples, Italy.

Background: Prostate-specific membrane antigen is overexpressed in prostate cancer and it is considered a good target for positron emission tomography/computed tomography imaging of primary cancer and recurrent/metastatic disease, as well as for radioligand therapy. Different PSMA-analogues labeled with [Ga]gallium have been investigated, showing excellent imaging properties; however, only small amounts can be produced for each radiolabeling. Recently, a [F]fluoride labeled PSMA-inhibitor, [F]PSMA-1007, has been introduced, and it has ensured large-scale productions, overcoming this limitation of [Ga]PSMAs. Read More

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October 2021

Immunoglobulin E Detection Method Based on Cascade Enzymatic Reaction Utilizing Portable Personal Glucose Meter.

Sensors (Basel) 2021 Sep 24;21(19). Epub 2021 Sep 24.

Material & Component Convergence R&D Department, Korea Institute of Industrial Technology (KITECH), Ansan 15588, Korea.

We herein describe a cascade enzymatic reaction (CER)-based IgE detection method utilizing a personal glucose meter (PGM), which relies on alkaline phosphatase (ALP) activity that regulates the amount of adenosine triphosphate (ATP). The amount of sandwich assay complex is determined according to the presence or absence of the target IgE. Additionally, the ALP in the sandwich assay catalyzes the dephosphorylation of ATP, a substrate of CER, which results in the changes in glucose level. Read More

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September 2021

Monitoring Lower Back Activity in Daily Life Using Small Unintrusive Sensors and Wearable Electronics in the Context of Rheumatic and Musculoskeletal Diseases.

Sensors (Basel) 2021 Sep 23;21(19). Epub 2021 Sep 23.

MNS, Department of Electrical Engineering (ESAT), University of Leuven, 3001 Leuven, Belgium.

Due to a sedentary lifestyle, the amount of people suffering from musculoskeletal back diseases has increased over the last few decades. To monitor and cure these disabilities, sensors able to monitor the patient for long-term measurement during daily life and able to provide real-time feedback are required. There are only a few wearable systems that are capable to acquire muscle activity (sEMG) and posture at the same time. Read More

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September 2021

Cr-Based Sputtered Decorative Coatings for Automotive Industry.

Materials (Basel) 2021 Sep 24;14(19). Epub 2021 Sep 24.

CEMMPRE-Centre for Mechanical, Department of Mechanical Engineering, Engineering Materials and Processes, University of Coimbra, Rua Luís Reis Santos, 3030-788 Coimbra, Portugal.

The present work aims to study the impact of O and N addition on Cr-sputtered coatings on plastic (polycarbonate, PC) used in automobile parts, as a promisor alternative for auto part metallization, while eliminating the usage of toxic hexavalent chromium. The coatings were deposited using DC magnetron sputtering from a single pure Cr target in a reactive atmosphere (N and/or O). The deposition of the coatings was performed maintaining the total pressure constant and close to 1 Pa by tuning Ar pressure while reactive gases were added. Read More

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September 2021

What Factors Predict the Use of Coercive Food Parenting Practices among Mothers of Young Children? An Examination of Food Literacy, Disordered Eating and Parent Demographics.

Int J Environ Res Public Health 2021 Oct 8;18(19). Epub 2021 Oct 8.

Centre for Mental Health, Melbourne School of Population and Global Health, University of Melbourne, 207 Bouverie Street, Carlton, VIC 3010, Australia.

Parents have the most significant influence on the development of young children's eating patterns. Understanding what parental factors best predict specific negative feeding practices is important for designing preventive interventions. We examined the relationship between parents' use of coercive food parenting practices (pressure to eat and restriction) and parents' disordered eating, food literacy, Body Mass Index (BMI) and socio-economic status (SES). Read More

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October 2021

DNA Binding Mode Analysis of a Core-Extended Naphthalene Diimide as a Conformation-Sensitive Fluorescent Probe of G-Quadruplex Structures.

Int J Mol Sci 2021 Sep 30;22(19). Epub 2021 Sep 30.

Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.

G-quadruplex existence was proved in cells by using both antibodies and small molecule fluorescent probes. However, the G-quadruplex probes designed thus far are structure- but not conformation-specific. Recently, a core-extended naphthalene diimide () was designed and found to provide fluorescent signals of markedly different intensities when bound to G-quadruplexes of different conformations or duplexes. Read More

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September 2021

Steroid Receptors in Breast Cancer: Understanding of Molecular Function as a Basis for Effective Therapy Development.

Cancers (Basel) 2021 Sep 24;13(19). Epub 2021 Sep 24.

Chair of Medical Biochemistry, Jagiellonian University Medical College, 7 Kopernika St., 31-034 Kraków, Poland.

Breast cancer remains one of the most important health problems worldwide. The family of steroid receptors (SRs), which comprise estrogen (ER), progesterone (PR), androgen (AR), glucocorticoid (GR) and mineralocorticoid (MR) receptors, along with a receptor for a secosteroid-vitamin D, play a crucial role in the pathogenesis of the disease. They function predominantly as nuclear receptors to regulate gene expression, however, their full spectrum of action reaches far beyond this basic mechanism. Read More

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September 2021

High-accuracy quantitative principle of a new compact digital PCR equipment: Lab On An Array.

Genomics Inform 2021 Sep 30;19(3):e34. Epub 2021 Sep 30.

Department of Bioconvergence Engineering, Dankook University, Yongin 16890, Korea.

Digital PCR (dPCR) is the third-generation PCR that enables real-time absolute quantification without reference materials. Recently, global diagnosis companies have developed new dPCR equipment. In line with the development, the Lab On An Array (LOAA) dPCR analyzer (Optolane) was launched last year. Read More

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September 2021

Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy.

J Pineal Res 2021 Oct 11:e12766. Epub 2021 Oct 11.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

Adopting an integrative approach, by combining studies of cardiovascular function with those at cellular and molecular levels, this study investigated whether maternal treatment with melatonin protects against programmed cardiovascular dysfunction in the offspring using an established rodent model of hypoxic pregnancy. Wistar rats were divided into normoxic (N) or hypoxic (H, 10% O ) pregnancy ± melatonin (M) treatment (5 μg·ml .day ) in the maternal drinking water. Read More

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October 2021

Iron Chelation Reduces DNA Damage in Sickle Cell Anemia.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211047230

441424Department of Biochemistry, University of Jeddah, Jeddah, KSA.

Sickle cell anemia (SCA) is a blood condition that causes severe pain. One of the therapeutic agents used for the treatment of SCA is hydroxyurea, which reduces the episodes of pain but causes DNA damage to white blood cells. The aim of this study was to evaluate the efficacy of the combination of hydroxyurea and iron chelation therapy in relation to the extent of DNA-associated damage. Read More

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October 2021

Amplification of Femtograms of Bacterial DNA Within 3 h Using a Digital Microfluidics Platform for MinION Sequencing.

ACS Omega 2021 Oct 23;6(39):25642-25651. Epub 2021 Sep 23.

Department of Surgery, Division of Surgical Research, Mayo Clinic, Rochester, Minnesota 55905-0002, United States.

Whole genome sequencing is emerging as a promising tool for the untargeted detection of a broad range of microbial species for diagnosis and analysis. However, it is logistically challenging to perform the multistep process from sample preparation to DNA amplification to sequencing and analysis within a short turnaround time. To address this challenge, we developed a digital microfluidic device for rapid whole genome amplification of low-abundance bacterial DNA and compared results with conventional in-tube DNA amplification. Read More

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October 2021

Efficient conjugation of anti-HBsAg antibody to modified core-shell magnetic nanoparticles ([email protected]/NH).

Bioimpacts 2021 28;11(4):237-244. Epub 2021 Apr 28.

Department of Immunology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Further development of magnetic-based detection techniques could be of significant use in increasing the sensitivity of detection and quantification of hepatitis B virus (HBV) infection. The present work addresses the fabrication and characterization of a new bio-nano composite based on the immobilization of goat anti-HBsAg antibody on modified core-shell magnetic nanoparticles (NPs) by (3-aminopropyl) triethoxysilane (APTES), named [email protected]/NH, and magnetic NPs modified by chitosan ([email protected]). At the first step, FeO was modified with the silica and APTES ([email protected]/NH) and chitosan ([email protected]) separately. Read More

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Culprits or consequences: Understanding the metabolic dysregulation of muscle in diabetes.

World J Biol Chem 2021 Sep;12(5):70-86

Health and Kinesiology, Texas A&M University, TX 77843, United States.

The prevalence of type 2 diabetes (T2D) continues to rise despite the amount of research dedicated to finding the culprits of this debilitating disease. Skeletal muscle is arguably the most important contributor to glucose disposal making it a clear target in insulin resistance and T2D research. Within skeletal muscle there is a clear link to metabolic dysregulation during the progression of T2D but the determination of culprits consequences of the disease has been elusive. Read More

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September 2021

A novel synthetic compound shows antioxidant and anti-inflammatory activity and alleviates cognitive deficits in rats for the treatment of Alzheimer's disease.

Ann Palliat Med 2021 Sep;10(9):9508-9515

Department of Pharmacy, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China.

Background: Alzheimer's disease (AD) is a progressive dementia, and β-amyloid (Aβ) accumulation is widely regarded as the primary pathogenesis of AD. A new synthetic compound, 8-hydroxyquinoline-resveratrol derivative (E)-5-(4-hydroxystyryl)quinolin-8-ol (10c) was evaluated as a possible anti-AD agent.

Method: (I) The total amount of ROS in SH-SY5Y cells was detected by dichlorofluorescein diacetate (DCFH-DA), and the antioxidant activity and neuroprotective effect of 10c in SH-SY5Y cells were evaluated; (II) Griess reagent was used to test the activity of Compound 10c against NO production in LPS-induced BV-2 microglial cells; (III) An automatic digital stereotaxic instrument was used to inject Aβ25-35 into the brain to establish an AD animal model to evaluate the protective effect of compound 10c on Aβ25-35-induced learning and memory dysfunction in rats. Read More

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September 2021

[Research progress of cancer stem cell biomarkers in head and neck squamous cell carcinoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Sep;35(9):854-858

Cancer stem cells (CSCs), as a few amount of tumors, have infinite replication, self-renewal, differentiation and regeneration of cell subsets with tumorigenicity, have close relationship with tumor occurrence and recurrence, which can be found in head and neck squamous cell carcinoma (HNSCC). One of the important measures to improve the patient prognosis is monitoring cancer stem cells and timely clinical intervention. Biomarker detection of cancer stem cells is an important method for clinical monitoring of cancer stem cells. Read More

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September 2021

NEW ASPECTS OF THE INTERACTION OF COPPER (II) WITH SERUM ALBUMIN: VOLTAMMETRIC AND MICROCALORIMETRIC STUDIES.

Georgian Med News 2021 Sep(318):139-142

1Ivane Beritashvili Center of Experimental Biomedicine, Tbilisi; 3Ivane Javakhishvili Tbilisi State University, Department of Physics, Georgia.

Structural organization of serum albumins - the most abundant globular proteins in serum plasma - gives rise to their extraordinary binding and functional capacity. Various classes of ligands, including the metal ions can be captured and transported by albumins. Metal binding to human serum albumin, HSA, that is an essential multipurpose target for the modern biomedicine, to its bovine equivalent, BSA, and other mammalian analogs have been extensively explored in the context of metabolism of essential metal ions, like Cu2+. Read More

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September 2021