622 results match your criteria amlodipine internal


Effects of Renin-Angiotensin-Aldosterone Inhibitors on Early Outcomes of Hypertensive COVID-19 Patients: A Randomized Triple-Blind Clinical Trial.

Am J Hypertens 2021 Jul 15. Epub 2021 Jul 15.

Department of Emergency Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Prehospital and Hospital Emergency Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: The role of angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) has been addressed in some studies related to the current coronavirus disease-2019 (COVID-19) pandemic with possible higher severity and mortality in patients with hypertension. A triple-blind randomized controlled trial was designed to evaluate the effects of these medications on the COVID-19 progression.

Methods: Patients were enrolled in this trial between April and September 2020. Read More

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Incidental diagnosis of nonfunctional bladder paraganglioma: a case report and literature review.

BMC Urol 2021 Jul 8;21(1):98. Epub 2021 Jul 8.

Department of Urology, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China.

Background: Nonfunctional bladder paragangliomas is a rare urological disease. It may present clinical, radiology and pathological features similar to bladder cancer, Only scarce reports have been reported. Urologist must identify this generally benign neuroendocrine neoplasm to avoid misdiagnosis. Read More

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Effect of Preeclampsia on Ultrastructure of Thyroid Gland, Hepatic Type 1 Iodothyronine Deiodinase, and Thyroid Hormone Levels in Rats.

Biomed Res Int 2021 20;2021:6681491. Epub 2021 Apr 20.

School of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China.

Background: Although hypothyroidism during pregnancy may develop grave outcomes for both mothers and offspring, management of which is still a challenge due to the insufficient understanding of this disease. The close correlation between hypothyroidism and preeclampsia is well documented, suggesting that preeclampsia is a potential risk factor for the development of maternal hypothyroidism. However, the exact role of preeclampsia in gestational hypothyroidism is still obscure. Read More

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Emerging treatments for scleroderma/systemic sclerosis.

Fac Rev 2021 5;10:43. Epub 2021 May 5.

Department of Dermatology, University of Texas at Southwestern Medical Center, Dallas, TX, USA.

Systemic sclerosis (SSc) is a connective tissue disease characterized by progressive fibrosis of the skin and internal organs and has significant clinical sequelae. Management of SSc cutaneous disease remains challenging and often is driven by extracutaneous manifestations. Methotrexate is the typical first-line therapy for patients with early progressive cutaneous disease. Read More

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Angiotensin Receptor Blocker and Calcium Channel Blocker Preventing Atrial Fibrillation Recurrence in Patients with Hypertension and Atrial Fibrillation: A Meta-analysis.

Cardiovasc Ther 2021 17;2021:6628469. Epub 2021 May 17.

Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Background: Atrial fibrillation (AF) is the most common serious cardiac rhythm disturbances and is responsible for substantial morbidity and mortality in general population. Hypertension is the most prevalent and potentially modifiable risk factor for AF. This study is aimed at evaluating the effect of angiotensin receptor blocker (ARB) or calcium channel blocker (CCB) on AF recurrence among patients with hypertension and AF. Read More

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"Two for One", Novel Dual Left Anterior Descending Artery (LAD) Variant: Type XIII.

Cureus 2021 Apr 27;13(4):e14717. Epub 2021 Apr 27.

Cardiology, Northwell Health, Manhasset, USA.

Dual left anterior descending artery (LAD) is a rare phenomenon that occurs in less than one percent of the population. To date, 12 variants have been identified. Proper identification of coronary vessels is crucial in emergent situations that require prompt action, such as percutaneous coronary intervention (PCI). Read More

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A 54-Year-Old Man With Chronic Cough and Recurrent Upper Respiratory Infection.

Chest 2021 Apr 6;159(4):e221-e224. Epub 2021 Apr 6.

Department of Pulmonary and Critical Care Medicine, Lenox Hill Hospital, New York, NY.

Case Presentation: A 54-year-old man sought treatment at the ED for a productive cough with green phlegm of approximately 6 months' duration that was accompanied by a 10-pound weight loss, night sweats, and occasional subjective fevers. He had made several prior visits to the ED for the cough and was hospitalized 4 months earlier for similar symptoms, at which time he underwent a bronchoscopy with BAL and was discharged with antibiotics for presumed pneumonia. He did not report any itching, rashes, sinus infections, joint swelling, joint pain, or GI symptoms. Read More

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An 84-Year-Old Physician With Progressive Dyspnea and Bilateral Upper Lobe Opacities.

Chest 2021 May;159(5):e325-e329

Department of Internal Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven, CT.

Case Presentation: An 84-year-old physician was seen in the pulmonary clinic with 10 days of progressive exertional dyspnea, night sweats, and dry cough. For the past 5 months, he had been taking ibuprofen for lumbar radiculopathy from spinal stenosis. Ten days earlier, ibuprofen was switched to naproxen 250 mg twice daily because of its longer half-life. Read More

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Survey of Hospital Chargemaster Transparency.

Appl Clin Inform 2021 03 5;12(2):391-398. Epub 2021 May 5.

Clinical Informatics Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States.

Background: In January 2019, the Centers for Medicare & Medicaid Services (CMS) required hospitals to list their standard charges (chargemasters) publicly in an effort to increase price transparency in health care. Surveying hospital chargemasters may be informative to assess the implementation of this rule and its utility to consumers.

Objective: We aimed to compare hospital chargemaster data within a local hospital market where patients would reasonably try to shop or compare services. Read More

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Fatal hemoperitoneum due to rupture of mesenteric artery in remission state of microscopic polyangiitis, concomitant with severe hypertension and posterior reversible encephalopathy syndrome: an autopsy case report.

CEN Case Rep 2021 May 4. Epub 2021 May 4.

Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan.

Microscopic polyangiitis (MPA) is a type of necrotizing vasculitis associated with high levels of myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA). While generally associated with renal dysfunction, MPA can also cause intraabdominal hemorrhage in rare cases. A 66-year-old man was admitted to our hospital for renal dysfunction, numbness, and weight loss for 3 months. Read More

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Long-term effect of masked hypertension management on cognitive functions in geriatric age: geriatric MASked hypertension and cognition follow-up study (G-MASH-cog MONITOR).

Blood Press Monit 2021 Aug;26(4):271-278

Division of Geriatric Medicine, Department of Internal Medicine, Hacettepe University Faculty of Medicine.

Objectives: Masked hypertension, defined as nonelevated clinic blood pressure with elevated out of clinic blood pressure, has been associated with increased cardiovascular events, mortality and cognitive impairment. No evidence exists regarding the effect of treating masked hypertension. In this study, we followed-up the patients in the G-MASH-cog study for 1 year and aimed to examine the effect of the management of masked hypertension on cognitive functions. Read More

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Awareness and Knowledge Among Internal Medicine House-Staff for Dose Adjustment of Cardiovascular Drugs in Chronic Kidney Disease.

High Blood Press Cardiovasc Prev 2021 Mar 24;28(2):177-184. Epub 2021 Feb 24.

Division of Nephrology and Hypertension, Department of Medicine, Nassau University Medical Center, 2201 Hempstead Turnpike, Box 49, East Meadow, NY, 11554, USA.

Introduction: Patients with chronic kidney disease (CKD) are vulnerable to adverse-drug events from cardiovascular drugs.

Aim: To evaluate awareness and knowledge for appropriate dose adjustment of cardiovascular drugs in CKD patients among Internal Medicine house-staff (IMHS).

Methods: Cross-sectional convenience sample survey in Fall 2015 among 341 IMHS from multiple academic institutions in the suburban New York City metropolitan area. Read More

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Amlodipine-Associated Schamberg Disease.

Am J Ther 2021 Feb 9. Epub 2021 Feb 9.

Department of Internal Medicine, SUNY Upstate Medical University, Syracuse, NY.

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February 2021

Low-Dose Triple Antihypertensive Combination Therapy in Patients with Hypertension: A Randomized, Double-Blind, Phase II Study.

Drug Des Devel Ther 2020 31;14:5735-5746. Epub 2020 Dec 31.

Cardiovascular Center, Dongguk University Ilsan Hospital, Goyang-si, Gyeonggi, Republic of Korea.

Purpose: We evaluated the dose-responsiveness, efficacy, and safety of low-dose triple antihypertensive combination therapies in patients with mild-to-moderate hypertension.

Patients And Methods: After a 1 to 2-week placebo run-in period, 248 patients were randomized to the half-dose triple combination (amlodipine 2.5 mg + losartan 25 mg + chlorthalidone 6. Read More

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December 2020

Determination of amlodipine, indapamide and perindopril in human plasma by a novel LC-MS/MS method: Application to a bioequivalence study.

Biomed Chromatogr 2021 May 22;35(5):e5048. Epub 2020 Dec 22.

Pharmaceutics Department, Faculty of Pharmacy, Deraya University, Egypt.

A robust and rapid UPLC-MS/MS method has been developed, optimized and validated for determination of amlodipine (AML), indapamide (IND) and perindopril (PRN) in human plasma. A positive electrospray ionization mode was used in a Xevo TQD LC-MS/MS instrument. A single sample preparation step using extraction technique was applied to extract the three analytes from plasma samples. Read More

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Amlodipine Induced Massive Ascites, a Rare Clinical Case.

Iran J Kidney Dis 2020 Dec;14(6):517-519

University of Health Science, Ankara City Hospital, Department of Internal Medicine, Ankara, Turkey.

Introduction: Calcium channel blockers (CCBs) are commonly used agents in the treatment of hypertension as part of monotherapy or combination therapy. Peripheral edema is the most common side effect that requires discontinuation or replacement of treatment. Some studies in the literature have shown that long-acting dihydropyridine type CCBs lead chylous ascites in peritoneal dialysis patients. Read More

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December 2020

Application of MEKC and UPLC with Fluorescence Detection for Simultaneous Determination of Amlodipine Besylate and Bisoprolol Fumarate.

J AOAC Int 2021 May;104(2):339-347

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt.

Objective: Two chromatographic methods were described for simultaneous determination of the antihypertensive drugs amlodipine besylate (AML) and bisoprolol fumarate (BIS).

Methods: Method I applies micellar electrokinetic capillary chromatography using a deactivated fused silica capillary (25 cm effective length × 50 μm internal diameter). The background electrolyte consisted of 0. Read More

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Comparative Effectiveness of Renin-Angiotensin System Inhibitors and Calcium Channel Blockers in Individuals With Advanced CKD: A Nationwide Observational Cohort Study.

Am J Kidney Dis 2021 05 24;77(5):719-729.e1. Epub 2020 Nov 24.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.

Rationale & Objective: It is unknown whether initiating renin-angiotensin system (RAS) inhibitor therapy in patients with advanced chronic kidney disease (CKD) is superior to alternative antihypertensive agents such as calcium channel blockers (CCBs). We compared the risks for kidney replacement therapy (KRT), mortality, and major adverse cardiovascular events (MACE) in patients with advanced CKD in routine nephrology practice who were initiating either RAS inhibitor or CCB therapy.

Study Design: Observational study in the Swedish Renal Registry, 2007 to 2017. Read More

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Drug-induced liver injury after switching from tamoxifen to anastrozole in a patient with a history of breast cancer being treated for hypertension and diabetes.

Ther Adv Chronic Dis 2020 16;11:2040622320964152. Epub 2020 Nov 16.

2nd Department of Internal Medicine, University Hospital Královské Vinohrady and Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Anastrozole is a selective non-steroidal aromatase inhibitor that blocks the conversion of androgens to estrogens in peripheral tissues. It is used as adjuvant therapy for early-stage hormone-sensitive breast cancer in postmenopausal women. Significant side effects of anastrozole include osteoporosis and increased levels of cholesterol. Read More

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November 2020

Post hoc study to investigate the potential causes of poor quality of cardiovascular medicines collected in sub-Saharan countries.

BMJ Open 2020 11 9;10(11):e039252. Epub 2020 Nov 9.

Laboratoire Matériaux et santé, Université Paris-Saclay, Chatenay-Malabry, France.

Objectives: The incidence of cardiovascular diseases is increasing and there is a growing need to provide access to quality cardio drugs in Africa. In the SEVEN study, we analysed 1530 cardiovascular drug samples randomly collected from 10 African countries. By that time, of the seven drugs products analysed, only those containing amlodipine and captopril had very low assay values with active substance contents that could be less than 75% of those expected. Read More

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November 2020

Telmisartan Plus S-Amlodipine Single-Pill Combination Therapy is Safe and Effective in Patients with Hypertension from Large-Scale Nationwide Surveillance Data in Korea (NOVEL) Study.

Adv Ther 2021 01 27;38(1):304-315. Epub 2020 Oct 27.

Department of Internal Medicine, Korea University Guro Hospital, Seoul, South Korea.

Introduction: We investigate the safety and efficacy of telmisartan plus S-amlodipine single-pill combination in a real-world population.

Methods: A total of 44,715 patients who had hypertension and received a telmisartan/S-amlodipine single-pill combination at least once were included for safety and efficacy evaluation from 2852 primary to tertiary hospitals in Korea from August 2013 to December 2019. They were followed up for 3-6 months in terms of safety and efficacy of blood pressure (BP) lowering. Read More

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January 2021

Antihypertensive therapy and short-term blood pressure variability.

J Hypertens 2021 Feb;39(2):349-355

Hypertension Unit and Cardiorenal Translational Laboratory, Hospital 12 de Octubre, Madrid, Spain.

Background And Aim: Blood pressure variability (BPV) is recognized as a prognostic contributor in hypertension. We aimed to assess differences in short-term BPV in treated hypertensive patients depending on the number, classes, combinations and individual compounds of the antihypertensive treatment.

Methods: We selected 38 188 treated patients from the Spanish Ambulatory BP Monitoring (ABPM) Registry. Read More

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February 2021

Amlodipine Compared with Benidipine in the Management of Hypertension: A Systematic Review and Meta-Analysis.

High Blood Press Cardiovasc Prev 2020 Dec 1;27(6):527-537. Epub 2020 Oct 1.

Faculty of Medicine, Fayoum University, Mesalla Aboudy St., Fayoum, 63511, Egypt.

Introduction: Benidipine and amlodipine are two well-known drugs used in hypertensive patients with chronic kidney disease (CKD).

Aim: In this systematic review we aimed to compare benidipine and amlodipine in terms of efficacy in the management of hypertensive patients.

Methods: We searched PubMed, Cochrane CENTRAL, SCOPUS and Web of Science for relevant clinical trials and excluded observational studies. Read More

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December 2020

Drug-drug interaction of rivaroxaban and calcium channel blockers in patients aged 80 years and older with nonvalvular atrial fibrillation.

Drug Metab Pers Ther 2020 09 4;35(3). Epub 2020 Sep 4.

Department of Clinical Pharmacology and Therapy of Federal State Budgetary Educational Institution of Further Professional Education "Russian Medical Academy of Continuous Professional Education" of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.

Objectives For revealing the peculiarities of the drug-drug interaction of rivaroxaban (substrate CYP3A4 and P-gp) and calcium channel blockers (CCBs) (verapamil - inhibitor CYP3A4 and P-gp and amlodipine - substrate CYP3A4) in patients 80 years and older with nonvalvular atrial fibrillation (NAF) we studied 128 patients. Methods All patients were divided into groups depending on the therapy taken: the 1st - rivaroxaban + amlodipine (n=51), the 2nd - rivaroxaban + verapamil (n=30), the control group - rivaroxaban without CCBs (n=47). A trough steady-state plasma concentration (C min,ss) of rivaroxaban, prothrombin time (PT) in the blood plasma and the event of clinically relevant non-major (CRNM) bleeding were assessed for each patient. Read More

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September 2020

The Ecology of Antihypertensives in the United States, 1997-2017.

J Gen Intern Med 2021 03 23;36(3):699-704. Epub 2020 Sep 23.

Department of Internal Medicine, Division of General Medicine, University of Michigan, Ann Arbor, MI, USA.

Objective: Antihypertensives are the most used medication type in the USA, yet there remains uncertainty about the use of different antihypertensives. We sought to characterize use of antihypertensives by and within medication class(es) between 1997 and 2017.

Patients And Methods: A repeated cross-sectional study of 493,596 adult individuals using the 1997-2017 Medical Expenditure Panel Survey (MEPS). Read More

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Efficacy and safety of co-administered telmisartan/amlodipine and rosuvastatin in subjects with hypertension and dyslipidemia.

J Clin Hypertens (Greenwich) 2020 10 16;22(10):1835-1845. Epub 2020 Sep 16.

Yuhan Research Institute, Yuhan Corporation, Yongin, Korea.

Single risk factors, such as hypertension and dyslipidemia, can combine to exacerbate the development and severity of cardiovascular disease. Treatment goals may be more effectively achieved if multiple disease factors are targeted with combination treatment. We enrolled 202 patients who were randomly divided into the following three groups: telmisartan/amlodipine 80/5 mg + rosuvastatin 20 mg, telmisartan 80 mg + rosuvastatin 20 mg, and telmisartan/amlodipine 80/5 mg. Read More

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October 2020

Vasospastic angina on coronary angiography.

BMJ Case Rep 2020 Sep 6;13(9). Epub 2020 Sep 6.

Cardiology, University of Florida College of Medicine - Jacksonville, Jacksonville, Florida, USA.

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September 2020

Drug-drug interaction of rivaroxaban and calcium channel blockers in patients aged 80 years and older with nonvalvular atrial fibrillation.

Drug Metab Pers Ther 2020 Sep 4. Epub 2020 Sep 4.

Department of Clinical Pharmacology and Therapy of Federal State Budgetary Educational Institution of Further Professional Education "Russian Medical Academy of Continuous Professional Education" of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.

Objectives For revealing the peculiarities of the drug-drug interaction of rivaroxaban (substrate CYP3A4 and P-gp) and calcium channel blockers (CCBs) (verapamil - inhibitor CYP3A4 and P-gp and amlodipine - substrate CYP3A4) in patients 80 years and older with nonvalvular atrial fibrillation (NAF) we studied 128 patients. Methods All patients were divided into groups depending on the therapy taken: the 1st - rivaroxaban + amlodipine (n=51), the 2nd - rivaroxaban + verapamil (n=30), the control group - rivaroxaban without CCBs (n=47). A trough steady-state plasma concentration (C min,ss) of rivaroxaban, prothrombin time (PT) in the blood plasma and the event of clinically relevant non-major (CRNM) bleeding were assessed for each patient. Read More

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September 2020

Acute idiopathic polyradiculoneuritis with secondary arterial hypertension in a 5-year-old male Siberian Husky.

Vet Q 2020 Dec;40(1):223-228

Department of Internal Medicine, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine" Ion Ionescu de la Brad" Iași, Iași, Romania.

Acute canine idiopathic polyradiculoneuritis (ACIP) is one of the most common generalised neuromuscular diseases affecting dogs. In this report, we describe a 5-year-old, 25-kg, male, intact, Siberian Husky dog with ACIP with secondary induced arterial hypertension {systolic blood pressure [mean (m) ± standard deviation (sd)], 214 ± 19 mmHg; mean blood pressure (m ± sd), 164 ± 6.36 mmHg; and diastolic blood pressure (m ± sd), 137 ± 0. Read More

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December 2020

Fixed-dose combination of amlodipine and atorvastatin improves clinical outcomes in patients with concomitant hypertension and dyslipidemia.

J Clin Hypertens (Greenwich) 2020 10 29;22(10):1846-1853. Epub 2020 Aug 29.

Division of Cardiology, Department of Internal Medicine, College of Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.

Hypertension and dyslipidemia are important risk factors for cardiovascular disease. However, the clinical outcomes of fixed-dose combination (FDC) versus free-equivalent combination (FEC) of amlodipine and atorvastatin in the treatment of concurrent hypertension and dyslipidemia remain unknown. In this study, we included patients with newly diagnosed hypertension and dyslipidemia, without previously established cardiovascular disease, and treated with either FDC or FEC of amlodipine and atorvastatin were identified from the National Health Insurance Research Database of Taiwan and follow-up for 5 years. Read More

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October 2020