9,027 results match your criteria amiodarone treatment


Timely Use of Venous-Arterial ECMO to Treat Congenital Pediatric Junctional Ectopic Tachycardia: A Case Report.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211034045

University of California, Irvine, CA, USA.

Supraventricular tachycardia is the most common tachyarrhythmia in pediatrics. Although postoperative junctional ectopic tachycardia (JET) is a known complication of congenital heart surgery that is typically transient, congenital JET is rare and requires aggressive treatment to maintain hemodynamic stability. We describe the case of a 3-month-old, previously healthy female who presented with heart failure and cardiogenic shock secondary to congenital JET for whom extracorporeal membrane oxygenation (ECMO) provided time for selection of effective therapy. Read More

View Article and Full-Text PDF

Treatment strategies for new onset atrial fibrillation in patients treated on an intensive care unit: a systematic scoping review.

Crit Care 2021 07 21;25(1):257. Epub 2021 Jul 21.

Centre for Reviews and Dissemination, University of York, York, UK.

Background: New-onset atrial fibrillation (NOAF) in patients treated on an intensive care unit (ICU) is common and associated with significant morbidity and mortality. We undertook a systematic scoping review to summarise comparative evidence to inform NOAF management for patients admitted to ICU.

Methods: We searched MEDLINE, EMBASE, CINAHL, Web of Science, OpenGrey, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects, ISRCTN, ClinicalTrials. Read More

View Article and Full-Text PDF

Association between Use of Pharmacokinetic-Interacting Drugs and Effectiveness and Safety of Direct Acting Oral Anticoagulants: Nested Case-Control Study.

Clin Pharmacol Ther 2021 Jul 19. Epub 2021 Jul 19.

Department of Medicine, Hadassah Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel.

Concomitant use of direct oral anticoagulants (DOACs) and medications with inhibition/induction effect on P-gp/CYP3A might increase risk of bleeding/treatment failure, respectively. We designed a nested case-control study within a Clalit cohort of atrial fibrillation (AF) patients and a cohort of venous thromboembolic patients, new users of a DOAC (1.1. Read More

View Article and Full-Text PDF

Treatment of Postoperative New Onset Atrial Fibrillation with Repolarization Delaying Agents after Heart Surgery.

Ann Thorac Cardiovasc Surg 2021 Jul 19. Epub 2021 Jul 19.

Department of Cardiac Surgery, Heinrich Heine University, Düsseldorf, Germany.

Purpose: The aim of this study was to evaluate the efficacy of the multichannel-blocker dronedarone for postoperative new onset atrial fibrillation (POAF) as compared to amiodarone.

Methods: Out of 990 patients who underwent cardiothoracic surgery between March 2011 and March 2012, 166 patients who developed POAF and treated with amiodarone or dronedarone were enrolled in this study.

Results: Eighty-nine patients were treated with amiodarone and 77 patients were treated with dronedarone at discharge. Read More

View Article and Full-Text PDF

Recipient and surgical factors trigger severe primary graft dysfunction after heart transplant.

J Heart Lung Transplant 2021 Jun 10. Epub 2021 Jun 10.

Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Background: Primary graft dysfunction (PGD) is a major cause of early mortality following heart transplant (HT). The International Society for Heart and Lung Transplantation (ISHLT) subdivides PGD into 3 grades of increasing severity. Most studies have assessed risk factors for PGD without distinguishing between PGD severity grade. Read More

View Article and Full-Text PDF

Identification of two different phenotypes of patients with amiodarone-induced thyrotoxicosis and positive thyrotropin receptor antibody tests.

Thyroid 2021 Jul 16. Epub 2021 Jul 16.

Università degli Studi di Pisa Facolta di Medicina e Chirurgia, 9310, Department of Clinical and Experimental Medicine, Pisa, Italy;

Introduction: Serum TSH receptor antibodies (TRAbs) are occasionally found in patients with AIT, and usually orient toward a diagnosis of type 1 AIT (AIT1) due to Graves' disease (GD). However, TRAb role and function in AIT are unsettled.

Methods: Retrospective cohort study of 309 AIT patients followed at a single Academic center over a 30-year period. Read More

View Article and Full-Text PDF

A case report about successful treatment of refractory ventricular tachycardia with ablation under prolonged haemodynamic support with extracorporeal membrane oxygenation.

Eur Heart J Case Rep 2021 Mar 10;5(3):ytab084. Epub 2021 Mar 10.

Department of Medicine, Solna Karolinska University Hospital D1:04, 171 76 Stockholm, Sweden.

Background: In patients with severe left ventricular dysfunction, recurrent ventricular tachycardia (VT) non-responsive to antiarrhythmic therapies may cause further deterioration of cardiac function and haemodynamic instability. The use of extracorporeal membrane oxygenation (ECMO) in the setting of haemodynamically unstable VT may allow rhythm stabilization and can be effective in providing haemodynamic stability during VT ablation procedures.

Case Summary: We describe the clinical course of a patient with ischaemic cardiomyopathy and recurrent VTs in the early post-myocardial infarction (MI) period. Read More

View Article and Full-Text PDF

Crucial Role of PLGA Nanoparticles in Mitigating the Amiodarone-Induced Pulmonary Toxicity.

Int J Nanomedicine 2021 8;16:4713-4737. Epub 2021 Jul 8.

Pharmaceutics Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Background: Amiodarone (AMD) is a widely used anti-arrhythmic drug, but its administration could be associated with varying degrees of pulmonary toxicity. In attempting to circumvent this issue, AMD-loaded polymeric nanoparticles (AMD-loaded NPs) had been designed.

Materials And Methods: AMD was loaded in NPs by the nanoprecipitation method using two stabilizers: bovine serum albumin and Kolliphor P 188. Read More

View Article and Full-Text PDF

Repetitive amiodarone administration causes liver damage via adipose tissue ER-stress dependent lipolysis, leading to hepatotoxic free fatty acid accumulation.

Am J Physiol Gastrointest Liver Physiol 2021 Jul 14. Epub 2021 Jul 14.

The Research Center for Digestive Tract and Liver Diseases, grid.413449.fTel-Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Drug-induced liver injury is an emerging form of acute and chronic liver disease that may manifest as fatty liver. Amiodarone (AMD), a widely used anti-arrhythmic drug, can cause hepatic injury and steatosis by a variety of mechanisms, not all completely understood. We hypothesized that repetitive AMD administration may induce hepatic lipotoxicity not only via effects on the liver, but also via effects on adipose tissue. Read More

View Article and Full-Text PDF

Vasoplegic syndrome after cardiovascular surgery: A review of pathophysiology and outcome-oriented therapeutic management.

J Card Surg 2021 Jul 12. Epub 2021 Jul 12.

Department of Cardiac Anaesthesia and Cardiothoracic and Vascular Surgery, GB Pant Hospital [GIPMER], New Delhi, India.

Background: Vasoplegic syndrome (VPS) is defined as systemic hypotension due to profound vasodilatation and loss of systemic vascular resistance (SVR), despite normal or increased cardiac index, and characterized by inadequate response to standard doses of vasopressors, and increased morbidity and mortality. It occurs in 9%-44% of cardiac surgery patients after cardiopulmonary bypass (CPB). The underlying pathophysiology following CPB consists of resistance to vasopressors (inactivation of Ca voltage gated channels) on the one hand and excessive activation of vasodilators (SIRS, iNOS, and low AVP) on the other. Read More

View Article and Full-Text PDF

Unusual cause of cardiomyopathy in a young woman.

Indian Pacing Electrophysiol J 2021 Jul 8. Epub 2021 Jul 8.

Cardiology Department. Hospital Universitario Fundación Alcorcón, Madrid, Spain.

Dual atrioventricular nodal nonreentrant tachycardia (DAVNNT) is a rare form of supraventricular tachycardia. In some patients, the presence of a dual pathway physiology results in two paths in the atrioventricular (AV) node with different conduction velocities. An atrial impulse arriving at the AV node may unfold and travel along these two pathways simultaneously, causing two ventricular activations. Read More

View Article and Full-Text PDF

Spontaneous Hemoptysis in a Patient With COVID-19.

Chest 2021 07;160(1):e39-e44

Department of Internal Medicine, Division of Infectious Diseases, Wayne State University, Detroit, MI.

Case Presentation: A 65-year-old man presented with shortness of breath, gradually worsening for the previous 2 weeks, associated with dry cough, sore throat, and diarrhea. He denied fever, chills, chest pain, abdominal pain, nausea, or vomiting. He did not have any sick contacts or travel history outside of Michigan. Read More

View Article and Full-Text PDF

Cost-Utility of Catheter Ablation for Atrial Fibrillation in Patients with Heart Failure: An Economic Evaluation.

J Am Heart Assoc 2021 Jul 9;10(14):e019599. Epub 2021 Jul 9.

Department of Medicine University of Alberta Edmonton AB Canada.

Background Recent trials comparing catheter ablation to medical therapy in patients with heart failure (HF) with symptomatic atrial fibrillation despite first-line management have demonstrated a reduction in adverse outcomes. We performed an economic evaluation to estimate the cost-utility of catheter ablation as second line therapy in patients with HF with reduced ejection fraction. Methods and Results A Markov model with health states of alive, dead, and alive with amiodarone toxicity was constructed, using the perspective of the Canadian healthcare payer. Read More

View Article and Full-Text PDF

Amiodarone-induced multiple organ damage in an Alström syndrome patient with end-stage renal disease and hepatic cirrhosis.

CEN Case Rep 2021 Jul 5. Epub 2021 Jul 5.

Aperesis and Dialysis Center, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Alström syndrome (AS) is an extremely rare disease accompanied by blindness, hearing loss, obesity, type 2 diabetes, dilated cardiomyopathy, and progressive hepatic and renal dysfunction. The life span of AS patients rarely exceeds 50 years, and thus there are very few reports describing the implementation of renal replacement therapy for these patients. We here report a case of AS patient who exhibited dilated cardiomyopathy, end-stage renal disease, and hepatic cirrhosis. Read More

View Article and Full-Text PDF

Quinidine in the Management of Recurrent Ventricular Arrhythmias: A Reappraisal.

JACC Clin Electrophysiol 2021 Jun 22. Epub 2021 Jun 22.

Cardiovascular Division, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Electronic address:

Objective: This study aimed to review the utility of quinidine in patients presenting with recurrent sustained ventricular arrhythmia (VA) and limited antiarrhythmic drug (AAD) options.

Background: Therapeutic options are often limited in patients with structural heart disease and recurrent VAs. Quinidine has an established role in rare arrhythmic syndromes, but its potential use in other difficult VAs has not been assessed in the present era. Read More

View Article and Full-Text PDF

Efficacy and safety of preoperative preparation with Lugol's iodine solution in euthyroid patients with Graves' disease (LIGRADIS Trial): Study protocol for a multicenter randomized trial.

Contemp Clin Trials Commun 2021 Jun 15;22:100806. Epub 2021 Jun 15.

Department of General and Digestive Surgery. Hospital Universitario 12 de Octubre, Av. de Córdoba s/n, 28041, Madrid, Spain.

Background: Currently, both the American Thyroid Association and the European Thyroid Association recommend preoperative preparation with Lugol's Solution (LS) for patients undergoing thyroidectomy for Graves' Disease (GD), but their recommendations are based on low-quality evidence. The LIGRADIS trial aims to provide evidence either to support or refute the systematic use of LS in euthyroid patients undergoing thyroidectomy for GD.

Methods: A multicenter randomized controlled trial will be performed. Read More

View Article and Full-Text PDF

The risk of worsening of myasthenia by cardiovascular medication as reflected by reporting frequency.

Eur J Neurol 2021 Jun 28. Epub 2021 Jun 28.

Department of Cardiology, University Hospital of Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.

Background And Purpose: Some groups of cardiovascular drugs (beta-blocking drugs, Ca antagonists, antiarrhythmics) are listed as potentially worsening myasthenia. An empirical basis for alternative recommendations for antihypertensive and antiarrhythmic therapy in myasthenia patients has not yet been provided.

Methods: From the World Health Organization pharmacovigilance database, we retrieved total and myasthenia-related counts of adverse drug reactions for various groups of drugs used in cardiovascular disease and drugs with related mechanism of action used in other indications. Read More

View Article and Full-Text PDF

Supraventricular tachycardias in neonates and infants: factors associated with fatal or near-fatal outcome.

Eur J Pediatr 2021 Aug 29;180(8):2669-2676. Epub 2021 Jun 29.

Gottsegen György Hungarian Institute of Cardiology, Budapest, Hungary.

Prognosis of supraventricular tachycardias in neonates and infants is thought to be excellent with rare fatal outcomes. Nevertheless, initial management can be challenging. The aim of this study was to perform a retrospective analysis in neonates/infants with non-pos-toperative supraventricular tachycardias regarding risk factors for clinical outcome and type of antiarrhythmic drug therapy. Read More

View Article and Full-Text PDF

Amiodarone-induced organizing pneumonia mimicking COVID-19: a case report.

Eur J Med Res 2021 Jun 27;26(1):62. Epub 2021 Jun 27.

Department of Internal Medicine, Legnano and Cuggiono Hospitals, ASST Ovest Milanese, Milan, Italy.

Background: Differential diagnosis of interstitial lung diseases (ILDs) during the COVID-19 pandemic is difficult, due to similarities in clinical and radiological presentation between COVID-19 and other ILDs on the one hand, and frequent false-negative swab results on the other. We describe a rare form of interstitial and organizing pneumonia resembling COVID-19, emphasizing some key aspects to focus on to get the right diagnosis and treat the patient properly.

Case Presentation: A 76-year-old man presented with short breath and dry cough in the midst of the COVID-19 outbreak. Read More

View Article and Full-Text PDF

Neonatal Arrhythmia.

Authors:
A Joshi S Humagain

Kathmandu Univ Med J (KUMJ) 2020 Oct.-Dec.;18(72):430-433

Department of Medicine, Dhulikhel Hospital, Kathmandu University Hospital, Kathmandu University School of Medical Sciences, Dhulikhel, Kavre, Nepal.

Arrhythmias are seldom observed in the newborn period and rarely lead to serious consequences. Because they may be a continuation of fetal arrhythmias, newborn arrhythmias are different from those occurring at later ages. Here we describe a case of a newborn presented with tachycardia at birth. Read More

View Article and Full-Text PDF

Effect of predictive nursing combined with amiodarone on the treatment of tachyarrhythmia in patients with coronary heart disease.

Am J Transl Res 2021 15;13(5):4987-4994. Epub 2021 May 15.

Department of Emergency, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430014, Hubei, China.

Objective: We aimed to investigate the clinical effect of predictive nursing combined with amiodarone on the treatment of tachyarrhythmia in patients with coronary heart disease (CHD).

Methods: The clinical data of 101 patients with CHD and tachyarrhythmia in our hospital were collected retrospectively and divided into two groups according to different intervention methods. Patients in group A (n=50) were treated with Propafenone, while patients in group B (n=51) were treated with Amiodarone. Read More

View Article and Full-Text PDF

Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions.

Chem Res Toxicol 2021 Jun 18. Epub 2021 Jun 18.

Department of Cardiovascular Pharmacotherapy and Toxicology, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, Osaka 569-1094, Japan.

Amiodarone is a benzofuran derivative used to treat arrhythmias, but its use is limited by adverse reactions. There is evidence that some of the severe adverse reactions such as liver injury and interstitial lung disease are immune-mediated; however, details of the mechanism have not been elucidated. We tested the ability of amiodarone to induce the release of danger-associated molecular patterns (DAMPs) that activate inflammasomes. Read More

View Article and Full-Text PDF

Therapeutic monitoring of amiodarone and desethylamiodarone after surgical ablation of atrial fibrillation-evaluation of the relationship between clinical effect and the serum concentration.

Saudi Pharm J 2021 May 31;29(5):369-376. Epub 2021 Mar 31.

Department of Clinical Pharmacology, Faculty of Medicine, University of Ostrava, Syllabova 19, 703 00 Ostrava, Czech Republic.

Background: Association between clinical effect and serum concentration of amiodarone (AMI) and its active metabolite desethylamidarone (DEA) in patients after surgical ablation (SA) of atrial fibrillation (AF) has not yet been studied.

Aims: We wanted to find a correlation between AMI and DEA serum concentration and maintaining sinus rhythm (SR) after SA of AF.

Methods: Sixty eight patients with AF who had undergone surgical ablation between 2014 and 2017 were included in a single-centre, prospective, observational study. Read More

View Article and Full-Text PDF

The effects of amiodarone on thyroid function in pediatric and adolescent patients.

Curr Opin Pediatr 2021 08;33(4):436-441

Division of Pediatric Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Purpose Of Review: Amiodarone-induced thyroid dysfunction is well established. The present review discusses recent literature related to the effects of amiodarone on the thyroid gland and thyroid function in pediatrics.

Recent Findings: Current guidelines in adults treated with amiodarone recommend baseline thyroid function testing followed by initiation of thyroid hormone monitoring after 3 months on therapy. Read More

View Article and Full-Text PDF

Variables affecting the quality of anticoagulation in atrial fibrillation patients newly initiating vitamin K antagonists: insights from the national and multicentre SULTAN registry.

Europace 2021 Jun 11. Epub 2021 Jun 11.

Department of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca, University of Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), CIBERCV, Ctra. Madrid-Cartagena s/n, 30120 El Palmar, Murcia, Spain.

Aims: Vitamin K antagonists (VKAs) are effective drugs reducing the risk for stroke in atrial fibrillation (AF), but the benefits derived from such therapy depend on the international normalized ratio (INR) maintenance in a narrow therapeutic range. Here, we aimed to determine independent variables driving poor anticoagulation control [defined as a time in therapeutic range (TTR) <65%] in a 'real world' national cohort of AF patients.

Methods And Results: The SULTAN registry is a multicentre, prospective study, involving patients with non-valvular AF from 72 cardiology units expert in AF in Spain. Read More

View Article and Full-Text PDF

Analysis of the physiological and pathological factors of hospitalized patients taking warfarin and the correlation between drug interactions and warfarin efficacy.

Ann Palliat Med 2021 May;10(5):5400-5406

Department of Pharmacy, Shenzhen Hospital of Southern Medical University, Shenzhen, China.

Background: To study the various factors affecting the anticoagulant effect of warfarin, and to promote the rational use of warfarin.

Methods: We collected the medical records of 125 hospitalized patients who used warfarin from January 2018 to December 2019. Statistical analysis was performed on characteristics such as gender, age, treatment, diabetes, hyperlipidemia, hyperthyroidism, hypothyroidism, hepatitis, renal insufficiency, and nephritis; along with other pathological factors, such as aspirin, clopidogrel, spironolactone, amiodarone, amlodipine, trimetazidine, bisoprolol, isosorbide, atorvastatin, furosemide, digoxin, metoprolol, acarbose, levamlodipine, enoxaparin, moxifloxacin, levofloxacin, other drug interactions, and comorbidities. Read More

View Article and Full-Text PDF