91,992 results match your criteria aminotransferase aspartate


Changes in phenotype and gene expression under lead stress revealed key genetic responses to lead tolerance in Medicago sativa L.

Gene 2021 May 9:145714. Epub 2021 May 9.

College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, Jilin, China. Electronic address:

Lead (Pb) is a serious heavy metal soil pollutant. It can be absorbed and accumulated by plant roots and impact plant growth. Medicago sativa L. Read More

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Comparative evaluation of cardioprotective activity of and juice against isoprenaline-induced cardiotoxicity in rats.

J Complement Integr Med 2021 May 12. Epub 2021 May 12.

Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India.

Objectives: Comparative evaluation of cardioprotective activity of and juice against isoprenaline induced cardiotoxicity in rats.

Methods: Rats (125-150 g) were orally administered (GA) and (FA) apple juice (3 mL/day, per oral) for 13 days. Myocardial injury was inducted on 14th and 15th day by the administration of Isoprenaline (85 mg/kg/day, subcutaneous). Read More

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Combining hepatic surface nodularity and serum tests better predicts hepatic fibrosis stages in chronic liver disease.

Abdom Radiol (NY) 2021 May 12. Epub 2021 May 12.

Department of Radiology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Republic of Korea.

Purpose: Hepatic surface nodularity quantified on CT images has shown promising results in staging hepatic fibrosis in chronic hepatitis C. The aim of this study was to evaluate hepatic surface nodularity, serum fibrosis indices, and a linear combination of them for staging fibrosis in chronic liver disease, mainly chronic hepatitis B.

Methods: We developed a semiautomated software quantifying hepatic surface nodularity on CT images. Read More

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Exploration of the optimal strategy for dietary calcium intervention against the toxicity of liver and kidney induced by cadmium in mice: An in vivo diet intervention study.

PLoS One 2021 11;16(5):e0250885. Epub 2021 May 11.

State Key Laboratory of Pollution Control & Resource Reuse, School of the Environment, Nanjing University, Nanjing, PR China.

Cadmium (Cd) is a toxic non-essential element, while calcium (Ca) is an essential element with high chemical similarity to Cd. Dietary intake is the major Cd exposure pathway for non-smokers. A multi-concentration dietary intervention experiment was designed to explore the optimum concentration of Ca in diet with obvious protective effects against the toxicity of livers and kidneys induced by Cd in mice. Read More

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Astragaloside alleviates alcoholic fatty liver disease by suppressing oxidative stress.

Kaohsiung J Med Sci 2021 May 11. Epub 2021 May 11.

Department of Preclinical Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, China.

Alcoholic fatty liver disease (AFLD) is the most common liver disease and can progress to fatal liver cirrhosis and carcinoma, affecting millions of patients worldwide. The functions of astragaloside on the cardiovascular system have been elucidated. However, its role in AFLD is unclear. Read More

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Clinical and Laboratory Predictors of Severity, Criticality, and Mortality in COVID-19: A Multisystem Disease.

Adv Exp Med Biol 2021 ;1318:369-402

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Coronavirus disease 2019 (COVID-19) pandemic continues devastating effects on healthcare systems. Such a crisis calls for an urgent need to develop a risk stratification tool. The present chapter aimed to identify laboratory and clinical correlates of adverse outcomes in patients with COVID-19. Read More

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CRP is a superior and prognostically significant inflammation biomarker for hepatocellular cancer patients treated by liver transplantation.

Clin Pract (Lond) 2021 ;18(2):1626-1632

Department of Surgery, Liver Transplantation Institute, Inonu University, Turkey.

Background: Inflammation and its markers are considered prognostically important for many cancers, including Hepatocellular Carcinoma (HCC). However, it is not really clear which markers are the best.

Aims: To assess in a cohort of prospectively-evaluated HCC patients who were treated with liver transplant and whose survival was known, multiple commonly used inflammatory markers in relation to survival and to both clinical and tumor aggressiveness parameters. Read More

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January 2021

Adaptive laboratory evolution accelerated glutarate production by Corynebacterium glutamicum.

Microb Cell Fact 2021 May 10;20(1):97. Epub 2021 May 10.

Genetics of Prokaryotes, Faculty of Biology & CeBiTec, Bielefeld University, Universitätsstr. 25, 33615, Bielefeld, Germany.

Background: The demand for biobased polymers is increasing steadily worldwide. Microbial hosts for production of their monomeric precursors such as glutarate are developed. To meet the market demand, production hosts have to be improved constantly with respect to product titers and yields, but also shortening bioprocess duration is important. Read More

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Prevalence of and risk factors for metabolic associated fatty liver disease in an urban population in China: a cross-sectional comparative study.

BMC Gastroenterol 2021 May 10;21(1):212. Epub 2021 May 10.

Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Background: Metabolic associated fatty liver disease (MAFLD) is a new definition for liver disease associated with known metabolic dysfunction. Based on new diagnostic criteria, we aimed to investigate its prevalence and risk factors in Chinese population.

Methods: We conducted this study in a health examination population who underwent abdominal ultrasonography in China. Read More

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Relation of gilthead seabream (Sparus aurata) seasonal reproductive activity to hematology, serum biochemistry, histopathology, and Brdt gene expression.

Fish Physiol Biochem 2021 May 10. Epub 2021 May 10.

Aquatic Hatchery Production Department, Fish Farming and Technology Institute, Suez Canal University, Ismailia, Egypt.

This study aimed to find the relation of Sparus aurata (gilthead seabream) reproductive activities to some blood parameters as complete blood count, liver enzymes, some hormones related to reproduction process and microscopic findings of gonads, as well as expression of Bromodomain testis-specific gene. Eighty-eight sexually mature seabream were collected and investigated through the four seasons. Red blood cells were higher in autumn and spring. Read More

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Hepatogenous photosensitisation in cows grazing turnips (Brassica rapa) in South Africa.

J S Afr Vet Assoc 2021 May 6;92(0):e1-e6. Epub 2021 May 6.

Humansdorp Veterinary Clinic, Humansdorp.

Holstein cows on a farm in the Humansdorp district, Eastern Cape province, South Africa, developed reddened, painful teat skin 3 days after grazing a mixed forage crop dominated by bulb turnip (Brassica rapa, Barkant cultivar). The crop was grazed 45 days after planting and 10% of the herd developed symptoms. More characteristic non-pigmented skin lesions started manifesting 1-2 days after the appearance of the teat lesions. Read More

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Development of a novel risk score for the prediction of critical illness amongst COVID-19 patients.

Int J Clin Pract 2021 Apr 22;75(4):e13915. Epub 2020 Dec 22.

Department of Internal Medicine, "Sotiria" General and Chest Diseases Hospital of Athens, Athens, Greece.

Objectives: Coronavirus disease-19 (COVID-19) is associated with various clinical manifestations, ranging from asymptomatic infection to critical illness. The aim of this study is to evaluate the clinical and laboratory characteristics of hospitalised COVID-19 patients and construct a predictive model for the discrimination of patients at risk of disease progression.

Methods: A single-centre cohort study was conducted including consecutively patients with COVID-19. Read More

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Identification of a novel MICU1 nonsense variant causes myopathy with extrapyramidal signs in an Iranian consanguineous family.

Mol Cell Pediatr 2021 May 9;8(1). Epub 2021 May 9.

Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Background: Ca as a universal second messenger regulates basic biological functions including cell cycle, cell proliferation, cell differentiation, and cell death. Lack of the protein mitochondrial calcium uptake1 (MICU1), which has been regarded as a gatekeeper of Ca ions, leads to the abnormal mitochondrial Ca handling, excessive production of reactive oxygen species (ROS), and increased cell death. Mutations in MICU1 gene causes a very rare neuromuscular disease, myopathy with extrapyramidal signs (MPXPS), due to primary alterations in mitochondrial calcium signaling which demonstrates the key role of mitochondrial Ca uptake. Read More

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Genotype Distribution of Vitamin D Receptor Polymorphisms among Indonesian Patients with Chronic Hepatitis B.

Rep Biochem Mol Biol 2021 Jan;9(4):463-469

Department of Clinical Pathology, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia.

Background: Chronic hepatitis B is a necro-inflammatory of the liver parenchyma caused by hepatitis B virus (HBV) infection leading to liver cirrhosis and hepatocellular carcinoma (HCC). Genetic variants including single nucleotide polymorphisms (SNPs) within genes regulating immune response may contribute to the progression of chronic hepatitis B (CHB) infection. This study aimed to examine the genotype distribution of vitamin D receptor (VDR) polymorphism among patients with CHB infection and to study its association with the development of cirrhosis and hepatoma. Read More

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January 2021

The Effects of Using Chemicals to Remove Slime from African Giant Land Snails Flesh during Processing on Some Nutritional and Biochemical Parameters.

Int J Food Sci 2021 21;2021:6691609. Epub 2021 Apr 21.

Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.

The effects of chemicals commonly used in Cameroon to eliminate slime from the flesh of the African giant land snail, , during processing on some nutritional and biochemical parameters were investigated. Groups of snails were processed with these chemicals at three different concentrations. Proximate analysis of all the treated snail groups was carried out, and groups with the highest concentration of each chemical were used to compose diets for experimental rats. Read More

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H. pylori is related to NAFLD but only in female: A Cross-sectional Study.

Int J Med Sci 2021 2;18(11):2303-2311. Epub 2021 Apr 2.

Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Recently, an increasing number of studies have focused on the extragastrointestinal effects of Helicobacter pylori (H. pylori), including metabolic syndrome, fatty liver, and rheumatic and skin diseases. Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease worldwide that conveys a heavy economic burden on patients and society. Read More

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Correlation between GPR, MHR and elderly essential hypertension with unstable angina pectoris.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Apr;46(4):373-378

Department of Cardiac Electrophysiology, Affiliated Hospital of Chengde Medical College, Chengde Hebei 067000.

Objectives: To investigate the level and significance of serum γ-glutamyl transferase-to-platelet ratio (GPR) and monocyte count to high-density lipoprotein ratio (MHR) in patients with essential hypertension (EH) and unstable angina (UA).

Methods: A total of 218 patients with coronary angiography aged ≥60 years, who were admitted to the EH hospital of the Department of Cardiac Medicine, Affiliated Hospital of Chengde Medical College, were selected from September 2018 to September 2019. They were divided into an EH+UA group (=113) and an EH group (=105). Read More

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Analysis on the value of soluble intercellular adhesion molecule-1 (sICAM-1), alpha fetoprotein (AFP), and aspartate aminotransferase/platelet ratio index (APRI) in predicting the prognostic survival of patients with primary liver cancer after radiofrequency ablation.

Ann Palliat Med 2021 Apr;10(4):4760-4767

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: To analyze the value of soluble intercellular adhesion molecule-1 (sICAM-1), alpha fetoprotein (AFP), and aspartate aminotransferase (AST)/platelet (PLT) ratio index (APRI) in predicting the prognostic survival of patients with primary liver cancer after radiofrequency ablation (RFA).

Methods: The data of 115 patients with primary liver cancer admitted to our hospital from June 2016 to June 2018 were retrospectively analyzed as the research group, and 120 healthy people who were examined during the same period were selected as the control group. Multivariate logistic regression analysis was used to analyze the risk factors that affect the prognostic survival of patients with primary liver cancer treated with RFA. Read More

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Effect of dietary Xiao-Chaihu-Decoction on growth performance, immune response, detoxification and intestinal microbiota of Pacific white shrimp (Litopenaeus vannamei).

Fish Shellfish Immunol 2021 May 6. Epub 2021 May 6.

The Key Laboratory of Mariculture, Ocean University of China, Ministry of Education, Qingdao, Shandong, 266003, China.

Xiao-Chaihu-Decoction (XCHD), a classical traditional Chinese medicine with diverse biological activities, is widely applied to prevent and treat many human diseases. Effects of dietary XCHD on growth performance, immune response, detoxification system, intestinal microbiota and resistance against aflatoxin B1(AFB) of Litopenaeus vannamei was studied. Four isonitrogenous and isolipidic diets were formulated to contain 0, 1, 2, and 5 g/kg (control, XCHD1, XCHD2 and XCHD3) of XCHD, respectively. Read More

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The combination of conventional ultrasound and shear-wave elastography in evaluating the segmental heterogeneity of liver fibrosis in biliary atresia patients after Kasai portoenterostomy.

Pediatr Surg Int 2021 May 9. Epub 2021 May 9.

Department of Medical Ultrasonics, Institute for Diagnostic and Interventional Ultrasound, The First Affiliated Hospital, Sun Yat-Sen University, No. 58, Zhongshan Er Road, Guangzhou, 510080, People's Republic of China.

Objective: To retrospectively assess the value of the combination of conventional ultrasound and shear-wave elastography (SWE) in evaluating the segmental heterogeneity of liver fibrosis in biliary atresia (BA) patients after Kasai portoenterostomy.

Methods: A total of 35 BA patients with liver segmental deformation were enrolled. The segmental deformation was assessed by conventional ultrasound followed with SWE examinations for evaluating the liver stiffness. Read More

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Zingiber roseum Rosc. rhizome: A rich source of hepatoprotective polyphenols.

Biomed Pharmacother 2021 May 6;139:111673. Epub 2021 May 6.

Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814, Bangladesh. Electronic address:

Zingiber roseum is native to Bangladesh and widely used in folk medicine. This present study was designed to assess the ameliorative potential of Zingiber roseum rhizome extract in carbon tetrachloride (CCl) induced hepatotoxicity in mice model. Seven phenolic compounds were identified and quantified by HPLC analysis in the plant extract, including quercetin, myricetin, catechin hydrate, trans-ferulic acid, trans-cinnamic acid, (-) epicatechin, and rosmarinic acid. Read More

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Long-term safety of lumacaftor-ivacaftor in children aged 2-5 years with cystic fibrosis homozygous for the F508del-CFTR mutation: a multicentre, phase 3, open-label, extension study.

Lancet Respir Med 2021 May 6. Epub 2021 May 6.

Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Stanley Manne Children's Research Institute, Chicago, IL, USA; Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, USA.

Background: A previous phase 3 study showed that lumacaftor-ivacaftor was generally safe and well tolerated over 24 weeks of treatment in children aged 2-5 years with cystic fibrosis homozygous for the F508del-CFTR mutation. In this study, we aimed to assess the long-term safety of lumacaftor-ivacaftor in a rollover study of children who participated in this previous phase 3 study.

Methods: In this multicentre, phase 3, open-label, extension study (study 116; VX16-809-116), we assessed safety of lumacaftor-ivacaftor in children included in a previous multicentre, phase 3, open-label study (study 115; VX15-809-115). Read More

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Associations between urinary phthalate metabolite concentrations and markers of liver injury in the US adult population.

Environ Int 2021 May 6;155:106608. Epub 2021 May 6.

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address:

Background: Phthalates have been largely used for years in varieties of products worldwide. However, research on the joint toxic effect of various phthalates exposure on the liver is lacking.

Objectives: We aimed to assess exposure to phthalates on liver function tests (LFTs). Read More

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Lysosomal acid lipase deficiency in pediatric patients: A scoping review.

J Pediatr (Rio J) 2021 May 5. Epub 2021 May 5.

Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, SC, Brazil; Universidade Federal de Santa Catarina, Laboratório de Pesquisa Clínica e Experimental- MENULab, Florianópolis, SC, Brazil; Universidade Federal de Santa Catarina, Departamento de Pediatria, Florianópolis, SC, Brazil.

Objective: Lysosomal acid lipase deficiency (LAL-D) is an underdiagnosed autosomal recessive disease with onset between the first years of life and adulthood. Early diagnosis is crucial for effective therapy and long-term survival. The objective of this article is to recognize warning signs among the clinical and laboratory characteristics of LAL-D in pediatric patients through a scope review. Read More

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[Inhibitory effect of citrus fermentation liquor on liver fibrosis in mice].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Apr;41(4):588-592

Clinical Research Center, TCM-Integrated Hospital of Southern Medical University, Guangzhou 510315, China.

Objective: To investigate the inhibitory effect of citrus fermentation liquor on liver fibrosis in mice.

Objective: Mouse models of liver fibrosis were established by intraperitoneal injection of CCl in 105 male C57BL/6 mice, followed by gavage of 0.1 mL 40% CCl olive oil 3 times a week (model group, =49) or daily gavage of citrus liquor at the dose of 0. Read More

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Ferulic acid positively modulates the inflammatory response to septic liver injury through the GSK-3β/NF-κB/CREB pathway.

Life Sci 2021 May 4:119584. Epub 2021 May 4.

Department of Emergency Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, PR China. Electronic address:

Aims: Ferulic acid (FA) is a component found in plants that has free radical scavenging and liver-protective properties. Acute liver injury (ALI) is a serious complication of sepsis and is closely associated with changes in the levels of inflammatory factors. This study was taken to examine the role of FA in cecal ligation and perforation (CLP)-induced murine ALI and lipopolysaccharide (LPS)-induced cellular ALI models. Read More

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Current and past infections of hepatitis B virus do not increase mortality in patients with COVID-19.

Hepatology 2021 May 7. Epub 2021 May 7.

Department of Medicine and Therapeutics, Hong Kong SAR, China.

Background & Aims: We compared risk of acute liver injury and mortality in COVID-19 patients with current, past, and no hepatitis B virus (HBV) infection.

Approach & Results: This was a territory-wide retrospective cohort study in Hong Kong. COVID-19 patients between 23 January 2020 and 1 January 2021 were identified. Read More

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[Clinical meaning of elevated aminotransferases].

MMW Fortschr Med 2021 05;163(9):51

Transplantationszentrum der LMU, Campus Großhadern, Marchioninistr. 15, 81377, München, Deutschland.

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A new syndrome of moyamoya disease, kidney dysplasia, aminotransferase elevation, and skin disease associated with de novo variants in RNF213.

Am J Med Genet A 2021 May 7. Epub 2021 May 7.

Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Ring-finger protein 213 (RNF213) encodes a protein of unknown function believed to play a role in cellular metabolism and angiogenesis. Gene variants are associated with susceptibility to moyamoya disease. Here, we describe two children with moyamoya disease who also demonstrated kidney disease, elevated aminotransferases, and recurrent skin lesions found by exome sequencing to have de novo missense variants in RNF213. Read More

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Saffron improves life and sleep quality, glycemic status, lipid profile and liver function in diabetic patients: A double-blind, placebo-controlled, randomized clinical trial.

Int J Clin Pract 2021 May 7:e14334. Epub 2021 May 7.

Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Type 2 diabetes (T2D) is a metabolic disorder that is related to hyperglycemia, hyperlipidemia, and liver dysfunction and has detrimental effects on a patient's mental health. Hence, the current study investigated the effects of saffron supplementation on dietary intake, anthropometric measures, mood, sleep quality, and metabolic biomarkers in overweight/obese patients with T2D.

Methods: In a double-blind, randomized controlled trial, 70 overweight/obese patients with T2D were randomly allocated to two groups and received 100 mg/day saffron or placebo for eight weeks. Read More

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