92,759 results match your criteria amine groups

Assembly of polycyclic N-heterocycles copper-catalyzed cycloamination of indolylquinones and aromatic amines.

Org Biomol Chem 2021 May 7. Epub 2021 May 7.

College of Chemistry and Life Science, Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules, Chengdu Normal University, Chengdu, 611130, P. R. China.

The copper-catalyzed cycloamination of indolylquinones and various (hetero)aromatic amines under ligand-free conditions for the synthesis of polycyclic N-heterocycles has been developed. This method allows facile access to polycyclic N-heterocycles with the tolerance of chloride, bromide, amino, thio, etc. groups in moderate to high yields (60-89%). Read More

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Amine-functionalized carbon-fiber microelectrodes for enhanced ATP detection with fast-scan cyclic voltammetry.

Anal Methods 2021 May 7. Epub 2021 May 7.

Department of Chemistry, University of Cincinnati, 312 College Dr., 404 Crosley Tower, Cincinnati, OH 45221-0172, USA.

Here, we provide evidence that functionalizing the carbon-fiber surface with amines significantly improves direct electrochemical adenosine triphosphate (ATP) detection with fast-scan cyclic voltammetry (FSCV). ATP is an important extracellular signaling molecule throughout the body and can function as a neurotransmitter in the brain. Several methods have been developed over the years to monitor and quantitate ATP signaling in cells and tissues; however, many of them are limited in temporal resolution or are not capable of measuring ATP directly. Read More

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Molecular Dynamics Studies of Therapeutic Liquid Mixtures and Their Binding to Mycobacteria.

Front Pharmacol 2021 20;12:626735. Epub 2021 Apr 20.

Red Glead Discovery AB, Lund, Sweden.

Tuberculosis is an highly contagious disease still considered by the WHO as one of most infectious diseases worldwide. The therapeutic approach, used to prevent and treat tuberculosis targets the complex, comprises a combination of drugs administrated for long periods of time, which, in many cases, could cause several adverse effects and, consequently, low compliance of the patient to the treatment and drug-resistance. Therefore, therapeutic liquid mixtures formulated with anti-tuberculosis drugs and/or adjuvants in tuberculosis therapy are an interesting approach to prevent toxic effects and resistance to anti-tuberculosis drugs. Read More

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Microporous Nickel-Coordinated Aminosilica Membranes for Improved Pervaporation Performance of Methanol/Toluene Separation.

ACS Appl Mater Interfaces 2021 May 6. Epub 2021 May 6.

Department of Chemical Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8527, Japan.

The nickel-doped bis [3-(trimethoxysilyl) propyl] amine (BTPA) derived membrane has a microporous coordinated network that has high potential to be an ideal separation barrier for methanol-toluene azeotropic mixtures via the pervaporation process. Ni-BTPA membranes were modified by employing a nickel dopant over amine groups in mole ratios (mol/mol) that ranged from 0.125 to 0. Read More

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[Controlling Cell Dynamics by Cell-surface Modification].

Yakugaku Zasshi 2021 ;141(5):661-665

Faculty of Medicine, Kindai University.

Although the concept of a drug delivery system (DDS) is usually applied to conventional drug therapy, it is also important for cell-based therapy. The surface manipulation of living cells represents a powerful tool for controlling cell behaviors in the body, such as enhancement of cell-cell interactions, targeted delivery of cells, and protection from immunological rejection. Functional groups, including amines, thiols, and carbonyls, offer excellent opportunities for chemical modification through the formation of covalent bonds with exogenous molecules. Read More

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January 2021

Enantioselective, Catalytic Multicomponent Synthesis of Homoallylic Amines Enabled by Hydrogen-Bonding and Dispersive Interactions.

J Am Chem Soc 2021 May 5. Epub 2021 May 5.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.

We report a one-step catalytic, enantioselective method for the preparation of homoallylic -Boc amines directly from acetals. Reactive iminium ion intermediates are generated through the combination of an acetal, a chiral thiourea catalyst, trialkylsilyl triflate, and -Boc carbamate and are subsequently trapped by a variety of allylsilane nucleophiles. No homoallylic ether byproducts are detected, consistent with allylation of the iminium intermediate being highly favored over allylation of the intermediate oxocarbenium ion. Read More

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Facile Surface Modification of Polyamide Membranes Using UV-Photooxidation Improves Permeability and Reduces Natural Organic Matter Fouling.

Environ Sci Technol 2021 May 5. Epub 2021 May 5.

Nanosystems Engineering Research Center for Nanotechnology-Enabled Water Treatment, School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, Arizona 85287, United States.

A new optimized ultraviolet (UV) technique induced a photooxidation surface modification on thin-film composite (TFC) polyamide (PA) brackish water reverse osmosis (BWRO) membranes that improved membrane performance (i.e., permeability and organic fouling propensity). Read More

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Zwitterionic polydopamine coatings suppress silicone implant-induced capsule formation.

Biomater Sci 2021 May;9(9):3425-3432

Department of Plastic and Reconstructive Surgery, Chungnam National University College of Medicine, Daejeon 35015, Republic of Korea.

A synthetic zwitterionic dopamine derivative (ZW-DOPA) containing both catechol and amine groups was recently shown to exhibit excellent antifouling activity on marine surfaces. Here, we have extended these analyses to investigate the effects of ZW-DOPA coating on silicone implants. Successful formation of ZW-DOPA coatings on silicone implants was confirmed based on a combination of decreased static water contact angles on silicone implants, evidence of new peaks at 400. Read More

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Synthesis and Characterization of Macroinitiators Based on Polyorganophosphazenes for the Ring Opening Polymerization of -Carboxyanhydrides.

Polymers (Basel) 2021 Apr 29;13(9). Epub 2021 Apr 29.

Institute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoy pr. 31, 199004 St. Petersburg, Russia.

Among the various biocompatible amphiphilic copolymers, biodegradable ones are the most promising for the preparation of drug delivery systems since they are destroyed under physiological conditions, that, as a rule, reduce toxicity and provide controlled release of the drug. Hybrid graft-copolymers consisting of the main inorganic polyphosphazene chain and polypeptide side chains are of considerable interest for the development of delivery systems with a controlled degradation rate, since the main and side chains will have different degradation mechanisms (chemical and enzymatic hydrolysis, respectively). Variable particle degradation rate, controlled by the adjusting the composition of substituents, will allow selective delivery in vivo and controlled drug release. Read More

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Crystal Structure of Agmatinase: Catalytic Mechanism and Residues Relevant for Substrate Specificity.

Int J Mol Sci 2021 Apr 30;22(9). Epub 2021 Apr 30.

Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Biológicas, Universidad de Concepción, Casilla 160-C, Concepción 4070386, Concepción, Chile.

Agmatine is the product of the decarboxylation of L-arginine by the enzyme arginine decarboxylase. This amine has been attributed to neurotransmitter functions, anticonvulsant, anti-neurotoxic, and antidepressant in mammals and is a potential therapeutic agent for diseases such as Alzheimer's, Parkinson's, and cancer. Agmatinase enzyme hydrolyze agmatine into urea and putrescine, which belong to one of the pathways producing polyamines, essential for cell proliferation. Read More

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Exploring Cyclic Sulfamidate Building Blocks for the Synthesis of Sequence-Defined Macromolecules.

Macromol Rapid Commun 2021 May 4:e2100193. Epub 2021 May 4.

Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich-Heine-University Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany.

The preparation of sequence-defined macromolecules using cyclic sulfamidates on solid-phase is outlined. The challenges surrounding an AB+CD approach are described with focus on understanding the formation of ring-opened side products when using amide coupling reagents. To avoid undesired side product formation, a strategy of iterative ring-openings of cyclic sulfamidates on solid-phase is explored. Read More

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Synthesis and characterization of bis(amine)palladium(II) carboxylate complexes as precursors of palladium nanoparticles.

Dalton Trans 2021 Apr 30. Epub 2021 Apr 30.

Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland.

The synthesis and characterization of the adducts of n-alkyl amine and palladium n-alkyl carboxylate, [Pd(R2NH2)2(R1COO)2] (R1 = 1, 7, and 11; R2 = 8, 12, and 16), as precursors for the synthesis of palladium nanoparticles (PdNPs) was carried out via differential scanning calorimetry, FT-IR, Raman and UV-Vis spectroscopy, NMR spectroscopy (1H, 13C pulsed field gradient spin-echo (PGSE), and 13C CP-MAS), and powder X-ray diffraction. Pd n-alkyl carboxylates were obtained by a ligand exchange reaction from palladium acetate and the appropriate aliphatic carboxylic acid. It is proposed that carboxyl moieties in the presence of amine ligands are bound to palladium ions via monodentate bonding as opposed to bridging bidentate coordination of pure palladium carboxylate which exists in the form of polymer aggregates. Read More

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Alternations in the liver metabolome, skin and serum antioxidant function of silver pomfret () is induced by jellyfish feeding.

3 Biotech 2021 Apr 25;11(4):192. Epub 2021 Mar 25.

East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai, China.

Many fish species are known to feed on jellyfish. Herein, we observed the effects of jellyfish feeding on silver pomfret using gas chromatography tandem time-of-flight mass spectrometry (GC-TOF-MS) based on metabolomics. We studied the effects of feeding on jellyfish on skin and serum immune of silver pomfret. Read More

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A Facile Strategy for the High Yielding, Quantitative Conversion of Polyglycol End-Groups to Amines.

Polymers (Basel) 2021 Apr 26;13(9). Epub 2021 Apr 26.

Applied Chemistry and Translational Biomaterials (ACTB) Group, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5001, Australia.

Amino end-group functionalised polyglycols are important intermediates in the synthesis of sophisticated polymeric architectures and biomaterials. Herein, we report a facile strategy for the end-group conversion of hydroxyl-terminated polyglycols to amino-terminated polyglycols in high isolated yields and with excellent end-group fidelity. Following traditional conversion of polyglycol hydroxyl end-groups to azides via the corresponding mesylate, reduction with zinc in the presence of ammonium chloride afforded a range of amino end-group functionalised poly(ethylene glycol) and poly(propylene glycol) homopolymers and copolymers with isolated yields of 82-99% and end-group conversions of >99% as determined by NMR spectroscopy and MALDI ToF MS. Read More

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Portable Electronic Nose for Analyzing the Smell of Nasal Secretions in Calves: Toward Noninvasive Diagnosis of Infectious Bronchopneumonia.

Vet Sci 2021 Apr 27;8(5). Epub 2021 Apr 27.

Laboratory of Diseases of the Reproductive Organs, Breast and Young Farm Animals, All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy, 114b Lomonosova Street, 394087 Voronezh, Russia.

The paper demonstrates a new approach to identify healthy calves ("healthy") and naturally occurring infectious bronchopneumonia ("sick") calves by analysis of the gaseous phase over nasal secretions using 16 piezoelectric sensors in two portable devices. Samples of nasal secretions were obtained from 50 red-motley Holstein calves aged 14-42 days. Calves were subjected to rectal temperature measurements, clinical score according to the Wisconsin respiratory scoring chart, thoracic auscultation, and radiography (Carestream DR, New York, USA). Read More

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Visual and Optical Absorbance Detection of Melamine in Milk by Melamine-Induced Aggregation of Gold Nanoparticles.

Nanomaterials (Basel) 2021 Apr 28;11(5). Epub 2021 Apr 28.

Faculty of Bioresources and Food Industry, Universiti Sultan Zainal Abidin, Besut 22200, Terengganu, Malaysia.

The present study reported a facile method for the determination of melamine in milk powder products based on the aggregation of reactant-free 5 nm gold nanoparticles (AuNPs). The strong electrostatic attraction between the positively charged exocyclic amine groups present in the melamine molecule and the negatively charged ions bound to the AuNPs induced aggregation of the AuNPs, resulting in visible color changes that could be seen with the naked eye and monitored by ultraviolet-visible (UV-Vis) absorbance spectra. The method shows high sensitivity with detection limits of 1 × 10 M for visual detection and 1 × 10 M for UV-Vis analysis, which is far below the safety limit of melamine ingestion in infant formula (1 ppm = 7. Read More

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Aliphatic Polyurethane Elastomers Quaternized with Silane-Functionalized TiO Nanoparticles with UV-Shielding Features.

Polymers (Basel) 2021 Apr 16;13(8). Epub 2021 Apr 16.

Polyaddition and Photochemistry Department, Petru Poni Institute of Macromolecular Chemistry, 41 A Grigore Ghica Voda Alley, 700487 Iasi, Romania.

The design of high-performance nanocomposites with improved mechanical, thermal or optical properties compared to starting polymers has generated special interest due to their use in a wide range of targeted applications. In the present work, polymer nanocomposites composed of polyurethane elastomers based on polycaprolactone or polycaprolactone/poly(ethylene glycol) soft segments and titanium dioxide (TiO) nanoparticles as an inorganic filler were prepared and characterized. Initially, the surface of TiO nanoparticles was modified with (3-iodopropyl) trimethoxysilane as a coupling agent, and thereafter, the tertiary amine groups from polyurethane hard segments were quaternized with the silane-modified TiO nanoparticles in order to ensure covalent binding of the nanoparticles on the polymeric chains. Read More

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Amine-Grafted Mesoporous Carbons as Benzocaine-Delivery Platforms.

Materials (Basel) 2021 Apr 24;14(9). Epub 2021 Apr 24.

Department of Pharmacognosy, Faculty of Pharmacy, Poznań University of Medical Sciences, Święcickiego 4, 61-781 Poznań, Poland.

Smart porous carriers with defined structure and physicochemical properties are required for releasing the therapeutic drug with precise control of delivery time and location in the body. Due to their non-toxicity, ordered structure, and chemical and thermal stability, mesoporous carbons can be considered modern carriers for active pharmaceutical ingredients whose effectiveness needs frequent dosing algorithms. Here, the novel benzocaine delivery systems based on ordered mesoporous carbons of the cubic structure were obtained with the use of a hard template method and functionalization with amine groups at 40 °C for 8 h. Read More

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Contribution of Attenuation of TNF-α and NF-κB in the Anti-Epileptic, Anti-Apoptotic and Neuroprotective Potential of Fruit and Its Chitosan Encapsulation.

Molecules 2021 Apr 17;26(8). Epub 2021 Apr 17.

Departament of Pharmacognosy, Riphah Institute of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Pakistan.

L. (Rosaceae) is one of the least reported and most understudied members of this family. It is native to the Himalayan regions of Pakistan and Nepal. Read More

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Mesomorphic Behavior of Symmetric Azomethine Dimers Containing Different Chromophore Groups.

Molecules 2021 Apr 10;26(8). Epub 2021 Apr 10.

"Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, 700487 Iasi, Romania.

A series of new azomethine dimers was synthesized by the condensation reaction of flexible bis-benzaldehydes with four aromatic amines containing phenyl, naphthyl, anthracene and pyrene groups. Their right structure was confirmed by FTIR and H-NMR spectroscopy and their thermal properties were investigated by thermogravimetric analysis, differential scanning calorimetry and polarized light optical microscopy. A view on their photophysical behavior was gained by UV-vis and photoluminescence spectroscopy. Read More

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Unveiling the Fundamental Mechanisms of Graphene Oxide Selectivity on the Ascorbic Acid, Dopamine, and Uric Acid by Density Functional Theory Calculations and Charge Population Analysis.

Sensors (Basel) 2021 Apr 14;21(8). Epub 2021 Apr 14.

Center of Excellence in Theoretical and Computational Science (TaCS-CoE), Faculty of Science, King Mongkut's University of Technology Thonburi (KMUTT), 126 Pracha Uthit Rd., Bang Mod, Thung Khru, Bangkok 10140, Thailand.

The selectivity of electrochemical sensors to ascorbic acid (AA), dopamine (DA), and uric acid (UA) remains an open challenge in the field of biosensing. In this study, the selective mechanisms for detecting AA, DA, and UA molecules on the graphene and graphene oxide substrates were illustrated through the charge population analysis from the density functional theory (DFT) calculation results. Our substrate models contained the 1:10 oxygen per carbon ratio of reduced graphene oxide, and the functionalized configurations were selected according to the formation energy. Read More

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Cross-Linked Polymer Brushes Containing -Halamine Groups for Antibacterial Surface Applications.

Polymers (Basel) 2021 Apr 14;13(8). Epub 2021 Apr 14.

Department of Chemistry, Amasya University, Ipekkoy, 05100 Amasya, Turkey.

Microbial contamination is a significant issue in various areas, especially in the food industry. In this study, to overcome microbial contamination, cross-linked polymer brushes containing -halamine were synthesized, characterized, and investigated for antibacterial properties. The cross-linked polymer brushes with different -halamine ratios were synthesized by in-situ cross-linking methods with reversible addition-fragmentation chain transfer (RAFT) polymerization using a bifunctional cross-linker. Read More

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Structural Insights into the Host-Guest Complexation between β-Cyclodextrin and Bio-Conjugatable Adamantane Derivatives.

Molecules 2021 Apr 21;26(9). Epub 2021 Apr 21.

Department of Chemistry, Zhejiang University, Hangzhou 310028, China.

Understanding the host-guest chemistry of α-/β-/γ- cyclodextrins (CDs) and a wide range of organic species are fundamentally attractive, and are finding broad contemporary applications toward developing efficient drug delivery systems. With the widely used β-CD as the host, we herein demonstrate that its inclusion behaviors toward an array of six simple and bio-conjugatable adamantane derivatives, namely, 1-adamantanol (adm-1-OH), 2-adamantanol (adm-2-OH), adamantan-1-amine (adm-1-NH), 1-adamantanecarboxylic acid (adm-1-COOH), 1,3-adamantanedicarboxylic acid (adm-1,3-diCOOH), and 2-[3-(carboxymethyl)-1-adamantyl]acetic acid (adm-1,3-diCHCOOH), offer inclusion adducts with diverse adamantane-to-CD ratios and spatial guest locations. In all six cases, β-CD crystallizes as a pair supported by face-to-face hydrogen bonding between hydroxyl groups on C2 and C3 and their adjacent equivalents, giving rise to a truncated-cone-shaped cavity to accommodate one, two, or three adamantane derivatives. Read More

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Nanofiltration Composite Membranes Based on KIT-6 and Functionalized KIT-6 Nanoparticles in a Polymeric Matrix with Enhanced Performances.

Membranes (Basel) 2021 Apr 21;11(5). Epub 2021 Apr 21.

National Institute for Research-Development of Biological Sciences, 060031 Bucharest, Romania.

The nanofiltration composite membranes were obtained by incorporation of KIT-6 ordered mesoporous silica, before and after its functionalization with amine groups, into polyphenylene-ether-ether-sulfone (PPEES) matrix. The incorporation of silica nanoparticles into PPEES polymer matrix was evidenced by FTIR and UV-VIS spectroscopy. SEM images of the membranes cross-section and their surface topology, evidenced by AFM, showed a low effect of KIT-6 silica nanoparticles loading and functionalization. Read More

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Lanthanide DO3A-Complexes Bearing Peptide Substrates: The Effect of Peptidic Side Chains on Metal Coordination and Relaxivity.

Molecules 2021 Apr 9;26(8). Epub 2021 Apr 9.

Centre de Biophysique Moléculaire, CNRS UPR 4301, Rue Charles Sadron, CEDEX 2, 45071 Orléans, France.

Two DO3A-type ligands conjugated to substrates of urokinase (L3) and caspase-3 (L4) via a propyl-amide linker were synthesized and their lanthanide(III) (Ln) complexes studied. A model compound without peptide substrate (L2) and an amine derivative ligand mimicking the state after enzymatic cleavage (L1) were also prepared. Proton Nuclear Magnetic Relaxation Dispersion (NMRD) profiles recorded on the gadolinium(III) (Gd) complexes, complemented with the assessment of hydration numbers via luminescence lifetime measurements on the Eu analogues, allowed us to characterize the lanthanide coordination sphere in the chelates. Read More

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Bioprinting Via a Dual-Gel Bioink Based on Poly(Vinyl Alcohol) and Solubilized Extracellular Matrix towards Cartilage Engineering.

Int J Mol Sci 2021 Apr 9;22(8). Epub 2021 Apr 9.

MERLN Institute for Technology Inspired Regenerative Medicine, Complex Tissue Regeneration, Maastricht University, 6229 Maastricht, The Netherlands.

Various hydrogel systems have been developed as biomaterial inks for bioprinting, including natural and synthetic polymers. However, the available biomaterial inks, which allow printability, cell viability, and user-defined customization, remains limited. Incorporation of biological extracellular matrix materials into tunable synthetic polymers can merge the benefits of both systems towards versatile materials for biofabrication. Read More

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Endophytic Bacteria Fabricated Silver Nanoparticles and Their Antimicrobial Activity.

Pharmaceutics 2021 Apr 8;13(4). Epub 2021 Apr 8.

Department of Biotechnology, Faculty of Applied Sciences, AIMST University, Bedong 08100, Kedah, Malaysia.

Antimicrobial resistance (AMR), one of the greatest issues for humankind, draws special attention to the scientists formulating new drugs to prevent it. Great emphasis on the biological synthesis of silver nanoparticles (AgNPs) for utilization in single or combinatorial therapy will open up new avenues to the discovery of new antimicrobial drugs. The purpose of this study was to synthesize AgNPs following a green approach by using an endophytic bacterial strain, , and to assess their antimicrobial potential against five pathogenic and four multidrug-resistant (MDR) microbes. Read More

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Interaction of Squid () Mantle Protein with a Mixtures of Potato and Corn Starch in an Extruded Snack, as Characterized by FTIR and DSC.

Molecules 2021 Apr 6;26(7). Epub 2021 Apr 6.

Centro de Investigación en Alimentación y Desarrollo, A.C. Unidad Culiacán, Culiacán 80110, Mexico.

The majority of snacks expanded by extrusion (SEE) are made with vegetable sources, to improve their nutritional content; it has been proposed to incorporate squid (), due to its high protein content, low price and high availability. However, the interaction of proteins of animal origin with starch during extrusion causes negative effects on the sensory properties of SEE, so it is necessary to know the type of protein-carbohydrate interactions and their effect on these properties. The objective of this research was to study the interaction of proteins and carbohydrates of SEE elaborated with squid mantle, potato and corn. Read More

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New Chloramphenicol Derivatives with a Modified Dichloroacetyl Tail as Potential Antimicrobial Agents.

Antibiotics (Basel) 2021 Apr 6;10(4). Epub 2021 Apr 6.

Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Patras, 26504 Patras, Greece.

To combat the dangerously increasing pathogenic resistance to antibiotics, we developed new pharmacophores by chemically modifying a known antibiotic, which remains to this day the most familiar and productive way for novel antibiotic development. We used as a starting material the chloramphenicol base, which is the free amine group counterpart of the known chloramphenicol molecule antibiotic upon removal of its dichloroacetyl tail. To this free amine group, we tethered alpha- and beta-amino acids, mainly glycine, lysine, histidine, ornithine and/or beta-alanine. Read More

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Development of antifungal biopolymers based on dynamic imines as responsive release systems for the postharvest preservation of blackberry fruit.

Food Chem 2021 Apr 20;357:129838. Epub 2021 Apr 20.

Food Safety and Preservation department. Instituto de Agroquímica y Tecnología de Alimentos, IATA-CSIC, Av. Agustín Escardino 7, 46980 Paterna, Spain. Electronic address:

This study describes the synthesis and reversibility of Schiff bases from chitosan and bioactive compounds, and their application in the antifungal packaging of fruit. Imine bonds between primary amine groups of chitosan and carbonyl groups of antifungal aldehydes were synthesised and their reversibility was assayed in an aqueous medium under different acidic conditions. The mechanism of action of the dynamers is based on the hydrolysis of imine bond and the release of the active agent. Read More

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