4,691 results match your criteria amh

Chemotherapy-induced ovarian failure in young women with early breast cancer: Prospective analysis of four randomised neoadjuvant/adjuvant breast cancer trials.

Eur J Cancer 2021 Jun 8;152:193-203. Epub 2021 Jun 8.

German Breast Group, Neu-Isenburg, Germany.

Background: Young women receiving chemotherapy for early breast cancer (EBC) have a high probability for ovarian failure, defined by chemotherapy-induced amenorrhea (CIA) as a surrogate. CIA is insufficiently reliable and reproducible. We analysed chemotherapy-induced ovarian failure (CIOF) by assessing hormone parameters, CIA, and antral follicle count (AFC). Read More

View Article and Full-Text PDF

Microbial Fabrication of Nanomaterial and Its Role in Disintegration of Exopolymeric Matrices of Biofilm.

Front Chem 2021 24;9:690590. Epub 2021 May 24.

Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata, India.

Bacterial biofilms are responsible for the development of various chronic wound-related and implant-mediated infections and confer protection to the pathogenic bacteria against antimicrobial drugs and host immune responses. Hence, biofilm-mediated chronic infections have created a tremendous burden upon healthcare systems worldwide. The development of biofilms upon the surface of medical implants has resulted in the failure of various implant-based surgeries and therapies. Read More

View Article and Full-Text PDF

Challenges in Measuring AMH in the Clinical Setting.

Front Endocrinol (Lausanne) 2021 24;12:691432. Epub 2021 May 24.

Discipline of Obstetrics & Gynaecology, School of Women's & Children's Health, University of New South Wales, Sydney, NSW, Australia.

Serum anti-Mullerian hormone (AMH) is a widely used marker of functional ovarian reserve in the assessment and treatment of infertility. It is used to determine dosing of gonadotropins used for superovulation prior to fertilization, as well as to determine the degree of damage to ovarian reserve by cytotoxic treatments such as chemotherapy. AMH is also now used to predict proximity to menopause and potentially provides a sensitive and specific test for polycystic ovarian syndrome. Read More

View Article and Full-Text PDF

The Effect of Free Androgen Index on the Quality of Life of Women With Polycystic Ovary Syndrome: A Cross-Sectional Study.

Front Physiol 2021 24;12:652559. Epub 2021 May 24.

Department of Academic Diabetes, Endocrinology, and Metabolism, Hull York Medical School, University of Hull, Hull, United Kingdom.

Free androgen index (FAI) and anti-Mullerian hormone (AMH) are independently associated with polycystic ovary syndrome (PCOS). This study aimed to describe the relationship between these two markers and health-related quality of life (HR-QoL) in women with PCOS. This cross-sectional study consisted of 81 women in the Hull PCOS biobank, who fulfilled the Rotterdam consensus criteria for the diagnosis of PCOS. Read More

View Article and Full-Text PDF

Analytical Evaluation of Lumipulse Anti-Mullerian Hormone Assay.

Clin Lab 2021 Jun;67(6)

Background: The measurement of serum Anti-Mullerian hormone (AMH) is used in daily practice to estimate the ovarian reserve in women.

Methods: The aim of this study was to evaluate the new Lumipulse AMH® immunoassay (Fujirebio) with regard to the reliability with two preexisting assays: Elecsys AMH Plus® (cobas®, Roche) and Vidas AMH® (bioMérieux). Precision of Lumipulse AMH was evaluated on the Lumipulse G600 II using the manufacturer's quality controls. Read More

View Article and Full-Text PDF

Live birth outcomes from IVF treatments in younger patients with low AMH.

JBRA Assist Reprod 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, Graduate School of Medicine, University of the Ryukyus. Nishihara, Okinawa, Japan.

Objective: Anti-Müllerian hormone (AMH) is used to predict in vitro fertilization outcomes. However, predicting live birth is difficult in younger patients with low AMH. Thus, this study aimed to determine the live birth rates from younger patients with low anti-Müllerian hormone levels. Read More

View Article and Full-Text PDF

The role of anti-Müllerian Hormone (AMH) in girls and adolescents.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Chair and Department of Gynecology, Obstetrics and Oncological Gynecology, School of Health Science in Katowice, Medical University of Silesia, Poland.

Anti-mullerian hormone (AMH) is produced by the granular cells of primary, preantral and antral follicles. The circulating levels of AMH in adult women reflect the number of remaining primordial follicles. AMH determination plays an increasingly important role in diagnostics in endocrinology and gynecology in adult women. Read More

View Article and Full-Text PDF

Tributyltin and high-refined carbohydrate diet lead to metabolic and reproductive abnormalities, exacerbating premature ovary failure features in the female rats.

Reprod Toxicol 2021 Jun 5. Epub 2021 Jun 5.

Department of Morphology, Health Sciences Center, Federal University of Espirito Santo, Av. Marechal Campos, 1468, CEP: 290440-090 Vitória, ES, Brazil. Electronic address:

Exposure to the obesogen tributyltin (TBT) alone or high carbohydrate diet (HCD) alone leads to obesity and reproductive complications, such as premature ovary failure (POF) features. However, little is known about interactions between TBT and nutrition and their combined impact on reproduction. In this study, we assessed whether acute TBT and HCD exposure results in reproductive and metabolic irregularities. Read More

View Article and Full-Text PDF

Low Anti-Mullerian Hormone Levels Are Associated with the Severity of Anxiety Experienced by Healthcare Professionals During the COVID-19 Pandemic.

Reprod Sci 2021 Jun 8. Epub 2021 Jun 8.

Department of Gynecology and Obstetrics, University of Health Sciences, Ankara, Turkey.

The objective of this study is to investigate a possible correlation between anxiety status and anti-Mullerian hormone (AMH) levels among healthcare professionals who provide medical care directly to COVID-19-positive patients during the recent pandemic. Fifty-two healthcare professionals (nurses, midwives, and residents) who provide medical care directly to COVID-19-positive patients in inpatient clinics or intensive care units were enrolled in this study. Serum AMH levels were analyzed to reflect ovarian reserve. Read More

View Article and Full-Text PDF

Age-group-specific reference intervals for anti-Müllerian hormone and its diagnostic performance for polycystic ovary syndrome in a Korean population.

J Clin Lab Anal 2021 Jun 7:e23861. Epub 2021 Jun 7.

Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: We established age-group-specific reference intervals for serum anti-Müllerian hormone (AMH) levels in a Korean population and investigated the effectiveness of AMH assay for polycystic ovary syndrome (PCOS) diagnosis.

Methods: We analyzed serum levels of AMH, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) from 1540 Korean women. Subjects were divided into three groups: healthy, benign gynecologic diseases, and PCOS. Read More

View Article and Full-Text PDF

Menopause, anti-Müllerian hormone and cognition in a cohort of women with persistent symptoms following TBI: a case for future research.

Brain Inj 2021 Jun 6:1-9. Epub 2021 Jun 6.

Rehabilitation Sciences Building, 500 University Ave, Toronto, Ontario, Canada.

: Primary: To explore anti-Müllerian Hormone (AMH) levels in community dwelling women following TBI. Secondary: To explore the relation of AMH to menstrual cycle, cognition, distress and symptoms of menopause. Large adult TBI outpatient clinic in Toronto Canada. Read More

View Article and Full-Text PDF

Different Clinical Manifestations Related to Subvirilization in Three XY Patients With the Same Pathogenic Variant of Steroidogenic Factor 1.

AACE Clin Case Rep 2021 Mar-Apr;7(2):145-148. Epub 2020 Dec 28.

Endocrinology Unit, División of Pediatric, Pontificia Universidad Católica, Santiago, Chile.

Objective: During the prenatal period, steroidogenic factor 1 is required for the development of the adrenal glands and for gonadal determination and differentiation, and after birth, it regulates gonadal progenitor cell formation and their survival. Here, we describe the clinical phenotype of three 46,XY patients (2 brothers and an unrelated subject) with disorder of sex development due to the same genetic variant.

Methods: All patients underwent hormonal and pelvic ultrasound studies. Read More

View Article and Full-Text PDF
December 2020

Evaluation of a new automated immunoassay for the quantification of anti-Müllerian hormone.

Pract Lab Med 2021 May 14;25:e00220. Epub 2021 Apr 14.

Département de Biochimie et Hormonologie, Centre de Ressources Biologiques, CHU de Montpellier, Montpellier, France.

Objectives: A newly developed fully automated Lumipulse G AMH method (Fujirebio Diagnostics) was recently introduced in clinical laboratories for quantitative determination of anti-Müllerian hormone (AMH) level in human serum or plasma. AMH has emerged as value-added biomarker in the assessment of ovarian reserve, in diagnosis of granulosa cells cancer and in the investigation of gonadal disorders. We compared Lumipulse G AMH assay performances with other methods largely applied for AMH measurements. Read More

View Article and Full-Text PDF

Effect of EPA on Neonatal Pig Sertoli Cells "": A Possible Treatment to Help Maintain Fertility in Pre-Pubertal Boys Undergoing Treatment With Gonado-Toxic Therapies.

Front Endocrinol (Lausanne) 2021 20;12:694796. Epub 2021 May 20.

Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

The incidence of cancer in pre-pubertal boys has significantly increased and, it has been recognized that the gonado-toxic effect of the cancer treatments may lead to infertility. Here, we have evaluated the effects on porcine neonatal Sertoli cells (SCs) of three commonly used chemotherapy drugs; cisplatin, 4-Hydroperoxycyclophosphamide and doxorubicin. All three drugs induced a statistical reduction of 5-hydroxymethylcytosine in comparison with the control group, performed by Immunofluorescence Analysis. Read More

View Article and Full-Text PDF

Transcriptomic study of the mechanism by which the Kai Yu Zhong Yu recipe improves oocyte quality in a stressed mouse model.

J Ethnopharmacol 2021 Jun 4;278:114298. Epub 2021 Jun 4.

Reproductive Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, And National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300381, China. Electronic address:

Ethnopharmacological Relevance: The Kai Yu Zhong Yu recipe (KYZY) is a classic herbal formula in traditional Chinese medicine (TCM) that has been used to treat infertility associated with psychological stress for more than three hundred years.

Aim Of The Study: Psychological stress has major impacts on fertility, with variable outcomes depending on the nature, strength, and duration of the stress. Stress can directly disturb ovulation, oocyte quality, maturation, and embryo development. Read More

View Article and Full-Text PDF

Association between premature ovarian insufficiency and gut microbiota.

BMC Pregnancy Childbirth 2021 Jun 5;21(1):418. Epub 2021 Jun 5.

Affiliated Shenzhen Maternity&Child Healthcare Hospital, Southern Medical University, No. 3012, Fuqiang Road, Futian District, Shenzhen City, 518000, Guangdong Province, China.

Background: Premature ovarian insufficiency (POI) is characterized by impairment of ovarian function on a continuum before the age of 40 years. POI is affected by multiple factors. Considering new insights from recent gut microbiome studies, this study aimed to investigate the relationship between gut microbial community structure and POI. Read More

View Article and Full-Text PDF

Serum and intratesticular inhibin B, AMH and spermatogonial numbers in trans*women at gender confirming surgery: An observational study.

Andrology 2021 Jun 4. Epub 2021 Jun 4.

Institute of Reproductive and Regenerative Medicine, Centre of Reproductive Medicine and Andrology, Albert-Schweitzer Campus 1, Building D11, Muenster, Germany.

Background: Anti-Müllerian hormone (AMH) and inhibin B are produced by Sertoli cells. AMH secretion indicates an immature Sertoli cell state. Inhibin B serves as a marker of male fertility. Read More

View Article and Full-Text PDF

The anti-Müllerian hormone gene's second exon is associated with the reproductive performance of Jinghai Yellow chickens.

Arch Anim Breed 2021 5;64(1):45-52. Epub 2021 Feb 5.

Jiangsu Key Laboratory of Animal Genetic Breeding and Molecular Design, College of Animal Science and Technology, Yangzhou University, Yangzhou, China.

Anti-Müllerian hormone (AMH), a member of the transforming growth factor- superfamily, plays important regulatory roles in follicular development and sex differentiation. Although much has been learned about the impact of polymorphisms of on reproduction in animals, the effect on chicken reproduction is not well explored. In this study, the polymorphism of five exons of gene and its effect on the reproductive performance of Jinghai Yellow chickens were studied. Read More

View Article and Full-Text PDF
February 2021

Effect of Laparoscopic Ovarian Cystectomy on Ovarian Reserve in Benign Ovarian Cysts.

J Hum Reprod Sci 2021 Jan-Mar;14(1):56-60. Epub 2021 Mar 30.

Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Background: Laparoscopic cystectomy is one of the common modes of treatment for benign ovarian cysts. The data related to the effect of cystectomy on ovarian reserve are limited.

Aim: The aim of this study was to investigate the effect of laparoscopic ovarian cystectomy on anti-Mullerian hormone (AMH) levels in benign ovarian cysts. Read More

View Article and Full-Text PDF

Adverse Health Effects in Women Farmers Indirectly Exposed to Pesticides.

Int J Environ Res Public Health 2021 May 31;18(11). Epub 2021 May 31.

Department of Nutrition, Food Chemistry and Toxicology, Faculty of Pharmacy, University of Sevilla, 41012 Sevilla, Spain.

Farmers are among the most vulnerable populations because of the exposure to low levels of pesticides. Acetylcholinesterase and butyrylcholinesterase activities are considered as biomarkers of pesticides poisoning. However, biomarkers of oxidative stress are also playing an important role in toxicity of these contaminants. Read More

View Article and Full-Text PDF

Use of the Microheterogeneous Model to Assess the Applicability of Ion-Exchange Membranes in the Process of Generating Electricity from a Concentration Gradient.

Membranes (Basel) 2021 May 28;11(6). Epub 2021 May 28.

Physical Chemistry Department, Faculty of Chemistry and High Technologies, Kuban State University, 350040 Krasnodar, Russia.

The paper shows the possibility of using a microheterogeneous model to estimate the transport numbers of counterions through ion-exchange membranes. It is possible to calculate the open-circuit potential and power density of the reverse electrodialyzer using the data obtained. Eight samples of heterogeneous ion-exchange membranes were studied, two samples for each of the following types of membranes: Ralex CM, Ralex AMH, MK-40, and MA-41. Read More

View Article and Full-Text PDF

Deslorelin Slow-Release Implants Delay Ovulation and Increase Plasma AMH Concentration and Small Antral Follicles in Haflinger Mares.

Animals (Basel) 2021 May 28;11(6). Epub 2021 May 28.

Artificial Insemination and Embryo Transfer, Department for Small Animals and Horses, Vetmeduni Vienna, Veterinärplatz 1, 1210 Vienna, Austria.

There is an increasing interest in the manipulation of ovarian follicular populations in large domestic animals because this could prove beneficial for assisted reproductive techniques such as ovum pick-up (OPU). The aim of the present study was to evaluate the effects of deslorelin slow-release implants (SRI) on the interovulatory interval, antral follicle count (AFC), number of follicles of different size ranges and plasma anti-Muellerian hormone (AMH) concentration in mares. To synchronize their estrous cycles, Haflinger mares ( = 12) were treated twice with a PGF analogue. Read More

View Article and Full-Text PDF

A Narrative Review of Current Understanding of the Pathophysiology of Polycystic Ovary Syndrome: Focus on Plausible Relevance of Vitamin D.

Int J Mol Sci 2021 May 5;22(9). Epub 2021 May 5.

Department of Obstetrics, Gynecology & Reproductive Sciences, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.

Polycystic ovarian syndrome (PCOS) is the most prevalent endocrinopathy of reproductive years. Salient features in presentation of patients PCOS include menstrual dysfunction, hyperandrogenism and/or polycystic appearance of ovaries on ultrasound. While the diagnosis of PCOS depends on presence of specified criteria, misdiagnoses are common. Read More

View Article and Full-Text PDF

Fibroinflammatory Signatures Increase with Age in the Human Ovary and Follicular Fluid.

Int J Mol Sci 2021 May 5;22(9). Epub 2021 May 5.

Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

The female reproductive system ages before any other organ system in the body. This phenomenon can have tangible clinical implications leading to infertility, miscarriages, birth defects and systemic deterioration due to estrogen loss. "Fibroinflammation" is a hallmark of aging tissues; there is an increase in inflammatory cytokines and fibrotic tissue in the aging ovarian stroma. Read More

View Article and Full-Text PDF

Hypo-glycosylated hFSH drives ovarian follicular development more efficiently than fully-glycosylated hFSH: enhanced transcription and PI3K and MAPK signaling.

Hum Reprod 2021 Jun 1. Epub 2021 Jun 1.

Department of Obstetrics and Gynecology, Olson Center for Women's Health, University of Nebraska Medical Center, Omaha, NE, USA.

Study Question: Does hypo-glycosylated human recombinant FSH (hFSH18/21) have greater in vivo bioactivity that drives follicle development in vivo compared to fully-glycosylated human recombinant FSH (hFSH24)?

Summary Answer: Compared with fully-glycosylated hFSH, hypo-glycosylated hFSH has greater bioactivity, enabling greater follicular health and growth in vivo, with enhanced transcriptional activity, greater activation of receptor tyrosine kinases (RTKs) and elevated phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and Mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling.

What Is Known Already: Glycosylation of FSH is necessary for FSH to effectively activate the FSH receptor (FSHR) and promote preantral follicular growth and formation of antral follicles. In vitro studies demonstrate that compared to fully-glycosylated recombinant human FSH, hypo-glycosylated FSH has greater activity in receptor binding studies, and more effectively stimulates the PKA pathway and steroidogenesis in human granulosa cells. Read More

View Article and Full-Text PDF

Sertoli cell replacement in explanted mouse testis tissue supporting host spermatogenesis.

Biol Reprod 2021 May 31. Epub 2021 May 31.

Laboratory of Biopharmaceutical and Regenerative Sciences, Institute of Molecular Medicine and Life Science, Yokohama City University Association of Medical Science, Yokohama 236-0004, Japan.

Spermatogenesis takes place in the seminiferous tubules, starting from the spermatogonial stem cell and maturing into sperm through multiple stages of cell differentiation. Sertoli cells, the main somatic cell constituting the seminiferous tubule, are in close contact with every germ cell and play pivotal roles in the progression of spermatogenesis. In this study, we developed an in vitro Sertoli cell replacement method by combining an organ culture technique and a toxin receptor-mediated cell knockout (Treck) system. Read More

View Article and Full-Text PDF

Predictive value of anti-Müllerian hormone on pregnancy outcomes in in-vitro fertilization/intracytoplasmic single sperm injection patients at different ages.

Arch Gynecol Obstet 2021 May 30. Epub 2021 May 30.

Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China.

Purpose: To investigate the predictive value of AMH level for pregnancy outcomes in different age groups of IVF/ICSI patients.

Methods: The study was a cohort study that included 11,484 patients that had their first IVF/ICSI procedure between 2016 and 2019. All patients who met the inclusion and exclusion criteria were divided into 6 groups according to 5-year age intervals, namely, Group 1: 20-24 years (n = 725); Group 2: 25-29 years (n = 4019); Group 3: 30-34 years (n = 3600); Group 4: 35-39 years (n = 1915); Group 5: 40-44 years (n = 1006); and Group 6: ≥ 45 years (n = 219). Read More

View Article and Full-Text PDF

Low dose hCG supplementation in a Gn-RH-agonist trigger protocol is associated with worse pregnancy outcomes: a retrospective cohort study.

Fertil Res Pract 2021 May 28;7(1):12. Epub 2021 May 28.

Obstetrics & Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Background: A number of studies have looked at dual triggers with hCG and GnRH agonist (GnRHa) in varying doses, but the question remains: what is the optimal dose of hCG to minimize ovarian hyperstimulation syndrome (OHSS) and still offer adequate pregnancy rates? The purpose of this study was to compare pregnancy and OHSS rates following dual trigger for oocyte maturation with GnRHa and a low-dose hCG versus hCG alone. A secondary objective was the assess pregnancy outcomes in subsequent frozen cycles for the same population.

Methods: A total of 963 women < 41 years old, with a BMI 18-40 kg/m and an AMH > 2 ng/mL who underwent fresh autologous in vitro fertilization (IVF) with GnRH antagonist protocol at a University-based fertility center were included in this retrospective cohort study. Read More

View Article and Full-Text PDF

Fertility in McCune Albright syndrome female: A case study focusing on AMH as a marker of ovarian dysfunction and a literature review.

J Gynecol Obstet Hum Reprod 2021 May 25;50(9):102171. Epub 2021 May 25.

INSERM U1256, Université de Lorraine, Vandœuvre-lès-Nancy, France; Department of Pathology, CHRU de Nancy, Université de Lorraine, Nancy, France.

Background: The molecular basis of McCune Albright syndrome (MAS) is a recurrent GNAS Postzygotic gain of function sporadic mutation, resulting in a mosaic disease. Most of girls present precocious puberty, caused by the development of recurrent ovarian cysts with autonomous Hyperestrogenic stimulation. After menarche, the majority of patients with ovarian GNAS mutation have menstrual disturbances and infertility. Read More

View Article and Full-Text PDF

Vitamin D and anti-Müllerian hormone concentration in human follicular fluid individually aspirated from all patient follicles.

Gynecol Endocrinol 2021 May 28:1-5. Epub 2021 May 28.

INVICTA Fertility and Reproductive Center, Warsaw, Poland.

Objective: The main aim of this prospective study was to investigate the relationship between intrafollicular vitamin D and anti-Müllerian hormone (AMH) concentration and its impact on oocyte quality and developmental competence.

Methods: The analysis was performed on 208 follicular fluid (FF) samples obtained from 33 patients undergoing ovarian stimulation as part of fertilization (IVF) treatment that included intracytoplasmic sperm injection.

Results: Our study shows that vitamin D concentration in FF varies according to the developmental stage of the oocyte and corelates with embryo development status on day 3, while AMH concentration in FF is not correlated with the developmental potential of an oocyte. Read More

View Article and Full-Text PDF