24,436 results match your criteria ambiguous


Unveiling the Microscopic Mechanism of Current Variation in the Sensing Region of the MspA Nanopore for DNA Sequencing.

J Phys Chem Lett 2021 Sep 15:9132-9141. Epub 2021 Sep 15.

BGI-ShenZhen, Shenzhen 518103, China.

Different nucleotides generate specific ionic currents that discriminate between the nucleotides while they are passing through the nanopore constriction. MspA is a commonly used nanopore for DNA sequencing. However, the reasons of the current variation remain ambiguous. Read More

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September 2021

[Patterns and research progress on the concomitant ipsilateral fractures of intracapsular femoral neck and extracapsular trochanter].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Sep;35(9):1079-1085

No.1 Department of Hip Injury and Disease, Luoyang Orthopedic-Traumatological Hospital of Henan Province (Henan Provincial Orthopedic Hospital), Luoyang Henan, 471000, P.R.China.

Objective: To summarize the patterns and research progress of the concomitant ipsilateral fractures of intracapsular femoral neck and extracapsular trochanter, and to provide a common language among orthopedic surgeons for scientific exchange.

Methods: According to related literature and authors own experiences concerning the anatomic border between femoral neck and trochanter region, the intertrochanteric line (or intertrochanteric belt) and its capsularligament attachment footprint, fracture patterns, and treatment strategies were reviewed and analyzed.

Results: With the rapid growing of geriatric hip fractures, an increased incidence was noted in recent years regarding the proximal femoral comminuted fractures that involving ipsilateral intracapsular neck and extracapsular trochanter regions simultaneously. Read More

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September 2021

Body mass index and type 2 diabetes and breast cancer survival: a Mendelian randomization study.

Am J Cancer Res 2021 15;11(8):3921-3934. Epub 2021 Aug 15.

Institute of Biomedical Sciences, Academia Sinica Taipei, Taiwan.

The causal relationship between body mass index (BMI) and type 2 diabetes (T2D) and breast cancer prognosis is still ambiguous. The aim of this study was to investigate the prognostic effect of BMI and T2D on breast cancer disease-free survival (DFS) among Asian individuals. In this two-sample Mendelian randomization (MR) study, the instrumental variables (IVs) were identified using a genome-wide association study (GWAS) among 24,000 participants in the Taiwan Biobank. Read More

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Xanthogranulomatous Pyelonephritis: A Narrative Review with Current Perspectives on Diagnostic Imaging and Management, Including Interventional Radiology Techniques.

Int J Nephrol Renovasc Dis 2021 7;14:359-369. Epub 2021 Sep 7.

Division of Interventional Radiology, Department of Radiology, University Hospital Waterford, Waterford City, X91 DWX0, Ireland.

Xanthogranulomatous Pyelonephritis (XGP) is a rare, chronic granulomatous inflammatory condition thought to arise secondary to a combination of obstruction, recurrent bacterial infection and an incomplete immune response resulting in focal or diffuse renal destruction. This destruction may be profound with the potential to infiltrate surrounding tissues and viscera. The imaging features of XGP can be ambiguous, mimicking malignancy, tuberculosis (TB) and malakoplakia earning the title of "the great imitator". Read More

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September 2021

How to use the Delphi method to aid in decision making and build consensus in pharmacy education.

Curr Pharm Teach Learn 2021 Oct 4;13(10):1376-1385. Epub 2021 Aug 4.

UNC Eshelman School of Pharmacy, 301 Pharmacy Lane, CB# 7574, Chapel Hill, NC 27599, United States. Electronic address:

Our Situation: As pharmacy educators, we often encounter situations such as designing new curricula or establishing shared values for an organization that may be ambiguous or controversial. To generate effective solutions, it is often necessary to build group consensus with key stakeholders. The purpose of this paper is to describe and provide recommendations for using the Delphi method, a process for facilitating discussions and aiding in decision making. Read More

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October 2021

Transforming trash to treasure Cultural ambiguity in foetal cell research.

Philos Ethics Humanit Med 2021 Sep 15;16(1). Epub 2021 Sep 15.

Department of Social Work, Faculty of Health and Society, Malmö University, Citadellsvägen 7, 205 06, Malmö, Sweden.

Background: Rich in different kind of potent cells, embryos are used in modern regenerative medicine and research. Neurobiologists today are pushing the boundaries for what can be done with embryos existing in the transitory margins of medicine. Therefore, there is a growing need to develop conceptual frameworks for interpreting the transformative cultural, biological and technical processes involving these aborted, donated and marginal embryos. Read More

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September 2021

Attitude theory and measurement in implementation science: a secondary review of empirical studies and opportunities for advancement.

Implement Sci 2021 Sep 14;16(1):87. Epub 2021 Sep 14.

Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Floor 3, Philadelphia, PA, 19104, USA.

Background: Implementation science studies often express interest in "attitudes," a term borrowed from psychology. In psychology, attitude research has an established methodological and theoretical base, which we briefly summarize here. We then review implementation studies designed to measure attitudes and compare their definitions and methods with those from psychology. Read More

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September 2021

Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review.

Reprod Biol Endocrinol 2021 Sep 14;19(1):142. Epub 2021 Sep 14.

Reproductive Endocrinology Center, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, 310000, China.

Background: Sequential embryo transfer has been proposed as a way to improve embryo implantation in women for in vitro fertilization (IVF), but the effect on pregnancy outcomes remains ambiguous. This systematic review was conducted to investigate the efficacy of sequential embryo transfer on IVF outcomes.

Methods: A literature search was performed in the PubMed, Web of Science, Cochrane Library, ScienceDirect and Wanfang databases. Read More

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September 2021

Efficient Mesh Interface Engineering: Insights from Bubble Dynamics in Electrocatalysis.

ACS Appl Mater Interfaces 2021 Sep 14. Epub 2021 Sep 14.

Key Laboratory of Semiconductor Materials Science, Beijing Key Laboratory of Low Dimensional Semiconductor Materials and Devices, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China.

Electrochemical catalysis offers great potential in energy and mass conversion in academy and industry. However, bubble dynamics and its influence on gas-evolving electrode systems remain ambiguous. Detailed information on the local transport process between different phases and the underlying mechanism are required for the full understanding of two-phase flow evolution and distribution. Read More

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September 2021

Reversible Fronto-occipitotemporal Signaling Complements Task Encoding and Switching under Ambiguous Cues.

Cereb Cortex 2021 Sep 14. Epub 2021 Sep 14.

Department of Biosciences and Informatics, Keio University, Yokohama 223-0061, Japan.

Adaptation to changing environments involves the appropriate extraction of environmental information to achieve a behavioral goal. It remains unclear how behavioral flexibility is guided under situations where the relevant behavior is ambiguous. Using functional brain mapping of machine learning decoders and directional functional connectivity, we show that brain-wide reversible neural signaling underpins task encoding and behavioral flexibility in ambiguously changing environments. Read More

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September 2021

Improvements of Statistical Learning Skills Allow Older Children to Go Beyond Single-Hypothesis Testing When Learning Words.

J Child Lang 2021 Sep 14:1-13. Epub 2021 Sep 14.

University of Oslo, Forskningsveien 3A, 0373 Oslo, Norway.

Children learn words in ambiguous situations, where multiple objects can potentially be referents for a new word. Yet, researchers debate whether children maintain a single word-object hypothesis - and revise it if falsified by later information - or whether children establish a network of word-object associations whose relative strengths are modulated with experience. To address this issue, we presented 4- to 12-year-old children with sets of mutual exclusivity (fast-mapping) trials: offering them with obvious initial hypotheses (that the novel object is the referent for the novel word). Read More

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September 2021

Circular RNA SMEK1 promotes neuropathic pain in rats through targeting microRNA-216a-5p to mediate Thioredoxin Interacting Protein (TXNIP) expression.

Bioengineered 2021 Dec;12(1):5540-5551

Department of Rehabilitation Medicine of Chinese Medicine Hospital of PuYang Henan, Puyang City, Henan Province, 457000, China.

Neuropathic pain (NP) is a disease induced by damage to the nervous system. A large number of studies have manifested that circular RNAs (circRNAs) are key in the development of neurological diseases. However, the role of circRNA in NP remains ambiguous. Read More

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December 2021

Characterisation of transient electromagnetic signals during fixed interference sources in tunnel structure.

Math Biosci Eng 2021 Aug;18(5):6907-6925

School of Transportation and Civil Engineering, Nantong University, Nantong 226019, China.

The detection effect of the transient electromagnetic method is ambiguous in engineering applications due to the existence of interference sources, so explaining the influence of these fixed interference sources on is crucial. In this paper, the response characterisation of transient electromagnetic signals of fixed interference sources are thoroughly investigated. First, the secondary field generated by these interference sources is analyzed, and a typical fixed interference source is calculated. Read More

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Making Sense of Sanctions: An Agent-Based Model of Sanction Recognition.

Nonlinear Dynamics Psychol Life Sci 2021 Oct;25(4):427-453

University of Koblenz, Germany.

Theories of norm emergence are a central building block for comprehending the emergence of society. The article investigates a central terminus in theories of norms, in particular rational choice theory: The notion of sanctions. Sanctions are an unexplained theoretical term for securing norm conformity. Read More

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October 2021

Sex disparities in COVID-19 outcomes of diabetic patients.

Eur J Endocrinol 2021 Sep 1. Epub 2021 Sep 1.

A Kautzky-Willer, Internal Medicine III, Medical University of Vienna, Wien, Austria.

In this SARS-COV2-pandemic, diabetes mellitus soon emerged as one of the most prominent risk factors for a severe course of COVID-19 and increased mortality due to hyperglycemia/insulin resistance, obesity, inflammation, altered immune status and cardiovascular complications. In general, men are at a higher risk of severe or fatal COVID-19 disease irrespective of age, region and despite comparable infection rates in both sexes. In COVID-19, there is also a male predominance among hospitalised patients with diabetes, however, overall, data among patients with diabetes are ambiguous so far. Read More

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September 2021

Ambiguity and conflict: Dissecting uncertainty in decision-making.

Behav Neurosci 2021 Sep 13. Epub 2021 Sep 13.

Department of Psychology, McGill University.

Making decisions is fundamental to how we navigate, survive, and thrive in our environment. The quality of information used to support decisions is rarely perfect. Many decisions are made under conditions of uncertainty, arising from ambiguous or conflicting information. Read More

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September 2021

Blind Spot: A Braille Patterned Novel Multiplex Lateral Flow Immunoassay Sensor Array for the Detection of Biothreat Agents.

ACS Omega 2021 Sep 23;6(35):22700-22708. Epub 2021 Aug 23.

Defense Biological Product Assurance Office (DBPAO), Joint Program Executive Office (JPEO) for Chemical, Biological, Radiological and Nuclear Defense (CBRND) Joint Project Lead (JPL) CBRND Enabling Biotechnologies (EB), Frederick, Maryland 21704, United States.

Lateral flow immunoassays (LFIs) are simple, point-of-care diagnostic devices used for detecting biological agents or other analytes of interest in a sample. LFIs are predominantly singleplex assays, interrogating one target analyte at a time. There is a need for multiplex LFI devices, e. Read More

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September 2021

Establishment of Repertoire of Placentome-Associated MicroRNAs and Their Appearance in Blood Plasma Could Identify Early Establishment of Pregnancy in Buffalo ().

Front Cell Dev Biol 2021 26;9:673765. Epub 2021 Aug 26.

Animal Genomics Laboratory, Animal Biotechnology Centre, National Dairy Research Institute, Karnal, India.

Precise early pregnancy diagnosis in dairy animals is of utmost importance for an efficient dairy production system. Not detecting a dairy animal pregnant sufficiently early after the breeding results to extending the unproductive time of their milk production cycle and causes substantial economic loss for a dairy producer. At present, the most conventional and authentic pregnancy confirmation practice in cows and buffaloes is rectal palpation of the reproductive organs at Days 35-40 after insemination, which sometime leads to considering an animal as false pregnant. Read More

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Regression Models Predicting the Number of Deaths from the New Coronavirus Infection.

Sovrem Tekhnologii Med 2020 ;12(2):6-11

Professor, Head of Department of Epidemiology, Microbiology and Evidence-Based Medicine, Privolozhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.

Predicting the development of epidemic infection caused by the COVID-19 coronavirus is a matter of the utmost urgency for health care and effective anti-epidemic measures. Given the rapidly changing initial information and the ambiguous quality of data coming from various sources, it is important to quickly optimize the existing prognostic models by using more sophisticated algorithms. is to test the originally developed mathematical algorithms for predicting the development of the COVID-19 epidemic process. Read More

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January 2020

Clinical features and prognosis of children with acute leukemias of ambiguous lineage under different diagnostic criteria.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Aug;23(8):835-840

Department of Hematology and Oncology/Ministry of Education Key Laboratory of Child Development and Disorders/National Clinical Research Center for Child Health and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Children's Hospital of Chongqing Medical University/Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.

Objectives: To study the clinical features and prognosis of children with acute leukemias of ambiguous lineage (ALAL) under different diagnostic criteria.

Methods: A retrospective analysis was performed on the medical data of 39 children with ALAL who were diagnosed and treated from December 2015 to December 2019. Among the 39 children, 34 received treatment. Read More

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Sequencing of neurofilament genes identified NEFH Ser787Arg as a novel risk variant of sporadic amyotrophic lateral sclerosis in Chinese subjects.

BMC Med Genomics 2021 Sep 11;14(1):222. Epub 2021 Sep 11.

Department of Neurology, Fujian Medical University Union Hospital, Fujian, 350001, China.

Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with neuronal cell inclusions composed of neurofilaments and other abnormal aggregative proteins as pathological hallmarks. Approximately 90% of patients have sporadic cases (sALS), and at least 4 genes, i.e. Read More

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September 2021

The general practitioners perspective regarding registration of persistent somatic symptoms in primary care: a survey.

BMC Fam Pract 2021 Sep 11;22(1):182. Epub 2021 Sep 11.

Health, Medical and Neuropsychology Department, Leiden University, Faculty of Social and Behavioral Sciences, Leiden, the Netherlands.

Background: Persistent somatic symptoms (PSS) are common in primary care and often accompanied by an increasing disease burden for both the patient and healthcare. In medical practice, PSS is historically considered a diagnosis by exclusion or primarily seen as psychological. Besides, registration of PSS in electronic health records (EHR) is unambiguous and possibly does not reflect classification adequately. Read More

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September 2021

Changing face of healthcare: digital therapeutics in the management of diabetes.

Curr Med Res Opin 2021 Sep 13:1-5. Epub 2021 Sep 13.

Pharmalytics Group, Vancouver, British Columbia, Canada.

Diagnosis, prevention, management and treatment of acute and chronic medical conditions have improved with technological advancements in terms of scalability, efficacy, access, and personalized approach. Digital therapeutic applications (DTx) (Blue Star®, Diabeo® System, Livongo Diabetes Program, Tidepool etc.,) use web-based applications/cloud platforms to provide evidence-based, personalized, rapid point of care management of chronic, behavior-modifiable conditions, including diabetes mellitus (DM). Read More

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September 2021

Serum anti-Müllerian hormone concentration as a diagnostic tool to identify testicular tissue in canine disorders of sexual development.

Domest Anim Endocrinol 2021 Jul 31;78:106654. Epub 2021 Jul 31.

Chair of Anatomy, Histology and Embryology, Department of Veterinary Sciences, Faculty of Veterinary Medicine, LMU Munich, Munich, Germany.

Disorders of sexual development (DSD) may have their origin in alterations of the chromosomal, gonadal or phenotypic sex. Affected animals are usually presented because of ambiguous external genitalia, seldom because of reproductive disorders. Anti-Müllerian hormone (AMH) is secreted in the gonads with higher amounts in males than in females and can be used to identify gonadal tissue in sexually normally developed dogs. Read More

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Postoperative lumbar spine MRI: How well does a radiology report that raises suspicion for infection correlate with true clinical infection?

J Clin Neurosci 2021 Oct 31;92:6-10. Epub 2021 Jul 31.

Division of Neurosurgery, Maimonides Medical Center, 4802 10th Avenue, Brooklyn, NY, USA.

Introduction: Interpretation of a lumbar spine MRI in the immediate postoperative period is challenging, as postoperative tissue enhancement and fluid collections may be mistaken for infection. Radiology reports may use ambiguous language, creating a clinical problem for a surgeon in determining whether a patient needs treatment with antibiotics or revision surgery. Moreover, retrospective criticism of management in instances of a true infection may lead to medicolegal ramifications. Read More

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October 2021

Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting miR-525-5p/VMA21 axis.

J Transl Med 2021 09 10;19(1):389. Epub 2021 Sep 10.

Department of Hematology and Oncology, Department of Geriatric Lung Cancer Laboratory, Geriatric Hospital of Nanjing Medical University, Jiangsu Province Geriatric Hospital, No.65 Jiangsu Road, Gulou District, Nanjing, 210000, Jiangsu Province, People's Republic of China.

Background: Lung adenocarcinoma (LUAD) is a common subtype of lung cancer with high recurrence rate and fatality. Circ_0001361 has been recognized as key regulators in various malignancies, but its roles in LUAD remain ambiguous.

Methods: Circ_0001361, miR-525-5p, and VMA21 levels were assessed by RT-qPCR. Read More

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September 2021

Does conservative kidney management offer a quantity or quality of life benefit compared to dialysis? A systematic review.

BMC Nephrol 2021 Sep 11;22(1):307. Epub 2021 Sep 11.

Department of Renal Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Aarhus, Denmark.

Background: Patients with stage 5 chronic kidney disease (CKD5) collaborate with their clinicians when choosing their future treatment modality. Most elderly patients with CKD5 may only have two treatment options: dialysis or conservative kidney management (CKM). The objective of this systematic review was to investigate whether CKM offers a quantity or quality of life benefit compared to dialysis for some patients with CKD5. Read More

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September 2021

A new approach to measuring the synergy in a syndemic: Revisiting the SAVA syndemic among urban MSM in the United States.

Authors:
Nicola Bulled

Glob Public Health 2021 Sep 10:1-11. Epub 2021 Sep 10.

University of Connecticut, Institute for Collaboration on Health, Intervention and Policy, Storrs, CT, USA.

Syndemic theory hypothesises that observed clusters of diseases are the result of harmful social conditions. Critiques of syndemics present the theory as ambiguous and lacking empirical evidence. Syndemics are evidenced through qualitative assessments drawing on observations, epidemiology, and biomedical evidence to explain bio-bio and bio-social interactions. Read More

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September 2021

A Clinical Update on the Prognostic Effect of microRNA Biomarkers for Survival Outcome in Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis.

Cancers (Basel) 2021 Aug 29;13(17). Epub 2021 Aug 29.

Northern Territory Institute of Research and Training, Darwin, NT 0909, Australia.

: Nasopharyngeal carcinoma (NPC), a relatively uncommon malignancy in the Western world, is highly prevalent in Southeast Asia where the treatment outcomes are poor. Despite recent improvements in diagnosis and treatment locoregional control, distant metastasis and chemoresistance continue to be a significant cause of mortality. Identification of a reliable and comprehensive prognostic biomarker is highly desirable. Read More

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Depth-Camera-Aided Inertial Navigation Utilizing Directional Constraints.

Sensors (Basel) 2021 Sep 2;21(17). Epub 2021 Sep 2.

Robotics Institute, University of Technology Sydney, Sydney, NSW 2006, Australia.

This paper presents a practical yet effective solution for integrating an RGB-D camera and an inertial sensor to handle the depth dropouts that frequently happen in outdoor environments, due to the short detection range and sunlight interference. In depth drop conditions, only the partial 5-degrees-of-freedom pose information (attitude and position with an unknown scale) is available from the RGB-D sensor. To enable continuous fusion with the inertial solutions, the scale ambiguous position is cast into a of the vehicle motion, which is, in essence, an epipolar constraint in multi-view geometry. Read More

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September 2021