180,312 results match your criteria alzheimer's


The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.

Cell Rep 2021 Sep;36(11):109694

Laboratorio Nazionale CIB (LNCIB), Area Science Park, Padriciano 99, 34149 Trieste, Italy; Department of Life Sciences (DSV), University of Trieste, 34127 Trieste, Italy; FIRC Institute of Molecular Oncology (IFOM), 20139 Milan, Italy. Electronic address:

Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer's disease (AD) and cancer. However, the mechanisms governing heterochromatin maintenance or its relaxation in pathological conditions remain poorly understood. Read More

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September 2021

Effects of COVID-19 on preclinical and clinical research in neurology: Examples from research on neurodegeneration and Alzheimer's disease.

Neuron 2021 Aug 24. Epub 2021 Aug 24.

Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University in St. Louis, 660 S. Euclid Ave., Box 8111, St. Louis, MO 63110, USA. Electronic address:

The COVID-19 pandemic has had a profound impact on neuroscientists, including those involved in translational research. In this NeuroView, we discuss the positive and negative effects of the pandemic on preclinical research and clinical studies in humans. Read More

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Adiponectin, leptin and resistin and the risk of dementia.

J Gerontol A Biol Sci Med Sci 2021 Sep 15. Epub 2021 Sep 15.

Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Adipokines are hormones secreted by adipose tissue with roles in energy homeostasis and regulation of metabolism. Their dysregulation is suggested to contribute to the increased risk of dementia seen with midlife obesity, but longitudinal studies investigating this are scarce. We determined the association between plasma levels of adiponectin, leptin and resistin with the risk of dementia. Read More

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September 2021

Unravelling the antimicrobial activity of peptide hydrogel systems: current and future perspectives.

Soft Matter 2021 Sep 15;17(35):8001-8021. Epub 2021 Sep 15.

Biofunctional Nanomaterials Group, School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, N. Ireland, BT9 7BL, UK.

The use of hydrogels has garnered significant interest as biomaterial and drug delivery platforms for anti-infective applications. For decades antimicrobial peptides have been heralded as a much needed new class of antimicrobial drugs. Self-assembling peptide hydrogels with inherent antimicrobial ability have recently come to the fore. Read More

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September 2021

Amyloid beta emerges from below the neck to disable the brain.

PLoS Biol 2021 Sep 15;19(9):e3001388. Epub 2021 Sep 15.

Buck Institute for Research on Aging, Novato, California, United States of America.

Accumulation of amyloid beta (Aβ) in the brain in Alzheimer disease drives pathophysiology. A study in this issue of PLOS Biology revealed that Aβ from the liver can promote brain pathology, supporting that peripheral Aβ can contribute to neurodegeneration. Read More

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September 2021

Ethical Considerations in Dementia Diagnosis and Care: AAN Position Statement.

Neurology 2021 Jul;97(2):80-89

From the Department of Neurology (W.C.), University of California San Francisco; Evidence-Based Practice Center (A.Y.T.), ECRI, Plymouth Meeting, PA; Division of Neurology (A.Y.T.), Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia; Department of Neurology (Z.S.), The Pennsylvania State University, Hershey; School of Law (R.J.B.), University of Virginia, Charlottesville; and Department of Neurology (J.A.R.), Lahey Medical Center, Burlington, MA.

Alzheimer disease and other dementias present unique practical challenges for patients, their families, clinicians, and health systems. These challenges reflect not only the growing public health effect of dementia in an aging global population, but also more specific ethical complexities including early loss of patients' capacity to make decisions regarding their own care, the stigma often associated with a dementia diagnosis, the difficulty of balancing concern for patients' welfare with respect for patients' remaining independence, and the effect on the physical, emotional, and financial well-being of family caregivers. Caring for patients with dementia requires respecting patient autonomy while acknowledging progressively diminishing decisional capacity and continuing to provide care in accordance with other core ethical principles (beneficence, justice, and nonmaleficence). Read More

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Cross-Seeded Fibrillation Induced by Pyroglutamate-3 and Truncated Aβ Variants Leads to Aβ Structural Polymorphism Modulation and Elevated Toxicity.

ACS Chem Neurosci 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemistry, Binghamton University, State University of New York, Binghamton, New York 13902, United States.

The pathological amyloid plaques in Alzheimer's disease (AD) patients contain not only the wild-type β-amyloid (wt-Aβ) peptide sequences but also a variety of post-translationally modified variants. The pyroglutamate-3 Aβ (pyroE3-Aβ), which is generated from its truncated precursors ΔE3-Aβ, shows the highest abundance among all modified Aβ variants. Previous works have shown that pyroE3-Aβ and/or ΔE3-Aβ, compared with the wild-type sequences, led to a more rapid fibrillation process and final fibrils with higher neuronal cytotoxicity levels. Read More

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September 2021

Control of hippocampal pKr-2 expression reduces neurotoxic symptoms in 5XFAD mice.

Br J Pharmacol 2021 Sep 15. Epub 2021 Sep 15.

School of Life Sciences, Kyungpook National University, Daegu, Korea.

Background And Purpose: There is a scarcity of information regarding the role of prothrombin kringle-2 (pKr-2), which can be generated by active thrombin, associated with hippocampal neurodegeneration and its mechanisms in Alzheimer's disease (AD).

Experimental Approach: To assess the role of pKr-2 in association with the neurotoxic symptoms of AD, we determined pKr-2 protein levels in the postmortem hippocampal tissues of patients with AD and the hippocampi of five familial AD (5XFAD) mice compared to those of age-matched controls and wild-type (WT) mice, respectively. In addition, we investigated whether the hippocampal neurodegeneration and object memory impairments shown in 5XFAD mice were mediated by the control of pKr-2 upregulation. Read More

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September 2021

The estimated prevalence of no reported dementia-related diagnosis in older Americans living with possible dementia by healthcare utilization.

Aging Clin Exp Res 2021 Sep 15. Epub 2021 Sep 15.

Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, NDSU Dept 2620, PO Box 6050, Fargo, ND, 58108, USA.

Background: Screening for dementia in relevant healthcare settings may help in identifying low cognitive functioning for comprehensive cognitive assessments and subsequent dementia treatment after diagnosis.

Aims: This study sought to estimate the prevalence of no reported dementia-related diagnosis in a nationally-representative sample of older Americans with a cognitive impairment consistent with dementia (CICD) by healthcare utilization.

Methods: The unweighted analytical sample included 1514 Americans aged ≥ 65 years that were identified as having a CICD without history of stroke, cancers, neurological conditions, or brain damage who participated in at least one-wave of the 2010-2016 waves of the Health and Retirement Study. Read More

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September 2021

Implication of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology.

Dis Model Mech 2021 Sep 15. Epub 2021 Sep 15.

Department of Medicine (Neurology), Center for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada.

Amyloid β (Aβ) peptides generated from the amyloid precursor protein (APP) play a critical role in the development of Alzheimer's disease (AD) pathology. Aβ-containing neuronal exosomes, which represent a novel form of intercellular communication, have been shown to influence function/vulnerability of neurons in AD. Unlike neurons, the significance of exosomes derived from astrocytes remains unclear. Read More

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September 2021

Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it's role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. A mini-review.

Braz J Biol 2021 10;83:e250179. Epub 2021 Sep 10.

Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, Pakistan.

Diabetes mellitus (DM) is a non-communicable disease throughout the world in which there is persistently high blood glucose level from the normal range. The diabetes and insulin resistance are mainly responsible for the morbidities and mortalities of humans in the world. This disease is mainly regulated by various enzymes and hormones among which Glycogen synthase kinase-3 (GSK-3) is a principle enzyme and insulin is the key hormone regulating it. Read More

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September 2021

A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling.

Elife 2021 Sep 15;10. Epub 2021 Sep 15.

Cornell University, Ithaca, United States.

Membrane protein recycling systems are essential for maintenance of the endosome-lysosome system. In yeast, retromer and Snx4 coat complexes are recruited to the endosomal surface where they recognize cargos. They sort cargo and deform the membrane into recycling tubules that bud from the endosome and target to the Golgi. Read More

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September 2021

Comparison shopping: Is neuropsychological evaluation more expensive than neuroimaging?

Clin Neuropsychol 2021 Sep 15:1-12. Epub 2021 Sep 15.

University of Texas Health Science Center at San Antonio, San Antonio, TX.

Objective: This study empirically examined if neuropsychological evaluation (NPE) is expensive compared to other diagnostic procedures such as neuroimaging.

Method: We aggregated data on charges for NPE and common neuroimaging procedures (e.g. Read More

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September 2021

Adiponectin improves amyloid-β 31-35-induced circadian rhythm disorder in mice.

J Cell Mol Med 2021 Sep 15. Epub 2021 Sep 15.

Basic Medical Sciences Center, Shanxi Medical University, Taiyuan, China.

Adiponectin is an adipocyte-derived hormone, which is closely associated with the development of Alzheimer's disease (AD) and has potential preventive and therapeutic significance. In the present study, we explored the relationship between adiponectin and circadian rhythm disorder in AD, the effect of adiponectin on the abnormal expression of Bmal1 mRNA/protein induced by amyloid-β protein 31-35 (Aβ31-35), and the underlying mechanism of action. We found that adiponectin-knockout mice exhibited amyloid-β deposition, circadian rhythm disorders and abnormal expression of Bmal1. Read More

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September 2021

Meta-analysis of association between migraine and risk of dementia.

Acta Neurol Scand 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Objectives: The association between migraine and dementia has rarely been investigated, and available results are conflicting. Thus, the aim of this meta-analysis was to evaluate whether an association exists between migraine and dementia.

Materials & Methods: We searched for cohort studies from databases including PubMed, EBSCO, Web of Science, and EMBASE database from inception to April 1, 2021, using subject and free words. Read More

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September 2021

Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE1.

J Biochem 2021 Sep 15. Epub 2021 Sep 15.

Department of Biological Sciences, Tokyo Metropolitan University, Minami-osawa, Hachioji, Tokyo 192-0397, Japan.

Lemur tail kinase 1 (LMTK1), previously called apoptosis-associated tyrosine kinase (AATYK), is an endosomal Ser/Thr kinase. We recently reported that LMTK1 regulates axon outgrowth, dendrite arborization and spine formation via Rab11-mediated vesicle transport. Rab11, a small GTPase regulating recycling endosome trafficking, is shown to be associated with late-onset Alzheimer's disease (LOAD). Read More

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September 2021

Contribution to the Discovery of a Novel Medicine for a Neuromuscular Disease and of other Promising Molecules for the Treatment of Neurodevelopmental and Neurodegenerative Diseases.

Authors:
Hasane Ratni

Chimia (Aarau) 2021 Aug;75(7):614-619

Roche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, Medicinal Chemistry Department, 124 Grenzacherstrasse, B 92 /6.76, CH-4070 Basel, Switzerland;, Email:

Nervous system disorders affect millions of people around the world, through a very broad range of diseases. Here we describe our contribution to find a treatment for patients suffering from three of those diseases. The first one, autism spectrum disorder (ASD), affects approximately one in every 59 children in US. Read More

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Reduced TREM2 activation in microglia of patients with Alzheimer's disease.

FEBS Open Bio 2021 Sep 15. Epub 2021 Sep 15.

Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, 26-Muraoka-higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan.

Loss-of-function variants of triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk of developing Alzheimer's disease (AD). The mechanism through which TREM2 contributes to the disease (TREM2 activation vs inactivation) is largely unknown. Here, we analyzed changes in a gene set downstream of TREM2 to determine whether TREM2 signaling is modified by AD progression. Read More

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September 2021

Neuroprotective potential of berberine in modulating Alzheimer's disease via multiple signaling pathways.

J Food Biochem 2021 Sep 14:e13936. Epub 2021 Sep 14.

Department of Pharmacognosy, Government College University, Faisalabad, Pakistan.

Berberine is one of the most important quinoline alkaloids, which has shown numerous pharmacological activities. There are pieces of evidence that berberine serves as a promising substance for treating Alzheimer's disease (AD). Recently, numerous studies on animal models have shown the neuroprotective role of berberine. Read More

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September 2021

Inverse Correlation Between Alzheimer's Disease and Cancer: Short Overview.

Mol Neurobiol 2021 Sep 14. Epub 2021 Sep 14.

Laboratory of Virology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114, Wroclaw, Poland.

The negative association between Alzheimer's disease (AD) and cancer suggests that susceptibility to one disease may protect against the other. When biological mechanisms of AD and cancer and relationship between them are understood, the unsolved problem of both diseases which still touches the growing human population could be overcome. Actual information about biological mechanisms and common risk factors such as chronic inflammation, age-related metabolic deregulation, and family history is presented here. Read More

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September 2021

Sulfuretin exerts diversified functions in the processing of amyloid precursor protein.

Genes Dis 2021 Nov 21;8(6):867-881. Epub 2020 Nov 21.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, 1 Youyi Road, Chongqing, 400016, PR China.

Sulfuretin is a flavonoid that protects cell from damage induced by reactive oxygen species and inflammation. In this study, we investigated the role of sulfuretin in the processing of amyloid precursor protein (APP), in association with the two catalytic enzymes the α-secretase a disintegrin and metalloproteinase (ADAM10), and the beta-site APP cleaving enzyme 1 (BACE1) that play important roles in the generation of β amyloid protein (Aβ) in Alzheimer's disease (AD). We found that sulfuretin increased the levels of the immature but not the mature form of ADAM10 protein. Read More

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November 2021

Suppression of a core metabolic enzyme dihydrolipoamide dehydrogenase () protects against amyloid beta toxicity in model of Alzheimer's disease.

Genes Dis 2021 Nov 20;8(6):849-866. Epub 2020 Aug 20.

School of Biological Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.

A decrease in energy metabolism is associated with Alzheimer's disease (AD), but it is not known whether the observed decrease exacerbates or protects against the disease. The importance of energy metabolism in AD is reinforced by the observation that variants of dihydrolipoamide dehydrogenase (DLD), is genetically linked to late-onset AD. To determine whether DLD is a suitable therapeutic target, we suppressed the gene in that express human Aβ peptide in either muscles or neurons. Read More

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November 2021

Evolution of blood-brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies.

Acta Pharm Sin B 2021 Aug 31;11(8):2306-2325. Epub 2020 Dec 31.

Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China.

Blood-brain barrier (BBB) strictly controls matter exchange between blood and brain, and severely limits brain penetration of systemically administered drugs, resulting in ineffective drug therapy of brain diseases. However, during the onset and progression of brain diseases, BBB alterations evolve inevitably. In this review, we focus on nanoscale brain-targeting drug delivery strategies designed based on BBB evolutions and related applications in various brain diseases including Alzheimer's disease, Parkinson's disease, epilepsy, stroke, traumatic brain injury and brain tumor. Read More

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Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation.

Theranostics 2021 19;11(18):8964-8976. Epub 2021 Aug 19.

Dept. of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.

Modulation of the innate immune system is emerging as a promising therapeutic strategy against Alzheimer's disease (AD). However, determinants of a beneficial therapeutic effect are ill-understood. Thus, we investigated the potential of 18 kDa translocator protein positron-emission-tomography (TSPO-PET) for assessment of microglial activation in mouse brain before and during chronic immunomodulation. Read More

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Alzheimer's disease-causing presenilin-1 mutations have deleterious effects on mitochondrial function.

Theranostics 2021 17;11(18):8855-8873. Epub 2021 Aug 17.

School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.

Mitochondrial dysfunction and oxidative stress are frequently observed in the early stages of Alzheimer's disease (AD). Studies have shown that presenilin-1 (PS1), the catalytic subunit of γ-secretase whose mutation is linked to familial AD (FAD), localizes to the mitochondrial membrane and regulates its homeostasis. Thus, we investigated how five mutations (A431E, E280A, H163R, M146V, and Δexon9) observed in FAD affect mitochondrial functions. Read More

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Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Aβ catabolic enzyme Neprilysin.

Theranostics 2021 11;11(18):8797-8812. Epub 2021 Aug 11.

Sir Run run Hospital, Nanjing Medical University, Nanjing, China.

Neprilysin (NEP) is a major endogenous catabolic enzyme of amyloid β (Aβ). Previous studies have suggested that increasing NEP expression in animal models of Alzheimer's disease had an ameliorative effect. However, the underlying signaling pathway that regulates NEP expression remains unclear. Read More

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Design, synthesis, and bio-evaluation of new isoindoline-1,3-dione derivatives as possible inhibitors of acetylcholinesterase.

Res Pharm Sci 2021 Oct 19;16(5):482-492. Epub 2021 Aug 19.

Department of Animal Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, I.R. Iran.

Background And Purpose: Alzheimer's disease is considered one of the lead causes of elderly death around the world. A significant decrease in acetylcholine level in the brain is common in most patients with Alzheimer's disease, therefore acetylcholinesterase (AChE) inhibitors such as donepezil and rivastigmine are widely used for patients with limited therapeutic results and major side effects.

Experimental Approach: A series of isoindoline-1,3-dione -N-benzyl pyridinium hybrids were designed, synthesized and evaluated as anti-Alzheimer agents with cholinesterase inhibitory activities. Read More

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October 2021

Effects of fruit and bark alcoholic extracts, alone and in combination, on scopolamine-induced memory impairment in mice.

Res Pharm Sci 2021 Oct 19;16(5):474-481. Epub 2021 Aug 19.

Department of Pharmacology and Toxicology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.

Background And Purpose: Alzheimer's disease is a progressive brain disorder that is thought to be triggered disruption of cholinergic neurons and enhanced oxidative stress. Therefore, antioxidant phytochemicals with the ability to fortify cholinergic function should help in preventing the progress of the disease. This study aimed at evaluating the combinational effects of two popular herbs one with anticholinesterase activity namely and the other with antioxidant capacity, . Read More

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October 2021