4,465 results match your criteria alveolar hemorrhage

Splenic Infarcts and Pulmonary Renal Syndrome in a Young Patient with Double-Positive Anti-GBM and ANCA-Associated Vasculitis.

Saudi J Kidney Dis Transpl 2021 Jan-Feb;32(1):240-244

Department of Medicine, King Abdulaziz Medical City, Ministry of the National Guard- Health Affairs, Riyadh, Saudi Arabia.

Double-positive disease, defined by double-seropositivity for serum anti-glomerular basement membrane (GBM) antibodies and anti-neutrophil cytoplasmic antibodies (ANCA) is a rare cause of pulmonary-renal syndrome. Here, we present an exceptional course of a 20-year-old male with seropositivity for anti-myeloperoxidase anti-neutrophil cytoplasmic antibodies and anti-GBM antibody, who presented first with renal impairment due to focal necrotizing crescentic glomerulonephritis. After receiving treatment, he presented two years later with a relapse manifesting with diffuse alveolar hemorrhage and multiple splenic infarcts. Read More

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Diffuse alveolar haemorrhage secondary to in a vaping patient.

BMJ Case Rep 2021 Jun 15;14(6). Epub 2021 Jun 15.

Department of Cardiothoracic Surgery, Aspirus Wausau Hospital, Wausau, Wisconsin, USA.

Diffuse alveolar haemorrhage (DAH) is known to occur from several infectious and non-infectious aetiologies. Among the infectious aetiologies, , an organism known to cause community-acquired pneumonia, has not been reported in association with DAH prior to this case. On the other hand, vaping, an evolving epidemic concern, has been linked to various types of lung injury, including DAH. Read More

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Effects of Ultrashort Wave Therapy on Inflammation and Macrophage Polarization after Acute Lung Injury in Rats.

Bioelectromagnetics 2021 Jun 15. Epub 2021 Jun 15.

Rehabilitation Medicine Center, The First Affiliated Hospital of University of South China, Hengyang, People's Republic of China.

Acute lung injury (ALI) features dysregulated pulmonary inflammation. Ultrashort waves (USWs) exert anti-inflammatory effects but no studies have evaluated their activity in ALI. Herein, we used an in vivo lipopolysaccharide (LPS)-induced ALI model to investigate whether the anti-inflammatory activity of USWs is mediated by altering the polarization of M1 to M2 macrophages. Read More

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ECMO Rescues Patients With Acute Respiratory Failure Related to GPA.

Front Med (Lausanne) 2021 28;8:671396. Epub 2021 May 28.

Department of Respiratory Medicine (Department of Respiratory and Critical Care Medicine), Xiangya Hospital, Central South University, Changsha, China.

Granulomatosis with polyangiitis (GPA) is a subtype of anti-neutrophil cytoplasmic antibody-associated vasculitis with a wide range of clinical symptoms related to the systemic involvement of small blood vessels. The respiratory system is one of the most frequently involved, and life-threatening acute respiratory failure could occur due to diffusive alveolar hemorrhage and tracheal stenosis. When maximum mechanical ventilation is unable to maintain oxygenation, extracorporeal membrane oxygenation (ECMO) should be considered as the final respiratory supportive method, if available. Read More

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Steroid myopathy in a child with diffuse alveolar hemorrhage: a case report.

Ann Palliat Med 2021 Jun 6. Epub 2021 Jun 6.

Department of Respiratory Medicine, Children's Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai, China.

Steroid myopathy (SM) is a side effect of glucocorticoid administration. Previous reports of SM after glucocorticoid therapy for respiratory diseases have focused on asthma and chronic obstructive pulmonary disease in adults or adolescents. To our knowledge, there have been no reports of SM after treatment with glucocorticoid for diffuse alveolar hemorrhage (DAH) in preschoolers. Read More

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Expert Perspective: Management of Microvascular and Catastrophic Antiphospholipid Syndrome.

Doruk Erkan

Arthritis Rheumatol 2021 Jun 11. Epub 2021 Jun 11.

Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery; Weill Cornell Medicine, New York, NY, USA.

A 50-year-old male with antiphospholipid syndrome (APS) presents to your office for the first time with a three-month history of worsening dyspnea, dry cough, and early morning blood-tinged sputum. His APS diagnosis was based on an unprovoked left lower extremity deep vein thrombosis, four years prior to the presentation, with persistent (multiple occasions) triple antiphospholipid antibody (aPL)-positivity, defined as lupus anticoagulant (LA) test positive performed while off anticoagulation, high titer [≥80 U] IgG anticardiolipin antibodies (aCL), and high titer IgG anti-β -glycoprotein-I (aβ GPI). He has no other past medical history; and he is on warfarin with a target international normalized ratio (INR) of 2. Read More

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Chronic eosinophilic pneumonitis due to the inhalation of aerosolized face lotion: A case report.

Medicine (Baltimore) 2021 May;100(19):e25860

Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association (JATA), Kiyose City, Tokyo.

Rationale: Inhalation of toxic agents can induce eosinophilic pneumonia. However, only a few case reports demonstrate that exposure to materials can induce chronic eosinophilic pneumonia (CEP). Here, we describe a rare case of CEP with mild alveolar hemorrhage due to the inhalation of aerosols from face lotion. Read More

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Electronic cigarettes, vaping-related lung injury and lung cancer: where do we stand?

Eur J Cancer Prev 2021 Jul;30(4):293-296

Department of Thoracic Surgery, IRCCS European Institute of Oncology.

Electronic cigarettes have been considered a promising alternative to nicotine replacement products to help heavy tobacco smokers quit smoking. They work thanks to a heating coil causing evaporation of the liquid rapidly followed by cooling, thus creating an aerosol, a completely different mechanism from the combustion of tobacco in traditional cigarettes. The term 'vaping' indicates the use of electronic cigarettes or other devices to inhale heated, aerosolized nicotine, or other substances like cannabidiol, tetrahydrocannabinol, or butane hash oils together with solvents, mainly propylene glycol and vegetable glycerine or their combination. Read More

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Pulmonary Involvement in Sweet's Syndrome.

Am J Respir Crit Care Med 2021 Jun 8. Epub 2021 Jun 8.

Westchester Medical Center, 8138, Pulmonary and Critical Care Medicine, Valhalla, New York, United States.

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Myxomavirus serpin alters macrophage function and prevents diffuse alveolar hemorrhage in pristane-induced lupus.

Clin Immunol 2021 Jun 2;229:108764. Epub 2021 Jun 2.

Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL 32610, United States of America.

C57BL/6 mice with pristane-induced lupus develop macrophage-dependent diffuse alveolar hemorrhage (DAH), which is blocked by treatment with liver X receptor (LXR) agonists and is exacerbated by low IL-10 levels. Serp-1, a myxomavirus-encoded serpin that impairs macrophage activation and plasminogen activation, blocks DAH caused by MHV68 infection. We investigated whether Serp-1 also could block DAH in pristane-induced lupus. Read More

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First evidence of infection in Aceh cattle: Pathomorphology and antigenic distribution in the lungs.

Vet World 2021 Apr 27;14(4):1007-1013. Epub 2021 Apr 27.

Department of Veterinary Clinic Reproduction and Pathology, Faculty of Veterinary Medicine, IPB University, Bogor, Indonesia.

Background And Aim: is an emerging zoonotic and foodborne pathogen worldwide. Hypervirulent (hvKp) was reported as the causative agent of bovine mastitis. This is the first study in Indonesia that has been conducted to determine the capsular serotype of , pulmonary gross pathology and histopathology, and distribution of hvKp in the lungs of Aceh cattle. Read More

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Differential Alveolar and Systemic Oxygenation during Preterm Resuscitation with 100% Oxygen during Delayed Cord Clamping.

Am J Perinatol 2021 Jun 1. Epub 2021 Jun 1.

Neonatal Research Institute, Sharp Mary Birch Hospital for Women and Newborns, San Diego, California.

Objective:  Delayed cord clamping (DCC) and 21 to 30% O resuscitation is recommended for preterm infants but is commonly associated with low pulmonary blood flow (Qp) and hypoxia. 100% O supplementation during DCC for 60 seconds followed by 30% O may increase Qp and oxygen saturation (SpO).

Study Design:  Preterm lambs (125-127 days of gestation) were resuscitated with 100% O with immediate cord clamping (ICC,  = 7) or ICC + 30% O, and titrated to target SpO ( = 7) or DCC + 100% O for 60 seconds, which followed by cord clamping and 30% O titration ( = 7). Read More

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Effect of Reduced-Dose vs High-Dose Glucocorticoids Added to Rituximab on Remission Induction in ANCA-Associated Vasculitis: A Randomized Clinical Trial.

JAMA 2021 06;325(21):2178-2187

Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan.

Importance: The current standard induction therapy for antineutrophil cytoplasm antibody (ANCA)-associated vasculitis is the combination of high-dose glucocorticoids and cyclophosphamide or rituximab. Although these regimens have high remission rates, they are associated with considerable adverse events presumably due to high-dose glucocorticoids.

Objective: To compare efficacy and adverse events between a reduced-dose glucocorticoid plus rituximab regimen and the standard high-dose glucocorticoid plus rituximab regimen in remission induction of ANCA-associated vasculitis. Read More

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Unilateral Diffuse Alveolar Hemorrhage Due to Selective Directionality of Mitral Regurgitant Jet in a Patient With Severe Aortic Stenosis.

Cureus 2021 Apr 27;13(4):e14714. Epub 2021 Apr 27.

Pulmonary and Critical Care Medicine, Ozarks Medical Center, West Plains, USA.

Diffuse alveolar hemorrhage (DAH) in cardiac diseases results from pulmonary capillary stress failure due to pulmonary venous hypertension. The most common cardiac causes of DAH are heart failure and mitral valvular disease. Patients typically manifest with hemoptysis, radiologic chest abnormalities, and anemia. Read More

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[Impact and mechanism of NEMO binding domain peptide on pulmonary inflammation and apoptosis of lung tissues in mice with acute respiratory distress syndrome].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Apr;33(4):410-415

Guizhou Medical University, Guiyang 550004, Guizhou, China. Wang Yahui is working on the Department of Emergency, the People's Hospital of Weining County, Weining 553100, Guizhou, China. Corresponding author: Shen Feng, Email:

Objective: To investigate the effect of NEMO binding domain peptide (NBDP) on lung inflammation and apoptosis in mice with acute respiratory distress syndrome (ARDS) and its mechanism.

Methods: Thirty-six male BALB/c mice were divided into normal saline (NS) control group, ARDS model group, NBDP negative control group and 6, 12 and 18 μg NBDP pretreatment group by random number table method, with 6 mice in each group. ARDS mouse model was reproduced by aerosol inhalation lipopolysaccharide (LPS) 50 μL. Read More

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Leptospirosis with pulmonary haemorrhage and multiple organ failure: a case report and literature review.

J Int Med Res 2021 May;49(5):3000605211019665

Department of Emergency, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi, China.

Pulmonary haemorrhage is an important complication of leptospirosis. We herein report an uncommon case of severe pulmonary haemorrhage and multiple organ failure caused by leptospirosis in a 49-year-old man who was previously healthy. He was a farm worker who was admitted to the hospital because of haemoptysis. Read More

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Anti-glomerular basement membrane disease associated with thin basement membrane nephropathy: A case report.

Medicine (Baltimore) 2021 May;100(20):e26095

Department of Internal Medicine.

Rationale: Simultaneous occurrence of anti-glomerular basement membrane (anti-GBM) disease and thin basement membrane nephropathy (TBMN), both of which invade the type IV collagen subunits, is very rare. Here, we present the case of a 20-year-old male patient diagnosed with both anti-GBM disease and TBMN upon presenting dyspnea and hemoptysis.

Patient Concerns: No laboratory abnormalities, except arterial hypoxemia (PaO275. Read More

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Hemoptysis in a cannabis user.

Am J Emerg Med 2021 May 4. Epub 2021 May 4.

Department of Imaging, Sanz Medical Center, Netanya, Israel.

A healthy young man presented to the emergency department with mild hemoptysis associated with cannabis abuse. He was on no medications and cocaine abuse was ruled out by both history and negative toxicology screens. There were neither signs of an infection, nor of a systemic or cardiac disease. Read More

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Lung histopathological findings in COVID-19 disease - a systematic review.

Infect Agent Cancer 2021 May 17;16(1):34. Epub 2021 May 17.

Department of Clinic and Experimental Medicine, University of Foggia, 71122, Foggia, Italy.

Since December 2019, the global burden of the COVID-19 pandemic has increased rapidly and has impacted nearly every country in the world, affecting those who are elderly or with underlying comorbidities or immunocompromised states. Aim of this systematic review is to summarize lung histopathological characteristics of COVID-19, not only for diagnostic purpose but also to evaluate changes that can reflect pathophysiological pathways that can inform clinicians of useful treatment strategies. We identified following histopathological changes among our patients:: hyaline membranes; endothelial cells/ interstitial cells involvement; alveolar cells, type I pneumocytes/ type II pneumocytes involvement; interstitial and/ or alveolar edema; evidence of hemorrhage, of inflammatory cells, evidence of microthrombi; evidence of fibrin deposition and of viral infection in the tissue samples. Read More

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Therapeutic Dilemmas Regarding Anticoagulation, Pulmonary Embolism, and Diffuse Alveolar Hemorrhage Due to Behçet's Disease.

Cureus 2021 Apr 12;13(4):e14429. Epub 2021 Apr 12.

Division of Rheumatology, Eskişehir Osmangazi University, Eskişehir, TUR.

The use of anticoagulants is still a matter of debate in deep venous thrombosis (DVT) and other thrombotic events in Behcet's disease (BD). Anticoagulant therapy is an integral part of treatment in cases of a pulmonary embolism (PE) that develops in other disorders. The issue of how to act when a pulmonary artery thrombosis is reported in the Behçet's patient may pose a major dilemma among emergency physicians. Read More

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Anti-neutrophil cytoplasmic antibody-associated vasculitis complicated with diffuse alveolar haemorrhage and central nervous system vasculitis.

SAGE Open Med Case Rep 2021 27;9:2050313X211011814. Epub 2021 Apr 27.

Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.

Diffuse alveolar haemorrhage and central nervous system vasculitis are life-threatening complications of anti-neutrophil cytoplasmic antibody-associated vasculitis. The simultaneous occurrence of diffuse alveolar haemorrhage and central nervous system vasculitis is a rare presentation of antibody-associated vasculitis. Its diagnosis by histopathology is difficult because biopsy is difficult to perform, and urgent treatment is needed. Read More

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Life-Threatening Diffuse Alveolar Hemorrhage as an Initial Presentation of Microscopic Polyangiitis: COVID-19 as a Likely Culprit.

Cureus 2021 Apr 10;13(4):e14403. Epub 2021 Apr 10.

Internal Medicine, Hackensack Meridian Health Palisades Medical Center, North Bergen, USA.

Microscopic polyangiitis (MPA) is a systemic small vessel vasculitis but it is rare to see life-threatening diffuse alveolar hemorrhage (DAH) in MPA as an initial presentation. MPA more commonly presents with renal involvement and develops pulmonary manifestations later in the disease course. Our patient is a 77-year-old female with a recent history of recovered COVID-19 infection who presented with sudden onset fever, dyspnea, and hemoptysis for three days. Read More

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Vasculitis and Breast Cancer: Mind the Hint.

Case Rep Oncol 2021 Jan-Apr;14(1):550-560. Epub 2021 Mar 22.

Internal Medicine Department, Hospital Beatriz Ângelo, Loures, Portugal.

Diffuse alveolar haemorrhage related to an anti-neutrophil cytoplasmic antibody (ANCA)-associated small vessel vasculitis is an extremely rare form of presentation of breast cancer. Here we report the case of a 77-year-old woman with a histological diagnosis of a papillary ductal carcinoma of the breast presenting with a diffuse alveolar haemorrhage secondary to a perinuclear ANCA-associated vasculitis. To our knowledge, this is the first case ever reported of a diffuse alveolar haemorrhage related to an ANCA-associated small vessel vasculitis as a form of presentation of breast cancer. Read More

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Alveolar hemorrhage in the setting of COVID-19: Report of a successful vascular intervention and embolization.

Radiol Case Rep 2021 Jul 4;16(7):1777-1779. Epub 2021 May 4.

Department of Radiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

The coronavirus disease 2019 (COVID-19) is characterized by viral pneumonia with mild to moderate symptoms. Emerging studies suggest that some patients may experience uncommon complications, such as thrombotic or hemorrhagic episodes. Here we present a 59-year-old male patient who had a hemorrhage episode from a branch of the pulmonary arteries and was treated by interventional embolization. Read More

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Pheochromocytoma presenting as an authentic small vessel vasculitis and complicated with pulmonary embolism: An original presentation.

Ann Cardiol Angeiol (Paris) 2021 Jun 4;70(3):168-170. Epub 2021 May 4.

Service de médecine interne, Hôpital Mongi Slim La Marsa, Tunis, Tunisia.

Diagnosis of pheochromocytoma can be simple when classic manifestations are present. It can also be challenging and complicated in some cases because of its wide array of faces and presentations. We present a case of a 30-year-old female patient who came with acute respiratory distress, chest pain, hemoptysis, asthenia, anorexia, weight loss of 20kg, and paresthesia in her lower limbs. Read More

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Ethanolic extract of C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice.

J Complement Integr Med 2021 May 6. Epub 2021 May 6.

Cellular and Molecular Research Center, Department of Anatomical Sciences, Birjand University of Medical Sciences, Birjand, Iran.

Objectives: Acute lung injury (ALI) is a life-threatening pulmonary dysfunction associated with severe inflammation. There are still no effective pharmacological therapies for the treatment of ALI. In this concern, several anti-inflammatory agents could be used as add-on therapy to inhibit inflammation. Read More

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CT Findings and Patterns of E-Cigarette or Vaping Product Use-Associated Lung Injury: A Multicenter Cohort of 160 Cases.

Chest 2021 May 3. Epub 2021 May 3.

Department of Radiology, University of Wisconsin School of Medicine and Public Health, WI.

Background: E-cigarette and vaping-induced lung injury (EVALI) causes a spectrum of CT lung injury patterns. Relative frequencies and associations with vaping behavior are unknown.

Research Question: What are the frequencies of imaging findings and CT patterns in EVALI and what is the relationship to vaping behavior?

Study Design And Methods: CT scans of 160 subjects with EVALI from 15 institutions were retrospectively reviewed. Read More

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Radiomics complements clinical, radiological, and technical features to assess local control of colorectal cancer lung metastases treated with radiofrequency ablation.

Eur Radiol 2021 May 5. Epub 2021 May 5.

Department of Diagnostic and Interventional Oncological Imaging, Institut Bergonié, Regional Comprehensive Cancer of Nouvelle-Aquitaine, 229, cours de l'Argonne, F-33076, Bordeaux cedex, France.

Objectives: Radiofrequency ablation (RFA) of lung metastases of colorectal origin can improve patient survival and quality of life. Our aim was to identify pre- and per-RFA features predicting local control of lung metastases following RFA.

Methods: This case-control single-center retrospective study included 119 lung metastases treated with RFA in 48 patients (median age: 60 years). Read More

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Implant therapy in the rehabilitation of mandibular arteriovenous malformations.

J Oral Implantol 2021 05 4. Epub 2021 May 4.

Aix-Marseille Universite Faculte de Medecine Oral surgery 264 Rue Saint-Pierre FRANCE Marseille 13385 Aix-Marseille Universite Faculte de Medecine.

Purpose: Mandibular arteriovenous malformations are rare congenital malformations which require multidisciplinary care. Implant-supported rehabilitation of significant bone defect after embolization and resection is poorly described in the literature.

Clinical Report: We present the case of a 24 year-old patient with a right sided mandibular arteriovenous malformations diagnosed after massive hemorrhage and treated by embolization and resection surgery. Read More

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Differentiation of pulmonary complications with extensive ground-glass attenuation on high-resolution CT in immunocompromised patients.

Jpn J Radiol 2021 May 4. Epub 2021 May 4.

Department of Radiology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan.

Purpose: The purpose of this study was to compare the high-resolution CT (HRCT) findings of pulmonary infectious and noninfectious complications with extensive ground-glass attenuation (GGA) in immunocompromised patients.

Materials And Methods: One hundred fifty-two immunocompromised patients with pulmonary complications that showed extensive GGA (> 50% of the whole lung on HRCT) were included in this study. The diagnoses of the 152 patients were as follows: pneumocystis pneumonia (PCP), n = 82; drug-induced pneumonia, n = 38; bacterial pneumonia, n = 9; cytomegalovirus pneumonia, n = 6; idiopathic pneumonia syndrome, n = 6; diffuse alveolar hemorrhage (DAH), n = 4; fungal infection, n = 3; tuberculosis, n = 2 and pulmonary edema, n = 2. Read More

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