Nutr Res 2021 May 21;91:44-56. Epub 2021 May 21.
Department of Nutrition, University of California, Davis, USA; Department of Food Science and Technology, University of California, Davis, USA. Electronic address:
Severe acute malnutrition (SAM), due to poor energy and/or protein intake, is associated with poor growth, depressed immune function, and long-term impacts on metabolic function. As the liver is a major metabolic organ and malnutrition poses metabolic stress, we hypothesize that SAM will be associated with alterations in the hepatic metabolome reflective of oxidative stress, gluconeogenesis, and ketogenesis. Thus, the purpose of this secondary analysis was to understand how SAM alters hepatic metabolism using a piglet model. Read More