1,172 results match your criteria alters glutathione

Anoxia-reoxygenation alters HO efflux and sensitivity of redox centers to copper in heart mitochondria.

Comp Biochem Physiol C Toxicol Pharmacol 2021 Jun 16:109111. Epub 2021 Jun 16.

Department of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown C1A 4P3, PE, Canada. Electronic address:

Mitochondrial reactive oxygen species (ROS) have been implicated in organ damage caused by environmental stressors, prompting studies on the effect of oxygen deprivation and metal exposure on ROS metabolism. However, how anoxia and copper (Cu) jointly influence heart mitochondrial ROS metabolism is not understood. We used rainbow trout heart mitochondria to probe the effects of anoxia-reoxygenation and Cu on hydrogen peroxide (HO) emission during oxidation of palmitoylcarnitine (PC), succinate, and glutamate-malate. Read More

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Biochemical and Behavioral Responses in Zebrafish Exposed to Imidacloprid Oxidative Damage and Antioxidant Responses.

Arch Environ Contam Toxicol 2021 Jun 17. Epub 2021 Jun 17.

Laboratory of Aquatic Toxicology, Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Center, Federal University of Santa Maria, 1000 Roraima Avenue, Santa Maria, RS, 97105-900, Brazil.

Imidacloprid (IMI) is an insecticide used worldwide, a neonicotinoid that could cause toxicity in non-target organisms. Zebrafish (Danio rerio) is a model organism widely used in different fields of research such as behavioral studies, biochemical parameters as well as neurotoxicity research. Here, we investigate whether the exposure to three concentrations (0. Read More

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Metabolomic changes in severe acute malnutrition suggest hepatic oxidative stress: a secondary analysis.

Nutr Res 2021 May 21;91:44-56. Epub 2021 May 21.

Department of Nutrition, University of California, Davis, USA; Department of Food Science and Technology, University of California, Davis, USA. Electronic address:

Severe acute malnutrition (SAM), due to poor energy and/or protein intake, is associated with poor growth, depressed immune function, and long-term impacts on metabolic function. As the liver is a major metabolic organ and malnutrition poses metabolic stress, we hypothesize that SAM will be associated with alterations in the hepatic metabolome reflective of oxidative stress, gluconeogenesis, and ketogenesis. Thus, the purpose of this secondary analysis was to understand how SAM alters hepatic metabolism using a piglet model. Read More

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Imidazole antifungal drug clotrimazole alters the behavior, brain acetylcholinesterase and oxidative stress biomarkers in African catfish Clarias gariepinus (Burchell 1822).

Comp Biochem Physiol C Toxicol Pharmacol 2021 Jun 11;248:109108. Epub 2021 Jun 11.

Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Nigeria. Electronic address:

This study was carried out to determine the effect of clotrimazole (CTZ), an imidazole fungicide on behavior, brain acetylcholinesterase, lipid peroxidation and oxidative stress parameters in Clarias gariepinus juveniles. Fish were acutely exposed to five nominal concentrations of CTZ and control to assess the behavioral effects on fish. To determine the effects on brain acetylcholinesterase, lipid peroxidation and oxidative stress parameters, fish were exposed to three sub-lethal concentrations vis 7. Read More

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N-acetylcysteine, xCT and suppression of Maxi-chloride channel activity in human placenta.

Placenta 2021 Jul 5;110:46-55. Epub 2021 Jun 5.

Faculty of Medicine, University of Southampton, UK; Institute for Life Sciences, University of Southampton, UK.

Introduction: Placental oxidative stress features in pregnancy pathologies but in clinical trials antioxidant supplementation has not improved outcomes. N-acetylcysteine (NAC) stimulates glutathione production and is proposed as a therapeutic agent in pregnancy. However, key elements of N-acetylcysteine biology, including its cellular uptake mechanism, remains unclear. Read More

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Comparative transcriptomic and metabolomic analyses reveal the protective effects of silicon against low phosphorus stress in tomato plants.

Plant Physiol Biochem 2021 May 28;166:78-87. Epub 2021 May 28.

College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang 471023, Henan, China. Electronic address:

Phosphorus (P) is an essential nutrient controlling plant growth and development through the regulation of basic metabolic processes. Soil P deficiency is one of the major limiting factors for sustainable crop production worldwide. Previous studies have demonstrated that silicon (Si), as a beneficial element, promotes plant nutrition, growth, development, and responses to low P (LP) stress; however, the molecular mechanisms underlying Si-mediated LP tolerance remain largely unclear. Read More

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Maternal polyphenol intake impairs cerebellar redox homeostasis in newborn rats.

Nutr Neurosci 2021 Jun 2:1-11. Epub 2021 Jun 2.

Programa de Pós-graduação em Ciências Biológicas: Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Introduction: Polyphenols are compounds found in plants that have been extensively studied due to the health benefits of its consumption in adulthood. Meanwhile, recent evidence suggests that polyphenol consumption during pregnancy may not be safe for the fetus.

Objective: The goal of this study was to evaluate the effect of naringenin supplementation during pregnancy on brain redox homeostasis and mitochondrial activity of the newborn rat. Read More

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Turmeric and vitamin C mitigate testicular atrophy induced by lead diacetate via regulation of GRP-78/17β-HSD pathways in rat's model.

Andrologia 2021 May 24:e14120. Epub 2021 May 24.

Department of Pharmacology and Toxicology, Pharmacy College, King Saud University, Riyadh, Saudi Arabia.

Occupational and ecological contacts to lead persist as a universal concern. Lead alters most of the physiological processes via enhancing oxidative stress. Thus, this study was purposed to assess the influence of turmeric (TMRC) and/or vitamin C (VIT-C) on Lead diacetate (Lead diAC)-induced testicular atrophy with an emphasis on oxidative stress, inflammation, BAX/STAR and GRP-78/17β-HSD signalling. Read More

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Green tea polyphenols supplementation alters immunometabolism and oxidative stress in dairy cows with hyperketonemia.

Anim Nutr 2021 Mar 19;7(1):206-215. Epub 2020 Dec 19.

Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana 61801, USA.

Peripartal cows often experience negative energy balance, and are therefore prone to suffering from metabolic diseases such as hyperketonemia, which causes financial losses in dairy farms. This study aimed to investigate the effect of green tea polyphenol (GTP) supplementation during the periparturient period on production performance, oxidative stress and immunometabolism in dairy cows with hyperketonemia. One hundred Holstein cows were assigned to GTP (0. Read More

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-Sitosterol Alters the Inflammatory Response in CLP Rat Model of Sepsis by Modulation of NFB Signaling.

Biomed Res Int 2021 29;2021:5535562. Epub 2021 Apr 29.

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Sepsis originates from the host inflammatory response, especially to bacterial infections, and is considered one of the main causes of death in intensive care units. Various agents have been developed to inhibit mediators of the inflammatory response; one prospective agent is -sitosterol (S), a phytosterol with a structure similar to cholesterol. This study is aimed at evaluating the effects of S on the biomarkers of inflammation and liver function in cecal ligation and puncture- (CLP-) induced septic rats. Read More

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Repeated endosulfan exposure induces changes in neurochemicals, decreases ATPase transmembrane ionic-pumps, and increased oxidative/nitrosative stress in the brains of rats: Reversal by quercetin.

Pestic Biochem Physiol 2021 Jun 26;175:104833. Epub 2021 Mar 26.

Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.

Neurochemical and ATPase deregulations play important role in toxicant-induced neurodegeneration. Previous studies have shown that loss of ATPase ionic-pumps alters neurochemical balance via increased ammonia, oxidative and nitrosative stress. Thus, this study investigated the ameliorative potentials of quercetin on neurochemical, ATPase changes, hyperammonemia and oxidative/nitrosative status in the brains of Wistar rats exposed to endosulfan, a known toxic environmental pesticide that is casually used in many developing countries. Read More

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Long-term exposure to environmentally relevant concentrations of ibuprofen and aluminum alters oxidative stress status on Danio rerio.

Comp Biochem Physiol C Toxicol Pharmacol 2021 May 14;248:109071. Epub 2021 May 14.

Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA, CSIC), Jordi Girona 18, 08017 Barcelona, Spain.

Despite the ubiquitous presence of multiple pollutants in aqueous environments have been extensively demonstrated, the ecological impact of chemical cocktails has not been studied in depth. In recent years, environmental studies have mainly focused on the risk assessment of individual chemical substances neglecting the effects of complex mixtures even though it has been demonstrated that combined effects exerted by pollutants might represent a greater hazard to the biocenosis. The current study evaluates the effects on the oxidative stress status induced by individual forms and binary mixtures of ibuprofen (IBU) and aluminum (Al) on brain, gills, liver and gut tissues of Danio rerio after long-term exposure to environmentally relevant concentrations (0. Read More

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Overexpression of SlGSNOR impairs in vitro shoot proliferation and developmental architecture in tomato but confers enhanced disease resistance.

J Plant Physiol 2021 Jun 30;261:153433. Epub 2021 Apr 30.

Department of Plant Breeding and Genetics, Faculty of Crop and Food Sciences, PMAS Arid Agriculture University Rawalpindi, Rawalpindi, 46300, Pakistan. Electronic address:

The pervasive presence of nitric oxide (NO) in cells and its role in modifying cystein residues through protein S-nitrosylation is a remarkable redox based signalling mechanism regulating a variety of cellular processes. S-NITROSOGLUTATHIONE REDUCTASE (GSNOR) governs NO bioavailability by the breakdown of S-nitrosoglutathione (GSNO), fine-tunes NO signalling and controls total cellular S-nitrosylated proteins. Most of the published data on GSNOR functional analysis is based on the model plant Arabidopsis with no previous report for its effect on in vitro regeneration of tissue cultured plants. Read More

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Fucoxanthin alters the apelin-13/APJ pathway in certain organs of γ-irradiated mice.

J Radiat Res 2021 Apr 29. Epub 2021 Apr 29.

Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt.

Apelin-13 and APJ are implicated in different key physiological processes. This work aims at exploring the radioprotective effect of fucoxanthin (FX) on γ-radiation (RAD)-induced changes in the apelin-13/APJ pathway, which causes damage in the liver, kidney, lung and spleen of mice. Mice were administered FX (10 mg kg-1 day-1, i. Read More

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Dietary Annatto-Extracted Tocotrienol Reduces Inflammation and Oxidative Stress, and Improves Macronutrient Metabolism in Obese Mice: A Metabolic Profiling Study.

Nutrients 2021 Apr 13;13(4). Epub 2021 Apr 13.

Department of Nutrition, University of California at Davis, Davis, CA 95616, USA.

Obesity and its related complications are a world-wide health problem. Dietary tocotrienols (TT) have been shown to improve obesity-associated metabolic disorders, such as hypercholesterolemia, hyperglycemia, and gut dysbiosis. This study examined the hypothesis that the antioxidant capacity of TT alters metabolites of oxidative stress and improves systemic metabolism. Read More

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Relationship between Oxidative Stress and Imatinib Resistance in Model Chronic Myeloid Leukemia Cells.

Biomolecules 2021 Apr 20;11(4). Epub 2021 Apr 20.

Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143 Street, 90-236 Lodz, Poland.

Chronic myeloid leukemia (CML) develops due to the presence of the BCR-ABL1 protein, a target of tyrosine kinase inhibitors (TKIs), such as imatinib (IM), used in a CML therapy. CML eradication is a challenge due to developing resistance to TKIs. BCR-ABL1 induces endogenous oxidative stress leading to genomic instability and development of TKI resistance. Read More

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Moxidectin toxicity to zebrafish embryos: Bioaccumulation and biomarker responses.

Environ Pollut 2021 Aug 8;283:117096. Epub 2021 Apr 8.

Laboratory for Risk Assessment of Novel Technologies (LabRisk), Department of Molecular Biology, Federal University of Paraiba, João Pessoa, Brazil. Electronic address:

Moxidectin is an antiparasitic drug belonging to the class of the macrocyclic lactones, subgroup mylbemicins. It is used worldwide in veterinary practice, but little is known about its potential environmental risks. Thus, we used the zebrafish embryo as a model system to study the potential effects of moxidectin on aquatic non-target organisms. Read More

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Sublethal diclofenac induced oxidative stress, neurotoxicity, molecular responses and alters energy metabolism proteins in Nile tilapia, Oreochromis niloticus.

Environ Sci Pollut Res Int 2021 Apr 14. Epub 2021 Apr 14.

College of Fisheries, Central Agriculture University, Agartala, Tripura, India.

Reports have shown that residues of pharmaceuticals and their metabolites can pose toxicological threats to organisms living in aquatic ecosystem. Nile tilapia, Oreochromis niloticus, was exposed at 0.17, 0. Read More

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Phenolic, Antioxidant, Antimicrobial, and Wound Healing Properties of L. Root Extract in Diabetic Rats.

Iran J Pharm Res 2020 ;19(4):264-274

Department of Biology, Faculty of Science, Gazi University, 06500, Ankara, Turkey.

As stated in many ethnobotany studies, genus is traditionally used in the treatment of wound healing. In this study, we aimed to investigate to time-course effects of the methanolic extract of (MEPE) on diabetic wounds. The subject of the experiments was 36 Wistar rats, divided into three main groups: non-diabetic control (NDM), diabetic control (STZ-DM), and -treated (MEPE). Read More

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January 2020

Oxidative Stress Mediates the Fetal Programming of Hypertension by Glucocorticoids.

Antioxidants (Basel) 2021 Mar 29;10(4). Epub 2021 Mar 29.

Biomolecular Sciences, Laurentian University, Sudbury, ON P3E 2C6, Canada.

The field of cardiovascular fetal programming has emphasized the importance of the uterine environment on postnatal cardiovascular health. Studies have linked increased fetal glucocorticoid exposure, either from exogenous sources (such as dexamethasone (Dex) injections), or from maternal stress, to the development of adult cardiovascular pathologies. Although the mechanisms are not fully understood, alterations in gene expression driven by altered oxidative stress and epigenetic pathways are implicated in glucocorticoid-mediated cardiovascular programming. Read More

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Complexed trace mineral supplementation alters antioxidant activities and expression in response to trailer stress in yearling horses in training.

Sci Rep 2021 Apr 1;11(1):7352. Epub 2021 Apr 1.

Texas A&M Department of Animal Science, Texas A&M AgriLife Research, College Station, TX, 77843, USA.

To test the hypothesis that complexed trace mineral supplementation would increase antioxidant capacity and decrease muscle oxidative stress and damage in young horses entering an exercise training program, Quarter Horses (mean [Formula: see text] SD; 9.7 ± 0.7 mo) balanced by age, sex, and BW were assigned to receive complexed (CTM; n = 8) or inorganic (INORG; n = 8) trace minerals at -12 week relative to this study. Read More

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Do peripheral immune and neurotrophic markers correlate with motor severity of Parkinson's disease?

J Neuroimmunol 2021 05 9;354:577545. Epub 2021 Mar 9.

Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India. Electronic address:

Background: Inflammation along with oxidative stress alters neuroplasticity which might contribute to neurodegeneration in Parkinson's disease (PD).

Objectives: We aimed to explore the correlation of inflammatory-oxidative and neurotrophic changes in PD and their association with clinical staging and motor severity.

Methods: Serum oxidative markers, pro and anti-inflammatory cytokines and BDNF levels were estimated by spectrophotometric and ELISA techniques. Read More

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Bacterial processing of glucose modulates C. elegans lifespan and healthspan.

Sci Rep 2021 Mar 15;11(1):5931. Epub 2021 Mar 15.

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, 01605, USA.

Intestinal microbiota play an essential role in the health of a host organism. Here, we define how commensal Escherichia coli (E. coli) alters its host after long term exposure to glucose using a Caenorhabditis elegans-E. Read More

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Compound C, a Broad Kinase Inhibitor Alters Metabolic Fingerprinting of Extra Cellular Matrix Detached Cancer Cells.

Front Oncol 2021 25;11:612778. Epub 2021 Feb 25.

Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Most of the cancer related deaths are caused mainly by metastasis. Therefore, it is highly important to unfold the major mechanisms governing metastasis process in cancer. Throughout the metastatic cascade, cells need the ability to survive without attachment to neighboring cells and the original Extra Cellular Matrix (ECM). Read More

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February 2021

Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease.

Mol Neurodegener 2021 03 8;16(1):15. Epub 2021 Mar 8.

Department of Cell Death and Proliferation, Institut d'Investigacions Biomèdiques de Barcelona (IIBB), Consejo Superior de Investigaciones Científicas (CSIC), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), C/ Rosselló 161, 6th Floor, 08036, Barcelona, Spain.

Background: Emerging evidence indicates that impaired mitophagy-mediated clearance of defective mitochondria is a critical event in Alzheimer's disease (AD) pathogenesis. Amyloid-beta (Aβ) metabolism and the microtubule-associated protein tau have been reported to regulate key components of the mitophagy machinery. However, the mechanisms that lead to mitophagy dysfunction in AD are not fully deciphered. Read More

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Chronic Exposure to 4-Nonylphenol Alters UDP-Glycosyltransferase and Sulfotransferase Clearance of Steroids in the Hard Coral, .

Front Physiol 2021 17;12:608056. Epub 2021 Feb 17.

Kewalo Marine Laboratory, University of Hawaii at Manoa, Honolulu, HI, United States.

The effects of the xenoestrogen 4-nonylphenol (4NP) on endocrine and metabolic homeostasis in the reef building coral, were investigated. The aim was to understand if ubiquitous nonylphenol ethoxylate contaminants in the marine environment result in altered homeostatic function. Coral colonies were chronically exposed (6 weeks) to a sublethal concentration (1 ppb) of 4NP and sampled over the coral's lunar reproductive cycle. Read More

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February 2021

Characterization of the differential expressed genes and transcriptomic pathway analysis in the liver of sub-adult red drum (Sciaenops ocellatus) exposed to Deepwater Horizon chemically dispersed oil.

Ecotoxicol Environ Saf 2021 May 2;214:112098. Epub 2021 Mar 2.

Mote Marine Laboratory, 1600 Ken Thompson Pkwy, Sarasota, FL 34236, USA.

The Deepwater Horizon blowout resulted in the second-largest quantity of chemical dispersants used as a countermeasure for an open water oil spill in the Gulf of Mexico. Of which, the efficacy of dispersant as a mitigation strategy and its toxic effects on aquatic fauna remains controversial. To enhance our understanding of potential sub-lethal effects of exposure to chemically dispersed-oil, sub-adult red drum (Sciaenops ocellatus) were continuously exposed to a Corexit 9500: DWH crude oil chemically enhanced water accommodated fraction (CEWAF) for 3-days and transcriptomic responses were assessed in the liver. Read More

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Physiological and Biochemical Dissection Reveals a Trade-off Between Antioxidant Capacity and Heat Tolerance in Bread Wheat ( L.).

Antioxidants (Basel) 2021 Feb 26;10(3). Epub 2021 Feb 26.

Institute of Biotechnology and Genetic Engineering (IBGE), Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur-1706, Bangladesh.

Heat stress alters photosynthetic components and the antioxidant scavenging system, negatively affecting plant growth and development. Plants overcome heat stress damage through an integrated network involving enzymatic and non-enzymatic antioxidants. This study aimed to assess physiological and biochemical responses in contrasting thermo-tolerant wheat varieties exposed to 25 °C (control) and 35 °C (heat stress), during the seedling stage. Read More

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February 2021

The DUG Pathway Governs Degradation of Intracellular Glutathione in Aspergillus nidulans.

Appl Environ Microbiol 2021 04 13;87(9). Epub 2021 Apr 13.

Department of Molecular Biotechnology and Microbiology, Faculty of Sciences and Technology, University of Debrecen, Debrecen, Hungary

Glutathione (GSH) is an abundant tripeptide that plays a crucial role in shielding cellular macromolecules from various reactive oxygen and nitrogen species in fungi. Understanding GSH metabolism is of vital importance for deciphering redox regulation in these microorganisms. In the present study, to better understand the GSH metabolism in filamentous fungi, we investigated functions of the and genes in the model fungus These genes are orthologues of and , which are involved in cytosolic GSH degradation in The deletion of , , or both resulted in a moderate increase in the GSH content in mycelia grown on glucose, reduced conidium production, and disturbed sexual development. Read More

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Hypobaria-Induced Oxidative Stress Facilitates Homocysteine Transsulfuration and Promotes Glutathione Oxidation in Rats with Mild Traumatic Brain Injury.

J Cent Nerv Syst Dis 2021 31;13:1179573520988193. Epub 2021 Jan 31.

Department of Anesthesiology and the Center for Shock, Trauma and Anesthesiology Research (STAR), University of Maryland School of Medicine, Baltimore, USA.

Background: United States service members injured in combat theatre are often aeromedically evacuated within a few days to regional military hospitals. Animal and epidemiological research indicates that early exposure to flight hypobaria may worsen brain and other injuries. The mechanisms by which secondary exposure to hypobaria worsen trauma outcomes are not well elucidated. Read More

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January 2021