Epidemiology 2021 Apr 12. Epub 2021 Apr 12.
Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA Department of Surgery, Division of Public Health Sciences, Washington University School of Medicine, St. Louis, MO, USA NoviSci, Durham, NC, USA Department of Population Health Sciences, Duke University, Durham, NC, USA.
Background: Important questions exist regarding the comparative effectiveness of alternative childhood vaccine schedules; however, optimal approaches to studying this complex issue are unclear.
Methods: We applied methods for studying dynamic treatment regimens to estimate the comparative effectiveness of different rotavirus vaccine (RV) schedules for preventing acute gastroenteritis-related emergency department visits or hospitalization. We studied the effectiveness of six separate protocols: one- and two-dose monovalent rotavirus vaccine (RV1); one-, two-, and three-dose pentavalent rotavirus vaccine (RV5); and no RV vaccine. Read More