Transl Res 2021 Apr 26. Epub 2021 Apr 26.
Department of Anesthesiology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157, USA; Department of Internal Medicine-Molecular Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157, USA. Electronic address:
GPER activation by G1 attenuates diastolic dysfunction from estrogen loss, which may be partly due to suppression of angiotensin II pathological actions. We aimed to determine the independent effects of 8 weeks of G1 (100 µg/kg/day, subcutaneous pellet), ACE-inhibition (ACEi; lisinopril 10 mg/kg, drinking water), or combination therapy versus vehicle in the ovariectomized (OVX) spontaneously hypertensive rat (SHR) on cardiac function and morphometrics (echocardiography), serum equilibrium of angiotensins (mass spectroscopy) and cardiac components of the RAS (Western blotting). G1 alone and when combined with ACEi enhanced myocardial relaxation (e´: 30 and 17%) and diastolic wall strain (DWS: 76 and 68%) while reducing relative wall thickness (RWT: 20 and 33%) and filling pressures (E/e´: 30 and 37%). Read More