32,566 results match your criteria allergic rhinitis

Prevalence and associated factors of respiratory allergies in the Kingdom of Saudi Arabia: A cross-sectional investigation, September-December 2020.

PLoS One 2021 23;16(6):e0253558. Epub 2021 Jun 23.

Department of Public Health, College of Public Health and Health Informatics, Qassim University, Al Bukairiyah, Saudi Arabia.

Background: Prevalence of different respiratory allergies is increasing in the Kingdom of Saudi Arabia (KSA). Environmental risk factors of respiratory allergy vary regionally, hence the prevalence. This necessitates the needs for regional studies. Read More

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Fermented Red Ginseng Alleviates Ovalbumin-Induced Inflammation in Mice by Suppressing Interleukin-4 and Immunoglobulin E Expression.

J Med Food 2021 Jun;24(6):569-576

R&BD Center, Korea Yakult Co., Ltd., Yongin, Korea.

Ginseng (the root of Meyer) has been reported to have many biologic therapeutic effects, including anti-inflammatory properties, and ginsenosides are considered as one of the factors responsible for these therapeutic effects. To improve their therapeutic action, probiotic bacteria are used to ferment and chemically transform ginsenosides in red ginseng (RG). In this study, we aimed to investigate the beneficial effects of RG fermented by probiotic bacteria (FRG) against ovalbumin (OVA)-induced allergic rhinitis in a mouse model. Read More

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Role of innate immunity and myeloid cells in susceptibility to allergic disease.

Ann N Y Acad Sci 2021 Jun 22. Epub 2021 Jun 22.

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

Allergic diseases, including asthma, food allergy, eczema, and allergic rhinitis, are common diseases increasing in prevalence. Allergy, a failure of immune tolerance to innocuous environmental allergens, is characterized by allergen-specific immune responses, including IgE antibodies and T helper and T follicular helper cells producing type 2 cytokines. Despite the central role of adaptive immunity in pathophysiology of allergy, there is a growing body of evidence indicating an important role for the innate immune system in allergic disease. Read More

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The Effectiveness of the Bacteria Derived Extremolyte Ectoine for the Treatment of Allergic Rhinitis.

Biomed Res Int 2021 1;2021:5562623. Epub 2021 Jun 1.

CRI Ltd, Genter Str. 7, 50672 Cologne, Germany.

Nonpharmacological therapies with a good tolerability and safety profile are of interest to many patients with allergic rhinitis, as a relevant proportion of them have reservations about guideline-concordant pharmacological therapies due to their local irritations and side effects. Ectoine is a bacterial-derived extremolyte with an ability to protect proteins and biological membranes against damage caused by extreme conditions of salinity, drought, irradiation, pH, and temperature. Evidence from preclinical and clinical studies attests its effectiveness in the treatment of several inflammatory diseases, including allergic rhinitis. Read More

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Wiad Lek 2021 ;74(4):902-905


Objective: The aim: the analysis of spectrum of causatively relevant aeroallergens of southern Ukraine which provoke allergic reaction in patients with pollinosis.

Patients And Methods: Materials and methods: ambulatory medical records data and skin prick-testing results of 477 patients afflicted with pollinosis in Kherson (250 women - 52,41 % and 227 men - 47,59 %) aged from 19 to 66 years old (38,05±0,45) have been analyzed retrospectively.

Results: Results: all patients revealed clinical implications mainly during the September-October period. Read More

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Exposure to ambient air pollution during trimesters of pregnancy and childhood allergic diseases in Wuhan, China.

Int J Environ Health Res 2021 Jun 22:1-11. Epub 2021 Jun 22.

Department of Medicine, City College, Wuhan University of Science and Technology, Wuhan, China.

The study explored the associations between maternal exposure to air pollution during different trimesters and allergic diseases including asthma, allergic rhinitis, allergic conjunctivitis or/and eczema. Individual exposure to air pollutants was assessed by an inverse distance weighted (IDW) method using daily concentrations of SO, NO, PM, and PM from air quality monitoring stations. Multiple logistic regression model was performed to estimate the associations between air pollution during each trimester of pregnancy and childhood allergic diseases. Read More

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Identification of OCA2 as a novel locus for the co-morbidity of asthma-plus-eczema.

Clin Exp Allergy 2021 Jun 22. Epub 2021 Jun 22.

Université de Paris, UMRS 1124, INSERM, Paris, France.

Background: Numerous genes have been associated with the three most common allergic diseases (asthma, allergic rhinitis or eczema) but these genes explain only a part of the heritability. In the vast majority of genetic studies, complex phenotypes such as co-morbidity of two of these diseases, have not been considered. This may partly explain missing heritability. Read More

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A systematic review of the clinical evidence and biomarkers linking allergy to adeno-tonsillar disease.

Int J Pediatr Otorhinolaryngol 2021 Jun 12;147:110799. Epub 2021 Jun 12.

Department of Neuroscience, Reproductive and Odontostomatological Sciences - ENT Section, University "Federico II", Naples, Italy.

Introduction: allergy may be an important risk factor for adenotonsillar disease in children, although conflicting results have been reported in the literature. In previous articles, authors often failed in distinguishing between adeno-tonsillar hypertrophy and recurrent tonsillitis and in not discriminating between isolated or combined adenoid and tonsillar hypertrophy.

Aim: to evaluate clinical evidence and biomarkers linking allergy to different phenotypes of adeno-tonsillar disease. Read More

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Expression Pattern of HMGB1 Differs Between Eosinophilic Chronic Rhinosinusitis With Nasal Polyp and Non-Eosinophilic Chronic Rhinosinusitis With Nasal Polyp: A Preliminary Study.

Am J Rhinol Allergy 2021 Jul 8;35(4):474-481. Epub 2020 Oct 8.

Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.

Background: Eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) is histologically distinct from non-eosinophilic CRSwNP (NECRSwNP) and exhibits a high frequency of recurrence. The differences between the pathogenesis of ECRSwNP and NECRSwNP are not well-characterized. HMGB1 has been implicated in the pathogenesis of CRSwNPs; however, its precise contributions to ECRSwNP and NECRSwNP have not been established. Read More

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Efficacy of Vitamin D Supplementation in Allergic Rhinitis.

Indian J Otolaryngol Head Neck Surg 2021 Jun 24;73(2):152-159. Epub 2020 Jun 24.

Sri Guru Ram Das University of Health Sciences, Amritsar, India.

Allergic Rhinitis is one of the most commonly recognised rhinitis globally. Though its not a life threatening entity but it is associated with severe impairment of quality of life along with substantial financial burden on patient. There has been a substantial rise in number of patients of allergic rhinitis over years and researchers worldwide have also found low levels of vitamin D in patients of allergic rhinitis. Read More

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Bronchopleural fistula in a 5- years old child with novel CARMIL 2 mutation: A rare disease and a rare case.

Ann Med Surg (Lond) 2021 Jun 6;66:102443. Epub 2021 Jun 6.

Department of Pediatric Thoracic Surgery and Intensive Care Medicine, Infectious Disease, and Immunology, Maternity and Children Hospital, Dammam, Saudi Arabia.

A five year girl had eczema and allergic rhinitis in the past, presented with a history of cough, shortness of breath for the last one month. Her chest -X-ray showed a left side pleural effusion, and a computed tomographic scan (CT) of the chest showed left side hydropneumothorax. Left side 21 Fr drain was inserted. Read More

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Effects of Yu-ping-feng granules combined with loratadine tablets on treatment efficacy and immune factor levels in allergic rhinitis patients.

Jinlan Song

Am J Transl Res 2021 15;13(5):5192-5199. Epub 2021 May 15.

Department of Otolaryngology, Tianjin Nankai Hospital Tianjin 300100, China.

Objective: This study was designed to explore the treatment efficacy of Yu-ping-feng combined with loratadine in allergic rhinitis patients.

Methods: A total of 88 patients with allergic rhinitis who were admitted to our hospital from July 2017 to September 2018 were collected as research subjects, 43 of whom were enrolled in group A and treated with loratadine, and another 45 cases were enrolled in group B and treated with Yu-ping-feng combined with loratadine. The immune factors and ventilation function of the two groups were observed, as well as the treatment efficacy, adverse reactions and quality of life of the two groups of patients. Read More

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Local Respiratory Allergy: From Rhinitis Phenotype to Disease Spectrum.

Front Immunol 2021 2;12:691964. Epub 2021 Jun 2.

Allergy Unit, Hospital Regional Universitario de Malaga, Malaga, Spain.

Local respiratory allergy (LRA) is defined by the negativity of atopy tests, a clinical history suggestive of airway allergy and a positive response to the nasal and/or bronchial allergen challenge. The clinical spectrum of LRA is comprised of three conditions: local allergic rhinitis (LAR) and local allergic asthma in non-atopic patients, and dual allergic rhinitis (coexistence of allergic rhinitis and LAR) in atopic individuals. LRA is an independent disease phenotype not progressing to atopy over time, but naturally evolving to the clinical worsening and the onset of comorbidities. Read More

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Heterogeneity in allergic rhinitis: explained by inducible mechanistic traits?

J Allergy Clin Immunol 2021 Jun 17. Epub 2021 Jun 17.

Dept of Parasitology, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, The Netherlands.

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Taurine promotes the production of CD4CD25FOXP3 Treg cells through regulating IL-35/STAT1 pathway in a mouse allergic rhinitis model.

Allergy Asthma Clin Immunol 2021 Jun 19;17(1):59. Epub 2021 Jun 19.

Department of Otorhinolaryngology, Head and Neck Surgery, Dahua Hospital, Laohumin Road No. 901, Shanghai, 200237, China.

Background: Allergic rhinitis (AR) is one of the most widespread immune conditions worldwide. However, common treatments often present with significant side effects or are cost-prohibitive for much of the population. A plethora of treatments have been used for the treatment of AR including antihistamines, steroids, and immune modulators. Read More

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Outcome of Immunoglobulin Replacement Therapy in Adults With Rhinosinusitis.

Laryngoscope 2021 Jun 19. Epub 2021 Jun 19.

Department of Otolaryngology, West Virginia University, Morgantown, West Virginia, U.S.A.

Objective: To evaluate the outcome of immunoglobulin (IG) replacement therapy in adults with rhinosinusitis and primary humoral immunodeficiency disorders (PID).

Study Design: Retrospective cohort study.

Methods: Retrospective chart review of adult (18 years and older) patients who were diagnosed with PID and had the diagnosis of recurrent acute rhinosinusitis (RARS) and chronic rhinosinusitis (CRS) and who are on IG replacement therapy. Read More

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Epicutaneous Allergen Administration with Microneedles as a Novel Method of Immunotherapy for House Dust Mite (HDM) Allergic Rhinitis.

Pharm Res 2021 Jun 18. Epub 2021 Jun 18.

Department of BioNano Technology, Gachon BioNano Research Institute, Gachon University, Seongnam, Republic of Korea.

Purpose: Epicutaneous immunotherapy (EPIT) is being studied as a method for treating allergic rhinitis because of skin immunology, user convenience and enhanced patient compliance. However, the use of EPIT is limited because of the very low skin permeability of the allergen. In this study, the limitations of EPIT were overcome by using sophisticated delivery with microneedles. Read More

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Homoeopathic Management of Allergic Rhinitis: Two Case Reports.

Altern Ther Health Med 2021 Jun 18. Epub 2021 Jun 18.

Allergic rhinitis is a commonly encountered condition affecting approximately 20% of the population, and exhibits symptoms either as seasonal or perennial allergic rhinitis. This study was undertaken to assess the efficacy of homoeopathic remedies in the treatment of allergic rhinitis, while also proving that totality of symptoms is important for successful treatment of the cases. The suspected cases of allergy were identified on the basis of clinical presentation. Read More

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Comparison of Isotonic Seawater Nasal Spray Containing Chamomile Liquid Extract and Other Isotonic Seawater Nasal Washing Solutions for Allergic Rhinitis.

Ann Otol Rhinol Laryngol 2021 Jun 18:34894211025411. Epub 2021 Jun 18.

Department of Otorhinolaryngology, University of Health Sciences, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey.

Objective: We aim to demonstrate the effect of an isotonic seawater spray containing chamomile liquid extract on symptoms and nasal mucociliary clearance in patients with allergic rhinitis by comparing it with other isotonic seawater nasal washing solutions.

Methods: The study included 123 patients. Based on Allergic Rhinitis and its Impact on Asthma guidelines, mometasone furoate intranasal spray treatment was started for all patients in the group diagnosed with allergic rhinitis. Read More

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Rupatadine Oral Solution Titration by Body Weight in Paediatric Patients Suffering from Allergic Rhinitis: A Population Pharmacokinetic Study.

Clin Pharmacol 2021 8;13:115-122. Epub 2021 Jun 8.

Departament de Farmacologia, de Terapèutica i de Toxicologia, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: Allergic rhinitis (AR) and chronic urticaria, both are treated in children with doses of second generation of antihistamines that have been mostly based on extrapolation of data obtained in adults. The objectives of this work were to develop a model to explain the pharmacokinetics (PK) of rupatadine, a second generation antihistamine, administered to children 2-11 years old and to calculate the non-compartmental PK parameters for two groups of age (2-5 and 6-11 years old) based on the individual Bayesian estimates from the selected model.

Methods: Data from two PK studies with rupatadine oral solution (1 mg/mL) were pooled: Study A, an extensive blood sampling study performed in 11 children (6-11 years old) who received a single oral dose of rupatadine; and Study B, a sparse blood sampling study in 40 children (2-5 years old) receiving multiple oral doses. Read More

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Arerugi 2021 ;70(4):315-320

Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University.

At the time of writing of this manuscript, four biologics were clinically available for treatment against severe asthma. The choice of four biologics has been taking into account of the results of several type 2 inflammationrelated biomarkers, and the comorbidities of asthma, such as eosinophilic chronic rhinosinusitis, allergic rhinitis, and atopic dermatitis.In this study, we have experienced a case of severe asthma complicated by eosinophilic chronic rhinosinusitis and eosinophilic otitis media, resulting in the use of four biologics, and we observed differential response of upper and lower airways. Read More

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Dupilumab elicits a favorable response in type-2 inflammatory comorbidities of severe atopic dermatitis.

Clin Mol Allergy 2021 Jun 16;19(1). Epub 2021 Jun 16.

Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, University of Bari Aldo Moro, Policlinico Di Bari, Bari, Italy.

Background: This case is the first report describing rapid, successful treatment of severe atopic dermatitis (AD) and comorbid type-2 inflammatory diseases in the same patient, with dupilumab treatment, with no side-effects.

Case Presentation: We report on effects of dupilumab in a patient with severe AD, a long-standing history of a mild, perennial allergic rhino-conjunctivitis, moderate asthma and chronic rhinosinusitis with nasal polyps (CRSwNP).

Conclusions: Patients suffering from AD, asthma, allergic rhinitis and CRSwNP may be eligible for dupilumab single treatment that is possibly advantageous also from the pharmaco-economic standpoint. Read More

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Pidotimod as add-on therapy in patients with pollen-induced allergic rhinitis and asthma and associated respiratory infections.

J Biol Regul Homeost Agents 2021 Jun 17;35(3). Epub 2021 Jun 17.

Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.

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Airborne Pollens and Their Association with Meteorological Parameters in the Atmosphere of Shiraz, Southwest Iran.

Iran J Allergy Asthma Immunol 2021 Jun 6;20(3):294-302. Epub 2021 Jun 6.

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.

Airborne pollen is considered one of the causative agents of hay fever, allergic rhinitis, conjunctivitis, and asthma. We aimed to investigate airborne pollens in the context of Shiraz located in the southwest of Iran and find their association with meteorological parameters.  The survey was conducted from October 2017 to September 2018, using seven days of volumetric Burkard spore trap, located in the center of the city. Read More

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Prevalence of Allergic Rhinitis and Eczema in Adolescents Living in Yazd City: Part of Global Asthma Network Survey.

Iran J Allergy Asthma Immunol 2021 Jun 6;20(3):271-278. Epub 2021 Jun 6.

Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Allergic rhinitis and eczema are two common global diseases that can lead to impaired quality of life. Determining the prevalence of these allergic disorders can be useful in planning prevention and treatment. This study aimed to investigate the prevalence and severity of allergic rhinitis and eczema in adolescents living in Yazd city. Read More

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The Prevalence of Allergic Rhinitis in Southwestern Iran and Its Association with Chronic Rhinosinusitis: A GA2LEN Study.

Iran J Allergy Asthma Immunol 2021 Jun 6;20(3):263-270. Epub 2021 Jun 6.

Department of Immunology and Allergy, The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.

Allergic rhinitis (AR) is a prevalent disease affecting the quality of life of patients throughout the world. This study aimed to assess the prevalence of AR and its association with chronic rhinosinusitis (CRS) in the adult population living in Bushehr, southwestern part of Iran. In this population-based study, a total of 5420  individuals aged 15-65 years were selected through a multi-stage, cluster, random sampling method from which 5201 of them completed the Global Allergy and Asthma Network of Excellence (GA2LEN) questionnaire (Response rate=96. Read More

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Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem.

Cell 2021 Jun 10. Epub 2021 Jun 10.

Department of Anesthesiology, Center for the Study of Itch and Sensory Disorders, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110, USA; Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

Sneezing is a vital respiratory reflex frequently associated with allergic rhinitis and viral respiratory infections. However, its neural circuit remains largely unknown. A sneeze-evoking region was discovered in both cat and human brainstems, corresponding anatomically to the central recipient zone of nasal sensory neurons. Read More

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Livin in synergy with Ras induces and sustains corticosteroid resistance in the airway mucosa.

Int J Biol Sci 2021 13;17(8):2089-2098. Epub 2021 May 13.

Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Shenzhen, China.

: Corticosteroid resistance (CR) seriously affects the therapeutic effects of steroids on many chronic inflammatory disorders, including airway allergy. The mechanism of CR development is unclear. Recent research indicates that livin, an apoptosis inhibitor, is associated with the regulation in cell activities. Read More

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Differential Clinical Diagnosis and Prevalence Rate of Allergic Rhinitis, Asthma, and Chronic Obstructive Pulmonary Disease among COVID-19 Patients.

Int J Clin Pract 2021 Jun 15:e14532. Epub 2021 Jun 15.

Clinical Pharmacy Department, Faculty of Pharmacy, Beni-suef University, Beni-suef, Egypt.

Background: There is a great need to make a rapid differential clinical diagnosis of COVID-19 among respiratory disease patients and determining the prevalence rate of these diseases among the COVID-19 population.

Method: Approximately 522 patients with allergic rhinitis, asthma, COPD, and COVID-19 were analyzed for demographic and clinical features. Radiological features were analyzed only for COVID-19 patients. Read More

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