J Allergy Clin Immunol 2021 Sep 21. Epub 2021 Sep 21.
Department of Cellular and Molecular Medicine, The University of Arizona, Tucson, AZ, 85721, USA; Asthma and Airway Disease Research Center, The University of Arizona, Tucson, AZ, 85721, USA; The BIO5 Institute, The University of Arizona, Tucson, AZ, 85721, USA; Arizona Center for the Biology of Complex Diseases, The University of Arizona.
Background: Microbial interventions against allergic asthma have robust epidemiologic underpinnings and the potential to recalibrate disease-inducing immune responses. Oral administration of OM-85, a standardized lysate of human airways bacteria, is widely used empirically to prevent respiratory infections and a clinical trial is testing its ability to prevent asthma in high-risk children. We previously showed that intra-nasal administration of microbial products from farm environments abrogates experimental allergic asthma. Read More