21,553 results match your criteria allergic inflammation

Antagonism of Protease Activated Receptor-2 by GB88 Reduces Inflammation Triggered by Protease Allergen Tyr-p3.

Front Immunol 2021 8;12:557433. Epub 2021 Sep 8.

Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, Taiwan.

The occurrence of allergic diseases induced by aeroallergens has increased in the past decades. Among inhalant allergens, mites remain the important causal agent of allergic diseases. Storage mites- are found in stored products or domestic environments. Read More

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September 2021

Perceptions of adolescents and young adults with allergy and/or asthma and their parents on EAACI guideline recommendations about transitional care: A European survey.

Allergy 2021 Sep 26. Epub 2021 Sep 26.

Faculty of Medicine, University of Southampton, Southampton, UK.

Background: The European Academy of Allergy and Clinical Immunology has developed a guideline to provide evidence-based recommendations for healthcare professionals to support the transitional care of adolescents and young adults (AYA) with allergy and/or asthma. The goal of this work was to ensure that the draft recommendations are also important for patients.

Methods: We surveyed patients aged 11-25 years with allergy and/or asthma and their parents across Europe between 17th February and 16th March 2020. Read More

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September 2021

Metabolomics Reveals Process of Allergic Rhinitis Patients with Single- and Double-Species Mite Subcutaneous Immunotherapy.

Metabolites 2021 Sep 9;11(9). Epub 2021 Sep 9.

Department of Allergy and Clinical Immunology, National Center for Respiratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institue of Respiratory Health, Guangzhou 510120, China.

Allergen immunotherapy (AIT) is the only treatment that can change the course of allergic diseases. However, there has not been any research on metabolic reactions in relation to AIT with single or mixed allergens. In this study, patients with allergic rhinitis caused by () and () were treated with single-mite () and double-mite (: = 1:1) subcutaneous immunotherapy (SCIT), respectively. Read More

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September 2021

Airway administration of OM-85, a bacterial lysate, blocks experimental asthma by targeting dendritic cells and the epithelium/IL-33/ILC2 axis.

J Allergy Clin Immunol 2021 Sep 21. Epub 2021 Sep 21.

Department of Cellular and Molecular Medicine, The University of Arizona, Tucson, AZ, 85721, USA; Asthma and Airway Disease Research Center, The University of Arizona, Tucson, AZ, 85721, USA; The BIO5 Institute, The University of Arizona, Tucson, AZ, 85721, USA; Arizona Center for the Biology of Complex Diseases, The University of Arizona.

Background: Microbial interventions against allergic asthma have robust epidemiologic underpinnings and the potential to recalibrate disease-inducing immune responses. Oral administration of OM-85, a standardized lysate of human airways bacteria, is widely used empirically to prevent respiratory infections and a clinical trial is testing its ability to prevent asthma in high-risk children. We previously showed that intra-nasal administration of microbial products from farm environments abrogates experimental allergic asthma. Read More

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September 2021

T-cell subsets in the skin and their role in inflammatory skin disorders.

Allergy 2021 Sep 24. Epub 2021 Sep 24.

Vrije Universiteit Brussel (VUB), Skin Immunology & Immune Tolerance (SKIN) Research Group, Laarbeeklaan 103, 1090, Brussels, Belgium.

T lymphocytes (T-cells) are major players of the adaptive immune response. Naive T-cells are primed in the presence of cytokines, leading to polarization into distinct T-cell subsets with specific functions. These subsets are classified based on their T-cell receptor profile, expression of transcription factors, surface cytokine and chemokine receptors, and their cytokine production, which together determine their specific function. Read More

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September 2021

Knockdown of miR‑205‑5p alleviates the inflammatory response in allergic rhinitis by targeting B‑cell lymphoma 6.

Mol Med Rep 2021 Nov 24;24(5). Epub 2021 Sep 24.

Department of Otorhinolaryngology, The Second Affiliated Hospital of Shenyang Medical College, Shenyang, Liaoning 110000, P.R. China.

Allergic rhinitis (AR) is an IgE‑mediated upper airway disease with a high worldwide prevalence. MicroRNA (miR)‑205‑5p upregulation has been observed in AR; however, its role is poorly understood. The aim of the present study was to investigate the effect of miR‑205‑5p on AR‑associated inflammation. Read More

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November 2021

Recent advances in understanding the role of IL-4 signaling.

Fac Rev 2021 7;10:71. Epub 2021 Sep 7.

Molecular and Cellular Immunoregulation Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA.

Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, but this cytokine acts on more than a dozen different target cells spanning the innate and adaptive immune systems and is produced by multiple different cellular sources. While IL-4 was discovered just under 40 years ago in 1982, the interest in and discoveries related to this cytokine continue to markedly expand. Read More

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September 2021

Immunogloboulin E-Mediated Food Sensitization in Children with Celiac Disease: A Single-Center Experience.

Pediatr Gastroenterol Hepatol Nutr 2021 Sep 8;24(5):492-499. Epub 2021 Sep 8.

Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and Allergology, Medical University of Bialystok, Bialystok, Poland.

Purpose: Celiac disease (CD) is an autoimmune disorder of the small intestine caused by an abnormal immune response to gluten proteins and is often characterized by gastrointestinal symptoms. Food allergy (FA) is an adverse immune sensitivity to ingested food proteins leading to inflammation in various organs including the gastrointestinal tract. The relationship between CD and FA remains unclear. Read More

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September 2021

Annexin A1 Mimetic Peptide Ac Modulates the Function of Murine Colonic and Human Mast Cells.

Front Immunol 2021 7;12:689484. Epub 2021 Sep 7.

Department of Biology, Institute of Bioscience, Humanities and Exact Science, São Paulo State University (Unesp), São José do Rio Preto, Brazil.

Mast cells (MCs) are main effector cells in allergic inflammation and after activation, they release stored (histamine, heparin, proteases) and newly synthesized (lipid mediators and cytokines) substances. In the gastrointestinal tract the largest MC population is located in the lamina propria and submucosa whereas several signals such as the cytokine IL-4, seem to increase the granule content and to stimulate a remarkable expansion of intestinal MCs. The broad range of MC-derived bioactive molecules may explain their involvement in many different allergic disorders of the gastrointestinal tract. Read More

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September 2021

Biotite-Calx Based Traditional Indian Medicine Prophylactically Mitigates Allergic Airway Inflammation in a Mouse Model of Asthma by Amending Cytokine Responses.

J Inflamm Res 2021 17;14:4743-4760. Epub 2021 Sep 17.

Drug Discovery and Development Division, Patanjali Research Institute, Haridwar, Uttarakhand, India.

Purpose: Asthma is a heterogeneous airway inflammatory disease with limited therapeutic options. Traditional medicine is extensively used for treating various ailments including asthma. (SPAB) is a biotite-calx based Indian medicine. Read More

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September 2021

The Underestimated Role of Mast Cells in the Pathogenesis of Rhinopathies.

Int Arch Allergy Immunol 2021 Sep 22:1-7. Epub 2021 Sep 22.

Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.

Mast cells (MCs) are involved in several biological processes, such as defense against pathogens, immunomodulation, tissue repair after injury, and angiogenesis. MCs have been shown to change from protective immune cells to potent pro-inflammatory cells, influencing the progression of many pathological conditions, including autoimmune diseases and cancers. The role of MCs in the pathogenesis of rhinopathies has often been underestimated, since previous studies have focused their attention on eosinophils and neutrophils, while MCs were considered involved exclusively in allergic rhinitis. Read More

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September 2021

Difference in the plasma level of miR-628-3p in atopic dermatitis patients with/without atopic keratoconjunctivitis.

Immun Inflamm Dis 2021 Sep 21. Epub 2021 Sep 21.

Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Introduction: Some but not all patients with atopic dermatitis (AD) present with allergic conjunctival disease (ACD) including severe types such as atopic keratoconjunctivitis (AKC) with/without giant papillae. We hypothesized that different factors are involved in the severity of ACD and AD. Recently we reported that hsa-miR-628-3p could affect the balance of innate immunity by suppressing pathogen-associated molecular patterns such as toll-like receptor 3 (TLR3), RIG-I, and MDA-5. Read More

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September 2021

The role of anti-elastin antibodies in a mouse model of asthma.

Asian Pac J Allergy Immunol 2021 Sep 5. Epub 2021 Sep 5.

Department of Respiratory Medicine and Clinical Immunology Dokkyo Medical University, Saitama Medical Center, Saitama, Japan.

Background: The role of anti-elastin antibody (Ab) in the lung is unclear, although they may be involved in chronic obstructive pulmonary disease (COPD). Recently, increased anti-elastin Ab levels were reported in asthma.

Objective: To elucidate the role of anti-elastin Ab in asthma, we created a murine asthma model. Read More

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September 2021

The antigenicity of silk-based biomaterials: sources, influential factors and applications.

J Mater Chem B 2021 Sep 20. Epub 2021 Sep 20.

Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Silk is an ancient material with essential roles in numerous biomedical applications, such as tissue regeneration and drug delivery, because of its excellent tunable mechanical properties and diverse physical structures. In addition to the necessary functionalities for biomedical applications, another critical factor for materials applied in biology is the appropriate immune interactions with the body. This review focuses on the immune responses of silk-based materials applied in biomedical applications, specifically antigenicity. Read More

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September 2021

Double-chamber plethysmography oscillometry to detect baseline airflow obstruction in a model of asthma in two mouse strains.

Exp Lung Res 2021 Sep 20:1-12. Epub 2021 Sep 20.

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Quebec City, Canada.

Aim Of The Study: The current gold standard to assess respiratory mechanics in mice is oscillometry, a technique from which several readouts of the respiratory system can be deduced, such as resistance and elastance. However, these readouts are often not altered in mouse models of asthma. This is in stark contrast with humans, where asthma is generally associated with alterations when assessed by either oscillometry or other techniques. Read More

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September 2021

COVID-19 vaccines: Current evidence and considerations.

Metabol Open 2021 Dec 11;12:100124. Epub 2021 Sep 11.

School of Nursing and Allied Medical Sciences, Maragheh University of Medical Sciences, Maragheh, Iran.

The coronavirus disease 2019 (COVID-19) pandemic is a global crisis, with devastating health, business and social impacts. Vaccination is a safe, simple, and effective way of protecting a person against COVID-19. By the end of August 2021, only 24. Read More

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December 2021

Targeting the human β receptor inhibits contact dermatitis in a transgenic mouse model.

J Invest Dermatol 2021 Sep 16. Epub 2021 Sep 16.

Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia.

Allergic contact dermatitis (ACD) is a prevalent and poorly controlled inflammatory disease caused by skin infiltration of T cells and granulocytes. The β cytokines GM-CSF, IL-3 and IL-5 are powerful regulators of granulocyte function that signal through their common receptor subunit β, a property that has made β an attractive target to simultaneously inhibit these cytokines. However, the species specificity of β has precluded testing of inhibitors of human β in mouse models. Read More

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September 2021

Lipoxin A4 inhibits ovalbumin-induced airway inflammation and airway remodeling in a mouse model of asthma.

Chem Biol Interact 2021 Sep 16;349:109660. Epub 2021 Sep 16.

Department of Respiratory Medicine, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, 271000, China. Electronic address:

Asthma is a chronic respiratory disease, which is characterized by airway inflammation, remodeling and airway hyperresponsiveness. Airway remodeling is caused by long-term inflammation of the airways. Lipoxin A4 (LXA4) is a natural eicosanoid with powerful anti-inflammatory properties, and has been shown to serve a critical role in orchestrating pulmonary inflammation and airway hyper-responsiveness in asthmatic mice. Read More

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September 2021

Cross-sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitisation.

Clin Exp Allergy 2021 Sep 18. Epub 2021 Sep 18.

Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.

Background: Fractional exhaled nitric oxide (FeNO) is a well-known marker of type-2 inflammation. FeNO is elevated in asthma and allergic rhinitis, with IgE sensitisation as a major determinant.

Objective: We aimed to see if there was an independent association between upper airway inflammatory disorders (UAID) and FeNO, after adjustment for asthma and sensitisation, in a multi-centre population-based study. Read More

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September 2021

The International EAACI/GA²LEN/EuroGuiDerm/APAAACI Guideline for the Definition, Classification, Diagnosis and Management of Urticaria.

Allergy 2021 Sep 18. Epub 2021 Sep 18.

Centre Hospitalier Université Laval/Centre Hospitalier Universitaire de Québec, Service d'allergie, Québec, QC, Canada.

This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA²LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), the European Dermatology Forum (EDF; EuroGuiDerm), and the Asia Pacific Association of Allergy, Asthma and Clinical Immunology with the participation of 64 delegates of 50 national and international societies and from 31 countries. The consensus conference was held on 3 December 2020. Read More

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September 2021

The Role of IgE in Upper and Lower Airway Disease: More Than Just Allergy!

Clin Rev Allergy Immunol 2021 Sep 18. Epub 2021 Sep 18.

Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA.

Immunoglobulin E (IgE) is a well-known key factor in allergic airway disease; however, its central role in non-allergic airway inflammation is often underestimated. In some airway diseases, IgE is produced as a result of allergic sensitization. However, in others, IgE production occurs despite the lack of a specific allergen. Read More

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September 2021

Pharmacological Properties of 2,4,6-Trihydroxy-3-Geranyl Acetophenone and the Underlying Signaling Pathways: Progress and Prospects.

Front Pharmacol 2021 31;12:736339. Epub 2021 Aug 31.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

2,4,6-Trihydroxy-3-geranyl acetophenone (tHGA) is a bioactive phloroglucinol compound found in (Champ. ex Benth.) T. Read More

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Huangbai Liniment Ameliorates Skin Inflammation in Atopic Dermatitis.

Front Pharmacol 2021 31;12:726035. Epub 2021 Aug 31.

Shandong Analysis and Test Center, Laboratory of Immunology for Environment and Health, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.

Atopic dermatitis (AD), also known as atopic eczema, is one of the most common skin diseases and is characterized by allergic skin inflammation, redness, and itchiness and is associated with a hyperactivated type 2 immune response. The leading causes of AD include an imbalance in the immune system, genetic predisposition, or environmental factors, making the development of effective pharmacotherapies complex. Steroids are widely used to treat AD; however, they provide limited efficacy in the long term and can lead to adverse effects. Read More

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Environmental allergens trigger type 2 inflammation through ripoptosome activation.

Nat Immunol 2021 Sep 16. Epub 2021 Sep 16.

Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Environmental allergens, including fungi, insects and mites, trigger type 2 immunity; however, the innate sensing mechanisms and initial signaling events remain unclear. Herein, we demonstrate that allergens trigger RIPK1-caspase 8 ripoptosome activation in epithelial cells. The active caspase 8 subsequently engages caspases 3 and 7, which directly mediate intracellular maturation and release of IL-33, a pro-atopy, innate immunity, alarmin cytokine. Read More

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September 2021

Unravelling the therapeutic potential of IL-33 for atrophic AMD.

Eye (Lond) 2021 Sep 16. Epub 2021 Sep 16.

Academic Unit of Ophthalmology, Translational Health Sciences, University of Bristol, Bristol, UK.

Age-related macular degeneration (AMD), a degenerative disease affecting the retinal pigment epithelium (RPE) and photoreceptors in the macula, is the leading cause of central blindness in the elderly. AMD progresses to advanced stages of the disease, atrophic AMD (aAMD), or in 15% of cases "wet" or neovascular AMD (nAMD), associated with substantial vision loss. Whilst there has been advancement in therapies treating nAMD, to date, there are no licenced effective treatments for the 85% affected by aAMD, with disease managed by changes to diet, vitamin supplements, and regular monitoring. Read More

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September 2021

Repeated exposure to inactivated Streptococcus pneumoniae induces asthma-like pathological changes in mice in the presence of IL-33.

Cell Immunol 2021 Sep 13;369:104438. Epub 2021 Sep 13.

Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China. Electronic address:

While environmental aeroallergens and epithelial alarmins such as IL-33 are firmly implicated in asthma, the possible role of Streptococcus pneumoniae (S. pneumoniae) antigens is less clear. To explore this, wild-type BALB/c mice were repeatedly challenged per-nasally with IL-33 and inactivated S. Read More

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September 2021

Response of upper and lower airway inflammation to bronchial challenge with house dust mite in Chinese asthmatics: a pilot study.

J Thorac Dis 2021 Aug;13(8):4988-4998

State Key Lab of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: Allergen nasal challenge can induce increase of eosinophils in sputum, but report about eosinophilic inflammation in upper airway after allergen bronchial challenge in Chinese asthmatics was rare. The article aims to evaluate response of upper and lower airways to house dust mite (HDM) allergen bronchial challenge.

Methods: HDM allergen bronchial challenge was carried out in asthmatic patients with allergic rhinitis (AR). Read More

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Respiratory Microbiota Profiles Associated With the Progression From Airway Inflammation to Remodeling in Mice With OVA-Induced Asthma.

Front Microbiol 2021 30;12:723152. Epub 2021 Aug 30.

Department of Endocrine, Genetics and Metabolism, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: The dysbiosis of respiratory microbiota plays an important role in asthma development. However, there is limited information on the changes in the respiratory microbiota and how these affect the host during the progression from acute allergic inflammation to airway remodeling in asthma.

Objective: An ovalbumin (OVA)-induced mouse model of chronic asthma was established to explore the dynamic changes in the respiratory microbiota in the different stages of asthma and their association with chronic asthma progression. Read More

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Resilient SARS-CoV-2 diagnostics workflows including viral heat inactivation.

PLoS One 2021 15;16(9):e0256813. Epub 2021 Sep 15.

King's College London Diagnostics Team at Guy's Campus, London, United Kingdom.

There is a worldwide need for reagents to perform SARS-CoV-2 detection. Some laboratories have implemented kit-free protocols, but many others do not have the capacity to develop these and/or perform manual processing. We provide multiple workflows for SARS-CoV-2 nucleic acid detection in clinical samples by comparing several commercially available RNA extraction methods: QIAamp Viral RNA Mini Kit (QIAgen), RNAdvance Blood/Viral (Beckman) and Mag-Bind Viral DNA/RNA 96 Kit (Omega Bio-tek). Read More

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September 2021

Melatonin prevents allergic airway inflammation in epicutaneously sensitized mice.

Biosci Rep 2021 Sep;41(9)

School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China.

Purpose: The pathological process of atopic dermatitis (AD) progressing into other types of allergic diseases such as asthma and allergic rhinitis during the first several years of life is often referred to as the atopic march. Although the phenomenon of atopic march has been recognized for decades, how asthma stems from AD is still not fully understood, confounding a universal strategy to effectively protect people from the atopic march.

Methods: We established experimental atopic march mice by first inducing allergic dermatitis with 0. Read More

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September 2021