140,923 results match your criteria allergic

The Concept of Pathogenic TH2 Cells: Collegium Internationale Allergologicum Update 2021.

Int Arch Allergy Immunol 2021 Apr 12;182(5):365-380. Epub 2021 Apr 12.

Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

T helper (TH) cells have evolved into distinct subsets that mediate specific immune responses to protect the host against a myriad of infectious and noninfectious challenges. However, if dysregulated, TH-cell subsets can cause inflammatory disease. Emerging evidence now suggests that human allergic disease is caused by a distinct subpopulation of pathogenic TH2 cells. Read More

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T helper 2-driven immune dysfunction in chronic arsenic-exposed individuals and its link to the features of allergic asthma.

Toxicol Appl Pharmacol 2021 Apr 9:115532. Epub 2021 Apr 9.

Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh. Electronic address:

Limited information is available regarding the effects of arsenic exposure on immune function. We have recently reported that chronic exposure to As was associated asthma, as determined by spirometry and respiratory symptoms. Because T helper 2 (Th2)-driven immune responses are implicated in the pathogenesis of allergic diseases, including asthma, we studied the associations of serum Th1 and Th2 mediators with the As exposure markers and the features of asthma among individuals exposed to As. Read More

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Increased Thrombin-Activatable Fibrinolysis Inhibitor in Response to Sublingual Immunotherapy for Allergic Rhinitis.

Laryngoscope 2021 Apr 12. Epub 2021 Apr 12.

Division of Otorhinolaryngology Head and Neck Surgery, Department of Sensory and Locomotor Medicine, University of Fukui, Yoshida, Fukui, Japan.

Objectives/hypothesis: The objective of this study was to determine the role of thrombin-activatable fibrinolysis inhibitor (TAFI) as a candidate biomarker for therapeutic efficacy of sublingual immunotherapy (SLIT) and to identify the role of TAFI in the pathogenesis of allergic rhinitis (AR).

Study Design: Retrospective cohort study and laboratory study.

Methods: Serum was collected from patients with allergies to Japanese cedar pollen before, during, and after treatment with SLIT. Read More

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Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice.

Neurotherapeutics 2021 Apr 12. Epub 2021 Apr 12.

Institute of Clinical Pharmacology, Medical Faculty, Goethe-University, Frankfurt, Germany.

Depletion of the enzyme cofactor, tetrahydrobiopterin (BH4), in T-cells was shown to prevent their proliferation upon receptor stimulation in models of allergic inflammation in mice, suggesting that BH4 drives autoimmunity. Hence, the clinically available BH4 drug (sapropterin) might increase the risk of autoimmune diseases. The present study assessed the implications for multiple sclerosis (MS) as an exemplary CNS autoimmune disease. Read More

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Effect of adjunctive sodium hyaluronate versus surfactant nasal irrigation on mucociliary clearance in allergic rhinitis: a single-blind, randomised, controlled study.

J Laryngol Otol 2021 Apr 12:1-4. Epub 2021 Apr 12.

Department of Otorhinolaryngology, Kecioren Research and Training Hospital, Ankara, Turkey.

Objective: To investigate the effects of nasal irrigation with sodium hyaluronate and surfactant solutions on mucociliary clearance time in patients with mild persistent allergic rhinitis.

Methods: A total of 120 patients diagnosed with mild persistent allergic rhinitis were enrolled in this prospective study. The patients were allocated randomly to the surfactant, sodium hyaluronate or isotonic saline (as a control) nasal irrigation group. Read More

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Is there a place for chlorhexidine in the European Baseline series?

Contact Dermatitis 2021 Apr 11. Epub 2021 Apr 11.

Clinic of Dermatology, University Hospital, Coimbra, Portugal.

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Patch Testing to Sodium Disulfite: North American Contact Dermatitis Group Experience, 2017-2018.

Contact Dermatitis 2021 Apr 11. Epub 2021 Apr 11.

Ohio University Heritage College of Osteopathic Medicine, Athens, OH.

Background: Sodium disulfite (SD), also known as sodium metabisulfite, is an increasingly recognized cause of allergic contact dermatitis.

Objectives: Characterize individuals with positive patch test reactions to SD as well as analyze reaction strength, clinical relevance and sources.

Methods: Retrospective analysis of patients patch tested to SD (1% pet) by the North American Contact Dermatitis Group (NACDG), 2017 to 2018. Read More

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Boosting Nitric Oxide in Stress and Respiratory Infection: Potential Relevance for Asthma and COVID-19.

Brain Behav Immun Health 2021 Apr 5:100255. Epub 2021 Apr 5.

Department of Psychology and Neuroscience, Baylor University, One Bear Place, 97334, Baylor Sciences Building, Suite B.309, Waco, TX, USA.

Nitric oxide (NO) is a ubiquitous signaling molecule that is critical for supporting a plethora of processes in biological organisms. Among these, its role in the innate immune system as a first line of defense against pathogens has received less attention. In asthma, levels of exhaled NO have been utilized as a window into airway inflammation caused by allergic processes. Read More

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RhoA and Cdc42 in T cells: Are they targetable for T cell-mediated inflammatory diseases?

Fukun Guo

Precis Clin Med 2021 Mar 7;4(1):56-61. Epub 2021 Jan 7.

Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Many inflammatory diseases are not curable, necessitating a better understanding of their pathobiology that may help identify novel biological targets. RhoA and Cdc42 of Rho family small GTPases regulate a variety of cellular functions such as actin cytoskeletal organization, cell adhesion, migration, proliferation, and survival. Recent characterization of mouse models of conditional gene knockout of RhoA and Cdc42 has revealed their physiological and cell type-specific roles in a number of cell types. Read More

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COVID-19 vaccination of patients with allergies and type-2 inflammation with concurrent antibody therapy (biologicals) - A Position Paper of the German Society of Allergology and Clinical Immunology (DGAKI) and the German Society for Applied Allergology (AeDA).

Allergol Select 2021 1;5:140-147. Epub 2021 Apr 1.

Allergology and Immunology, Department of Dermatotology, Venereology and Allergology, Charité Universitätsmedizin Berlin, Germany.

Background: After the beginning and during the worldwide pandemic caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), patients with allergic and atopic diseases have felt and still feel insecure. Currently, four vaccines against SARS-CoV-2 have been approved by the Paul Ehrlich Institute in Germany, and vaccination campaigns have been started nationwide. In this respect, it is of utmost importance to give recommendations on possible immunological interactions and potential risks of immunomodulatory substances (monoclonal antibodies, biologicals) during concurrent vaccination with the approved vaccines. Read More

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The clinicopathological features of drug-induced acute kidney injury-a single-center retrospective analysis.

Ann Transl Med 2021 Mar;9(5):400

Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Background: This study aimed to analyze changes to the drug spectrum and clinicopathological features of drug-induced acute kidney injury (AKI) with recent medication habits changes.

Methods: A retrospective analysis of the characteristics of patients diagnosed with drug-induced AKI from January 2012 to October 2016 period at the First Affiliated Hospital of the Medical College of Zhejiang University was conducted.

Results: Between January 2012 and October 2016, 909 patients were diagnosed with AKI. Read More

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A single-center, self-controlled, phase I clinical trial of mitoxantrone hydrochloride injection for lymph tracing for sentinel lymph node identification of breast cancer.

Gland Surg 2021 Mar;10(3):992-1001

Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: Mitoxantrone hydrochloride injection for lymph tracing (MHI) is a novel lymphatic tracer for sentinel lymph node (SLN) in patients with early breast cancer but exhibited remarkable liver, kidney, and hematologic toxicities in previous studies. Here, the pharmacokinetics and pharmacodynamics profiles of MHI were evaluated to surmise safety and tolerability.

Methods: Phase 1 open-label, single center, and dose escalation study was performed. Read More

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IRAK-M knockout promotes allergic airway inflammation, but not airway hyperresponsiveness, in house dust mite-induced experimental asthma model.

J Thorac Dis 2021 Mar;13(3):1413-1426

Departments of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: IL-1 receptor associated-kinase (IRAK)-M, expressed by airway epithelium and macrophages, was shown to regulate acute and chronic airway inflammation exhibiting a biphasic response in an OVA-based animal model. House dust mite (HDM) is a common real-life aeroallergen highly relevant to asthma pathogenesis. The role of IRAK-M in HDM-induced asthma remains unknown. Read More

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Vascular access cannulation and haemostasis: a national observational study of French practices.

Clin Kidney J 2021 Apr 2;14(4):1261-1268. Epub 2020 Oct 2.

Department of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception, Marseille, France.

Background: We report the results of an observational study of arteriovenous fistula (AVF) cannulation and haemostasis practices in France.

Methods: The study (sponsored by Brothier Pharmaceutical Inc.) was conducted in 150 dialysis units. Read More

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Innovative Systems to Deliver Allergen Powder for Epicutaneous Immunotherapy.

Front Immunol 2021 26;12:647954. Epub 2021 Mar 26.

Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.

Allergy is a disorder owing to hyperimmune responses to a particular kind of substance like food and the disease remains a serious healthcare burden worldwide. This unpleasant and sometimes fatal allergic disease has been tackled vigorously by allergen-specific immunotherapy over a century, but the progress made so far is far from satisfactory for some allergies. Herein, we introduce innovative, allergen powder-based epicutaneous immunotherapies (EPIT), which could potentially serve to generate a new stream of technological possibilities that embrace the features of super safety and efficacious immunotherapy by manipulating the plasticity of the skin immune system sufficient delivery of not only allergens but also tolerogenic adjuvants. Read More

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Avenanthramide C Suppresses Matrix Metalloproteinase-9 Expression and Migration Through the MAPK/NF- κB Signaling Pathway in TNF-α-Activated HASMC Cells.

Front Pharmacol 2021 25;12:621854. Epub 2021 Mar 25.

Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon, South Korea.

In oat ingredients, flavonoids and phenolic acids are known to be the most important phenolic compounds. In phenolic compounds, wide-ranging biological responses, including antioxidative, anti-inflammatory, anti-allergic, and anti-cancer properties, were reported. Avenanthramide C (Avn C), a component of the phenolic compound of oats, has been reported to be highly antioxidant and anti-inflammatory, but its role in an anti-atherosclerosis response is unknown. Read More

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Wheat oral immunotherapy.

Curr Opin Allergy Clin Immunol 2021 Mar 31. Epub 2021 Mar 31.

Department of Pediatrics, Yale School of Medicine Department of Medicine, Yale School of Medicine Department of Pediatrics, NYU Grossman School of Medicine, Hassenfeld Childrens' Hospital Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.

Purpose Of Review: The prevalence of food allergy is increasing on a global scale, and therefore increased attention is being paid to specific food allergy epidemiology and management. There has been a large amount of progress made in the last decade on human trials of wheat oral immunotherapy (WOIT).

Recent Findings: To date, there has been one multicenter, double-blind, randomized controlled trial of WOIT, one randomized, noncontrolled trial of WOIT, and several smaller, nonrandomized clinical trials of WOIT. Read More

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Burden of allergic rhinitis and impact of MP-AzeFlu from the patient perspective: pan European patient survey.

Curr Med Res Opin 2021 Apr 12. Epub 2021 Apr 12.

Power Project GmbH, Vienna Challenge Chamber, Vienna, Austria.

The aims of this survey were to (1) assess the burden of allergic rhinitis (AR) from the patient perspective, (2) investigate MP-AzeFlu use in real life and its impact on patients' lives and (3) explore factors associated with treatment satisfaction. A cross-sectional, quantitative, online, questionnaire-based survey was conducted in 7 European countries (March-June 2019). Questions explored AR burden and treatment satisfaction. Read More

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IgE antibodies increase honeybee venom responsiveness and detoxification efficiency of mast cells.

Allergy 2021 Apr 11. Epub 2021 Apr 11.

Dept. of Pathology, Stanford University School of Medicine, Stanford, CA, 94305-5176, USA.

Background: In contrast to theirclearly defined rolesin allergic diseases, the physiologic functions of Immunoglobulin E antibodies (IgEs) and mast cells (MCs) remainenigmatic. Recent research supports the toxin hypothesis,showing thatMCs and IgE-related type 2 immune responses can enhance host defense against certain noxious substances, including honeybee venom (BV). However, the mechanisms by whichMCs can interfere with BV toxicity are unknown. Read More

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You might owe your mother more than you think.

Allergy 2021 Apr 11. Epub 2021 Apr 11.

Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy.

Immunoglobulin E (IgE)-mediated activation of mast cells (MC) has been historically linked to allergic reactions [1]. Nevertheless,antibody-dependent MC degranulation can also be triggered by venoms from insects or reptiles. Of note, MC mediators provide efficient protection againstthe toxic compounds of venoms [2]. Read More

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Relevance of Major Allergens in Weed Pollen Allergy.

Int Arch Allergy Immunol 2021 Apr 9:1-5. Epub 2021 Apr 9.

Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-University of Munich, Munich, Germany.

Introduction: Weed pollen allergy is an important and in prevalence increasing cause of pollinosis in Europe and across the world. In this study we focus on the value of common diagnostic tools for detection of a sensitization to mugwort and English plantain, especially with regard to the clinical relevance of the sensitization.

Methods: Eighty weed pollen sensitized patients (41 to mugwort and 39 to English plantain) were assessed retrospectively regarding their clinical anamnesis, in-vivo tests (skin prick test [SPT] and allergen specific provocation) and in-vitro tests (immunoglobulin E [IgE] reactivity to purified natural allergen extract and specific allergen components in serum). Read More

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Comparison of immediate hypersensitivity reactions to preoperative antibiotics in patients labeled as penicillin allergic.

Surgery 2021 Apr 8. Epub 2021 Apr 8.

University of Colorado Anschutz Medical Campus, Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO. Electronic address:

Background: Cefazolin is routinely recommended as the first-line agent for surgical antibiotic prophylaxis because it prevents more surgical site infections than second-line antibiotics. Clinicians often avoid administering cefazolin to patients who are labeled as penicillin allergic due to concerns of cross-reactivity. The aim of this study was to compare the incidence of hypersensitivity reactions between cefazolin and the second-line antibiotics vancomycin and clindamycin. Read More

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Dehydrodiisoeugenol inhibits colorectal cancer growth by endoplasmic reticulum stress-induced autophagic pathways.

J Exp Clin Cancer Res 2021 Apr 10;40(1):125. Epub 2021 Apr 10.

State Key Laboratory of Silkworm Genome Biology, College of Sericulture, Textile and Biomass sciences, Southwest University, #2, Tiansheng Rd., Beibei District, Chongqing, 400716, China.

Background: Dehydrodiisoeugenol (DEH), a novel lignan component extracted from nutmeg, which is the seed of Myristica fragrans Houtt, displays noticeable anti-inflammatory and anti-allergic effects in digestive system diseases. However, the mechanism of its anticancer activity in gastrointestinal cancer remains to be investigated.

Methods: In this study, the anticancer effect of DEH on human colorectal cancer and its underlying mechanism were evaluated. Read More

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The high affinity IgE receptor: a signaling update.

Curr Opin Immunol 2021 Apr 7;72:51-58. Epub 2021 Apr 7.

Laboratory of Allergic Diseases, Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Dermatology, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.

Here we update receptor proximal and distant signaling events of the mast cell high affinity IgE receptor (FcεRI) launching immediate type I hypersensitivity and an inflammatory cytokine-chemokine cascade. Different physiologic antigen concentrations, their affinity, and valency for the IgE ligand produce distinct intracellular signaling events with different outcomes. Investigating mast cell degranulation has revealed a complex molecular machinery that relays proximal signaling to cytoskeletal reorganization, granule transport and membrane fusion. Read More

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Epitope-imprinted polydopamine electrochemical sensor for ovalbumin detection.

Bioelectrochemistry 2021 Mar 26;140:107805. Epub 2021 Mar 26.

Department of Food, Agriculture and Bioresources, School of Environment, Resources and Development, Asian Institute of Technology, 58 Moo 9, Km. 42, Paholyothin Highway, Klong Luang, Pathumthani 12120, Thailand. Electronic address:

A novel, sensitive and selective electrochemical sensor based on epitope-imprinted polydopamine (PDA) was developed for ovalbumin (OVA) detection. Molecularly imprinted polydopamine was synthesized on an AuNP-coated screen-printed carbon electrode (SPCE) via electropolymerization in the presence of OVA IgE-binding epitope as the template. Key process parameters including template concentration, electropolymerization cycle, pH, time required for template removal and rebinding were optimized. Read More

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Omalizumab response in patients with asthma by number and type of allergen.

Ann Allergy Asthma Immunol 2021 Apr 7. Epub 2021 Apr 7.

University of South Florida, Tampa, Florida.

Background: The anti-IgE therapy omalizumab improves asthma control and reduces exacerbations in patients with moderate-to-severe allergic asthma. However, it has been suggested that omalizumab should be reserved for highly allergic patients with multiple allergen sensitivities or perennial-only sensitivities.

Objective: To examine impact of allergy burden, including number and type of allergen sensitivities, on omalizumab response in a real-world setting. Read More

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Outcome of trimethoprim-sulfamethoxazole (TMP-SMX) challenge in previously reported sulfa antibiotic allergic patients.

Ann Allergy Asthma Immunol 2021 Apr 7. Epub 2021 Apr 7.

Department of Medicine, University of Washington, Seattle, WA; Kaiser Permanente Washington.

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Legends of Allergy and Immunology: Sergio Bonini.

Allergy 2021 Apr 10. Epub 2021 Apr 10.

Tor Vergata, Former Executive Director European Medicines Agency, University of Rome, Rome, Italy.

In life, you are lucky if you meet people who can inspire and motivate. Sergio Bonini is one of those people. He can be regarded as a legend for his successful journey through the rapidly evolving discipline of Allergy and Clinical Immunology in the last 50 years. Read More

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The relevance of CYSLTR1 gene polymorphism to the severity of allergic rhinitis and clinical responsiveness of montelukast in children.

Eur Arch Otorhinolaryngol 2021 Apr 10. Epub 2021 Apr 10.

Department of Otolaryngology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwuweiqi Road, Jinan, 250021, Shandong Province, China.

Purpose: The etiology of allergic rhinitis (AR) is closely correlated with the complex interactions between genetic and environmental factors. This study explored the effect of single-nucleotide polymorphisms (SNPs) of CYSLTR1 gene on the risk of AR and clinical response to montelukast treatment in children.

Methods: A total of 135 children with AR and 100 healthy children were included for subsequent analyses. Read More

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Contact Dermatitis 2021 Apr 9. Epub 2021 Apr 9.

University of Minnesota Department of Dermatology, Minneapolis, MN.

Background: Data regarding teledermatology for patch testing are limited.

Objectives: Compare patch test readings and final interpretation by 2 in-person dermatologists (IPDs) with 8 teledermatologists (TDs).

Methods: Patch tested patients had photographs taken of 70 screening series allergens at 48-hour (48H) and second (2nd) readings. Read More

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