Scand J Immunol 2008 Feb;67(2):140-51
Institute of Respiratory Medicine, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
CD4(+)CD25(+)Foxp3(+)Regulatory T cells (Tregs) play important roles in regulating allergic inflammation. To analyse if allergen-DNA-modified dendritic cells (DC) can suppress allergic responses and what roles Treg cells play in DC-based allergen-specific immunotherapy. Immature DC were transfected with retrovirus encoding Der p2 DNA, and administered to mice that sensitized and challenged with Der p2 protein. Read More