1,347 results match your criteria alkaline setting

Identification of Regorafenib Prognostic Index (REP Index) via Recursive Partitioning Analysis in Patients with Advanced Hepatocellular Carcinoma Receiving Systemic Treatment: A Real-World Multi-Institutional Experience.

Target Oncol 2021 Sep 7. Epub 2021 Sep 7.

Unit of Oncology, IRCCS-San Raffaele Scientific Institute, Università Vita-Salute, Milan, Italy.

Background: The results of the pivotal RESORCE trial led to the approval of the tyrosine kinase inhibitor regorafenib as second-line treatment in advanced hepatocellular carcinoma (HCC) after sorafenib failure. Data about prognostic factors in a second-line HCC setting are scarce.

Objective: The aim of the present study was to investigate prognostic factors in a cohort of patients with advanced HCC treated with regorafenib after progressing on sorafenib. Read More

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September 2021

The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm.

Hum Reprod 2021 Sep 6. Epub 2021 Sep 6.

Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.

Study Question: Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect the function of human sperm?

Summary Answer: The SSRI antidepressant Sertraline (e.g. Zoloft) inhibits the sperm-specific Ca2+ channel CatSper and affects human sperm function in vitro. Read More

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September 2021

The biocompatibility and mineralization potential of mineral trioxide aggregate containing calcium fluoride-An in vitro study.

J Dent Sci 2021 Oct 10;16(4):1080-1086. Epub 2021 Jun 10.

Department of Conservative Dentistry, College of Dentistry, Dankook University, Cheonan, South Korea.

Background/purpose: MTA is used to induce hard tissue regeneration in various procedures. This study evaluated the biocompatibility and mineralization potential of mineral trioxide aggregate (MTA) containing calcium fluoride (CaF). To verify if the change of components affected physical properties, the setting time, solubility, and surface roughness were measured. Read More

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October 2021

LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in obese adults with modest hypertriglyceridemia.

J Clin Endocrinol Metab 2021 Aug 25. Epub 2021 Aug 25.

Novartis Institutes for BioMedical Research, Cambridge, MA, USA and Basel, Switzerland.

Purpose: To evaluate the safety and potential efficacy of LLF580, a genetically engineered variant of human fibroblast growth factor-21, for triglyceride lowering, weight loss, and hepatic fat reduction.

Methods: A multicenter, double-blind, parallel design trial in obese, mildly hypertriglyceridemic adults randomized (1:1) to LLF580 300 mg or placebo subcutaneously every four weeks for three doses.

Results: Of 64 randomized study participants, 61 (mean±SD: age 45±11 years, 49% male, 80/15/5% Caucasian/African American/Other, BMI 36. Read More

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Interrelationships between sclerostin, secondary hyperparathyroidism, and bone metabolism in patients on hemodialysis.

J Clin Endocrinol Metab 2021 Aug 23. Epub 2021 Aug 23.

Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan.

Context: Sclerostin is an osteocyte-derived inhibitor of bone formation and is increased in kidney failure, but its role in the pathogenesis of renal bone disease remains unknown.

Objective: To explore the association of serum sclerostin with bone metabolism in patients undergoing hemodialysis, with a particular focus on parathyroid hormone (PTH)-dependent and PTH-independent pathways.

Design: Cross-sectional and prospective cohort study. Read More

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Obstructive jaundice, a rare presentation of lung cancer: A case report.

Respir Med Case Rep 2021 11;33:101425. Epub 2021 May 11.

VA New Jersey Healthcare System East Orange Campus, 385 Tremont Avenues, East Orange, NJ, 07018, USA.

Lung cancer metastases to the pancreas are rare but potentially life-threatening. Oftentimes, the presence of symptoms is indicative of extensive disease burden. This report describes a case of primary lung adenocarcinoma metastasizing to the head of the pancreas presenting as obstructive jaundice. Read More

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New insight into the role of a combination of zinc oxide and turmeric rhizome liquid extract in osteogenic marker expression.

J Indian Prosthodont Soc 2021 Jul-Sep;21(3):262-268

Department of Dental Material, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.

Aim: This research was aimed to determine the potential for treating osteogenesis with a combination of zinc oxide and turmeric (ZOT) rhizome liquid extract.

Setting And Design: In vivo, post test-control group design.

Material And Methods: The mandibular incisors of Wistar rats were extracted and left untreated or received an application of zinc oxideeugenol (ZOE) 10% or ZOT rhizome liquid extract at various concentrations (10%, 20%, and 40%). Read More

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FAM20C plays a critical role in the development of mouse vertebra.

Spine J 2021 Jul 31. Epub 2021 Jul 31.

Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, USA. Electronic address:

Background Context: Family with sequence similarity 20-member C (FAM20C) is a protein kinase that is responsible for the phosphorylation of many secretory proteins; however, its roles in spine or vertebra development have not be studied.

Purpose: The aim of this investigation is to analyze the roles of FAM20C in vertebra development.

Study Design/setting: A mouse study of the Fam20c gene using conditional knockout to assess the effects of its inactivation on vertebra development. Read More

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Magnetic resonance imaging is a valuable tool to evaluate the therapeutic efficacy of burosumab in children with X-linked hypophosphatemia.

Eur J Endocrinol 2021 Aug 27;185(4):475-484. Epub 2021 Aug 27.

AP-HP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, Filière OSCAR, EndoRare, BOND ERN and Platform of Expertise for Rare Diseases Paris-Saclay, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, France.

Purpose: To examine the MRI diagnostic performance in the assessment of therapeutic response to burosumab in children with X-linked hypophosphatemia (XLH).

Design: Prospective longitudinal open cohort.

Patients: Seventeen children with XLH, average age of 10. Read More

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Multicentre, prospective study on local treatment of metastatic prostate cancer (LoMP study).

BJU Int 2021 Jul 21. Epub 2021 Jul 21.

Department of Urology, Ghent University Hospital, Ghent, Belgium.

Objectives: To investigate the role of cytoreductive radical prostatectomy in addition to standard of care for patients with newly diagnosed metastatic prostate cancer.

Materials And Methods: This multicentre, prospective study included asymptomatic patients from 2014 to 2018 (NCT02138721). Cytoreductive radical prostatectomy was offered to all fit patients with resectable tumours, resulting in 40 patients. Read More

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Plausible Emergence and Self Assembly of a Primitive Phospholipid from Reduced Phosphorus on the Primordial Earth.

Orig Life Evol Biosph 2021 Jul 19. Epub 2021 Jul 19.

Instituto de Astrobiología de Colombia, Bogotá, Colombia.

How life arose on the primitive Earth is one of the biggest questions in science. Biomolecular emergence scenarios have proliferated in the literature but accounting for the ubiquity of oxidized (+ 5) phosphate (PO) in extant biochemistries has been challenging due to the dearth of phosphate and molecular oxygen on the primordial Earth. A compelling body of work suggests that exogenous schreibersite ((Fe,Ni)P) was delivered to Earth via meteorite impacts during the Heavy Bombardment (ca. Read More

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Sclerostin-Mediated Impaired Osteogenesis by Fibroblast-Like Synoviocytes in the Particle-Induced Osteolysis Model.

Front Mol Biosci 2021 23;8:666295. Epub 2021 Jun 23.

Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, South Korea.

Engineered biomaterials are envisioned to replace, augment, or interact with living tissues for improving the functional deformities associated with end-stage joint pathologies. Unfortunately, wear debris from implant interfaces is the major factor leading to periprosthetic osteolysis. Fibroblast-like synoviocytes (FLSs) populate the intimal lining of the synovium and are in direct contact with wear debris. Read More

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Arsenic fate in upper Indus river basin (UIRB) aquifers: Controls of hydrochemical processes, provenances and water-aquifer matrix interaction.

Sci Total Environ 2021 Nov 3;795:148734. Epub 2021 Jul 3.

Department of Geology and Geophysics, Indian Institute of Technology Kharagpur, WB 721302, India.

Major river basins of the Himalayas contain a significant amount of arsenic (As) in the geological matrix, which tends to contaminate the groundwater at a local and regional scale. Although As enrichment in Quaternary deposits has been linked to primary provenances (Himalayan orogeny), limited studies have reported As enrichment in bedrock aquifers. In the present study, the hard rock and groundwater samples were collected across the upper Indus river basin (UIRB), Ladakh to assess the hydrogeochemical processes and environments responsible for As mobilization and release. Read More

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November 2021

Creation of a Pediatric Choledocholithiasis Prediction Model.

J Pediatr Gastroenterol Nutr 2021 Jun 29. Epub 2021 Jun 29.

Division of Pediatric Gastroenterology, Hepatology, and Nutrition. Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA H. Milton School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA Section of Pediatric Surgery, Department of Surgery, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA.

Background: Definitive non-invasive detection of pediatric choledocholithiasis could allow more efficient identification of those patients who are most likely to benefit from therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for stone extraction.

Objective: To craft a pediatric choledocholithiasis prediction model using a combination of commonly available serum laboratory values and ultrasound results.

Methods: A retrospective review of laboratory and imaging results from 316 pediatric patients who underwent intraoperative cholangiogram or ERCP due to suspicion of choledocholithiasis were collected and compared to presence of common bile duct stones on cholangiography. Read More

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Impact of rural versus urban setting on kidney markers: a cross-sectional study in South-Kivu, DRCongo.

BMC Nephrol 2021 Jun 25;22(1):234. Epub 2021 Jun 25.

Department of Nephrology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

Background: Most studies of chronic kidney disease (CKD) in Sub-Saharan Africa (SSA) have been conducted in urban settings. They relied on GFR estimated from serum creatinine alone and on the inexpensive, convenient urinary dipstick to assess proteinuria. The dipstick for proteinuria has not been directly compared with the gold standard albumin-to-creatinine ratio (ACR) in a large-sized study in SSA. Read More

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Strontium-calcium phosphate hybrid cement with enhanced osteogenic and angiogenic properties for vascularised bone regeneration.

J Mater Chem B 2021 Aug;9(30):5982-5997

Institute of Orthopedics and Department of Orthopedics, The First Affiliated Hospital, Soochow University, No. 708 Renmin Road, Suzhou 215006, P. R. China and Center for Health Science and Engineering (CHSE), School of Materials Science and Engineering, Hebei University of Technology, No. 8 Guangrong Road, Tianjin 300130, P. R. China.

Vascularized bone tissue engineering is regarded as one of the optimal treatment options for large bone defects. The lack of angiogenic properties and unsatisfactory physicochemical performance restricts calcium phosphate cement (CPC) from application in vascularized bone tissue engineering. Our previous studies have developed a starch and BaSO4 incorporated calcium phosphate hybrid cement (CPHC) with improved mechanical strength and handling properties. Read More

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A novel degradable tricalcium silicate/calcium polyphosphate/polyvinyl alcohol organic-inorganic composite cement for bone filling.

J Biomater Appl 2021 Jun 9:8853282211020399. Epub 2021 Jun 9.

College of Physical Science and Technology, Sichuan University, Chengdu, P.R. China.

In this study, tricalcium silicate (CS) calcium/polyphosphate/polyvinyl alcohol organic-inorganic self-setting composites were successfully designed. A variety of tests were conducted to characterize their self-setting properties, mechanical properties, degradation properties, and related biological properties. The composite bone cements showed a short setting time (5. Read More

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The Effect of (L.) Less. Tea on Blood Glucose and Lipid Profile in People with Prediabetes: A Randomized Clinical Trial.

J Altern Complement Med 2021 Aug 1;27(8):669-677. Epub 2021 Jun 1.

Department of Preclinical Sciences, Institute of Science, Suranaree University of Technology, Nakhonratchasima, Thailand.

Diabetes mellitus and dyslipidemia are currently increasing dramatically, and conventional medicine in the treatment of them has limited efficacies and serious adverse effects. (L.) Less. Read More

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New identification and significance of Early Cretaceous mafic rocks in the interior South China Block.

Sci Rep 2021 May 31;11(1):11396. Epub 2021 May 31.

Guangxi Institute of Geological Survey, Guangxi Bureau of Geology and Mineral Prospecting and Exploitation, Nanning, 530023, China.

Early Cretaceous mafic rocks are first reported in the northern Guangxi region from the western Qin-Hang belt in the interior South China Block. A systematic investigation of zircon U-Pb dating, whole-rock geochemistry, Sm-Nd isotopes and zircon Hf-O isotopes for these mafic rocks reveals their petrogenesis and the mantle composition as well as a new window to reconstruct lithospheric evolution in interior South China Block during Late Mesozoic. Zircon U-Pb dating yielded ages of 131 ± 2 Ma to 136 ± 2 Ma for diabase and gabbro from Baotan area, indicating the first data for Early Cretaceous mafic magmatism in the western Qing-Hang belt. Read More

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Potential of biomarkers during pharmacological therapy setting for postmenopausal osteoporosis: a systematic review.

J Orthop Surg Res 2021 May 31;16(1):351. Epub 2021 May 31.

Department of Orthopaedic Surgery, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Background: Biochemical markers of bone turnover (BTMs), such as the bone alkaline phosphatase (bALP), procollagen type I N propeptide (PINP), serum cross-linked C-telopeptides of type I collagen (bCTx), and urinary cross-linked N-telopeptides of type I collagen (NTx), are used to manage therapy monitoring in osteoporotic patients. This systematic review analyzed the potential of these BMTs in predicting the clinical outcomes in terms of BMD, t-score, rate of fractures, and adverse events during the therapy setting in postmenopausal osteoporosis.

Methods: All randomized clinical trials (RCTs) reporting data on biomarkers for postmenopausal osteoporosis were accessed. Read More

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Monitoring response to conventional treatment in children with XLH: Value of ALP and Rickets Severity Score (RSS) in a real world setting.

Bone 2021 10 28;151:116025. Epub 2021 May 28.

Royal Manchester Children's Hospital, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Introduction: X-linked hypophosphataemia (XLH) is conventionally managed with oral phosphate and active vitamin D analogues.

Objectives: To evaluate long term treatment response by assessing biochemical disease activity [serum alkaline phosphatase (ALP)], radiological rickets severity score (RSS), growth and morbidity in patients with XLH on conventional therapy and assess the correlation between serum ALP and RSS.

Methods: XLH patients from 3 UK tertiary centres with ≥3 radiographs one year apart were included. Read More

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October 2021

Sarcoidosis Masquerading as Long-Standing Cholestasis.

Gastroenterology Res 2021 Apr 21;14(2):112-115. Epub 2021 Apr 21.

Division of Gastroenterology, Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, MI, USA.

Hepatic sarcoidosis is an exceedingly rare extrapulmonary manifestation of sarcoidosis, with the majority remaining stable for years without clinical clues, only displaying biochemical abnormalities. Amongst the literature, the timeline to cirrhosis has not been parsed out; hepatomegaly develops in 50% and cirrhosis in 33% of all hepatic sarcoidosis patients, making this an essential issue in this patient population. Interestingly, the risk for hepatocellular carcinoma remains high regardless of cirrhosis development. Read More

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Physicochemical properties and effect of bioceramic root canal filling for primary teeth on osteoblast biology.

J Appl Oral Sci 2021 3;29:e20200870. Epub 2021 May 3.

Universidade Estadual Paulista "Julio de Mesquita Fillho" (UNESP) - Faculdade de Odontologia de Araraquara - Departamento de Odontologia Restauradora - Araraquara - SP - Brasil.

Objective: Bio-C Pulpecto (Bio-CP) was recently developed as the first bioceramic root filling material for primary teeth. To evaluate the physicochemical properties of radiopacity, setting time, pH, cytocompatibility and potential of Bio-CP to induce mineralisation, compared with (1) Calen thickened with zinc oxide (Calen-ZO), and (2) zinc oxide and eugenol (ZOE).

Methodology: Physicochemical properties were evaluated according to ISO 6876. Read More

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Zircon U-Pb chronology on plutonic rocks from northeastern Cambodia.

Heliyon 2021 Apr 15;7(4):e06752. Epub 2021 Apr 15.

Geochemical Research Center, Graduate School of Science, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0064, Japan.

Zircon U-Pb geochronology was carried out on plutonic rocks from Phnom Daek, Phnom Koy Rmeas, Svay Chras, Kon Mom, Koh Nheak, Andong Meas, Oyadav South, Svay Leu, and Phnom Soporkaley. The zircon U-Pb ages from the plutonic rocks determined in this study can be roughly divided into two groups. One is the Late Permian to Triassic ages of 278-202 Ma for the Phnom Daek, Phnom Koy Rmeas, Oyadav South, Svay Leu, and Phnom Soporkaley, and the other is the early Cretaceous ages of 118-98 Ma for the Svay Chras, Kon Mom, Koh Nheak, and Andong Meas samples. Read More

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Tetracalcium Phosphate/Monetite/Calcium Sulfate Hemihdrate Biocement Powder Mixtures Prepared by the One-Step Synthesis for Preparation of Nanocrystalline Hydroxyapatite Biocement-Properties and In Vitro Evaluation.

Materials (Basel) 2021 Apr 22;14(9). Epub 2021 Apr 22.

Department of Functional and Hybrid Materials, Institute of Materials Research of SAS, Watsonova 47, 04 001 Kosice, Slovakia.

A modified one-step process was used to prepare tetracalcium phosphate/monetite/calcium sulfate hemihydrate powder cement mixtures (CAS). The procedure allowed the formation of monetite and calcium sulfate hemihydrate (CSH) in the form of nanoparticles. It was hypothesized that the presence of nanoCSH in small amounts enhances the in vitro bioactivity of CAS cement in relation to osteogenic gene markers in mesenchymal stem cells (MSCs). Read More

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Positive Influence of Liquid Sodium Silicate on the Setting Time, Polymerization, and Strength Development Mechanism of MSWI Bottom Ash Alkali-Activated Mortars.

Materials (Basel) 2021 Apr 12;14(8). Epub 2021 Apr 12.

School of Mechanics and Civil Engineering, China University of Mining and Technology, Xuzhou 21116, No 1, Daxue Road, Xuzhou 221116, China.

Setting time and mechanical properties are key metrics needed to assess the properties of municipal solid waste incineration (MSWI) bottom ash alkali-activated samples. This study investigated the solidification law, polymerization, and strength development mechanism in response to NaOH and liquid sodium silicate addition. Scanning electron microscopy and X-ray diffraction were used to identify the formation rules of polymerization products and the mechanism of the underlying polymerization reaction under different excitation conditions. Read More

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Setting Time and Strength Monitoring of Alkali-Activated Cement Mixtures by Ultrasonic Testing.

Materials (Basel) 2021 Apr 10;14(8). Epub 2021 Apr 10.

Structural Concrete Institute (IfB), Leipzig University of Applied Sciences (HTWK Leipzig), Karl-Liebknecht-Str. 132, 04277 Leipzig, Germany.

Alkali-activated cement (AAC) is a promising binder that replaces ordinary Portland cement (OPC). In this study, the development of setting time and strength of AAC mixes were studied using ultrasonic testing method. The test results were compared with traditional Vicat setting time and compressive and flexural strengths. Read More

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Effect of Apabetalone on Cardiovascular Events in Diabetes, CKD, and Recent Acute Coronary Syndrome: Results from the BETonMACE Randomized Controlled Trial.

Clin J Am Soc Nephrol 2021 05 27;16(5):705-716. Epub 2021 Apr 27.

Imperial Centre for Cardiovascular Disease Prevention, Imperial College, London, United Kingdom.

Background And Objectives: CKD and type 2 diabetes mellitus interact to increase the risk of major adverse cardiovascular events (, cardiovascular death, nonfatal myocardial infarction, or stroke) and congestive heart failure. A maladaptive epigenetic response may be a cardiovascular risk driver and amenable to modification with apabetalone, a selective modulator of the bromodomain and extraterminal domain transcription system. We examined this question in a prespecified analysis of BETonMACE, a phase 3 trial. Read More

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The Pathologic Fracture Mortality Index: A Novel Externally Validated Tool for Predicting 30-day Postoperative Mortality.

J Am Acad Orthop Surg 2021 Apr 13. Epub 2021 Apr 13.

From the Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

Introduction: Current mortality predictive tools, in the setting of completed or impending pathologic fractures, are nonspecific. Clinical decision making and mortality prediction in research would benefit from creation of a high-fidelity scoring system for calculating the risk of 30-day postoperative mortality. The purpose of this study is to develop a validated research and clinical tool that is superior to existing methods in estimating postoperative mortality risk after fixation of pathologic fractures. Read More

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Oxidized sulfur-rich arc magmas formed porphyry Cu deposits by 1.88 Ga.

Nat Commun 2021 Apr 13;12(1):2189. Epub 2021 Apr 13.

Canadian Centre for Isotopic Microanalysis, University of Alberta, Edmonton, AB, Canada.

Most known porphyry Cu deposits formed in the Phanerozoic and are exclusively associated with moderately oxidized, sulfur-rich, hydrous arc-related magmas derived from partial melting of the asthenospheric mantle metasomatized by slab-derived fluids. Yet, whether similar metallogenic processes also operated in the Precambrian remains obscure. Here we address the issue by investigating the origin, fO, and S contents of calc-alkaline plutonic rocks associated with the Haib porphyry Cu deposit in the Paleoproterozoic Richtersveld Magmatic Arc (southern Namibia), an interpreted mature island-arc setting. Read More

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