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A Reinforcement Learning-Based Framework for Crowdsourcing in Massive Health Care Internet of Things.

Big Data 2021 Jul 28. Epub 2021 Jul 28.

Department of Electrical Engineering, Yeungnam University, Gyeongsan, Republic of Korea.

Rapid advancements in the internet of things (IoT) are driving massive transformations of health care, which is one of the largest and critical global industries. Recent pandemics, such as coronavirus 2019 (COVID-19), include increasing demands for ubiquitous, preventive, and personalized health care to be provided to the public at reduced risks and costs with rapid care. Mobile crowdsourcing could potentially meet the future massive health care IoT (mH-IoT) demands by enabling anytime, anywhere sense and analyses of health-related data to tackle such a pandemic situation. Read More

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Robust joint modelling of longitudinal and survival data: Incorporating a time-varying degrees-of-freedom parameter.

Biom J 2021 Jul 28. Epub 2021 Jul 28.

Department of Statistics, Lund University, Lund, Sweden.

Monitoring of individual biomarkers has the potential of explaining the hazard of survival outcomes. In practice, these measurements are intermittently observed and are known to be subject to substantial measurement error. Joint modelling of longitudinal and survival data enables us to associate intermittently measured error-prone biomarkers with risks of survival outcomes and thus plays an important role in the analysis of medical data. Read More

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Review of control strategies for lower-limb exoskeletons to assist gait.

J Neuroeng Rehabil 2021 Jul 27;18(1):119. Epub 2021 Jul 27.

Biorobotics laboratory (BioRob), EPFL, Lausanne, Switzerland.

Background: Many lower-limb exoskeletons have been developed to assist gait, exhibiting a large range of control methods. The goal of this paper is to review and classify these control strategies, that determine how these devices interact with the user.

Methods: In addition to covering the recent publications on the control of lower-limb exoskeletons for gait assistance, an effort has been made to review the controllers independently of the hardware and implementation aspects. Read More

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Short and long-run causal effects of agriculture, forestry, and other land use on greenhouse gas emissions: evidence from China using VECM approach.

Environ Sci Pollut Res Int 2021 Jul 26. Epub 2021 Jul 26.

OYAGSB, Universiti Utara Malaysia, Sintok, Malaysia.

Climate change caused by different anthropogenic activities is a subject of attention globally. There is a concern on how to maintain a clean environment and at the same time achieve optimal use of land. To this end, this study examines the causal effects of land use including agricultural, forestry, and other land categories on greenhouse gas (GHG) emissions. Read More

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Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation.

Nat Immunol 2021 Aug 26;22(8):1008-1019. Epub 2021 Jul 26.

Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.

Exhausted CD8 T cells (T) are a distinct state of T cell differentiation associated with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade can reinvigorate T cells, but reinvigoration is not durable. A major unanswered question is whether T cells differentiate into functional durable memory T cells (T) upon antigen clearance. Read More

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Detection of Cholera Toxin with Surface Plasmon-Field Enhanced Fluorescent Spectroscopy (SPFS).

Biotechnol Appl Biochem 2021 Jul 23. Epub 2021 Jul 23.

Department of Material Science and Engineering, Gebze Technical University, Kocaeli, Turkey.

In this work, a biosensor based on Surface Plasmon-Field Enhanced Florescence Spectroscopy (SPFS) method was successfully constructed to detect the truncated form of cholera toxin, i.e., its beta subunit (CTX-B). Read More

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Quantification of tumor microenvironment acidity in glioblastoma using principal component analysis of dynamic susceptibility contrast enhanced MR imaging.

Sci Rep 2021 Jul 22;11(1):15011. Epub 2021 Jul 22.

Department of Radiology, Perelman School of Medicine, Hospital of University of Pennsylvania, University of Pennsylvania, Philadelphia, PA, USA.

Glioblastoma (GBM) has high metabolic demands, which can lead to acidification of the tumor microenvironment. We hypothesize that a machine learning model built on temporal principal component analysis (PCA) of dynamic susceptibility contrast-enhanced (DSC) perfusion MRI can be used to estimate tumor acidity in GBM, as estimated by pH-sensitive amine chemical exchange saturation transfer echo-planar imaging (CEST-EPI). We analyzed 78 MRI scans in 32 treatment naïve and post-treatment GBM patients. Read More

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High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro.

Sci Rep 2021 07 22;11(1):14961. Epub 2021 Jul 22.

Bioengineering Division, Draper, Cambridge, MA, 02139, USA.

Influenza and other respiratory viruses present a significant threat to public health, national security, and the world economy, and can lead to the emergence of global pandemics such as from COVID-19. A barrier to the development of effective therapeutics is the absence of a robust and predictive preclinical model, with most studies relying on a combination of in vitro screening with immortalized cell lines and low-throughput animal models. Here, we integrate human primary airway epithelial cells into a custom-engineered 96-device platform (PREDICT96-ALI) in which tissues are cultured in an array of microchannel-based culture chambers at an air-liquid interface, in a configuration compatible with high resolution in-situ imaging and real-time sensing. Read More

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[2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-d-glucoside alleviates lipopolysaccharide-induced acute lung injury in rats].

Authors:
J Chen H Liu

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jul;41(7):1101-1106

Department of General Practice, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510030, China.

Objective: To observe the protective effect of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-d-glucoside (TSG) against lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats and explore the underlying mechanism.

Methods: Thirty-six SD rats were randomized equally into 4 groups: the normal control group, ALI model group, and low- and high-dose TSG groups (treated with 50 and 100 mg/kg TSG via intragastric administration, respectively). In all but the normal control group, the rats were subjected to tail vein injection of LPS to induced ALI. Read More

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Community radio-based blended learning model: A promising learning model in remote area during pandemic era.

Heliyon 2021 Jul 9;7(7):e07511. Epub 2021 Jul 9.

Universitas Ahmad Dahlan, Jl. Kapas 9, Semaki, Umbulharjo, Yogyakarta, Indonesia.

The COVID-19 pandemic is a big challenge for education worldwide because education has to be done virtually to stop the spread of the COVID-19. The problem is that there are students who live in areas far from cities, while learning in an interconnected world should be done virtually. Diverse geographical conditions in Indonesia consisting of mountains, lowlands, highlands, and valleys and some areas that are far away from cities make students difficult to connect to the internet and thus, virtual teaching is challenging. Read More

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Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation.

Front Cell Dev Biol 2021 8;9:676789. Epub 2021 Jul 8.

College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.

The dairy cattle suffer from severe liver dysfunction during the pathogenesis of ketosis. The Ufm1 conjugation system is crucial for liver development and homeostasis. Ufm1 binding protein (Ufbp1) is a putative Ufm1 target and an integral component, but its role in ketosis-induced liver injury is unclear so far. Read More

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Phenylethanoid Glycosides From Callicarpa kwangtungensis Chun Attenuate TNF-α-Induced Cell Damage by Inhibiting NF-κB Pathway and Enhancing Nrf2 Pathway in A549 Cells.

Front Pharmacol 2021 7;12:693983. Epub 2021 Jul 7.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.

Acute lung injury (ALI) is a complicated and severe lung disease, which is often characterized by acute inflammation. Poliumoside (POL), acteoside (ACT) and forsythiaside B (FTB) are phenylethanoid glycosides (PGs) with strong antioxidant, anti-inflammatory, and anti-apoptotic properties, which are extracted from (CK). The aim of this study was to investigate the protective effects of POL, ACT, and FTB against TNF-α-induced damage using an ALI cell model and explore their potential mechanisms. Read More

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Rat model of smoke inhalation-induced acute lung injury.

BMJ Open Respir Res 2021 Jul;8(1)

Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA

Background: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a lethal disease with limited therapeutic options and an unacceptably high mortality rate. Understanding the complex pathophysiological processes involved in the development of ALI/ARDS is critical for developing novel therapeutic strategies. Smoke inhalation (SI) injury is the leading cause of morbidity and mortality in patients with burn-associated ALI/ARDS; however, to our knowledge few reliable, reproducible models are available for pure SI animal model to investigate therapeutic options for ALI/ARDS without the confounding variables introduced by cutaneous burn or other pathology. Read More

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Real Time Multipurpose Smart Waste Classification Model for Efficient Recycling in Smart Cities Using Multilayer Convolutional Neural Network and Perceptron.

Sensors (Basel) 2021 Jul 19;21(14). Epub 2021 Jul 19.

Department of Biocybernetics and Biomedical Engineering, Faculty of Electrical Engineering, Automatics, Computer Science and Biomedical Engineering, AGH University of Science and Technology, al. A. Mickiewicza 30, 30-059 Kraków, Poland.

Urbanization is a big concern for both developed and developing countries in recent years. People shift themselves and their families to urban areas for the sake of better education and a modern lifestyle. Due to rapid urbanization, cities are facing huge challenges, one of which is waste management, as the volume of waste is directly proportional to the people living in the city. Read More

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Psychosocial Work Environment and Teachers' Psychological Well-Being: The Moderating Role of Job Control and Social Support.

Int J Environ Res Public Health 2021 Jul 8;18(14). Epub 2021 Jul 8.

Faculty of Business, Economics and Social Development, Universiti Malaysia Terengganu, Kuala Nerus 21030, Terengganu, Malaysia.

Nowadays, the issue of teachers' psychological well-being causes serious concern, especially in Malaysia. Many studies related to psychological well-being have focused on students rather than on the health and well-being of teachers. Thus, the current study investigated the determinants of psychological well-being (depression, anxiety and stress) from the psychosocial work environment (job control, job demands and social support), and examined the moderating role of job control and social support in the relationship between job demands and psychological well-being among teachers. Read More

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Contribution of Heparan Sulphate Binding in CCL21-Mediated Migration of Breast Cancer Cells.

Cancers (Basel) 2021 Jul 10;13(14). Epub 2021 Jul 10.

Theme-Immunity and Inflammation, Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, 3rd Floor Leech Building, Newcastle upon Tyne NE2 4HH, UK.

Chemokine receptor CCR7 is implicated in the metastasis of breast cancer to the lymph nodes. Chemokine function is dependent upon their binding to both cell-surface heparan sulphate (HS) and to their specific receptors; thus, the role of HS in CCR7-mediated lymph node metastasis was investigated by creating a non-HS binding chemokine CCL21 (mut-CCL21). Mut-CCL21 (Δ103-134) induced leukocyte chemotaxis in diffusion gradients but did not stimulate trans-endothelial migration of PBMCs ( < 0. Read More

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The effect of FTY720 at different doses and time-points on LPS-induced acute lung injury in rats.

Int Immunopharmacol 2021 Jul 20;99:107972. Epub 2021 Jul 20.

North Sichuan Medical College, Nanchong, China. Electronic address:

We sought to assess the protective effect of different doses of Fingolimod (FTY720) in a rat model of acute lung injury (ALI) induced by intratracheal instillation of lipopolysaccharide (LPS) and explored the underlying mechanisms. The ALI model was established in rats and different doses of FTY720 (0.1 mg/kg, 0. Read More

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A Predictive Model for Progression of CKD to Kidney Failure Based on Routine Laboratory Tests.

Am J Kidney Dis 2021 Jul 11. Epub 2021 Jul 11.

Chair and Institute of Functional Genomics, University of Regensburg, Regensburg, Germany. Electronic address:

Rationale & Objective: Stratification of chronic kidney disease (CKD) patients at risk for progressing to end-stage kidney disease (ESKD) requiring kidney replacement therapy (KRT) is important for clinical decision-making and trial enrollment.

Study Design: Four independent prospective observational cohort studies.

Setting & Participants: The development cohort was comprised of 4,915 CKD patients and three independent validation cohorts were comprised of a total of 3,063. Read More

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Identification of inflammation related lncRNAs and Gm33647 as a potential regulator in septic acute lung injury.

Life Sci 2021 Jul 21;282:119814. Epub 2021 Jul 21.

Department of Critical Care Medicine, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, PR China. Electronic address:

Sepsis is commonly complicated by acute lung injury (ALI). We aimed to determine the long non-coding RNAs (lncRNAs) and mRNAs expression profiles. Septic acute lung injury mouse model was established by cecal ligation and puncture. Read More

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MicroRNA-495/TGF-β/FOXC1 axis regulates multidrug resistance in metaplastic breast cancer cells.

Biochem Pharmacol 2021 Jul 20:114692. Epub 2021 Jul 20.

Division of Cancer, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom. Electronic address:

Triple-negative metaplastic breast carcinoma (MBC) poses a significant treatment challenge due to lack of targeted therapies and chemotherapy resistance. We isolated a novel MBC cell line, BAS, which showed a molecular and phenotypic profile different from the only other metaplastic cell model, HS578T cells. To gain insight behind chemotherapeutic resistance, we generated doxorubicin (HS-DOX, BAS-DOX) and paclitaxel (HS-TX, BAS-TX) resistant derivatives of both cell lines. Read More

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Efficacy and safety of N-acetylcysteine for the treatment of non-acetaminophen-induced acute liver failure: an updated systematic review and meta-analysis.

Clin Exp Hepatol 2021 Jun 30;7(2):156-164. Epub 2021 Jun 30.

Medical Unit 1, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.

Aim Of The Study: N-acetylcysteine (NAC) is the treatment of choice for acetaminophen-induced liver injury. However, recent years have witnessed growing interest in its role in the treatment of acute liver failure (ALF) due to other aetiologies. This study aims to determine both its safety and efficacy by pooling data from multiple studies. Read More

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Cancer mortality in a population-based cohort of American Indians - The strong heart study.

Cancer Epidemiol 2021 Jul 19;74:101978. Epub 2021 Jul 19.

MedStar Health Research Institute, 6525 Belcrest Road, Suite 700, Hyattsville, MD, 20782, USA; Georgetown, Howard Universities Center for Clinical and Translational Research, Washington, DC, 2000, USA. Electronic address:

Background: Cancer mortality among American Indian (AI) people varies widely, but factors associated with cancer mortality are infrequently assessed.

Methods: Cancer deaths were identified from death certificate data for 3516 participants of the Strong Heart Study, a population-based cohort study of AI adults ages 45-74 years in Arizona, Oklahoma, and North and South Dakota. Cancer mortality was calculated by age, sex and region. Read More

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DBP-GAPred: An intelligent method for prediction of DNA-binding proteins types by enhanced evolutionary profile features with ensemble learning.

J Bioinform Comput Biol 2021 Jul 21:2150018. Epub 2021 Jul 21.

Department of Computer Science, Abdul Wali Khan University Mardan, Pakistan.

DNA-binding proteins (DBPs) perform an influential role in diverse biological activities like DNA replication, slicing, repair, and transcription. Some DBPs are indispensable for understanding many types of human cancers (i.e. Read More

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Clustered regularly interspaced short palindromic repeats as an advanced treatment for Parkinson's disease.

Brain Behav 2021 Jul 21. Epub 2021 Jul 21.

Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, P. R. China.

Recently, genome-editing technology like clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 has improved the translational gap in the treatments mediated through gene therapy. The advantages of the CRISPR system, such as, work in the living cells and tissues, candidate this technique for the employing in experiments and the therapy of central nervous system diseases. Parkinson's disease (PD) is a widespread, disabling, neurodegenerative disease induced by dopaminergic neuron loss and linked to progressive motor impairment. Read More

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Qualification of Soybean Responses to Flooding Stress Using UAV-Based Imagery and Deep Learning.

Plant Phenomics 2021 28;2021:9892570. Epub 2021 Jun 28.

Division of Plant Sciences, University of Missouri, Columbia, MO 65211, USA.

Soybean is sensitive to flooding stress that may result in poor seed quality and significant yield reduction. Soybean production under flooding could be sustained by developing flood-tolerant cultivars through breeding programs. Conventionally, soybean tolerance to flooding in field conditions is evaluated by visually rating the shoot injury/damage due to flooding stress, which is labor-intensive and subjective to human error. Read More

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A novel microphysiological colon platform to decipher mechanisms driving human intestinal permeability.

Cell Mol Gastroenterol Hepatol 2021 Jul 17. Epub 2021 Jul 17.

Emulate Inc., 27 Drydock Avenue, Boston, MA, 02210, USA. Electronic address:

Background & Aims: The limited availability of organoid systems that mimic the molecular signatures and architecture of human intestinal epithelium has been an impediment to allowing them to be harnessed for the development of therapeutics as well as physiological insights. We developed a microphysiological Organ-on-Chip platform designed to mimic properties of human intestinal epithelium leading to insights into barrier integrity.

Methods: We combined the human biopsy-derived LGR5+ organoids and Organ-on-Chip technologies to establish a micro-engineered human Colon Intestine-Chip. Read More

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An Efficient Dynamic-Decision Based Task Scheduler for Task Offloading Optimization and Energy Management in Mobile Cloud Computing.

Sensors (Basel) 2021 Jul 1;21(13). Epub 2021 Jul 1.

Department of Computer Engineering, Jeju National University, Jeju 63243, Korea.

Restricted abilities of mobile devices in terms of storage, computation, time, energy supply, and transmission causes issues related to energy optimization and time management while processing tasks on mobile phones. This issue pertains to multifarious mobile device-related dimensions, including mobile cloud computing, fog computing, and edge computing. On the contrary, mobile devices' dearth of storage and processing power originates several issues for optimal energy and time management. Read More

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Chitosan/activated coal composite as an effective adsorbent for Mn(VII): Modeling and interpretation of physicochemical parameters.

Int J Biol Macromol 2021 Jul 16;186:750-758. Epub 2021 Jul 16.

Faculty of Earth Science, Beni-Suef University, Egypt. Electronic address:

Chitosan was impregnated into porous activated coal to produce a multifunctional chitosan/activated coal (Cs/Ac) composite. The resulted Cs/Ac was characterized and utilized as a cost-effective adsorbent for Mn(VII) at altered temperatures (i.e. Read More

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Thymus Vulgaris Inhibit Lung Fibrosis Progression and Oxidative Stress Induced by Bleomycin in Wistar Rats.

Nutr Cancer 2021 Jul 19:1-11. Epub 2021 Jul 19.

Laboratory of Physiology, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating and fatal disease characterized by aberrant fibroblasts proliferation, oxidative stress and collagen accumulation in the interstitial tissue. We aimed to evaluate in the present study the efficacy of Thymus vulagris extract (TVE) on an experimental model of pulmonary fibrosis induced by bleomycin (BLM). Wistar rats were given a single dose of BLM (4 mg/kg, intratracheal), while TVE (50, 100 and 200 mg/kg, intraperitoneal) was administered 3 days later and continued for 4 weeks. Read More

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Protective effect of taurine on sepsis‑induced lung injury via inhibiting the p38/MAPK signaling pathway.

Mol Med Rep 2021 Sep 19;24(3). Epub 2021 Jul 19.

Department of Critical Care Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu 211100, P.R. China.

Sepsis, a leading cause of acute lung injury (ALI), is characterized by an overwhelming systemic inflammatory response and widespread organ injury, particularly in the lungs. Taurine, an intracellular free amino acid, has been used for the treatment of various diseases, including lung injury; however, the underlying mechanisms are unclear. The present study aimed to investigate the protective effect of taurine on septic ALI and the underlying mechanism. Read More

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September 2021