3,084 results match your criteria alginate hydrogels


Efficient heavy metal removal from water by alginate-based porous nanocomposite hydrogels: The enhanced removal mechanism and influencing factor insight.

J Hazard Mater 2021 Jun 8;418:126358. Epub 2021 Jun 8.

School of Hydraulic Engineering, Changsha University of Science & Technology, Changsha 410114, China; Key Laboratory of Dongting Lake Aquatic Eco-Environmental Control and Restoration of Hunan Province, Changsha 410114, China. Electronic address:

Novel porous alginate-based nanocomposite hydrogels were prepared by incorporating polyaniline-polypyrrole modified graphene oxide ([email protected]) as reinforcing fillers into the alginate matrix ([email protected]/SA) for Cr(VI) and Cu(II) removal from water. Different in-situ co-polymerization functionalized GO with Py-to-An mass ratios of monomers (from nil to 1:1) and contents of [email protected] (from nil to 2.0%(w/v)) were embedded into the alginate backbone to improve the sorption performance. Read More

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One-pot synthesis of sodium alginate-grafted-terpolymer hydrogel for As(III) and V(V) removal: In situ anchored comonomer and DFT studies on structures.

J Environ Manage 2021 Jun 12;294:112932. Epub 2021 Jun 12.

Advanced Polymer Laboratory, Department of Polymer Science and Technology, Government College of Engineering and Leather Technology (Post-Graduate), Maulana Abul Kalam Azad University of Technology, Salt Lake, Kolkata 700106, West Bengal, India. Electronic address:

In this work, an optimum sodium alginate (NaAlg)-grafted-[sodium 2-methylenesuccinate-co-sodium 2-((2-(isobutyryloxy)ethoxy)methyl)succinate-co-ethylene glycol methacrylate, i.e., SMS-co-SIBEMS-co-EGMA, i. Read More

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Alginate/cartilage extracellular matrix-based injectable interpenetrating polymer network hydrogel for cartilage tissue engineering.

J Biomater Appl 2021 Jun 14:8853282211024020. Epub 2021 Jun 14.

Polymer Technology, School of Chemical Engineering, Aalto University, Espoo, Finland.

In the present study, alginate/cartilage extracellular matrix (ECM)-based injectable hydrogel was developed incorporated with silk fibroin nanofibers (SFN) for cartilage tissue engineering. The forming hydrogels were composed of different ionic crosslinked alginate concentrations with 1% w/v enzymatically crosslinked phenolized cartilage ECM, resulting in an interpenetrating polymer network (IPN). The response surface methodology (RSM) approach was applied to optimize IPN hydrogel's mechanical properties by varying alginate and SFN concentrations. Read More

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Preparation of covalently bonded silica-alginate hybrid hydrogels by SCHIFF base and sol-gel reactions.

Carbohydr Polym 2021 Sep 10;267:118186. Epub 2021 May 10.

Dept. Polymeric Nanomaterials and Biomaterials, ICTP-CSIC, Madrid, Spain. Electronic address:

Organic-inorganic hybrid materials overcome drawbacks associated with alginate hydrogels. In this work, covalently coupled silica-alginate hybrids were prepared by Schiff base formation and sol-gel reaction using alginate dialdehyde (ADA), (3-Aminopropyl) triethoxysilane (APTES), and APTES/tetraethylorthosilicate (TEOS) precursors. The influence of the polysaccharide/inorganic ratio, the nature of the inorganic precursor and the ionic crosslinking ability are studied. Read More

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September 2021

Nanocomposite hydrogel based on sodium alginate, poly (acrylic acid), and tetraamminecopper (II) sulfate as an efficient dye adsorbent.

Carbohydr Polym 2021 Sep 8;267:118182. Epub 2021 May 8.

Department of Chemistry, Faculty of Science, Imam Khomeini International University, P.O. Box 288, Qazvin, Iran. Electronic address:

In this study, a novel nanocomposite hydrogel (NCH) was prepared by in situ crosslinking and radical polymerization of acrylic acid (AA) in the presence of sodium alginate (Na-Alg), followed by loading of Cu ions and reaction with ammonia. The main advantage of the synthesized NCH is the high adsorption of dye due to the large contact area. The structure of the NCH was studied by FT-IR spectroscopy, TEM, and SEM. Read More

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September 2021

Ultrafast in-situ forming halloysite nanotube-doped chitosan/oxidized dextran hydrogels for hemostasis and wound repair.

Carbohydr Polym 2021 Sep 11;267:118155. Epub 2021 May 11.

Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, China; Guangdong Key Lab of Orthopedic Technology and Implant Materials, General Hospital of Southern Theater Command of PLA, The First School of Clinical Medicine of Southern Medical University, Guangzhou 510010, China. Electronic address:

A series of halloysite nanotube (HNT)-doped chitosan (CS)/oxidized dextran (ODEX) adhesive hydrogels were developed through a Schiff base reaction. The resultant CS/ODEX/HNT hydrogels could not only form in situ on wounds within only 1 s when injected, but could also adapt to wounds of different shapes and depths after injection. We established four rat and rabbit hemorrhage models and demonstrated that the hydrogels are better than the clinically used gelatin sponge for reducing hemostatic time and blood loss, particularly in arterial and deep noncompressible bleeding wounds. Read More

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September 2021

Highly absorbent hydrogels comprised from interpenetrated networks of alginate-polyurethane for biomedical applications.

J Mater Sci Mater Med 2021 Jun 12;32(6):70. Epub 2021 Jun 12.

Universidad Politécnica de Pénjamo, Carretera Irapuato - La Piedad Km 44, Pénjamo, 36921, Guanajuato, México.

Developing new approaches to improve the swelling, degradation rate, and mechanical properties of alginate hydrogels without compromising their biocompatibility for biomedical applications represents a potential area of research. In this work, the generation of interpenetrated networks (IPN) comprised from alginate-polyurethane in an aqueous medium is proposed to design hydrogels with tailored properties for biomedical applications. Aqueous polyurethane (PU) dispersions can crosslink and interpenetrate alginate chains, forming amide bonds that allow the structure and water absorption capacity of these novel hydrogels to be regulated. Read More

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Anisotropically Fatigue-Resistant Hydrogels.

Adv Mater 2021 Jun 10:e2102011. Epub 2021 Jun 10.

Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.

Nature builds biological materials from limited ingredients, however, with unparalleled mechanical performances compared to artificial materials, by harnessing inherent structures across multi-length-scales. In contrast, synthetic material design overwhelmingly focuses on developing new compounds, and fails to reproduce the mechanical properties of natural counterparts, such as fatigue resistance. Here, a simple yet general strategy to engineer conventional hydrogels with a more than 100-fold increase in fatigue thresholds is reported. Read More

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Manganese silicate nanospheres-incorporated hydrogels:starvation therapy and tissue regeneration.

Bioact Mater 2021 Dec 15;6(12):4558-4567. Epub 2021 May 15.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai, 200050, China.

To prevent postoperative skin tumor recurrence and repair skin wound, a glucose oxidase (GOx)-loaded manganese silicate hollow nanospheres (MS HNSs)-incorporated alginate hydrogel (G/MS-SA) was constructed for starvation-photothermal therapy and skin tissue regeneration. The MS HNSs showed a photothermal conversion efficiency of 38.5%, and endowed composite hydrogels with satisfactory photothermal effect. Read More

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December 2021

Colorimetric ammonia (NH) sensor based on an alginate-methylcellulose blend hydrogel and the potential opportunity for the development of a minced pork spoilage indicator.

Food Chem 2021 May 18;362:130151. Epub 2021 May 18.

Division of Packaging Technology, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand.

Hydrogels based on alginate and methylcellulose were developed as a colorimetric indicator for monitoring minced pork spoilage. The hydrogel was fabricated by an external gelation method using Ca as the crosslinking agent. The pH-sensitive dye bromothymol blue was incorporated into the hydrogel to act as an indicator. Read More

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Marine polysaccharide-based composite hydrogels containing fucoidan: Preparation, physicochemical characterization, and biocompatible evaluation.

Int J Biol Macromol 2021 Jun 1;183:1978-1986. Epub 2021 Jun 1.

Institute for Translational Medicine, Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266003, China; School of Stomatology, Qingdao University, Qingdao 266003, China. Electronic address:

Marine polysaccharide-based hydrogels have drawn much attention for diversified biomedical applications owing to their excellent (bio)physicochemical properties. In the present work, a series of marine polysaccharide-based hydrogels composed of chitosan, alginate, or fucoidan are prepared via a facile chemical cross-linking approach in an alkali/urea aqueous system. The prepared hydrogels possess tunable microporous architecture, swelling, and biodegradable properties by changing the components and proportions of marine polysaccharides. Read More

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Bioactive nanoparticle reinforced alginate/gelatin bioink for the maintenance of stem cell stemness.

Mater Sci Eng C Mater Biol Appl 2021 Jul 19;126:112193. Epub 2021 May 19.

Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department, PLA General Hospital, 51 Fu Cheng Road, Beijing 100048, PR China. Electronic address:

Mesenchymal cells (MSCs) are an attractive option as seed cells for bioprinting. However, loss of stemness and undesired differentiation reduces their effectiveness. In this study, 12 nm bioactive nanoparticles (BNPs) which could release silicon (Si) ions were used to enhance the properties of alginate/gelatin hydrogel bioink to maintain MSC stemness. Read More

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Improved drug delivery and accelerated diabetic wound healing by chondroitin sulfate grafted alginate-based thermoreversible hydrogels.

Mater Sci Eng C Mater Biol Appl 2021 Jul 14;126:112169. Epub 2021 May 14.

Department of Pharmacy, COMSATS University, Islamabad, Abbottabad Campus, 22010, Pakistan.

Injectable hydrogels with multifunctional tunable properties comprising biocompatibility, anti-oxidative, anti-bacterial, and/or anti-infection are highly preferred to efficiently promote diabetic wound repair and its development remains a challenge. In this study, we report chondroitin sulphate (CS) and sodium alginate (SA)-based injectable hydrogel using solvent casting method loaded with curcumin that could potentiate reepithelization, increase angiogenesis, and collagen deposition at wound microenvironment to endorse healing cascade. The physical interaction and self-assembly of chondroitin sulfate grafted alginate (CS-Alg-g-PF127) hydrogel were confirmed using nuclear magnetic resonance (H NMR) and Fourier transformed infrared spectroscopy (FT-IR), and cytocompatibility was confirmed by fibroblast viability assay. Read More

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Bio-functional strontium-containing photocrosslinked alginate hydrogels for promoting the osteogenic behaviors.

Mater Sci Eng C Mater Biol Appl 2021 Jul 24;126:112130. Epub 2021 Apr 24.

Hubei Tumor Biological Behavior Key Laboratory, Center of stomatology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China. Electronic address:

In recent years, photocrosslinked alginate hydrogel has been widely studied in bone tissue engineering, owing to its numerous advantages. However, there are still some shortcomings like insufficient mechanical strength and lack of bone induction. To compensate for these deficiencies, in this work, a novel doped strontium (Sr) photocrosslinked methacrylated alginate (Sr-PMA) hydrogel was developed. Read More

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RGD-Modified Alginate-GelMA Hydrogel Sheet Containing Gingival Mesenchymal Stem Cells: A Unique Platform for Wound Healing and Soft Tissue Regeneration.

ACS Biomater Sci Eng 2021 Jun 3. Epub 2021 Jun 3.

Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, California 90095, United States.

Soft tissue reconstruction has remained a major clinical challenge in dentistry and regenerative medicine. Although current methods have shown partial success, there are several disadvantages associated with these approaches. Gingival mesenchymal stem cells (GMSCs) can be simply obtained in the oral cavity for soft tissue augmentation. Read More

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Double network laminarin-boronic/alginate dynamic bioink for 3D bioprinting cell-laden constructs.

Biofabrication 2021 May 28;13(3). Epub 2021 May 28.

CICECO-Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.

The design of dynamically crosslinked hydrogel bioinks for three-dimensional (3D) bioprinting is emerging as a valuable strategy to advance the fabrication of mechanically tuneable cell-laden constructs for 3Ddisease modelling and tissue engineering applications. Herein, a dynamic bioink comprising boronic acid-functionalised laminarin and alginate is explored for bioprinting 3D constructs under physiologically relevant conditions. The formulated bioink takes advantage of a double crosslinked network that combines covalent but reversible boronate ester bonds and ionic gelation via divalent cations. Read More

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Phenolated alginate-collagen hydrogel induced chondrogenic capacity of human amniotic mesenchymal stem cells.

J Biomater Appl 2021 Jun 1:8853282211021692. Epub 2021 Jun 1.

Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Horseradish peroxidase (HRP)-catalyzed hydrogels are considered to be an important platform for tissue engineering applications. In this study, we investigated the chondrogenic capacity of phenolated (1.2%) alginate-(0. Read More

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Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone.

Int J Mol Sci 2021 May 27;22(11). Epub 2021 May 27.

TNI Group, Department of Radiology, Leiden University Medical Center (LUMC), 2333 ZA Leiden, The Netherlands.

Hydrogels obtained from combining different polymers are an interesting strategy for developing controlled release system platforms and tissue engineering scaffolds. In this study, the applicability of sodium alginate-g-(QCL-co-HEMA) hydrogels for these biomedical applications was evaluated. Hydrogels were synthesized by free-radical polymerization using a different concentration of the components. Read More

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Accelerated and Improved Vascular Maturity after Transplantation of Testicular Tissue in Hydrogels Supplemented with VEGF- and PDGF-Loaded Nanoparticles.

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

Gynecology-Andrology Unit, Institute of Experimental and Clinical Research, Medical School, Catholic University of Louvain, UCLouvain, 1200 Brussels, Belgium.

Avascular transplantation of frozen-thawed testicular tissue fragments represents a potential future technique for fertility restoration in boys with cancer. A significant loss of spermatogonia was observed in xeno-transplants of human tissue most likely due to the hypoxic period before revascularization. To reduce the effect of hypoxia-reoxygenation injuries, several options have already been explored, like encapsulation in alginate hydrogel and supplementation with nanoparticles delivering a necrosis inhibitor (NECINH) or VEGF. Read More

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Preparation of Alginate-Based Biomaterials and Their Applications in Biomedicine.

Mar Drugs 2021 May 10;19(5). Epub 2021 May 10.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.

Alginates are naturally occurring polysaccharides extracted from brown marine algae and bacteria. Being biocompatible, biodegradable, non-toxic and easy to gel, alginates can be processed into various forms, such as hydrogels, microspheres, fibers and sponges, and have been widely applied in biomedical field. The present review provides an overview of the properties and processing methods of alginates, as well as their applications in wound healing, tissue repair and drug delivery in recent years. Read More

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Classification and Production of Polymeric Foams among the Systems for Wound Treatment.

Polymers (Basel) 2021 May 16;13(10). Epub 2021 May 16.

Department of Chemical, Material and Industrial Production Engineering (DICMAPI), University of Naples Federico II, Piazzale Vincenzo Tecchio 80, 80125 Napoli, Italy.

This work represents an overview on types of wounds according to their definition, classification and dressing treatments. Natural and synthetic polymeric wound dressings types have been analyzed, providing a historical overview, from ancient to modern times. Currently, there is a wide choice of materials for the treatment of wounds, such as hydrocolloids, polyurethane and alginate patches, wafers, hydrogels and semi-permeable film dressings. Read More

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Alginate-chitosan oligosaccharide-ZnO composite hydrogel for accelerating wound healing.

Carbohydr Polym 2021 Aug 24;266:118100. Epub 2021 Apr 24.

Key Laboratory of Marine Drugs, Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China. Electronic address:

Moist, breathable and antibacterial microenvironment can promote cell proliferation and migration, which is beneficial to wound healing. Here, we fabricated a novel sodium alginate-chitosan oligosaccharide‑zinc oxide (SA-COS-ZnO) composite hydrogel by spontaneous Schiff base reaction, using aldehydated sodium alginate (SA), chitosan oligosaccharide (COS), and zinc oxide (ZnO) nanoparticles, which can provide a moist and antibacterial environment for wound healing. The porosity and swelling degree of SA-COS-ZnO hydrogel are 80% and 150%, respectively, and its water vapor permeability is 682 g/m/24h. Read More

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Manganese-Doped Calcium Silicate Nanowire Composite Hydrogels for Melanoma Treatment and Wound Healing.

Research (Wash D C) 2021 7;2021:9780943. Epub 2021 May 7.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.

Melanoma is a serious malignant skin tumor. Effectively eliminating melanoma and healing after-surgical wounds are always challenges in clinical studies. To address these problems, we propose manganese-doped calcium silicate nanowire-incorporated alginate hydrogels (named MCSA hydrogels) for photothermal ablation of melanoma followed by the wound healing process. Read More

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State-of-the-art of 3D printing technology of alginate-based hydrogels-An emerging technique for industrial applications.

Adv Colloid Interface Sci 2021 May 8;293:102436. Epub 2021 May 8.

Department of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark N J 07102, USA.

Recently, three-dimensional (3D) printing (also known as additive manufacturing) has received unprecedented consideration in various fields owing to many advantages compared to conventional manufacturing equipment such as reduced fabrication time, one-step production, and the ability for rapid prototyping. This promising technology, as the next manufacturing revolution and universal industrial method, allows the user to fabricate desired 3D objects using a layer-by-layer deposition of material and a 3D printer. Alginate, a versatile polysaccharide derived from seaweed, is popularly used for this advanced bio-fabrication technique due to its printability, biodegradability, biocompatibility, excellent availability, low degree of toxicity, being a relatively inexpensive, rapid gelation in the presence of Ca divalent, and having fascinating chemical structure. Read More

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Selected Phase Separation Renders High Strength and Toughness to Polyacrylamide/Alginate Hydrogels with Large-Scale Cross-Linking Zones.

ACS Appl Mater Interfaces 2021 Jun 20;13(21):25383-25391. Epub 2021 May 20.

State Key Laboratory of Bio-Fibers and Eco-Textiles, Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, Institute of Marine Biobased Materials, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China.

High water content usually contradicts the mechanics for hydrogels, and achieving both characteristics is extremely challenging. Herein, a novel confined-chain-aggregation (CCA) strategy is developed to fabricate ultrastrong and tough hydrogels without sacrificing their inherent water capacity. Based on the popular polyacrylamide/alginate (PAAm/Alg) system with a double network (DN), a poor solvent exchange is induced once PAAm is fully cross-linked but prior to ionic cross-linking of alginate. Read More

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Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress.

Int J Bioprint 2021 20;7(2):333. Epub 2021 Apr 20.

Centro de Biotecnología-FEMSA, Tecnologico de Monterrey, Monterrey, NL, 64849, Mexico.

This scientometric analysis of 393 original papers published from January 2000 to June 2019 describes the development and use of bioinks for 3D bioprinting. The main trends for bioink applications and the primary considerations guiding the selection and design of current bioink components (i.e. Read More

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Tuning Viscoelasticity in Alginate Hydrogels for 3D Cell Culture Studies.

Curr Protoc 2021 May;1(5):e124

Department of Mechanical Engineering, Stanford University, Stanford, California.

Physical properties of the extracellular matrix (ECM) affect cell behaviors ranging from cell adhesion and migration to differentiation and gene expression, a process known as mechanotransduction. While most studies have focused on the impact of ECM stiffness, using linearly elastic materials such as polyacrylamide gels as cell culture substrates, biological tissues and ECMs are viscoelastic, which means they exhibit time-dependent mechanical responses and dissipate mechanical energy. Recent studies have revealed ECM viscoelasticity, independent of stiffness, as a critical physical parameter regulating cellular processes. Read More

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Printable homocomposite hydrogels with synergistically reinforced molecular-colloidal networks.

Nat Commun 2021 05 14;12(1):2834. Epub 2021 May 14.

Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC, USA.

The design of hydrogels where multiple interpenetrating networks enable enhanced mechanical properties can broaden their field of application in biomedical materials, 3D printing, and soft robotics. We report a class of self-reinforced homocomposite hydrogels (HHGs) comprised of interpenetrating networks of multiscale hierarchy. A molecular alginate gel is reinforced by a colloidal network of hierarchically branched alginate soft dendritic colloids (SDCs). Read More

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Microfluidic encapsulation of nanoparticles in alginate microgels gelled via competitive ligand exchange crosslinking.

Biopolymers 2021 May 13:e23432. Epub 2021 May 13.

Department of Biophysics, Federal University of São Paulo, São Paulo, Brazil.

Efficient delivery of nanometric vectors complexed with nanoparticles at a target tissue without spreading to other tissues is one of the main challenges in gene therapy. One means to overcome this problem is to confine such vectors within microgels that can be placed in a target tissue to be released slowly and locally. Herein, a conventional optical microscope coupled to a common smartphone was employed to monitor the microfluidic production of monodisperse alginate microgels containing nanoparticles as a model for the encapsulation of vectors. Read More

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Cell-Laden Multiple-Step and Reversible 4D Hydrogel Actuators to Mimic Dynamic Tissue Morphogenesis.

Adv Sci (Weinh) 2021 05 1;8(9):2004616. Epub 2021 Mar 1.

Department of Biomedical Engineering Case Western Reserve University 10900 Euclid Avenue Cleveland OH 44106 USA.

Shape-morphing hydrogels bear promising prospects as soft actuators and for robotics. However, they are mostly restricted to applications in the abiotic domain due to the harsh physicochemical conditions typically necessary to induce shape morphing. Here, multilayer hydrogel actuator systems are developed using biocompatible and photocrosslinkable oxidized, methacrylated alginate and methacrylated gelatin that permit encapsulation and maintenance of living cells within the hydrogel actuators and implement programmed and controlled actuations with multiple shape changes. Read More

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