4,318 results match your criteria alf

Pressure ulcer risk assessment-registered nurses´ experiences of using PURPOSE T: A focus group study.

J Clin Nurs 2021 Jun 9. Epub 2021 Jun 9.

Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.

Aim: To evaluate the clinical usability of PURPOSE T among registered nurses in Sweden.

Background: Pressure ulcers are an adverse event and a problem worldwide. Risk assessment is a cornerstone, and a first step in pressure ulcer prevention is to identify possible risk patients and/or pressure ulcers. Read More

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Evaluation of F-AlF-NOTA-octreotide for imaging neuroendocrine neoplasms: comparison with Ga-DOTATATE PET/CT.

EJNMMI Res 2021 Jun 9;11(1):55. Epub 2021 Jun 9.

Department of Nuclear Medicine, XiangYa Hospital, Central South University, No. 87 XiangYa Road, ChangSha, Hunan Province, People's Republic of China.

Objective: To evaluate the diagnostic efficacy of F-AlF-NOTA-octreotide (F-OC) PET/CT compared with that of Ga-DOTATATE PET/CT.

Materials And Methods: Twenty patients (mean age: 52.65 years, range: 24-70 years) with biopsy-proven neuroendocrine neoplasms (NENs) were enrolled in this prospective study. Read More

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Clinical Outcomes of Children Diagnosed Dengue-Associated Acute Liver Failure with or without N-Acetylcysteine Treatment: A Retrospective Cohort Study.

J Trop Pediatr 2021 May;67(2)

Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

Objectives: N-acetylcysteine (NAC) has been shown to prevent hepatic damage and improve microcirculatory blood flow and oxygen delivery to the tissue. Previous studies have proposed the benefit of NAC in dengue-associated acute liver failure (ALF). However, most studies are descriptive and lack comparison between groups. Read More

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Associations of cerebrospinal fluid amyloidogenic nanoplaques with cytokines in Alzheimer's disease.

Transl Neurodegener 2021 Jun 8;10(1):18. Epub 2021 Jun 8.

Department of Geriatric Medicine, The Memory Clinic, Oslo University Hospital, Oslo, Norway.

Background: The aggregation of amyloid β (Aβ) is central in the pathogenesis of Alzheimer's disease (AD). Recently it has been shown that specifically, larger, Thioflavin T-binding Aβ aggregates are associated with increased neuroinflammation and cytokine release. This study was aimed to quantify fibrillary amyloid aggregates, so-called nanoplaques, and investigate their relationship with cytokines in the cerebrospinal fluid (CSF). Read More

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Creatinine-lactate score predicts mortality in non-acetaminophen-induced acute liver failure in patients listed for liver transplantation.

BMC Gastroenterol 2021 Jun 7;21(1):252. Epub 2021 Jun 7.

Laboratorio de Investigaçao Medica 37, Departamento de Gastroenterologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo - HCFMUSP, Sao Paulo, SP, Brazil.

Background: The aim of this study was to analyze prognostic indicators of in-hospital mortality among patients listed for urgent liver transplantation (LT) for non-acetaminophen (APAP)-induced acute liver failure (ALF).

Methods: ALF patients listed for LT according to the King's College Criteria were retrospectively reviewed. Variables were recorded from medical records and electronic databases (HCMED and RedCap). Read More

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Rehabilitation needs and mortality associated with the Covid-19 pandemic: a population-based study of all hospitalised and home-healthcare individuals in a Swedish healthcare region.

EClinicalMedicine 2021 Jun 30;36:100920. Epub 2021 May 30.

Department of Rehabilitation Medicine and Department of Health, Medicine and Caring sciences, Linköping University, S-58185, Linköping, Sweden.

Background: This first report of the Linköping Covid-19 Study (LinCoS) aimed at determination of Covid-19-associated mortality, impairments, activity and participation limitations denoting rehabilitation needs four months after discharge from hospital.

Methods: An ambidirectional population-based cohort study including all confirmed Covid-19 cases admitted to hospital during 1/03-31/05 and those living in home healthcare settings identified through a regional registry and evaluated through medical records, including WHO Clinical Progression Scale (CPS). All patients discharged from hospital were followed-up by structured telephone interview at 4 months post-discharge. Read More

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What Is Uncommon Can Be Critical: A Case of Quinolone-Induced Acute Liver Failure.

Cureus 2021 Apr 30;13(4):e14780. Epub 2021 Apr 30.

Internal Medicine, Texas Tech University Health Sciences Center School of Medicine at the Permian Basin, Odessa, USA.

Many drugs are known to potentially cause liver injury; however, only a few reports investigate the association between levofloxacin and acute liver failure (ALF).  The case describes a 65-year-old man who was admitted with primary diagnoses of cerebrovascular accident (CVA) and acute coronary syndrome (ACS) who developed an upper respiratory tract infection for which he was started on levofloxacin. Following its administration, serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) increased more than 100-fold above the upper limit of normal. Read More

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Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status.

World Allergy Organ J 2021 May 18;14(5):100544. Epub 2021 May 18.

Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden.

Background: Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation used both to support diagnosis of asthma and follow up asthma patients. The associations of FeNO with lung function decline and bronchodilator (BD) response have been studied only scarcely in large populations.

Objectives: To study the association between FeNO and a) retrospective lung function decline over 20 years, and b) lung function response to BD among asthmatic subjects compared with non-asthmatic subjects and with regards to current smoking and sex. Read More

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Patient-derived scaffolds influence secretion profiles in cancer cells mirroring clinical features and breast cancer subtypes.

Cell Commun Signal 2021 Jun 5;19(1):66. Epub 2021 Jun 5.

Department of Laboratory Medicine, Sahlgrenska Center for Cancer Research, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Medicinaregatan 1G, 41390, Gothenburg, Sweden.

Background: Breast cancer is a common malignancy with varying clinical behaviors and for the more aggressive subtypes, novel and more efficient therapeutic approaches are needed. Qualities of the tumor microenvironment as well as cancer cell secretion have independently been associated with malignant clinical behaviors and a better understanding of the interplay between these two features could potentially reveal novel targetable key events linked to cancer progression.

Methods: A newly developed human derived in vivo-like growth system, consisting of decellularized patient-derived scaffolds (PDSs) recellularized with standardized breast cancer cell lines (MCF7 and MDA-MB-231), were used to analyze how 63 individual patient specific microenvironments influenced secretion determined by proximity extension assays including 184 proteins and how these relate to clinical outcome. Read More

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Insight into the immune and microbial response of the white-leg shrimp Litopenaeus vannamei to microplastics.

Mar Environ Res 2021 May 30;169:105377. Epub 2021 May 30.

Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, 510642, China. Electronic address:

Microplastics (MPs) are a new type of environmental pollutant. To investigate the response of shrimp and their microflora to MPs, Litopenaeus vannamei (L. vannamei) was exposed to different concentrations of MPs (0, 50, 500, and 5000 μg/L, i. Read More

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Camellia japonica diminishes acetaminophen-induced acute liver failure by attenuating oxidative stress in mice.

Environ Sci Pollut Res Int 2021 Jun 4. Epub 2021 Jun 4.

College of Veterinary Medicine and Bio-safety Research Institute, Jeonbuk National University, Iksan, 54596, South Korea.

This experiment was to explore the possible defensive properties and potential molecular mechanisms of Camellia japonica (CJ) against APAP-stimulated acute liver failure (ALF) in mice. In this study, we investigated the effects of CJ on APAP-induced hepatotoxicity. Mice were orally treated with CJ before or after challenge with APAP. Read More

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What Is the Persistence to Methotrexate in Rheumatoid Arthritis, and Does Machine Learning Outperform Hypothesis-Based Approaches to Its Prediction?

ACR Open Rheumatol 2021 Jun 4. Epub 2021 Jun 4.

Karolinska Institutet, Solna, Sweden.

Objective: The objectives of this study were to assess the 1-year persistence to methotrexate (MTX) initiated as the first ever conventional synthetic disease-modifying antirheumatic drug in new-onset rheumatoid arthritis (RA) and to investigate the marginal gains and robustness of the results by increasing the number and nature of covariates and by using data-driven, instead of hypothesis-based, methods to predict this persistence.

Methods: Through the Swedish Rheumatology Quality Register, linked to other data sources, we identified a cohort of 5475 patients with new-onset RA in 2006-2016 who were starting MTX monotherapy as their first disease-modifying antirheumatic drug. Data on phenotype at diagnosis and demographics were combined with increasingly detailed data on medical disease history and medication use in four increasingly complex data sets (48-4162 covariates). Read More

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Acute Liver Failure Etiology is an Independent Predictor of Waitlist Outcome, but not Post-Transplant Survival in a National Cohort.

Liver Transpl 2021 Jun 3. Epub 2021 Jun 3.

Division of Gastroenterology / Transplant Hepatology, University of Pennsylvania, Philadelphia.

The impact of acute liver failure (ALF) etiology on waitlist and post-transplant outcomes, independent of severity of illness is incompletely characterized. All adults (N=1,691) listed for primary liver transplantation (LT) between 2002-2019 with ALF due to acetaminophen (APAP), drug-induced liver injury (DILI), autoimmune hepatitis (AIH) and hepatitis B virus (HBV) were identified in the United Network for Organ Sharing database. ALF etiology was evaluated as an independent predictor of waitlist mortality and spontaneous survivorship (SS; versus outcome of LT), as well as post-LT overall survival, graft survival and in-hospital mortality using multivariable models that accounting for differences in clinical parameters at listing. Read More

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A Multicenter Observational Study Evaluating Outcomes Associated With Antibiotic Combination Versus Monotherapy in Patients With Septic Shock.

Crit Care Explor 2021 May 12;3(5):e0383. Epub 2021 May 12.

Department of Intensive Care and Anaesthesia, Skane University Hospital, Malmö, Sweden.

Objectives: To explore the association between antibiotic combination therapy and in-hospital mortality in patients with septic shock in two tertiary ICUs in different countries.

Design: Retrospective observational study.

Setting: ICUs of two tertiary hospitals, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia, and Rigshospitalet, Copenhagen, Denmark. Read More

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The utility of biomarkers in prognosis assessment of patients with acute liver failure.

Hepatol Res 2021 May 15. Epub 2021 May 15.

Department of Gastroenterology and Hepatology, Ghent University Hospital, Gent, Belgium.

Background: Acute liver failure (ALF) is a rare but potential lethal condition characterized by the sudden development of jaundice, coagulopathy and hepatic encephalopathy in patients without underlying liver disease. In selected patients, emergency liver transplantation is required. Selection of these patients is based on clinical criteria such as the Kings College Criteria (KCC) or the Clichy criteria. Read More

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Rare genetic mutation triggering acute liver failure in a toddler requiring a liver transplant.

Pediatr Transplant 2021 Jun 2:e14048. Epub 2021 Jun 2.

Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH, USA.

APS-1 is an extremely rare, autosomal recessive condition that often presents with candidiasis, adrenal insufficiency, and hypoparathyroidism. This condition is associated with autoimmune hepatitis in less than 20% of cases, and there have only been a few reports of children with the condition who developed ALF. We present a unique case of an infant with APS-1 who developed ALF and subsequently required liver transplantation. Read More

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Implanting melatonin at lambing enhances lamb growth and maintains high fat content in milk.

Vet Res Commun 2021 Jun 2. Epub 2021 Jun 2.

Instituto de Investigación en Ciencias Ambientales de Aragón (IUCA), Universidad de Zaragoza, Miguel Servet, 177, 50013, Zaragoza, Spain.

Three experiments were designed to study the effects of melatonin implantation of ewes and lambs after lambing on the growth of lambs and milk quality throughout lactation. In experiment 1, 53 lambs either did (n = 28) or did not (n = 25) receive a subcutaneous 18-mg melatonin implant at the base of the left ear. In experiment 2, 55 lambs and their mothers either did (lambs: n = 28; ewes: n = 15) or did not (lambs: n = 27; ewes: n = 16) receive a melatonin implant. Read More

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ICU Admission in Children With Acute Lymphoblastic Leukemia in Sweden: Prevalence, Outcome, and Risk Factors.

Pediatr Crit Care Med 2021 May 2. Epub 2021 May 2.

Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. Pediatric Oncology, Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. ECMO Centre Karolinska, Department of Pediatric Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden. Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Institution of Clinical Sciences, Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Sweden. Department of Anesthesia, Södertälje Hospital, Södertälje, Sweden. Department of Anaesthesia and Intensive Care, Karolinska Institutet at Danderyd Hospital (KIDS), Danderyd, Sweden. Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden. Department of Women's and Children's Health, Uppsala University and Pediatric Oncology, Uppsala University Hospital, Uppsala, Sweden. Department of Pediatric Oncology, Skåne University Hospital, Lund University, Lund, Sweden. Department of Pediatrics, Linköping University Hospital, Linköping, Sweden.

Objectives: Despite progress in the treatment of childhood acute lymphoblastic leukemia, severe complications are common, and the need of supportive care is high. We explored the cumulative prevalence, clinical risk factors, and outcomes of children with acute lymphoblastic leukemia, on first-line leukemia treatment in the ICUs in Sweden.

Design: A nationwide prospective register and retrospective chart review study. Read More

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Insulin-Like Growth Factor-II and Ischemic Stroke-A Prospective Observational Study.

Life (Basel) 2021 May 29;11(6). Epub 2021 May 29.

Institute of Medicine, Department of Internal Medicine and Clinical Nutrition, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.

Insulin-like growth factor-II (IGF-II) regulates prenatal brain development, but the role in adult brain function and injury is unclear. Here, we determined whether serum levels of IGF-II (s-IGF-II) are associated with mortality and functional outcome after ischemic stroke (IS). The study population comprised ischemic stroke cases (n = 492) and controls (n = 514) from the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). Read More

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Long-Term Survival and Recurrence in Oropharyngeal Squamous Cell Carcinoma in Relation to Subsites, HPV, and p16-Status.

Cancers (Basel) 2021 May 23;13(11). Epub 2021 May 23.

Department of Clinical Science, Intervention and Technology-CLINTEC Division of Ear, Nose and Throat Diseases, Karolinska Institutet, Karolinska University Hospital, 171 64 Stockholm, Sweden.

Long-term survival data in relation to sub-sites, human papillomavirus (HPV), and p16 (p16) for patients with oropharyngeal squamous cell carcinoma (OPSCC) is still sparse. Furthermore, reports have indicated atypical and late recurrences for patients with HPV and p16 positive OPSCC. Therefore, we assessed long-term survival and recurrence in relation to oropharyngeal subsite and HPV/p16 status. Read More

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Comprehending the Proteomic Landscape of Ovarian Cancer: A Road to the Discovery of Disease Biomarkers.

Proteomes 2021 May 25;9(2). Epub 2021 May 25.

Department of Immunotechnology, Lund University, 22100 Lund, Sweden.

Despite recent technological advancements allowing the characterization of cancers at a molecular level along with biomarkers for cancer diagnosis, the management of ovarian cancers (OC) remains challenging. Proteins assume functions encoded by the genome and the complete set of proteins, termed the proteome, reflects the health state. Comprehending the circulatory proteomic profiles for OC subtypes, therefore, has the potential to reveal biomarkers with clinical utility concerning early diagnosis or to predict response to specific therapies. Read More

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MET Expression and Cancer Stem Cell Networks Impact Outcome in High-Grade Serous Ovarian Cancer.

Genes (Basel) 2021 May 14;12(5). Epub 2021 May 14.

Division of Oncology, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, 223 81 Lund, Sweden.

Overexpression of the receptor tyrosine kinase MET has been linked to poor survival in several cancer types, and MET has been suggested to interact with stem cell networks. In vitro studies have further suggested a possible benefit of a combined treatment using PARP and MET inhibitors. We used a tissue microarray (TMA) with 130 samples of advanced-stage high-grade serous fallopian tube/ovarian cancer (HGSC) to investigate the prognostic value of MET protein expression alone and in combination with the stem cell factor SOX2. Read More

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Cryopreservation of Whole Tumor Biopsies from Rectal Cancer Patients Enable Phenotypic and In Vitro Functional Evaluation of Tumor-Infiltrating T Cells.

Cancers (Basel) 2021 May 17;13(10). Epub 2021 May 17.

Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.

TILs comprise functionally distinct conventional and unconventional T cell subsets and their role in responses to CRC treatments is poorly understood. We explored recovery of viable TILs from cryopreserved tumor biopsies of (chemo)-radiated patients with rectal cancer to establish a platform for retrospective TIL analyses of frozen tumors from pre-selected study cohorts. Frequencies of TIL subsets and their capacity to mount IFN-γ responses in cell suspensions of fresh vs. Read More

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Regional lithium prescription rates and recurrence in bipolar disorder.

Int J Bipolar Disord 2021 Jun 1;9(1):18. Epub 2021 Jun 1.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Blå Stråket 15, 413 45, Gothenburg, Sweden.

Background: Lithium is the best documented maintenance treatment in bipolar disorder, but its use varies considerably across and within countries. It is not known whether regional differences in lithium prescription rates translate to differing regional outcomes.

Aims: To estimate associations between county specific lithium prescription rates and county specific recurrence odds of bipolar disorder in Sweden. Read More

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Lack of association between recent cannabis use and advanced liver fibrosis among HIV-positive heavy drinkers.

Curr HIV Res 2021 May 19. Epub 2021 May 19.

Clinical Addiction Research and Education Unit. Section of General Internal Medicine, Department of Medicine. Boston University School of Medicine/Boston Medical Center. Boston (MA), United States.

Aims: To analyze the association between any past month cannabis use and advanced liver fibrosis.

Background: Cannabinoid receptors play a role in acute and chronic liver injury, but human studies addressing the impact of cannabis use on liver fibrosis have shown mixed results.

Objectives: To explore and estimate the association between past month cannabis use and advanced liver fibrosis (ALF) in a cohort of Russian HIV-positive individuals with heavy alcohol use and high prevalence of hepatitis C virus (HCV) coinfection. Read More

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VEGF gene-modified human umbilical cord blood mesenchymal stem cells protect against acute liver failure in rats.

J Gene Med 2021 May 31:e3369. Epub 2021 May 31.

Department of Infectious Diseases, Hunan Provincial People's Hospital & First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China.

Background: Human umbilical cord blood mesenchymal stem cells (HUCB-MSCs) can exert protective effect on rat models of acute liver failure (ALF). Vascular endothelial growth factor 165 (VEGF ) is the predominant VEGF isoform and possesses a strong pro-angiogenic function. In this study, HUCB-MSC was served as the gene-delivery vehicle for VEGF gene, and we explored the therapeutic effects of this system on ALF. Read More

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Prognosis and outcome determinants after heart failure diagnosis in patients who underwent aortic valvular intervention.

ESC Heart Fail 2021 May 31. Epub 2021 May 31.

Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Aims: To study clinical phenotype, prognosis for all-cause and cardiovascular (CV) mortality and predictive factors in patients with incident heart failure (HF) after aortic valvular intervention (AVI) for aortic stenosis (AS).

Methods And Results: In this retrospective, observational study we included patients from the Swedish Heart Failure Registry (SwedeHF) recorded 2003-2016, with AS diagnosis and AVI before HF diagnosis. The AS diagnosis was established according to International Classification of Diseases 10th revision (ICD-10) codes, thus without information concerning clinical or echocardiographical data on the aortic valve disease. Read More

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Copeptin as a predictive marker of incident heart failure.

ESC Heart Fail 2021 May 30. Epub 2021 May 30.

Perinatal and Cardiovascular Epidemiology, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.

Aims: Heart failure (HF) is a common disease with increasing prevalence and poor prognosis. The vasopressin (VP) marker copeptin predicts development of diabetes mellitus, diabetic heart disease, coronary artery disease, and premature mortality. Copeptin is elevated in HF patients and predicts a worse outcome. Read More

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Optic Nerve Sheath Diameter in Acute Liver Failure: A Prospective Cohort Study.

GE Port J Gastroenterol 2021 Apr 2;28(3):170-178. Epub 2020 Dec 2.

Intensive Care Unit, Curry Cabral Hospital, Lisbon, Portugal.

Introduction: Acute liver failure (ALF) is a rare disease that may lead to cerebral edema and death. An increased optic nerve sheath diameter (ONSD) may reflect an early increase in intracranial pressure. We assessed the feasibility and safety of the ONSD measurement and its association with outcomes in patients with ALF. Read More

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Cerebral palsy in ART children has declined substantially over time: a Nordic study from the CoNARTaS group.

Hum Reprod 2021 May 29. Epub 2021 May 29.

Fertility Department, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Study Question: Are the decreasing multiple birth rates after ART associated with a simultaneous drop in the incidence of cerebral palsy (CP) in ART children over time?

Summary Answer: The relative odds of CP in ART children have declined in the Nordic countries over the past two decades concurrently with declining multiple birth rates.

What Is Known Already: In the Nordic countries, the rate of twin pregnancies after ART has decreased from 30% in the early 1990s to 4-13% in 2014, following the implementation of elective single embryo transfer (SET). Consequently, preterm birth rates have declined substantially in ART pregnancies. Read More

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