53 results match your criteria alcohol pval

Construction of Nanocrystalline Cellulose-Based Composite Fiber Films with Excellent Porosity Performances via an Electrospinning Strategy.

ACS Omega 2021 Feb 11;6(7):4958-4967. Epub 2021 Feb 11.

State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, P. R. China.

Cellulose nanocrystals (CNCs) not only have environmental protection characteristics of being lightweight, degradable, green, and renewable but also have some nanocharacteristics of high strength, large specific surface area, and obvious small size effect, so they are often used as a reinforcing agent in various polymers. However, the hydrogen bonding between CNC molecules is relatively strong, and they can easily aggregate and get entangled with each other. In this work, several large-porosity composite nanofiber films, KH550-CNC/waterborne polyurethane (WPU)/poly(vinyl alcohol) (PVAL) with KH550-modified CNCs, are prepared using poly(vinyl alcohol) (PVAL) solution and electrospinning technology. Read More

View Article and Full-Text PDF
February 2021

Development and characterization of thermopressed polyvinyl alcohol films for buccal delivery of benznidazole.

Mater Sci Eng C Mater Biol Appl 2021 Feb 30;119:111546. Epub 2020 Sep 30.

Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Campus Reitor João David Ferreira Lima, s/n - Trindade, Florianópolis, SC 88040-900, Brazil. Electronic address:

Given that oral preparations of benznidazole (BZN) have demonstrated limited efficacy in the treatment of Chagas' disease due to pharmacokinetic or toxicological problems, the development of buccal polymeric films was purposed in this study. These systems ensure high patient acceptability and direct access to the systemic circulation, improving drug bioavailability and toxicological profile. Polymer films were prepared through a thermopressing method by mixing BZN and polyvinyl alcohol (PVAL). Read More

View Article and Full-Text PDF
February 2021

Inorganic matter modified water-based copolymer prepared by chitosan-starch-CMC-Na-PVAL as an environment-friendly coating material.

Carbohydr Polym 2020 Apr 27;234:115925. Epub 2020 Jan 27.

College of Land and Environment, Shenyang Agricultural University, Shenyang 110866, Liaoning, China; National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Resources, Shenyang 110866, Liaoning, China; Key Laboratory of Arable Land Conservation (Northeast China), Ministry of Agriculture, Shenyang 110866, Liaoning, China.

Inorganic matter modifications were used to improve the hydrophobic properties and slow-release effects of water-based copolymer films. Water-based copolymers were prepared by aqueous polymerization of polyvinyl alcohol, starch, chitosan, and sodium carboxymethyl cellulose, and then, zeolite powder, volcanic ash or biochar were added to prepare the inorganic matter modified water-based copolymer films. The results showed that the inorganic matter modified water-based copolymer films had enhanced thermal stability, reductions in O-H and water vapour permeability, and increased crystallinity and roughness. Read More

View Article and Full-Text PDF

Comparison of three collection methods for the sodium rhodizonate detection of gunshot residues on hands.

Sci Justice 2020 01 16;60(1):63-71. Epub 2019 Sep 16.

Ecole des Sciences Criminelles, University of Lausanne, Lausanne, Switzerland.

The aim of this study was to compare three gunshot residue (GSR) collection methods used in conjunction with chemographic detection applied by different regional Swiss police services. The specimens were collected from the hands of a shooter with either filter paper (Filter method) or adhesive foil. The adhesive foil was then either applied against photographic paper during visualisation (AF Photo method) or coated with a layer of polyvinyl alcohol (AF PVAL method). Read More

View Article and Full-Text PDF
January 2020

Prescriber responses to a pain clinic law: Cease or modify?

Drug Alcohol Depend 2020 01 27;206:107591. Epub 2019 Sep 27.

Department of Health Policy, Vanderbilt School of Medicine, 2525 West End Ave Suite 1200, Nashville, TN, 37203, USA. Electronic address:

Background: Pain clinic laws are designed to cease or modify high-risk prescribing behavior. However, prior evaluations have not differentiated between these types of prescriber responses in their analysis, even though they may have different implications for patients. The purpose of this analysis is to investigate the effect of a 2016 Tennessee pain clinic law on the two types of prescriber responses. Read More

View Article and Full-Text PDF
January 2020

Feasibility of an accelerated PVAL method for the collection of GSR and biological traces.

Int J Legal Med 2020 May 5;134(3):1051-1059. Epub 2019 Nov 5.

Institute of Forensic Medicine, Goethe University Medical School, Kennedyallee 104, 60596, Frankfurt/Main, Germany.

The polyvinyl alcohol method (PVAL) is known as an effective technique to thoroughly collect traces of gunshot residue (GSR) from different surfaces, e.g., from hands or gunshot wounds. Read More

View Article and Full-Text PDF

Ketalization of 2-heptanone to prolong its activity as mite repellant for the protection of honey bees.

J Sci Food Agric 2019 Nov 12;99(14):6267-6277. Epub 2019 Aug 12.

School of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, NY, USA.

Background: 2-Heptanone is a volatile liquid known to be effective in protecting honey bees from parasitic mite infestations in hives. The present study aimed to show that chemical derivatives of 2-heptanone would release the ketone for a significantly longer time than it takes for the pure ketone to evaporate and preferably for as long as two brood cycles of a honey bee (42 days).

Results: A liquid ketal of 2-heptanone with glycerol (Glyc-Ket) and solid ketals of the ketone with polyvinyl alcohol (PVAl-Ket), containing different amounts of the ketone, were synthesized. Read More

View Article and Full-Text PDF
November 2019

Low-Cost Flexible ZnO Microwires Array Ultraviolet Photodetector Embedded in PAVL Substrate.

Nanoscale Res Lett 2018 Sep 10;13(1):277. Epub 2018 Sep 10.

Institute of Optoelectronic Material and Technology, South China Normal University, Guangzhou, 510631, People's Republic of China.

With the advent of wearable device technology, fabrication of inorganic semiconductor devices on flexible organic substrates is of great interest. In this paper, a fascinating method and a low-cost flexible substrate material polyvinyl alcohol (PVAL) have been utilized to embed ZnO microwire (MW) array to produce ultraviolet (UV) photodetector (PD) with decent photoresponsivity. The flexible PVAL substrate is relatively cheap and has better bendability as compared to polyethylene terephthalate (PET) and other traditional flexible substrate materials, which makes it unique in comparison to traditional devices. Read More

View Article and Full-Text PDF
September 2018

RNA/DNA co-analysis from bloodstains on aged polyvinyl-alcohol gloves prepared for securing evidence from the hands of victims of fatal gunshot injuries.

Int J Legal Med 2018 Jan 27;132(1):53-66. Epub 2017 Sep 27.

Institute of Forensic Medicine, University of Bern, Bühlstraße 20, 3012, Bern, Switzerland.

In contrast to cumulative techniques (e.g., tape-lift) for qualitative gunshot residues (GSR) analysis, topographic methods are commonly applied to preserve the integrity of evidence from a shooter's or victim's hand in cases of gun-related crimes. Read More

View Article and Full-Text PDF
January 2018

Development of a phantom to test fully automated breast density software - A work in progress.

Radiography (Lond) 2017 Feb 3;23(1):e14-e19. Epub 2016 Oct 3.

School of Health Sciences, University of Salford, Salford M6 6PU, Greater Manchester, UK; Karolinska Institute, Stockholm, Sweden.

Objectives: Mammographic density (MD) is an independent risk factor for breast cancer and may have a future role for stratified screening. Automated software can estimate MD but the relationship between breast thickness reduction and MD is not fully understood. Our aim is to develop a deformable breast phantom to assess automated density software and the impact of breast thickness reduction on MD. Read More

View Article and Full-Text PDF
February 2017

Use of Polyvinyl Alcohol as a Solubility Enhancing Polymer for Poorly Water-Soluble Drug Delivery (Part 2).

AAPS PharmSciTech 2016 Feb 10;17(1):180-90. Epub 2016 Feb 10.

Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, 1 University Station, Campus Mail Code A1902, Austin, Texas, 78712, USA.

The KinetiSol® Dispersing (KSD) technology has enabled the investigation into the use of polyvinyl alcohol (PVAL) as a concentration enhancing polymer for amorphous solid dispersions. Our previous study revealed that the 88% hydrolyzed grade of PVAL was optimal for itraconazole (ITZ) amorphous compositions with regard to solid-state properties, non-sink dissolution performance, and bioavailability enhancement. The current study investigates the influence of molecular weight for the 88% hydrolyzed grades of PVAL on the properties of KSD processed ITZ:PVAL amorphous dispersions. Read More

View Article and Full-Text PDF
February 2016

Use of Polyvinyl Alcohol as a Solubility-Enhancing Polymer for Poorly Water Soluble Drug Delivery (Part 1).

AAPS PharmSciTech 2016 Feb 4;17(1):167-79. Epub 2015 Dec 4.

Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, 1 University Station, Campus Mail Code A1902, Austin, Texas, 78712, USA.

Polyvinyl alcohol (PVAL) has not been investigated in a binary formulation as a concentration-enhancing polymer owing to its high melting point/high viscosity and poor organic solubility. Due to the unique attributes of the KinetiSol® dispersing (KSD) technology, PVAL has been enabled for this application and it is the aim of this paper to investigate various grades for improvement of the solubility and bioavailability of poorly water soluble active pharmaceutical ingredients. Solid amorphous dispersions were created with the model drug, itraconazole (ITZ), at a selected drug loading of 20%. Read More

View Article and Full-Text PDF
February 2016

The Effect of Montmorillonite Clay on the Crystallinity of Poly(vinyl alcohol) Nanocomposites Obtained by Solution Intercalation and In Situ Polymerization.

J Nanosci Nanotechnol 2015 Apr;15(4):2814-20

In this study, PVAL/sodic clay nanocomposite materials were obtained using different clay ratios. The nanocomposites were prepared by solution and in situ polymerization. They were characterized through proton relaxometry and X-ray diffraction, the latter technique used to determine the crystallinity of the PVAL matrix in the nanocomposites through the addition of unmodified montmorillonite clay. Read More

View Article and Full-Text PDF

Adsorption Removal of Environmental Hormones of Dimethyl Phthalate Using Novel Magnetic Adsorbent.

ScientificWorldJournal 2015 16;2015:903706. Epub 2015 Jul 16.

Department of Environmental Engineering, National I-Lan University, Yilan 260, Taiwan.

Magnetic polyvinyl alcohol adsorbent M-PVAL was employed to remove and concentrate dimethyl phthalate DMP. The M-PVAL was prepared after sequential syntheses of magnetic Fe3O4 (M) and polyvinyl acetate (M-PVAC). The saturated magnetizations of M, M-PVAC, and M-PVAL are 57. Read More

View Article and Full-Text PDF

Breast tissue phantoms to assist compression study for cancer detection using microwave radiometry.

Annu Int Conf IEEE Eng Med Biol Soc 2014 ;2014:1119-22

Microwave radiometry is a passive imaging modality proposed for breast cancer detection without the need for ionizing radiation. Detection of breast tumor using radiometry is challenging as the intensity of thermal radiation received by the antenna is influenced by tumor stage, location, physiological conditions and the imaging setup. The controllable parameters for setting up a good imaging modality for early detection of breast cancer are ambient temperature (Ta), convection cooling of tissue surface (h), and tissue compression (c). Read More

View Article and Full-Text PDF
October 2016

Fabrication of a tunable glucose biosensor based on zinc oxide/chitosan-graft-poly(vinyl alcohol) core-shell nanocomposite.

Talanta 2012 Sep 31;99:283-7. Epub 2012 May 31.

Department of Polymer Science, Bhaskaracharya College of Applied Sciences, University of Delhi, New Delhi 110 075, India.

A potentiometrically tuned-glucose biosensor was fabricated using core-shell nanocomposite based on zinc oxide encapsulated chitosan-graft-poly(vinyl alcohol) (ZnO/CHIT-g-PVAL). In a typical experiment, ZnO/CHIT-g-PVAL core-shell nanocomposite containing <20 nm ZnO nanoparticles was synthesized using wet-chemical method. The glucose responsive bio-electrode, i. Read More

View Article and Full-Text PDF
September 2012

An elastically compressible phantom material with mechanical and x-ray attenuation properties equivalent to breast tissue.

Phys Med Biol 2010 Feb 28;55(4):1177-88. Epub 2010 Jan 28.

Department of Medical Physics and Bioengineering, University College London, London WC1E 6BT, UK.

We have developed a novel phantom material: a solution of polyvinyl alcohol (PVAL) in ethanol and water, freeze-thawed to produce a solid yet elastically compressible gel. The x-ray attenuation and mechanical properties of these gels are compared with published measurements of breast tissue. Gels with PVAL concentrations from 5 to 20% w/v were produced. Read More

View Article and Full-Text PDF
February 2010

Toward the understanding of the photodynamic activity of m-THPP encapsulated in PLGA nanoparticles: correlation between nanoparticle properties and in vivo activity.

J Drug Target 2009 Sep;17(8):599-609

Department of Pharmaceutics and Biopharmaceutics, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland.

Biodegradable polymeric nanoparticles (NP) are promising delivery systems for photosensitizers (PS). A hydrophobic PS, the meso-tetra(p-hydroxyphenyl)porphyrin (m-THPP) was encapsulated into NP made of poly(D,L-lactide-co-glycolide) using an emulsification-diffusion method, and poly(vinyl alcohol) (PVAL) as stabilizing agent during the emulsification step. Three batches of NP with mean diameters of 117, 285, and 593 nm, respectively, were prepared. Read More

View Article and Full-Text PDF
September 2009

Stabilization of aerosolizable nano-carriers by freeze-drying.

Pharm Res 2009 Jan 8;26(1):129-38. Epub 2008 Oct 8.

Department of Pharmaceutics and Biopharmacy, Philipps-University, Ketzerbach 63, 35032, Marburg, Germany.

Purpose: This study investigates the feasibility of freeze-drying aerosolizable nano-carriers (NC) by the use of different lyoprotective agents (LPA) and the influence of the freeze-drying on the physicochemical properties of these nano-carriers and on their aerosolization.

Methods: Nano-carriers were prepared from fast-degrading polymers, DMAPA(24)-PVAL-g-PLGA(1:7.5) and DEAPA(26)-PVAL-g-PLGA(1:10), and freeze-dried using increasing concentrations of different LPA. Read More

View Article and Full-Text PDF
January 2009

On the design of in situ forming biodegradable parenteral depot systems based on insulin loaded dialkylaminoalkyl-amine-poly(vinyl alcohol)-g-poly(lactide-co-glycolide) nanoparticles.

J Control Release 2007 Nov 16;123(2):131-40. Epub 2007 Aug 16.

Department of Pharmaceutics and Biopharmacy, Philipps-Universität, D-35037 Marburg, Ketzerbach 63, 35032 Marburg, Germany.

The feasibility to generate in situ forming parenteral depot systems from insulin loaded dialkylaminoalkyl-amine-poly(vinyl alcohol)-g-poly(lactide-co-glycolide) nanoparticles, was investigated. Biodegradable nanoparticles formed polymeric semi-solid depots upon injection into isotonic phosphate buffered saline (PBS) with no additional initiators. Nanoparticles (NP) prepared from the different amine-modified polyesters displayed a pronounced positive zeta-potential of >25 mV. Read More

View Article and Full-Text PDF
November 2007

[Absorption characteristics of FRLP-Cu(II) metal complexes].

Guang Pu Xue Yu Guang Pu Fen Xi 2007 May;27(5):961-5

The School of Material Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China.

The technical pure azo dye FRL was purified by recrystallization with the solvent composed of ethanol and water whose volume ratio is 1:1. The azo dye FRLP was obtained by coincidence reaction with phen after reoxidation reaction by purified FRL and sodium nitrite, which can be cooperated with Cu2+. And at room temperature the UV-Vis spectrum of FRLP-Cu2+ was studied. Read More

View Article and Full-Text PDF

Heat expanded starch-based compositions.

J Agric Food Chem 2007 May 14;55(10):3936-43. Epub 2007 Apr 14.

Bioproduct Chemistry and Engineering Research, Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, 800 Buchanan Street, Albany, California 94710, USA.

A heat expansion process similar to that used for expanded bead polystyrene was used to expand starch-based compositions. Foam beads made by solvent extraction had the appearance of polystyrene beads but did not expand when heated due to an open-cell structure. Nonporous beads, pellets, or particles were made by extrusion or by drying and milling cooked starch slurries. Read More

View Article and Full-Text PDF

Volume changes of experimental carotid sidewall aneurysms due to embolization with liquid embolic agents: a multidetector CT angiography study.

Cardiovasc Intervent Radiol 2006 Nov-Dec;29(6):1053-9

Department of Radiology, Charité, Campus Virchow Clinic, Berlin, Germany.

Iodine-containing polyvinyl alcohol polymer (I-PVAL) is a novel precipitating liquid embolic that allows for artifact-free evaluation of CT angiography (CTA). As accurate aneurysm volumetry can be performed with multidetector CTA, we determined volumes of experimental aneurysms before, immediately after, and 4 weeks after embolization of 14 porcine experimental carotid sidewall aneurysms with this liquid embolic. An automated three-dimensional software measurement tool was used for volumetric analysis of volume-rendering CTA data. Read More

View Article and Full-Text PDF

Influence of additives and storage temperature on physicochemical and microbiological properties of eye drops containing cefazolin.

Acta Pol Pharm 2006 May-Jun;63(3):225-34

Department of Drug Form Technology, Nicolaus Copernicus University Collegium Medicum in Bydgoszcz.

The purpose of the studies was to choose additives for eye drops containing cefazolin and the assessment of the influence of used additives and the storage temperature on the physicochemical properties and the stability of the eye drops. The drops were 1% sterile solutions of cefazolin in citrate buffer of pH 6.15-6. Read More

View Article and Full-Text PDF

Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung.

Toxicol Appl Pharmacol 2006 Aug 21;215(1):100-8. Epub 2006 Mar 21.

Department of Pharmaceutics and Biopharmacy, Philipps-University, D-35037 Marburg, Germany.

Particulate nanocarriers have been praised for their advantageous drug delivery properties in the lung, such as avoidance of macrophage clearance mechanisms and long residence times. However, instilled non-biodegradable polystyrene nanospheres with small diameters and thus large surface areas have been shown to induce pulmonary inflammation. This study examines the potential of biodegradable polymeric nanoparticles composed of poly(lactic-co-glycolic acid) (PLGA) and the novel PLGA derivative, diethylaminopropylamine polyvinyl alcohol-grafted-poly(lactic-co-glycolic acid) (DEAPA-PVAL-g-PLGA), to provoke inflammatory responses in the murine lung after intratracheal instillation. Read More

View Article and Full-Text PDF

DNA nano-carriers from biodegradable cationic branched polyesters are formed by a modified solvent displacement method.

J Control Release 2006 Apr 24;111(3):371-81. Epub 2006 Feb 24.

Department of Pharmaceutics and Biopharmacy, Philipps-University, Ketzerbach 63, D-35037 Marburg, Germany.

DNA nano-carriers were formulated relying on biodegradable polyesters consisting of amine-modified poly(vinyl alcohol) (PVAL) backbones grafted with PLGA, based on the Marangoni effect thus avoiding detrimental shear or ultrasonic forces. These amine modified high molecular weight biodegradable polyesters combine specific characteristics, such as electrostatic interactions between DNA and cationic branched polyesters facilitating loading of NP with DNA. The resulting DNA containing NP showed hydrodynamic diameters in the range of 175-285 nm and highly positive xi-potentials, depending on the nitrogen to phosphate (N/P) ratio used for the particle formation. Read More

View Article and Full-Text PDF

Adaptation and optimization of the emulsification-diffusion technique to prepare lipidic nanospheres.

Eur J Pharm Sci 2005 Oct;26(2):211-8

School of Pharmaceutical Sciences, University of Geneva, Quai Ernest-Ansermet 30, 1211 Geneva 4, Switzerland.

In this study, the emulsification-diffusion method traditionally used to prepare polymeric nanoparticles was adapted to obtain lipidic nanospheres (LN) using four model lipids. The method consists of dissolving the lipid in a partially water-miscible solvent (previously saturated with water) at room temperature or at controlled temperature depending on lipid solubility. This organic phase is emulsified in an aqueous solution of a stabilizing agent (saturated with solvent) by conventional stirring at the same temperature used to dissolve the lipid. Read More

View Article and Full-Text PDF
October 2005

Remediation of soil contaminated with the heavy metal (Cd2+).

J Hazard Mater 2005 Jun 14;122(1-2):7-15. Epub 2005 Apr 14.

Department of Chemical Engineering, National Yunlin University of Science and Technology, Taiwan, ROC.

Soil contamination by heavy metals is increasing. The biosorption process for removal of the heavy metal Cd(2+) from contaminated soil is chosen for this study due to its economy, commercial applications, and because it acts without destroying soil structure. The study is divided into four parts (1) soil leaching: the relationships between the soil leaching effect and agitation rates, solvent concentrations, ratios of soil to solvent, leaching time and pH were studied to identify their optimum conditions; (2) adsorption Cd(2+) tests of immobilized Saccharomycetes pombe beads: different weight percentages of chitosan and polyvinyl alcohol (PVAL) were added to alginate (10 wt. Read More

View Article and Full-Text PDF

Comparative scale-up of three methods for producing ibuprofen-loaded nanoparticles.

Eur J Pharm Sci 2005 Jul-Aug;25(4-5):357-67

Pharmapeptides, Centre Interuniversitaire de recherche et d'enseignement, 74166 Archamps, France.

The lack of information related to the scaling-up of technologies used for preparing polymeric nanoparticles (NP) might hinder the introduction of these colloidal carriers into the pharmaceutical market. In the present study, the scale-up of ibuprofen-loaded NP produced by three manufacturing processes--salting-out, emulsification-diffusion and nanoprecipitation--was assessed at pilot-scale by increasing 20-fold the laboratory-batch volume from 60 ml to 1.5l. Read More

View Article and Full-Text PDF
October 2005

Preparation and characterization of triclosan nanoparticles for periodontal treatment.

Int J Pharm 2005 Apr;294(1-2):217-32

Departamento de Posgrado en Farmacia, Facultad de Estudios Superiores Cuautitlán, UNAM. Av. 1st de Mayo s/n, Campo 1, Cuautitlán Izcalli, C.P. 54704, Estado de México, México.

The aim of this work was to produce and characterize triclosan-loaded nanoparticles (NPs) by the emulsification-diffusion process, in an attempt to obtain a novel delivery system adequate for the treatment of periodontal disease. The NPs were prepared using poly(D,L-lactide-co-glycolide) (PLGA), poly(D,L-lactide) (PLA) and cellulose acetate phthalate (CAP). Poly(vinyl alcohol) (PVAL) was used as stabilizer. Read More

View Article and Full-Text PDF