43,715 results match your criteria albicans lines


Preparation of cellulose based wipes treated with antimicrobial and antiviral silver nanoparticles as novel effective high-performance coronavirus fighter.

Int J Biol Macromol 2021 Apr 14. Epub 2021 Apr 14.

Spinning and Weaving Engineering Department, Textile Industries Research Division, National Research Centre, 33 El Bohouth St., Dokki, P.O. 12622, Cairo, Egypt.

Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). We successful to prepare disinfectant cellulose-based wipes treated with antimicrobial and antiviral silver nanoparticles to be used for prevention of contamination and transmission of several pathogenic viruses and microbes to human in critical areas such as hospitals and healthcare centers especially coronavirus. In this work, the antimicrobial and antiviral activities of silver nanoparticles (AgNPs) prepared with four different techniques were investigated for the utilization as a disinfectant for cellulose-based wipes. Read More

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A new kind of barrel chest: alcoholic fermentation due to Candida albicans in a pleural effusion.

Am J Med 2021 Apr 14. Epub 2021 Apr 14.

Department of Anaesthesiology and Intensive Care Medicine, Faculty of Medicine and University Hospital of Cologne. Electronic address:

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Role of the high-affinity reductive iron acquisition pathway of Candida albicans in prostaglandin E2 production, virulence, and interaction with Pseudomonas aeruginosa.

Med Mycol 2021 Apr 16. Epub 2021 Apr 16.

Pathogenic Yeast Research Group, Department of Microbial, Biochemical and Food Biotechnology, University of the Free State, Bloemfontein 9300, South Africa.

Components of the iron reductive pathway of Candida albicans have been implicated in the production of prostaglandin E2 (PGE2) and virulence. However, it is unknown whether other components of this pathway influence PGE2. We investigated the role of the iron reductive pathway of C. Read More

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Antivirulence activity and in vivo efficacy of a thiazole derivative against candidiasis.

J Mycol Med 2021 Apr 6;31(2):101134. Epub 2021 Apr 6.

Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, PO Box 486, 31270-901 Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Candida albicans is a pathogen equipped with a variety of commensal and virulence traits that help it colonize the microbiota and invade host tissue during infection. In this study, we investigated the potential anticandidal activity of 3-[2-(4-(4-methoxyphenyl)thiazol-2-yl)hydrazino)]butan-1-ol (MT), a thiazolylhydrazone compound synthesized by our group, and identified it as a promising antifungal agent. The activity of MT was evaluated in vitro and in vivo against C. Read More

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Relationships of irrigation water and soil physical and chemical characteristics with yield, chemical composition and antimicrobial activity of Damask rose essential oil.

Authors:
Mansureh Ghavam

PLoS One 2021 16;16(4):e0249363. Epub 2021 Apr 16.

Department of Range and Watershed Management, Faculty of Natural Resources and Earth Sciences, University of Kashan, Kashan, Iran.

Damask rose (Rosa damascena Mill.) is an aromatic medicinal plant rich in bioactive compounds with high value in the food, pharmaceutical and cosmetic industries. Knowledge of the factors affecting the quantitative and qualitative properties of the compounds in its essential oil (EO) and the bioactivity of this EO is important in optimizing Damask rose cultivation and production. Read More

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The Effects of Nutraceuticals and Herbal Medicine on Candida albicans in Oral Candidiasis: A Comprehensive Review.

Adv Exp Med Biol 2021 ;1308:225-248

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Candida albicans is part of the healthy flora in the oral cavity. It can also cause opportunistic infection, which can be deleterious. The most typical type of chronic oral candidiasis is denture stomatitis, and C. Read More

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January 2021

A photo-triggered antifungal nanoplatform with efflux pump and heat shock protein reversal activity for enhanced chemo-photothermal synergistic therapy.

Biomater Sci 2021 Apr 16. Epub 2021 Apr 16.

Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing 211800, China. and School of Chemistry and Materials Science, Nanjing University of Information Science & Technology, Nanjing 210044, China.

Drug-resistant pathogens are less sensitive to traditional antibiotics in many stubborn infections. It is imminently desirable to have an effective alternative therapeutic agent for combating drug-resistant pathogen infections. Herein, a photo-triggered multifunctional nanoplatform (TMOB/FLU@PCM NPs) with efflux pump and heat shock protein expression reversal activity is developed for the highly effective eradication of drug-resistant fungi. Read More

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The zinc cluster transcription factor Czf1 regulates cell wall architecture and integrity in Candida albicans.

Mol Microbiol 2021 Apr 15. Epub 2021 Apr 15.

Institute for Molecular Infection Biology, University of Würzburg, Würzburg, Germany.

The fungal cell wall is essential for the maintenance of cellular integrity and mediates interactions of the cells with the environment. It is a highly flexible organelle whose composition and organization is modulated in response to changing growth conditions. In the pathogenic yeast Candida albicans, a network of signaling pathways regulates the structure of the cell wall, and mutants with defects in these pathways are hypersensitive to cell wall stress. Read More

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Gene expression of Candida albicans strains isolates from patients with denture stomatitis submitted to treatments with photodynamic therapy and nystatin.

Photodiagnosis Photodyn Ther 2021 Apr 12:102292. Epub 2021 Apr 12.

Department of Dental Materials and Prosthodontics, School of Dentistry at Araraquara, Univ Estadual Paulista - UNESP, Rua Humaitá, 1680, 14801-903, Araraquara, SP, Brazil. Electronic address:

The study evaluated the effect of antimicrobial photodynamic therapy (aPDT) and nystatin (NYS) in the expression of genes (ACT1, ALS1, CAP1, CAT1, EFG1, HWP1, LIP3, PLB1, SAP1, and SOD1) involved in the virulence of Candida albicans strains recovered from patients with denture stomatitis (DS). These strains were isolated from the patients before (initial) and after treatment (final), and 45 days after the treatments (follow-up). For gene expression analyses, RNA was isolated from the clinical strains, followed by cDNA synthesis and qPCR using specific primers for each target gene. Read More

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Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi‡.

Nucleic Acids Res 2021 Apr 15. Epub 2021 Apr 15.

State Key Laboratory of Crop Stress Biology in Arid Areas, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, China.

Telomerase plays critical roles in cellular aging, in the emergence and/or development of cancer, and in the capacity for stem-cell renewal, consists of a catalytic telomerase reverse transcriptase (TERT) and a template-encoding RNA (TER). TERs from diverse organisms contain two conserved structural elements: the template-pseudoknot (T-PK) and a helical three-way junction (TWJ). Species-specific features of the structure and function of telomerase make obtaining a more in-depth understanding of the molecular mechanism of telomerase particularly important. Read More

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One-Pot Reducing Agent-Free Synthesis of Silver Nanoparticles/Nitrocellulose Composite Surface Coating with Antimicrobial and Antibiofilm Activities.

Biomed Res Int 2021 27;2021:6666642. Epub 2021 Mar 27.

Dept. of Chemistry, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

Nitrocellulose with silver nanoparticle (AgNP/NC) composite was prepared using Ag(CHCO) and nitrocellulose without any reducing agent. The composite materials synthesized were spray coated onto glass substrates to obtain thin films. The AgNPs/NC composites were characterized by ultraviolet-visible, Fourier transform infrared, X-ray photoelectron spectroscopy, scanning electron microscopy, and transmission electron microscopy. Read More

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Heat-cured poly(methyl methacrylate) resin incorporated with different food preservatives as an anti-microbial denture base material.

J Dent Sci 2021 Mar 26;16(2):706-712. Epub 2020 Sep 26.

The Siam Cement Public Company Limited (SCG), Bangkok, Thailand.

Background/purpose: The colonization of microorganisms onto denture bases is one common problem that can contribute to oral diseases. Herein, three food preservatives, including zinc oxide, potassium sorbate, and sodium metabisulfite were introduced as anti-microbial additives into a heat-polymerized poly(methyl methacrylate) (PMMA).

Materials And Methods: Relative microbial reductions of the modified PMMA resins against , , and were evaluated. Read More

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lumbar spondylodiscitis contiguous to infected abdominal aortic aneurysm in an intravenous drug user.

BMJ Case Rep 2021 Apr 14;14(4). Epub 2021 Apr 14.

Department of Orthopaedic Surgery, Kudanzaka Hospital, Tokyo, Japan.

While the incidence of spondylodiscitis is rising because of longer life expectancy and the increasing use of immunosuppressant drug, indwelling devices and spinal surgeries, the fungal aetiology remains rare, sometimes affecting intravenous drug users. spondylodiscitis is an extremely rare complication post aortic aneurysm repair. It is potentially fatal due to the risk of aneurysm rupture and septic complications. Read More

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Oral Candidiasis and COVID-19 in Users of Removable Dentures: Is Special Oral Care Needed?

Gerontology 2021 Apr 14:1-6. Epub 2021 Apr 14.

Department of Restorative Dentistry, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Elderly patients with systemic disorders and immunocompromised patients seem to have a higher risk of developing morbidity from COVID-19. Candida albicans (C. albicans) is a potentially dangerous pathogen for these patients, especially for denture wearers with prosthetic stomatitis who require mechanical ventilation. Read More

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Fungal and bacterial coinfections increase mortality of severely ill COVID-19 patients.

J Hosp Infect 2021 Apr 11. Epub 2021 Apr 11.

Department of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Background: SARS-CoV-2 predisposes patients to secondary infections; however, a better understanding of the impact of coinfections on the outcome of hospitalized COVID-19 patients is still necessary.

Aim: To analyse death risk due to coinfections in COVID-19 patients.

Methods: We evaluated the Odds of death of 212 severely ill COVID-19 patients, with detailed focus on the risks for each pathogen, site of infection, comorbidities and length of hospitalization. Read More

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MORPHOLOGICAL EFFICACY EVALUATION OF GEL WITH CARBON DIOXIDE EXTRACT OF HOPS IN CASE OF COMPLICATED WOUND INFECTION ACNE VULGARIS.

Wiad Lek 2021 ;74(1):112-117

KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.

Objective: The aim of the study is to reveal in the experiment the morphological features of the infected skin wounds healing, which are a manifestation of acne vulgaris severe and very severe forms, using a gel with carbon dioxide extract of hops.

Patients And Methods: Materials and methods: An experimental study was carried out on 80 male WAG rats of three months of age. The animals were divided into 9 groups. Read More

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Radiation-induced synthesis of copper sulfide nanotubes with improved catalytic and antibacterial activities.

Environ Sci Pollut Res Int 2021 Apr 14. Epub 2021 Apr 14.

Materials Science Lab, Radiation Physics Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.

In the current paper, copper sulfide nanotubes have been successfully synthesized via the green, simple, and effective gamma-radiolysis method without adding any capping or reducing agents. The structural and morphological characteristics of the as-prepared CuS nanotubes were investigated by X-ray diffraction (XRD), N adsorption-desorption measurements at 77 K, transmission electron microscopy (TEM), and ultraviolet-visible (UV-vis) spectroscopy, which all demonstrated the formation of pure CuS covellite phase with tubular morphology. The synthesized CuS nanotubes possessed not only high activity towards the reduction of both cationic (methylene blue) and anionic (Congo red) dyes in the presence of NaBH but also exhibited excellent reusability. Read More

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Data of common and species-specific transcriptional host responses to pathogenic fungi.

Data Brief 2021 Apr 4;35:106928. Epub 2021 Mar 4.

Department of Internal Medicine and Radboudumc Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands.

Using a comparative RNA-Sequencing based transcriptional profiling approach, responses of primary human peripheral blood mononuclear cells (PBMCs) to common human pathogenic fungi have been characterized (Bruno et al. Computational and Structural Biology Journal). Primary human PBMCs were stimulated in vitro with the fungi , and after which RNA was isolated and sequenced. Read More

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Preparation and evaluation of chitosan-polyvinyl alcohol/polyhexamethylene guanidine hydrochloride antibacterial dressing to accelerate wound healing for infectious skin repair.

Ann Transl Med 2021 Mar;9(6):482

Department of Burn Surgery, the Third Affiliated Hospital of Inner Mongolia Medical University (Inner Mongolia Baogang Hospital), Baotou, China.

Background: Wound infections, especially multidrug-resistant (MDR) bacterial infections, are a major challenge in clinical medicine.

Methods: In this study, a new type of antibacterial sponge was prepared from a solution containing a chitosan-polyvinyl alcohol (CTS-PVA) emulsion with added polyhexamethylene guanidine hydrochloride (PHMG) in a homogeneous medium using lyophilization technology. The antibacterial ability of and CTS-PVA/PHMG sponge against , , , , Methicillin-resistant , multidrug-resistant , and multidrug-resistant in vitro. Read More

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Chemotype of damask rose with oleic acid (9 octadecenoic acid) and its antimicrobial effectiveness.

Sci Rep 2021 Apr 13;11(1):8027. Epub 2021 Apr 13.

Department Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.

Essential oils are natural products that have great antimicrobial potential value against many fungi and bacteria. Rosa damascena Mill. is one of the most important aromatic species of the Rosaceae family from which essential oil and economically valuable products can be obtained. Read More

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Natural photosensitizers from Tripterygium wilfordii and their antimicrobial photodynamic therapeutic effects in a Caenorhabditis elegans model.

J Photochem Photobiol B 2021 Mar 29;218:112184. Epub 2021 Mar 29.

Natural Product Informatics Research Center, Gangneung Institute of Natural Products, Korea Institute of Science and Technology, Gangwon-do 25451, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology (UST), Gangneung, Gangwon-do 25451, Republic of Korea. Electronic address:

Tripterygium wilfordii Hook. f. is a traditional medicinal plant and has long been used in East Asia to treat many diseases. Read More

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Synthesis, antimicrobial activity, density functional modelling and molecular docking with COVID-19 main protease studies of benzoxazole derivative: 2-(p-chloro-benzyl)-5-[3-(4-ethly-1-piperazynl) propionamido]-benzoxazole.

J Mol Struct 2021 Apr 8:130413. Epub 2021 Apr 8.

Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Trakya University TR-22030 Edirne, Turkey.

This study contains synthesis, antimicrobial activity, density functional modelling and molecular docking studies of benzoxazole derivative: 2-(p-chloro-benzyl)-5-[3-(4-ethly-1-piperazynl) propionamido]-benzoxazole. The synthetic procedure of investigated compound is given in detail. The newly synthesized benzoxazole compound and standard drugs were evaluated for their antimicrobial activity against some Gram-positive, Gram-negative bacteria and fungus and their drug-resistant isolates. Read More

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Novel Prosopis juliflora leaf ethanolic extract as natural antimicrobial agent against food spoiling microorganisms.

Sci Rep 2021 Apr 12;11(1):7871. Epub 2021 Apr 12.

Department of Biological and Environmental Sciences, College of Art and Science, Qatar University, P.O. Box 2713, Doha, Qatar.

Fresh produces spoilage is a worldwide concern that accompany the global increase in food demand. Adverse human health and environmental effects of commercial spoilage control agents are major public concern. In this study, Prosopis juliflora leaves and fruit extracts had their antimicrobial activities evaluated against the growth of selected bacteria and yeast, and against mycelial growth and conidial germination of selected mycotoxins-producing fungi. Read More

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Micafungin population PK analysis in plasma and peritoneal fluid in septic patients with intra-abdominal infections: a prospective cohort study.

Antimicrob Agents Chemother 2021 Apr 12. Epub 2021 Apr 12.

Service des Réanimations, Pôle Anesthésie Réanimation Douleur Urgence, CHU Nîmes, Nîmes, France.

To describe the pharmacokinetics (PK) of micafungin in plasma and peritoneal fluid in septic patients with intra-abdominal infections. Twelve patients with secondary peritonitis in septic shock receiving 100 mg micafungin once daily were included. Total micafungin plasma and peritoneal fluid were subject to a population pharmacokinetic analysis using Pmetrics®. Read More

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Antifungal activity and potential mechanism of Asiatic acid alone and in combination with fluconazole against Candida albicans.

Biomed Pharmacother 2021 Apr 10;139:111568. Epub 2021 Apr 10.

Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, Shandong Province 250014, People's Republic of China. Electronic address:

Candida albicans (C. albicans) infection remains a challenge to clinicians due to the limited available antifungals. With the widespread use of antifungals in the clinic, the drug resistance has been emerging continuously, especially fluconazole. Read More

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Caspofungin pharmacokinetics and probability of target attainment in ICU patients in China.

J Glob Antimicrob Resist 2021 Apr 9. Epub 2021 Apr 9.

Department of intensive care unit, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Background: Effective antifungal therapy is important for reducing the mortality of patients with invasive fungal diseases. Numerous factors affect the pharmacokinetic (PK)/pharmacodynamic (PD) parameters in critically ill patients. To guide the individualized administration of the antifungal drug caspofungin in critically ill patients, it is of great significance to investigate the population pharmacokinetics of caspofungin. Read More

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Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from .

J Enzyme Inhib Med Chem 2021 Dec;36(1):914-921

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.

Pathogenic yeasts frequently cause infections in hospitals. Antifungal drugs lose effectiveness due to other species and resistance. New medications are thus required. Read More

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December 2021

Direct Detection and Identification of the Most Common Bacteria and Fungi Causing Otitis Externa by a Stepwise Multiplex PCR.

Front Cell Infect Microbiol 2021 25;11:644060. Epub 2021 Mar 25.

Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Considering the importance of differential diagnosis of infectious otitis externa (OE), a stepwise PCR-based assay using universal and genus- or species-specific primers for the detection/identification of the most prevalent bacterial and fungal OE was developed and evaluated on the ear aspiration specimens of clinically suspected patients.

Methods And Materials: A total of 120 ear aspiration specimens with otomycosis suspicion were subjected to manual DNA extraction using phenol-chloroform extraction after tissue digestion with a lysis buffer. The multiplex PCR was initially performed using pan-fungal and bacterial homemade primers. Read More

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Bioadhesive-Thermosensitive Vaginal Gel of the Gel Flake-Solid Dispersion of Itraconazole for Enhanced Antifungal Activity in the Treatment of Vaginal Candidiasis.

ACS Appl Mater Interfaces 2021 Apr 11. Epub 2021 Apr 11.

School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, United Kingdom.

The poor solubility of itraconazole (ITZ) has limited its efficacy in the treatment of vaginal candidiasis. Accordingly, the improvement of ITZ solubility using a solid dispersion technique was important to enhance its antifungal activity. Besides, as the purpose of this research was to develop local-targeting formulations, bioadhesive-thermosensitive vaginal gel combined with the gel-flake system was found to be the most suitable choice. Read More

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Fabrication of different SnO nanorods for enhanced photocatalytic degradation and antibacterial activity.

Environ Sci Pollut Res Int 2021 Apr 10. Epub 2021 Apr 10.

King Abdullah Institute for Nanotechnology, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.

The acid-mediated (oxalic acid [OXA], cinnamic acid [CA], and itaconic acid [IA]) SnO nanorods were synthesized by the hydrothermal method. The synthesized SnO nanorods, in turn, were analyzed with various physico-chemical techniques such as the X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), and Raman spectroscopy. Furthermore, the photocatalytic activity of the different SnO nanorods was investigated with the malachite green (MG) dye under visible light illumination. Read More

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