43,869 results match your criteria albicans

Synthesis, antimicrobial, anti-cancer and in silico studies of new urea derivatives.

Bioorg Chem 2021 Apr 29;112:104953. Epub 2021 Apr 29.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Sadat City, Menoufia, Egypt.

The reaction of an alkyl or aryl isocyanates with some primary amines in acetonitrile at room temperature afforded the corresponding alkyl- and aryl-urea derivatives. All the prepared urea compounds have been elucidated by FTIR, NMR, and elemental analysis. The compounds 1 and 3 were confirmed by single-crystal X-ray diffraction. Read More

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Genetic diversity and molecular epidemiology of Candida albicans from vulvovaginal candidiasis patients.

Infect Genet Evol 2021 May 5:104893. Epub 2021 May 5.

Department of Clinical Laboratory, The Third People's Hospital of Hangzhou, Zhejiang 310009, China.

Candida albicans (C. albicans) is a common cause of vulvovaginal candidiasis (VVC). In this paper, the genetic diversity and molecular epidemiology of 173C. Read More

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Design, synthesis and biological evaluation of a series of iron and copper chelating deferiprone derivatives as new agents active against Candida albicans.

Bioorg Med Chem Lett 2021 May 5:128087. Epub 2021 May 5.

Department of Chimica e Tecnologia del Farmaco, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.

Candida albicans, in specific conditions, is responsible of severe invasive systemic candidiasis that are related to its ability to produce biofilm on biological and artificial surfaces. Many studies reported the role of iron in fungal growth and virulence and the ability of metal chelating agents to interfere with C. albicans metabolism, virulence and biofilm formation. Read More

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p-Coumaric acid loaded into liquid crystalline systems as a novel strategy to the treatment of vulvovaginal candidiasis.

Int J Pharm 2021 May 5:120658. Epub 2021 May 5.

Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.

Vulvovaginal candidiasis (VVC) is an extremely common type of vaginal infection, which is mainly caused by Candida albicans. However, non-albicans Candida species are frequently more resistant to conventional antifungal agents and can represent up to 30% of cases. Due to side effects and increasing antifungal resistance presented by standard therapies, phenolic compounds, such as p-coumaric acid (p-CA), have been studied as molecules from natural sources with potential antifungal activity. Read More

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A peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infection.

Nat Commun 2021 May 7;12(1):2560. Epub 2021 May 7.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.

The commensal fungus Candida albicans often causes life-threatening infections in patients who are immunocompromised with high mortality. A prominent but poorly understood risk factor for the C. albicans commensal‒pathogen transition is the use of broad-spectrum antibiotics. Read More

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Safety, immunogenicity, and efficacy of NDV-3A against Staphylococcus aureus colonization: A phase 2 vaccine trial among US Army Infantry trainees.

Vaccine 2021 May 4. Epub 2021 May 4.

NovaDigm Therapeutics, Inc., Grand Forks, ND, United States.

Background: Military trainees are at increased risk for Staphylococcus aureus colonization and infection. Disease prevention strategies are needed, but a S. aureus vaccine does not currently exist. Read More

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The Value of Perfusion Fluid Culture Analysis in Deceased Donor Renal Transplants: A 10-Year Single-Center Experience.

Transplant Proc 2021 May 4. Epub 2021 May 4.

Royal Free London NHS Foundation Trust, Microbiology, London, UK.

Microbiological analysis of kidney perfusion/transport solution is not routinely performed in all transplant centers. This paper gives a 10-year descriptive single-center experience of the routine culture of perfusion fluid in deceased donor renal transplant recipients as well as the prophylactic treatment of certain organisms if identified. Data were collected retrospectively on all deceased donor transplants performed between 2009 and 2018. Read More

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Comparative evaluation of the Bruker Biotyper and Vitek MS matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) systems for non-albicans Candida and uncommon yeast isolates.

J Microbiol Methods 2021 May 4:106232. Epub 2021 May 4.

University of Health Sciences, Sisli Etfal Training and Research Hospital, Turkey.

Introduction: Rapid and accurate diagnosis is critically important in invasive and disseminated fungal infections for appropriate antifungal treatment.

Hypothesis: MALDI-TOF MS systems are effective for fast and accurate identification of Candida species.

Aim: We aimed to compare two MALDI-TOF MS systems for the rapid identification of non-albicans Candida and rare clinical yeast species. Read More

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A novel use for an old drug: resistance reversal in by combining dihydroartemisinin with fluconazole.

Future Microbiol 2021 May 7. Epub 2021 May 7.

Department of Pharmacy, Shandong Cancer Hospital & Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China.

To investigate the effects of dihydroartemisinin combined with fluconazole against and to explore the underlying mechanisms. Checkerboard microdilution assay and time-kill curve method were employed to evaluate the static and dynamic antifungal effects against . Reactive oxygen species (ROS) was measured by a fluorescent probe. Read More

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No Impact of Fluconazole to Echinocandins Replacement as First-Line Therapy on the Epidemiology of Yeast Fungemia (Hospital-Driven Active Surveillance, 2004-2017, Paris, France).

Front Med (Lausanne) 2021 20;8:641965. Epub 2021 Apr 20.

Institut Pasteur, CNRS, Unité de Mycologie Moléculaire, Centre National de Référence Mycoses Invasives et Antifongiques, Paris, France.

Replacement of fluconazole by echinocandins as the first-line therapy for yeast-related fungemia could have an impact on both the mortality rate and the epidemiology of yeast species responsible for candidemia. We analyzed the individual clinical and microbiological data collected through the active surveillance program on yeast fungemia (YEASTS program, 2004-2016, Paris area, France) within 14 University Hospitals. The cohort included 3,092 patients [male:female ratio: 1. Read More

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Synergistic and Antagonistic Effects of Biogenic Silver Nanoparticles in Combination With Antibiotics Against Some Pathogenic Microbes.

Front Bioeng Biotechnol 2021 20;9:652362. Epub 2021 Apr 20.

Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.

The latest advances in green nanoparticle synthesis have preserved natural and non-renewable resources and decreased environmental pollution. The current study was designed to evaluate silver nanoparticles (AgNPs) fabricated using aqueous extracts of two medicinal plants, L. (Kaff Maryam) and . Read More

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Fungal Melanonychia as a Solitary Black Linear Vertical Nail Plate Streak: Case Report and Literature Review of Candida-Associated Longitudinal Melanonychia Striata.

Cureus 2021 Apr 1;13(4):e14248. Epub 2021 Apr 1.

Pain Management/Palliative Care, Scripps Memorial Hospital, La Jolla, USA.

Longitudinal melanonychia striata, presenting as a black linear vertical band of the nail plate, can be caused by pigmented lesions and non-pigmented etiologies. A fungal infection of the nail plate, also referred to as onychomycosis or tinea unguim, can result from dermatophytes, non-dermatophyte molds, and . Albeit rare, -associated fungal melanonychia can present as a longitudinal black nail plate streak. Read More

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Synthesis of cyclotetrapeptide analogues of c-PLAI and evaluation of their antimicrobial properties.

R Soc Open Sci 2021 Mar 24;8(3):201822. Epub 2021 Mar 24.

Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.

Antimicrobial peptides (AMPs) are interesting compounds owing to their ability to kill several pathogens. In order to identify new AMPs, c-PLAI analogues were synthesized and evaluated together with their linear precursors for their antimicrobial properties against two Gram-positive bacteria ( and ), two Gram-negative bacteria ( and ), and two fungal strains ( and ). The new c-PLAI analogues were prepared through a combination of solid- and solution-phase syntheses, as previously employed for the synthesis of c-PLAI. Read More

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The cross-kingdom interaction between Helicobacter pylori and Candida albicans.

PLoS Pathog 2021 May 6;17(5):e1009515. Epub 2021 May 6.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu, China.

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Cis- and Trans-chromosomal Interactions Define Pericentric Boundaries in the Absence of Conventional Heterochromatin.

Genetics 2019 Aug;212(4):1121-1132

Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560064, India.

The molecular cues for CENPA positioning in epigenetically regulated centromeres is elusive. Candida albicans has small regional non-repetitive centromeres that do not harbor conventional heterochromatin. Deletion of native centromere leads to activation of a neocentromere. Read More

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Repurposing the FDA-approved anticancer agent ponatinib as a fluconazole potentiator by suppression of multidrug efflux and Pma1 expression in a broad spectrum of yeast species.

Microb Biotechnol 2021 May 6. Epub 2021 May 6.

State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Fungal infections have emerged as a major global threat to human health because of the increasing incidence and mortality rates every year. The emergence of drug resistance and limited arsenal of antifungal agents further aggravates the current situation resulting in a growing challenge in medical mycology. Here, we identified that ponatinib, an FDA-approved antitumour drug, significantly enhanced the activity of the azole fluconazole, the most widely used antifungal drug. Read More

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The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.

FEMS Microbiol Rev 2021 May;45(3)

NEXBIOME Therapeutics, 22 allée Alan Turing, 63000 Clermont-Ferrand, France.

Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial barriers and immune defences. Their perturbation can lead to fungal outgrowth and the development of mucosal infections such as oropharyngeal or vulvovaginal candidiasis, and patients with compromised immunity are susceptible to life-threatening systemic infections. Read More

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An Opaque Cell-Specific Expression Program of Secreted Proteases and Transporters Allows Cell-Type Cooperation in Candida albicans.

Genetics 2020 Oct;216(2):409-429

Department of Microbiology and Immunology, University of California, San Francisco, California 94143.

The opportunistic human fungal pathogen Candida albicans switches between two distinct, heritable cell types named "white" and "opaque." Lohse et al. show that opaque cells, in respons. Read More

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October 2020

The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation.

Front Immunol 2021 19;12:661990. Epub 2021 Apr 19.

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.

Long-term changes in the immune system of successfully treated people living with HIV (PLHIV) remain incompletely understood. In this study, we assessed 108 white blood cell (WBC) populations in a cohort of 211 PLHIV on stable antiretroviral therapy and in 56 HIV-uninfected controls using flow cytometry. We show that marked differences exist in T cell maturation and differentiation between PLHIV and HIV-uninfected controls: PLHIV had reduced percentages of CD4+ T cells and naïve T cells and increased percentages of CD8+ T cells, effector T cells, and T helper 17 (Th17) cells, together with increased Th17/regulatory T cell (Treg) ratios. Read More

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Synthesis, Antifungal Activity, and Cytotoxicity of AgBr-NP@CTMAB Hybrid and Its Application in PMMA.

Int J Nanomedicine 2021 29;16:3091-3103. Epub 2021 Apr 29.

Fujian Key Laboratory of Oral Diseases, Fujian Biological Materials Engineering and Technology Center of Stomatology, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, Fujian, 350004, People's Republic of China.

Objective: To synthesize and determine the antifungal activity of AgBr-nanoparticles (NP) @CTMAB (cetyltrimethyl-ammonium bromide) against () for use in the field of denture cleaning.

Methods: The morphology and structure of AgBr-NP@CTMAB were characterized by IR, UV-Vis, XRD and SEM. The antifungal potential of AgBr-NP@CTMAB against was determined by colony formation assay and growth curve analysis. Read More

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Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.

Sci Rep 2021 May 5;11(1):9540. Epub 2021 May 5.

Department of Basic Sciences, Deanship of Preparatory Year and Supporting Studies, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, 34212, Saudi Arabia.

Novel synthesized Chitosan-Copper oxide nanocomposite (Cs-CuO) was prepared using pomegranate peels extract as green precipitating agents to improve the biological activity of Cs-NP's, which was synthesized through the ionic gelation method. The characterization of biogenic nanoparticles Cs-NP's and Cs-CuO-NP's was investigated structurally, morphologically to determine all the significant characters of those nanoparticles. Antimicrobial activity was tested for both Cs-NP's and Cs-CuO-NP's via minimum inhibition concentration and zone analysis against fungus, gram-positive and gram-negative. Read More

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Genetic Analysis of Sirtuin Deacetylases in Hyphal Growth of .

mSphere 2021 May 5;6(3). Epub 2021 May 5.

Department of Biological Sciences, State University of New York at Buffalo, Buffalo, New York, USA

is a major human fungal pathogen that encounters varied host environments during infection. In response to environmental cues, switches between ovoid yeast and elongated hyphal growth forms, and this morphological plasticity contributes to virulence. Environmental changes that alter the cell's metabolic state could be sensed by sirtuins, which are NAD-dependent deacetylases. Read More

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The effects of secreted aspartyl proteinase inhibitor ritonavir on azoles-resistant strains of Candida albicans as well as regulatory role of SAP2 and ERG11.

Immun Inflamm Dis 2021 May 5. Epub 2021 May 5.

The Department of Dermatovenereology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Background: Candida albicans, the main human fungal pathogen, can cause fungal infection and seriously affect people's health and life. This study aimed to investigate the effects of ritonavir (RIT) on C. albicans and the correlation between SAP2 as well as ERG11 and drug resistance. Read More

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Frequency of Pathogenic Microorganisms in Removable Orthodontic Appliances and Oral Mucosa in Children.

J Clin Pediatr Dent 2021 Apr;45(2):135-139

Objective: The aim of this study was to evaluate the frequency of Staphylococcus aureus, Pseudomonas aeruginosa, and Candida species in removable orthodontic appliances (ROA) and the support oral mucosa in children.

Study Design: The study participants comprised 55 patients aged 6-12 years requiring ROA. The samples of biofilm colonization from the support oral mucosa and the ROA were taken prior to the use of the ROA (T0) and 4 weeks (T1) after ROA placement. Read More

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Extensive microbiological respiratory tract specimen characterization in critically ill COVID-19 patients.

APMIS 2021 May 5. Epub 2021 May 5.

The Regional Department of Clinical Microbiology, Zealand University Hospital, Denmark.

Background: Microbial co-infections may contribute to the pulmonary deterioration in COVID-19 patients needing intensive care treatment. The present study portray the extent of co-infections in COVID-19 ICU patients.

Methods: Conventional culture, molecular detections for atypical aetiologies, QiaStat-Dx® respiratory panel V2 detecting 21 respiratory pathogens and ribosomal DNA genes 16S/18S amplicon-based microbiome analyses were performed on respiratory samples from 34 COVID-19 patients admitted to the ICU. Read More

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Rosmarinus officinalis L. (rosemary) extract has antibiofilm effect similar to the antifungal nystatin on Candida samples.

An Acad Bras Cienc 2021 30;93(2):e20190366. Epub 2021 Apr 30.

Universidade Estadual Paulista(UNESP), Instituto de Ciência e Tecnologia, Departamento de Biociências e Diagnóstico Bucal, Av. Engenheiro Francisco José Longo, 777, 12245-000 São José dos Campos, SP, Brazil.

Candida spp. are naturally opportunistic and can promote infections. These yeasts can form biofilm, after penetration and adhesion to the biotic or abiotic surfaces. Read More

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ROS-generating rare-earth coordination networks for photodynamic inactivation of .

Dalton Trans 2021 May;50(17):5853-5864

Instituto de Investigaciones en Tecnología Química (INTEQUI-CONICET), Alte. Brown 1450, 5700 San Luis, Argentina and Área de Química General e Inorgánica "Dr G. F. Puelles", Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Ejercito de los Andes 950, 5700 San Luis, Argentina.

Water-ethanol suspensions of 2D coordination network (CN) based on rare earth elements and mixed ligands were evaluated as reactive oxygen species (ROS) generators under UV light irradiation, in contact with a biomimetic substrate (tryptophan) or an O2(1Δg) quencher (1,3-diphenylisobenzofuran; 1,3-DPBF). A combination of bottom-up and top-down strategies was implemented in order to obtain nano-sized CN particles and the subsequent colloidal suspensions were also tested towards photodynamic inactivation of Candida albicans (C. albicans). Read More

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antimicrobial activity of selected essential oils against bacteria and yeasts isolated from the genital tract of mares.

Nat Prod Res 2021 May 5:1-6. Epub 2021 May 5.

Department of Veterinary Science, University of Pisa, Pisa, Italy.

The aim of the present study, the first to test clinical equine isolates, was to evaluate the antimicrobial activity of commercial essential oils (EOs) obtained from and against spp., spp., and spp. Read More

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A spacer infection by Candida albicans secondary to a Staphylococcus capitis prosthetic joint infection: a case report.

BMC Infect Dis 2021 May 4;21(1):416. Epub 2021 May 4.

IRCCS Istituto Ortopedico Galeazzi, Laboratory of Clinical Chemistry and Microbiology, Via R. Galeazzi 4, 20161, Milan, Italy.

Background: Prosthetic joint infection (PJI) is one of the most feared complications following total arthroplasty surgeries. Gram-positive bacteria are the most common microorganisms implicated in PJIs, while infections mediated by fungi only account for 1% of cases. When dealing with PJIs, a two-stage revision arthroplasty is widely used. Read More

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Virulence Factors and Antifungal Susceptibility Profile of Isolated from Various Clinical Specimens in Alexandria, Egypt.

J Fungi (Basel) 2021 Apr 29;7(5). Epub 2021 Apr 29.

Department of Microbiology, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt.

Background: The incidence of candidiasis caused by non- (NAC) species is increasing. has emerged as one of the most important NAC species. This study aims to examine the antifungal susceptibility profile and some virulence factors of isolated from various clinical specimens. Read More

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