16,327 results match your criteria aki


In situ electrokinetic (EK) remediation of the total and plant available cadmium (Cd) in paddy agricultural soil using low voltage gradients at pilot and full scales.

Sci Total Environ 2021 Apr 23;785:147277. Epub 2021 Apr 23.

Faculty of Biological and Environmental Sciences, Ecosystems and Environment Research Programme, University of Helsinki, Niemenkatu 73, FI-15140 Lahti, Finland; Natural Resources Institute Finland Luke, Itäinen Pitkäkatu 4A, 20520 Turku, Finland. Electronic address:

Electrokinetic (EK) remediation has been widely studied at laboratory scales. However, field-scale research is far less. In this study, a 14-day EK remediation was carried out, in a field pilot (4 m) test and a full-scale (200 m) application for the first time, in a cadmium (Cd) contaminated paddy agricultural field near a mining area. Read More

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Long Non-Coding RNA CASC2 Overexpression Ameliorates Sepsis-Associated Acute Kidney Injury by Regulating MiR-545-3p/PPARA axis.

J Surg Res 2021 May 3;265:223-232. Epub 2021 May 3.

Department of orthopedics, Chengdu Second People's Hospital; Sichuau, China. Electronic address:

Background: Long non-coding RNAs (lncRNAs) have been demonstrated to be involved in the progression of sepsis-induced acute kidney injury (AKI). In this study, we aimed to explore the functions of lncRNA cancer susceptibility candidate 2 (CASC2) in sepsis-induced AKI.

Methods: The sepsis cell models were established by exposing HK2 and HEK293 cells into lipopolysaccharide (LPS). Read More

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Factors associated with acyclovir nephrotoxicity in children: data from 472 pediatric patients from the last 10 years.

Eur J Pediatr 2021 May 6. Epub 2021 May 6.

Department of Pediatric Infectious Diseases, Dr. Sami Ulus Children's Health and Diseases Research and Training Hospital, Ankara, Turkey.

Acyclovir may cause acute kidney injury (AKI) due to the accumulation of relatively insoluble acyclovir crystals in renal tubules. The aim of this study was to evaluate risk factors associated with acyclovir-related AKI in children. Between January 2010 and December 2019, pediatric recipients of intravenous (IV) acyclovir were evaluated retrospectively. Read More

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Acute kidney injury successfully treated with autologous granulocyte colony-stimulating factor-mobilized peripheral blood CD34-positive cell transplantation: A first-in-human report.

Stem Cells Transl Med 2021 May 6. Epub 2021 May 6.

Kidney Disease and Transplant Center, Shonan Kamakura General Hospital, Kamakura, Japan.

A 36-year-old man with severe acute kidney injury (AKI) was admitted to Shonan Kamakura General Hospital in Japan. He was diagnosed with refractory hypertension based on a severely elevated blood pressure of 224/116 mmHg and retinal, cardiac, and brain damage revealed by electrocardiogram, fundoscopy, and magnetic resonance imaging, respectively. Although hemodialysis was withdrawn following strict blood pressure control by an angiotensin receptor blocker, severe kidney insufficiency persisted. Read More

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CRRT in developing world.

Semin Dial 2021 May 6. Epub 2021 May 6.

Renown Clinical Services, Hyderabad, India.

Continuous renal replacement therapy (CRRT) has become a mainstay therapy in the intensive care unit (ICU) and its utilization continues to increase in developed countries. The wide variations of CRRT practice, however, are evident in developing countries while clinicians in these resource-limited countries encounter various barriers such as a limited number of nephrologists and trained staff, a gap of knowledge, machine unavailability, cultural and socioeconomic aspects, high-cost therapy without reimbursement, and administrative as well as governmental barriers. In this article, we demonstrate the situation of CRRT and discuss the barriers of CRRT in a resource-limited setting. Read More

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Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass.

Pediatr Nephrol 2021 May 5. Epub 2021 May 5.

Department of Anesthesiology, University of Colorado, Aurora, CO, USA.

Background: We sought to determine differences in the circulating metabolic profile of infants with or without acute kidney injury (AKI) following cardiothoracic surgery with cardiopulmonary bypass (CPB).

Methods: We performed a secondary analysis of preoperative and 24-h postoperative serum samples from infants ≤ 120 days old undergoing CPB. Metabolic profiling of the serum samples was performed by targeted analysis of 165 serum metabolites via tandem mass spectrometry. Read More

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NaHS Alleviated Cell Apoptosis and Mitochondrial Dysfunction in Remote Lung Tissue after Renal Ischemia and Reperfusion via Nrf2 Activation-Mediated NLRP3 Pathway Inhibition.

Biomed Res Int 2021 15;2021:5598869. Epub 2021 Apr 15.

Department of Urology, Tianjin Medical University General Hospital, Tianjin Heping District Anshan Road 154, Tianjin 300052, China.

Objective: Acute kidney injury (AKI) is a common and severe complication in critically ill patients, often caused by renal ischemia-reperfusion (RIR). Previous studies have confirmed that lung injury, rather than renal injury, is one of the leading causes of AKI-induced death. The pathophysiological mechanisms of acute lung injury (ALI) resulting from AKI are very complex and remain unclear. Read More

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The combination of vitamin D3 and erythropoietin alleviates acute kidney injury induced by ischemia-reperfusion via inhibiting inflammation and apoptosis.

Iran J Basic Med Sci 2021 Feb;24(2):167-174

Department of Nephrology, Guizhou Provincial People's Hospital & NHC Key Laboratory of Pulmonary Immunological Disease (Guizhou Provincial People's Hospital), Guiyang, Guizhou, 550002, P.R. China.

Objectives: Acute renal ischemia may cause acute renal dysfunction due to lack of blood supply; the manifestations are renal tubular cell apoptosis, infiltration of macrophages, and microvascular destruction. Many studies have shown that erythropoietin (EPO) and vitamin D3 (VD3) can be used to prevent or treat renal ischemia-reperfusion (I/R) injury, and VD3 may interact with EPO. In the present study, the effects of the combination of VD3 and EPO in I/R acute kidney injury were studied. Read More

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February 2021

Quantification of the early pupillary dilation kinetic to assess rod and cone activity.

Sci Rep 2021 May 5;11(1):9549. Epub 2021 May 5.

Neuro-Ophtalmology, Department of Ophthalmology, University of Lausanne, Hôpital Ophtalmique Jules Gonin, Lausanne, Switzerland.

Rods, cones and melanopsin contribute in various proportions, depending on the stimulus light, to the pupil light response. This study used a first derivative analysis to focus on the quantification of the dynamics of pupillary dilation that immediately follows light-induced pupilloconstriction in order to identify novel parameters that reflect rod and cone activity. In 18 healthy adults, the pupil response to a 1 s blue light stimulus ranging from - 6. Read More

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Renoprotective Effect of Oridonin in a Mouse Model of Acute Kidney Injury via Suppression of Macrophage Involved Inflammation.

Biol Pharm Bull 2021 ;44(5):714-723

Research Center for Integrated Chinese and Western Medicine, Affiliated Traditional Medicine Hospital, Southwest Medical University.

Ischemia-reperfusion injury (IRI) is the major cause of acute kidney injury (AKI). The previous studies demonstrated that Oridonin can protect kidney against IRI-induced AKI, but the underlying molecular mechanism is unclear. In this study, it showed that Oridonin significantly improved kidney damage, and inhibited the expression of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and MCP-1, as well as macrophage marker F4/80 in kidney and the secretion of inflammatory cytokins in serum of AKI mice in vivo. Read More

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January 2021

Barriers to ACEI/ARB Use in Proteinuric Chronic Kidney Disease: An Observational Study.

Mayo Clin Proc 2021 May 2. Epub 2021 May 2.

Division of Nephrology, Stanford University School of Medicine, Palo Alto, CA.

Objective: To assess present angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) use among patients with proteinuric chronic kidney disease (CKD) and examine barriers limiting this guideline-concordant care.

Patients And Methods: Using a nationwide database containing patient-level claims and integrated clinical information, we examined current ACEI/ARB prescriptions on the index date (April 15, 2017) and prior ACEI/ARB use in 41,743 insured adults with proteinuric CKD. Using multivariable logistic regression, we estimated adjusted associations between current ACEI/ARB use and putative barriers including past acute kidney injury (AKI), hyperkalemia, advanced CKD, and lack of nephrology care. Read More

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The association between neutrophil-to-lymphocyte ratio and contrast-induced acute kidney injury in patients with carotid artery stenting.

Vascular 2021 May 6:17085381211012562. Epub 2021 May 6.

Department of Radiology, Siyami Ersek Thoracic and Cardiovascular Surgery Centre, Training and Research Hospital, Istanbul, Turkey.

Objectives: Contrast-induced acute kidney injury (CI-AKI) is a life-threatening complication that leads to comorbidities and prolonged hospital stay lengths in the setting of peripheral interventions. The presence of some CI-AKI risk factors has already been investigated. In this study, we evaluated the predictors of CI-AKI after carotid artery stenting. Read More

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Association between Diabetes Mellitus and Contrast-Associated Acute Kidney Injury: A Systematic Review and Meta-Analysis of 1.1 Million Contrast Exposure Patients.

Nephron 2021 May 5:1-11. Epub 2021 May 5.

Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangzhou, China.

Background: Although diabetes mellitus (DM) has been a common risk factor of contrast-associated acute kidney injury (CA-AKI) for a long time, several current studies showed that DM is not an independent risk factor. Due to this diverse finding, we aim to conduct a systematic review assessing the effect of DM on CA-AKI.

Methods: We searched Ovid Medline, Embase, and Cochrane Database of Systematic Reviews (to June 1, 2020) for studies assessing the association between DM and CA-AKI. Read More

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Increased mortality with REBOA only mitigated by strong unmeasured confounding: an expanded analysis using the National Trauma Data Bank.

J Trauma Acute Care Surg 2021 May 5. Epub 2021 May 5.

Department of Surgery, Yale School of Medicine Applied Mathematics Program, Department of Mathematics, Yale University Department of Statistics and Data Science, Yale University.

REBOA is being increasingly adopted to manage non-compressible torso hemorrhage, but a recent analysis of the 2015-2016 Trauma Quality Improvement Project (TQIP) dataset showed that placement of REBOA was associated with higher rates of death, lower extremity amputation, and acute kidney injury (AKI). We expand this analysis by including the 2017 dataset, quantifying the potential role of residual confounding, and distinguishing between traumatic and ischemic lower extremity amputation.

Methods: This retrospective study used the 2015-2017 TQIP database and included patients older than 18 years old, with signs of life on arrival, no aortic injury, and were not transferred. Read More

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Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion.

Am J Physiol Lung Cell Mol Physiol 2021 May 5. Epub 2021 May 5.

Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, United Statesgrid.430503.1.

Acute kidney injury (AKI) is a complex disease associated with increased mortality that may be due to deleterious distant organ effects. AKI associated with respiratory complications, in particular, has a poor outcome. In murine models, AKI is characterized by increased circulating cytokines, lung chemokine upregulation, and neutrophilic infiltration, similar to other causes of indirect acute lung injury (ALI)(e. Read More

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Methods for dose quantification in continuous renal replacement therapy: towards a more precise approach.

Artif Organs 2021 May 5. Epub 2021 May 5.

Department of Health Sciences, Section of Anaesthesiology, Intensive Care and Pain Medicine, University of Florence, Italy.

Periodic dose assessment is quintessential for dynamic dose adjustment and quality control of continuous renal replacement therapy (CRRT) in critically ill patients with acute kidney injury (AKI). The flows-based methods to estimate dose are easy and reproducible methods to quantify (estimate)CRRT dose at the bedside. In particular, quantification of effluent flow and, mainly, the current dose (adjusted for dialysate, replacement, blood flows and net ultrafiltration) is routinely used in clinical practice. Read More

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COVID-19 and Diabetic Ketoacidosis: Report of Eight Cases.

Cureus 2021 Mar 31;13(3):e14223. Epub 2021 Mar 31.

Hematology and Oncology, Saint Joseph's University Medical Center, Paterson, USA.

Aim To describe the clinical characteristics and outcome of hospitalized COVID-19 patients with diabetic ketoacidosis (DKA). Methods We report eight cases of diabetic ketoacidosis in COVID-19 who presented to our institution in New Jersey, USA. COVID-19 was diagnosed by nasopharyngeal swab reverse transcription polymerase chain reaction (RT-PCR). Read More

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Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection.

Nat Commun 2021 05 4;12(1):2506. Epub 2021 May 4.

Institute of Immunology, PLA, Third Military Medical University, Chongqing, P. R. China.

It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can directly infect human kidney, thus leading to acute kidney injury (AKI). Here, we perform a retrospective analysis of clinical parameters from 85 patients with laboratory-confirmed coronavirus disease 2019 (COVID-19); moreover, kidney histopathology from six additional COVID-19 patients with post-mortem examinations was performed. We find that 27% (23/85) of patients exhibited AKI. Read More

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C/EBP β mediates the aberrant inflammatory response and cell cycle arrest in LPS-stimulated human renal tubular epithelial cells by regulating NF-κB pathway.

Arch Med Res 2021 May 1. Epub 2021 May 1.

Emergency department, The second affiliated hospital of Xi'an Jiaotong University, (Xibei Hospital), Xi'an 710004, China. Electronic address:

Background And Aims: The main cause of sepsis-induced Acute kidney injury (AKI) is acute infection after surgery and subsequent progression. However, the mechanism by which AKI is caused and developed from sepsis are not completely known. Herein, we determined the role of CCAAT/enhancer-binding protein β (C/EBP β) in sepsis-induced AKI METHODS: C/EBP β expression was up or down-regulated in LPS-stimulated human renal tubular epithelial cells in vitro by recombinant adenoviruses or siRNA. Read More

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Reciprocal assessment of urinary beta-2-microglobulin and BUN levels in renal dysfunction of neonates with birth asphyxia.

J Matern Fetal Neonatal Med 2021 May 4:1-7. Epub 2021 May 4.

Faculty of Medicine, Department of Immunology, Guilan University of Medical Sciences, Rasht, Iran.

Objective: Asphyxia at birth is one of the major causes of morbidity and mortality in all neonates due to various organ dysfunctions, for example, kidneys. Recent advances in this area have suggested new urinary proteins for the assessment of renal damage, including beta-2 microglobulin (β2-MG). The aim of this study was to investigate the changes of urinary β2-MG in asphyxiated neonates and to evaluate the value of combined detection of multiple biomarkers in the early diagnosis of acute kidney injury (AKI) in asphyxiated neonates. Read More

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Urgent-start dialysis in patients referred early to a nephrologist-the CKD-REIN prospective cohort study.

Nephrol Dial Transplant 2021 May 4. Epub 2021 May 4.

Université Paris-Saclay, UVSQ, Inserm, Clinical Epidemiology Team, CESP (Centre de recherche en Epidémiologie et Santé des Populations), Villejuif, France.

Background: The lack of a well-designed prospective study of the determinants of urgent dialysis start led us to investigate its individual- and provider-related factors in patients seeing nephrologists.

Methods: CKD-REIN is a prospective cohort study that included 3033 patients with CKD (mean age, 67 years; 65% men; mean estimated glomerular filtration rate (eGFR), 32 mL/min/1.73 m2) from 40 nationally representative nephrology clinics from 2013-16, who were followed annually through 2020. Read More

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Severe rhabdomyolysis induced by co-administration of cocaine and heroin in a 45 years old man treated with rosuvastatin: a case report.

Acta Biomed 2021 Apr 30;92(S1):e2021089. Epub 2021 Apr 30.

Academy of Emergency Medicine and Care (AcEMC), Pavia, Italy.

The term rhabdomyolysis describes a damage involving striated muscle cells or fibers, often complicated by acute kidney injury. This syndrome can have different causes, but it is generally divided into two main categories: traumatic and non-traumatic rhabdomyolysis. Among medical causes, drugs and abuse substances play a pivotal role, being opioids, alcohol, cocaine and other substances of abuse. Read More

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Venous bicarbonate and creatine kinase as diagnostic and prognostic tools in the setting of acute traumatic rhabdomyolysis.

S Afr Med J 2021 Mar 31;111(4):333-337. Epub 2021 Mar 31.

Department of Surgery, Tygerberg Hospital and Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Department of Surgery, Khayelitsha District Hospital and Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Background: Myorenal or crush syndrome often develops following soft-tissue traumatic injury. It is a spectrum of disease that may result in severe renal dysfunction and kidney injury requiring renal replacement therapy.

Objectives: To review a large cohort of patients with so-called myorenal or crush syndrome and assess the biochemical markers of venous bicarbonate and creatine kinase as predictors for the development of acute kidney injury (AKI). Read More

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Circ_0023404 sponges miR-136 to induce HK-2 cells injury triggered by hypoxia/reoxygenation via up-regulating IL-6R.

J Cell Mol Med 2021 May 4. Epub 2021 May 4.

Department of Nephrology, Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China.

The significance of circular RNAs (circRNAs) is reported in various kidney diseases including acute kidney injury (AKI). Specific circRNAs have the capacity to function as novel indicators of AKI. Circ_0023404 exhibits an important role in several diseases. Read More

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Ultrasound enhances the therapeutic potential of mesenchymal stem cells wrapped in greater omentum for aristolochic acid nephropathy.

Stem Cell Res Ther 2021 May 3;12(1):261. Epub 2021 May 3.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing, 100853, China.

Background: Mesenchymal stem cells (MSCs) have been reported to promote regeneration in both subjects with acute kidney injury (AKI) and chronic kidney disease (CKD), but their efficacy remains limited, probably because most of the cells accumulate in the lungs, liver, and spleen after an intravenous infusion. Therefore, ultrasound-guided administration of MSCs represents a possible approach to solve this problem. The greater omentum is used to promote cell survival due to its rich vasculature. Read More

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Prehospital blood pressure and lactate are early predictors of acute kidney injury after trauma.

J Surg Res 2021 Apr 30;265:180-186. Epub 2021 Apr 30.

Department of Emergency and Critical Care Medicine, Wakayama Medical University, School of Medicine, Wakayama, Japan.

Background: The purpose of this study is to report the prevalence of acute kidney injury (AKI) after trauma in our center, describe the risk factors associated with AKI, and determine whether these risk factors help avoid AKI.

Materials And Methods: We retrospectively analyzed the data which were prospectively collected from a single center trauma registry from January 2017 to December 2018. Patients who were <16 years of age, patients with burns, and patients with chronic kidney disease were excluded from the present study. Read More

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Drug dosing considerations in continuous renal replacement therapy.

Semin Dial 2021 May 3. Epub 2021 May 3.

Clinical Pharmacy, UC San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, CA, USA.

Acute kidney injury (AKI) is a common complication in critically ill patients, which is associated with increased in-hospital mortality. Delivering effective antibiotics to treat patients with sepsis receiving continuous renal replacement therapy (RRT) is complicated by variability in pharmacokinetics, dialysis delivery, lack of primary literature, and therapeutic drug monitoring. Pharmacokinetic alterations include changes in absorption, distribution, protein binding (PB), metabolism, and renal elimination. Read More

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Impact of diabetes mellitus on short-term prognosis, length of stay, and costs in patients with acute kidney injury: A nationwide survey in China.

PLoS One 2021 3;16(5):e0250934. Epub 2021 May 3.

Department of Nephrology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong, China.

Background: International data suggest that people with diabetes mellitus (DM) are at increased risk for worse acute kidney injury (AKI) outcomes; however, the data in China are limited. Therefore, this study aimed to describe the association of DM with short-term prognosis, length of stay, and expenditure in patients with AKI.

Methods: This study was based on the 2013 nationwide survey in China. Read More

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Clinical determinants of the severity of COVID-19: A systematic review and meta-analysis.

PLoS One 2021 3;16(5):e0250602. Epub 2021 May 3.

Department of Epidemiology and Health Statistics, School of Health Sciences, Wuhan University, Wuhan, Hubei, China.

Objective: We aimed to systematically identify the possible risk factors responsible for severe cases.

Methods: We searched PubMed, Embase, Web of science and Cochrane Library for epidemiological studies of confirmed COVID-19, which include information about clinical characteristics and severity of patients' disease. We analyzed the potential associations between clinical characteristics and severe cases. Read More

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Predictors and Outcomes of Dengue-Associated Acute Kidney Injury.

Am J Trop Med Hyg 2021 May 3. Epub 2021 May 3.

2Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Dengue viral infections present with a wide clinical spectrum ranging from asymptomatic to severe manifestations with organ involvement. The term "expanded dengue syndrome" has been commonly used to illustrate the unusual or atypical manifestations; acute kidney injury (AKI) is one of the atypical manifestations of this syndrome. The use of heterogeneous criteria to determine the presence of AKI in dengue patients due to the vast diversity in populations led to difficulties in assessing the true incidence of dengue-associated AKI. Read More

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