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Metaproteomics associated with severe early childhood caries highlights the differences in salivary proteins.

Arch Oral Biol 2021 Jul 29;131:105220. Epub 2021 Jul 29.

Formerly visiting scientist at Zhejiang University, Hangzhou, Zhejiang Province, PR China; Amity Institute of Microbial Technology (AIMT), Amity University Uttar Pradesh (AUUP), Sector 125, Super Express Way, Noida, 201 303, UP, India.

Objective: To investigate the salivary metaproteomic characteristics of the children with and without severe early childhood caries (S-ECC).

Design: In this study, we collected unstimulated saliva samples from 34 children (age 3-4 years) with caries free (NC, dmfs (= index of decayed, missing due to caries, or filled tooth surfaces) = 0, n = 23) and with S-ECC (dmfs≥10, n = 11). Salivary proteins were extracted and reduced, and then a Liquid Chromatography/Mass Spectrometry system was used to identify proteins. Read More

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Influence of intrauterine growth status on aortic intima-media thickness and aortic diameter in near-term fetuses: a comparative cross-sectional study.

J Dev Orig Health Dis 2021 Jun 15:1-8. Epub 2021 Jun 15.

Maternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Aga Khan University, Pakistan.

Intrauterine undernutrition may lead to fetal vascular programming. We compared abdominal aortic intima-media thickness (aIMT) and aortic diameter (aD) between appropriate for gestational age (AGA) and growth-restricted fetuses (GRF). We recruited 136 singleton fetuses at 34-37 weeks of gestation from Fetal Medicine Unit of Aga Khan University Hospital, Karachi (January-November 2017). Read More

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Phenotypic and Clonal Stability of Antigen-Inexperienced Memory-like T Cells across the Genetic Background, Hygienic Status, and Aging.

J Immunol 2021 05 15;206(9):2109-2121. Epub 2021 Apr 15.

Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic;

Ag-inexperienced memory-like T (AIMT) cells are functionally unique T cells, representing one of the two largest subsets of murine CD8 T cells. However, differences between laboratory inbred strains, insufficient data from germ-free mice, a complete lack of data from feral mice, and an unclear relationship between AIMT cells formation during aging represent major barriers for better understanding of their biology. We performed a thorough characterization of AIMT cells from mice of different genetic background, age, and hygienic status by flow cytometry and multiomics approaches, including analyses of gene expression, TCR repertoire, and microbial colonization. Read More

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The Role of Far Infrared Therapy in the Unassisted Maturation of Arterio-venous Fistula in Patients with Chronic Kidney Disease.

Indian J Nephrol 2020 Sep-Oct;30(5):307-315. Epub 2020 Aug 27.

Department of Community Medicine, Velammal Medical College Hospital, Madurai, Tamil Nadu, India.

Introduction: The goal of arterio-venous fistula (AVF) creation is to achieve a well-functioning access that can be cannulated repetitively and can provide adequate flow for the dialysis. The objective of this study was to assess the role of far infrared (FIR) therapy in the unassisted maturation of newly created AVF in patients with chronic kidney disease (CKD).

Materials And Methods: In this prospective open labeled randomised control trial, 107 patients were randomized. Read More

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Copeptin as a Biomarker of Atherosclerosis in Type 1 Diabetic Patients.

Open Access Maced J Med Sci 2019 Dec 13;7(23):3975-3978. Epub 2020 Dec 13.

Pediatrics Department, National Research Centre, Cairo, Egypt.

Aim: To evaluate copeptin as an early marker of atherosclerosis in adolescent type 1 diabetics.

Methods: Sixty-two type 1 diabetic patients and 50 healthy volunteers were enrolled in the study. Serum copeptin, glycosylated haemoglobin (HbA1c), lipid profile, oxidised low-density lipoprotein (OxLDL), urinary albumin/creatinine ratio, carotid intimal medial thickness (cIMT), aortic intimal medial thickness (aIMT) and resistivity index were assessed for all participants in the study. Read More

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December 2019

Phytoplankton diversity in relation to physicochemical attributes and water quality of Mandakini River, Garhwal Himalaya.

Environ Monit Assess 2020 Dec 1;192(12):799. Epub 2020 Dec 1.

Department of Environmental Sciences, H.N.B. Garhwal University (A Central University), Srinagar Garhwal, Uttarakhand, 246174, India.

Phytoplankton are important biological indicators of water quality. This current study assessed the physicochemical parameters and phytoplankton diversity of Mandakini River, an important tributary of the River Ganga. Water and phytoplankton samples were collected from three sampling sites located at three different altitudes for a period of twelve months (July 2018-June 2019). Read More

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December 2020

Increased circulating endothelial progenitor cells (EPCs) in prepubertal children born prematurely: a possible link between prematurity and cardiovascular risk.

Pediatr Res 2021 Jul 10;90(1):156-165. Epub 2020 Oct 10.

Neonatal Unit, First Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Background: Endothelial progenitor cells (EPCs) ensure vascular integrity and neovascularization. No studies have investigated EPCs in preterm-born children beyond infancy.

Methods: One hundred and thirty-six prepubertal children were enrolled: 63 preterm and 73 born at term (controls). Read More

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Aortic intima-media thickness in neonates exposed to early-onset preeclampsia.

Early Hum Dev 2020 12 25;151:105166. Epub 2020 Aug 25.

Neonatal Intensive Care Unit, Department of Pediatrics, University of Patras Medical School, Greece.

Aortic intima-media thickness (aIMT) and its ratio to aortic diameter (aIMT/AoD) were measured on the second and fifth postnatal day in 39 neonates exposed to early-onset preeclampsia and 39 controls. Both aIMT and aIMT/AoD were higher in neonates exposed to preeclampsia (P < 0.001 for all comparisons). Read More

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December 2020

Narcissistic T cells: reactivity to self makes a difference.

FEBS J 2021 03 10;288(6):1778-1788. Epub 2020 Aug 10.

Laboratory of Adaptive Immunity, Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic.

It has been appreciated for more than three decades that the interactions between the T-cell antigen receptor and self-antigens are the major determinants of the cell fates of developing thymocytes and the establishment of central tolerance. However, recent evidence shows that the level of self-reactivity substantially contributes to fate choices of positively selected mature T cells in homeostasis, as well as during immune responses. This implies that individual clones of peripheral T cells are predisposed to specific functional properties based on the self-reactivity of their antigen receptors. Read More

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Evaluation of Plasma Asymmetric Dimethylarginine Levels and Abdominal Aortic Intima-Media Thickness in Infants of Smoker Mothers.

Am J Perinatol 2020 Jul 19. Epub 2020 Jul 19.

Department of Pediatrics, Patnos State Hospital, Agri, Turkey.

Objective:  Smoking during pregnancy has harmful effects on the fetus and infant. Although some studies suggest that exposure to fetal-maternal smoking adversely affects both fetal growth and cardiovascular development, the mechanisms and biochemical consequences of smoking in pregnancy and newborns are not yet fully understood. We aimed to investigate whether maternal smoking during pregnancy causes fetal cardiovascular effect by measuring serum asymmetric dimethylarginine (ADMA) level and abdominal aortic intima-media thickness (aIMT). Read More

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Impact of lifestyle and cardiovascular risk factors on early atherosclerosis in a large cohort of healthy adolescents: The Early Vascular Ageing (EVA)-Tyrol Study.

Atherosclerosis 2020 07 13;305:26-33. Epub 2020 Jun 13.

Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:

Background And Aims: Atherosclerosis starts early in life. We aimed to assess the dimension and progression of the intima-media thickness, a surrogate marker for early vascular aging, and its association with a broad palette of cardiovascular risk and lifestyle factors in a large cohort of healthy adolescents.

Methods: The EVA-Tyrol cohort study enrolled 1573 adolescents with a mean age of 16. Read More

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Correlation of Aortic Intima-Media Thickness With Birthweight in Healthy Term and Near Term Neonates.

Indian Pediatr 2020 09 12;57(9):795-797. Epub 2020 Jun 12.

Department of Pediatrics, Apollo BGS hospital, Mysore, Karnataka, India. Correspondence to: Dr Girish Gururaja, Consultant Neonatologist, Apollo BGS hospital, Adichunchanagiri road, Kuvempunagar, Mysore, Karnataka 570 023, India.

Objectives: The primary objective was to correlate aortic intima-media thickness (aIMT) measured at L1-L2 with birth weight in neonates born at ≥35 week of gestation. The secondary objective was to compare aIMT in small for gestational age (SGA) and appropriate for gestational age (AGA) babies in this cohort.

Methods: Prospective observational study enrolling 200 newborns. Read More

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September 2020

Combining results from hip impingement and range of motion tests can increase diagnostic accuracy in patients with FAI syndrome.

Knee Surg Sports Traumatol Arthrosc 2020 Oct 25;28(10):3382-3392. Epub 2020 Apr 25.

Department of Health Sciences, Lund University, PO Box 157, 22100, Lund, Sweden.

Purpose: Clinical examination is an important part in the diagnosis of femoroacetabular impingement (FAI) syndrome. However, knowledge on reliability and validity of clinical diagnostic tests is scarce. The aims were to evaluate the inter-rater agreement and diagnostic accuracy of clinical tests to detect patients with FAI syndrome. Read More

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October 2020

Ultraviolet photolysis of metformin: mechanisms of environmental factors, identification of intermediates, and density functional theory calculations.

Environ Sci Pollut Res Int 2020 May 7;27(14):17043-17053. Epub 2020 Mar 7.

School of Environment and Energy, South China University of Technology, Higher Education Mega Center, Panyu District, Guangzhou, 510006, People's Republic of China.

As a commonly used anti-diabetic drug, metformin (MEF) is frequently detected in different water bodies which pose a potential threat to human health and the ecological environment. In this study, oxidative degradation of MEF under ultraviolet (UV) light was studied, and its influencing factors, photolysis mechanism, and intermediates identification carried out as well. The results showed that the hydroxyl radical contributed 73% during the 6 h MEF photolysis process among the reactive oxygen species (ROS). Read More

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Osteopontin for Early Detection of Microvascular and Macrovascular Type 1 Diabetic Complication.

Open Access Maced J Med Sci 2019 Nov 13;7(21):3619-3622. Epub 2019 Nov 13.

Clinical Pathology Department, National Research Centre, Cairo, Egypt.

Aim: To evaluate the relationship between osteopontin and diabetes complication in type 1 diabetic patient.

Patients And Methods: Seventy types 1 diabetic and 60 healthy volunteers were studied. Full history, examination, laboratory tests of glycosylated haemoglobin (HbA1c), serum lipids {cholesterol, triglyceride (Tg), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein - cholesterol (LDL-c)}, oxidised low-density lipoprotein (OxLDL), Osteopontin and urinary microalbuminuria (albumin/creatinine ratio) were done. Read More

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November 2019

Impact of Abdominal Obesity on Proximal and Distal Aorta Wall Thickness in African Americans: The Jackson Heart Study.

Obesity (Silver Spring) 2019 09 22;27(9):1527-1532. Epub 2019 Jul 22.

Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Objective: Abdominal obesity and wall thickness of the central arteries have been associated with higher risk of cardiovascular disease. Despite the higher burden of overweight and cardiovascular disease among African Americans, limited data are available on the association of abdominal obesity with aortic wall thickness in African Americans. We assessed the cross-sectional and the longitudinal associations of abdominal obesity with aortic intima-media thickness (aIMT) in a cohort of African Americans from the Jackson Heart Study. Read More

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September 2019

Cardiovascular risk factors in children with type 1 diabetes mellitus.

J Pediatr Endocrinol Metab 2019 Jul;32(7):699-705

Department of Endocrinology, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai 200062, China, Phone/Fax: +86-021-62474880.

Objective Cardiovascular disease is a major complication among children with type 1 diabetes mellitus (T1DM). This prospective study aimed at examining the presence of cardiovascular risk factors in children with T1DM. Methods We evaluated several cardiovascular risk factors, including atherosclerosis, artery intima-media thickness (IMT) and metabolic responses, in 175 children with T1DM, with 150 non-diabetic children as normal controls. Read More

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Profiling of Mycobacterium avium subspecies paratuberculosis in the milk of lactating goats using antigen-antibody based assays.

Comp Immunol Microbiol Infect Dis 2019 Jun 14;64:53-60. Epub 2019 Feb 14.

AIMT & AIB, Amity University Rajasthan, Jaipur, India. Electronic address:

Johne's disease, caused by Mycobacterium avium subspecies paratuberculosis is endemic in the domestic livestock population, still it is not priority for control in the country. First time we used 'multiple assays' for screening raw milk of 465 goats (farm/farmer's herds) to estimate bio-load and bio-type profile of bacilli. Each sample was screened by six tests and compared their sensitivity and specificity. Read More

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The relationship between serum vitamin D levels and intima-media thickness in term infants.

Eur J Pediatr 2019 Jul 22;178(7):1087-1093. Epub 2019 May 22.

Department of Radiology, Ordu University Maternity and Children's Research and Training Hospital, Ordu, Turkey.

Increasing epidemiologic evidence indicates that vitamin D deficiency is linked to a series of diseases, including cardiovascular disease. This prospective study was designed to determine the relationship between 25 hydroxyvitamin D (25(OH)D) level and aortic intima-media thickness (aIMT) and carotid intima-media thickness (cIMT) in term healthy neonates. A total of 135 term, healthy infants were included in the study. Read More

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Non-Alcoholic Fatty Pancreas Disease is Associated with Increased Epicardial Adipose Tissue and Aortic Intima-Media Thickness.

Acta Cardiol Sin 2019 Mar;35(2):118-125

Department of Cardiology, Saglik Bilimleri Universitesi (University of Health Sciences), Samsun Education and Research Hospital, Samsun 55000 61040, Turkey.

Background: We aimed to investigate whether non-alcoholic fatty pancreas disease (NAFPD) is associated with epicardial adipose tissue (EAT), which is a kind of ectopic fat accumulation, and aortic intima-media thickness (aIMT), which is associated with subclinical atherosclerosis.

Methods: Fifty-four patients with NAFPD (22 men; mean age: 52 ± 10 years) and 49 without NAFPD (16 men; mean age: 49 ± 8 years) were included in this study. NAFPD and aIMT were evaluated using transabdominal ultrasonography (TUS). Read More

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Thoracic Aortic Intima-Media Thickness in Preschool Children Born Small for Gestational Age.

J Pediatr 2019 05 4;208:81-88.e2. Epub 2019 Feb 4.

Cardiovascular Risk Unit, Consorcio Hospital General Universitario, University of Valencia, Valencia, Spain.

Objective: To assess thoracic aortic intima-media thickness (aIMT) as a marker of thoracic aortic remodeling in children born small for gestational age (SGA).

Study Design: We assessed thoracic aIMT, carotid intima-media thickness (cIMT), and pulse wave velocity (PWV) in 239 patients (117 SGA; 122 appropriate for gestational age controls) age 6-8 years. Each SGA participant was matched 1:1 based on sex, gestational age, and birth date. Read More

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Fetal Abdominal Aorta: Doppler and Structural Evaluation of Endothelial Function in Intrauterine Growth Restriction and Controls.

Ultraschall Med 2019 Feb 25;40(1):55-63. Epub 2018 Sep 25.

Department of Woman's and Child' s Health, University of Padua, Padua, Italy., Universita degli Studi di Padova, Italy.

Purpose:  The human aorta stores strain energy in the distended wall during systole through the extracellular matrix of the tunica media that could be influenced by blood pressure, flow, or increased peripheral resistance. In intrauterine growth restriction (IUGR) fetuses, the increased aorta intima media thickness (aIMT) could reflect a different extracellular matrix composition and, therefore, functionality. The aim of this study was to analyze the resistance to flow in the fetal descending aorta and its relation to aIMT and systolic and diastolic fetal abdominal aorta diameters in IUGR fetuses and controls. Read More

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February 2019

Coronary Artery Disease Severity Is Associated With Abdominal Aortic Intima-Media Thickness in Patients With Non-ST-Segment Elevation Myocardial Infarction.

Angiology 2019 Jul 16;70(6):561-566. Epub 2018 Aug 16.

3 Internal Medicine Department, Health Sciences University, Adana Health Practice and Research Center, Adana, Turkey.

The aim of this study was to evaluate the relationship between aortic intima-media thickness (aIMT) and coronary artery disease (CAD) severity in patients with non-ST-segment elevation myocardial infarction (NSTEMI). SYNTAX score (SS) was calculated. Patients were categorized into 2 main groups according to the SS: patient with high risk (SS ≥ 13) and low risk (SS < 13). Read More

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Formation and occurrence of transformation products of metformin in wastewater and surface water.

Sci Total Environ 2018 Jul 20;628-629:1121-1129. Epub 2018 Feb 20.

Hölderlinstraße 12, 72074 Tübingen, Germany. Electronic address:

The aim of this work was to investigate the occurrence and fate of the antidiabetic metformin (MF) and its transformation products (TPs) in wastewater and surface water samples. New TPs of MF were approached by electrochemical degradation with a boron-doped-diamond electrode (at 1.5V for 10min). Read More

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'Nano-immuno test' for the detection of live Mycobacterium avium subspecies paratuberculosis bacilli in the milk samples using magnetic nano-particles and chromogen.

Vet Res Commun 2018 Sep 26;42(3):183-194. Epub 2018 Apr 26.

AIMT & AIB, Amity University of Rajasthan, Jaipur, Rajasthan, 302 002, India.

Early rapid detection of Mycobacterium avium subspecies paratuberculosis (MAP) bacilli in milk samples is the major challenge since traditional culture method is time consuming and laboratory dependent. We report a simple, sensitive and specific nano-technology based 'Nano-immuno test' capable of detecting viable MAP bacilli in the milk samples within 10 h. Viable MAP bacilli were captured by MAP specific antibody-conjugated magnetic nano-particles using resazurin dye as chromogen. Read More

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September 2018

Osteopontin as a marker of vasculopathy in pediatric patients with type 1 diabetes mellitus: Relation to vascular structure.

Pediatr Diabetes 2018 Apr 23. Epub 2018 Apr 23.

Pediatrics Department, Ain Shams University, Cairo, Egypt.

Background: Type 1 diabetes mellitus (T1DM) is associated with serious micro-vascular and macro-vascular complications. Osteopontin (OPN) has emerged as a strong predictor of incipient diabetic nephropathy and a first-ever cardiovascular event in adults with T1DM. OPN is linked to coronary atherosclerosis in type 2 diabetes. Read More

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Anti-Mullerian Hormone and Inhibin B Levels in Obese Boys; Relations with Cardiovascular Risk Factors.

Exp Clin Endocrinol Diabetes 2018 Sep 29;126(8):528-533. Epub 2018 Jan 29.

Department of Radiology, Konya Training and Research Hospital, Konya, Turkey.

Objective: Obesity may reduce sertoli cell functions in men. The aim of the study was to investigate antimullerian hormone (AMH) and inhibin B levels (sertoli cell markers) in obese boys and their relations to cardiovascular risk factors such as insulin sensitivity index, aortic intima media thickness (aIMT) and high sensitive c-reactive protein (hsCRP).

Patients, Methods: 121 obese and 38 healthy lean adolescents were included in the study. Read More

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September 2018

Evaluation of aortic intima-media thickness in newborns with Down syndrome.

Adv Clin Exp Med 2017 Nov;26(8):1253-1256

Department of Biochemistry, Faculty of Medicine, Acıbadem University, Istanbul, Turkey.

Background: Health care programs for children with Down syndrome (DS) help improve the overall outcome and quality of life of these children. It is therefore very important to focus on the most common and serious problems of these patients, such as congenital heart defects and cardiac problems, and to keep medical guidelines updated with regard to these problems.

Objectives: The aim of this study was to evaluate aortic intima-media thickness (aIMT), lipid profiles and blood pressure in DS patients in comparison with a control group of ageand gender-matched neonates without DS. Read More

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November 2017

Subclinical Atherosclerosis in Pediatric Liver Transplant Recipients: Carotid and Aorta Intima-Media Thickness and Their Predictors.

J Pediatr 2018 02 7;193:119-127.e1. Epub 2017 Dec 7.

Department of Pediatrics, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA; Department of Surgery, UCSF Benioff Children's Hospital, University of California, San Francisco, San Francisco, CA.

Objective: To investigate prevalence and predictors of cardiovascular risk in pediatric liver transplant recipients using noninvasive markers of subclinical atherosclerosis: carotid intima-media thickness (cIMT) and aorta intima-media thickness (aIMT).

Study Design: Cross-sectional study of 88 pediatric liver transplant recipients. The cIMT and aIMT were measured by ultrasound imaging using standardized protocol. Read More

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February 2018

Aortic, carotid intima-media thickness and flow- mediated dilation as markers of early atherosclerosis in a cohort of pediatric patients with rheumatic diseases.

Clin Rheumatol 2018 Jun 12;37(6):1675-1682. Epub 2017 Oct 12.

Department of Paediatrics and Infant Neuropsychiatry, Sapienza University of Rome, Rome, Italy.

The aims of this study were to identify the presence of endothelial dysfunction as a marker of early atherosclerosis by measuring aortic and carotid intimal-medial thickness (aIMT and cIMT) and flow-mediated dilation (FMD) and their correlation with traditional and no traditional risk factors for atherosclerosis in children with rheumatic diseases. Thirty-nine patients (mean age 15.3 ± 5. Read More

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