9,758 results match your criteria aims discuss


Methods and techniques for in vitro subcellular localization of radiopharmaceuticals and radionuclides.

Nucl Med Biol 2021 Apr 22;98-99:18-29. Epub 2021 Apr 22.

Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, United Kingdom. Electronic address:

In oncology, the holy grail of radiotherapy is specific radiation dose deposition in tumours with minimal healthy tissue toxicity. If used appropriately, injectable, systemic radionuclide therapies could meet these criteria, even for treatment of micrometastases and single circulating tumour cells. The clinical use of α and β particle-emitting molecular radionuclide therapies is rising, however clinical translation of Auger electron-emitting radionuclides is hampered by uncertainty around their exact subcellular localisation, which in turn affects the accuracy of dosimetry. Read More

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Fetal MRI assessment of posterior fossa anomalies: A review.

J Neuroimaging 2021 May 8. Epub 2021 May 8.

Edward B. Singleton Department of Radiology, Texas Children's Hospital, Houston, Texas, USA.

Prenatal ultrasound (US) is the first prenatal imaging tool for screening and evaluation of posterior fossa malformations since it is noninvasive, widely available, and safe for both mother and child. Fetal MRI is a widely used secondary technique to confirm, correct, or complement questionable US findings and plays an essential role in evaluating fetuses with suspected US findings and /or positive family history. The main sequences of fetal MRI consist of T2-weighted (T2w) ultrafast, single-shot sequences. Read More

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Estimating the connection of information technology, foreign direct investment, trade, renewable energy and economic progress in Pakistan: evidence from ARDL approach and cointegrating regression analysis.

Environ Sci Pollut Res Int 2021 May 8. Epub 2021 May 8.

Faculty of Tourism, Anadolu University, Eskişehir, Turkey.

The present study aims to investigate the effects of information and communication technology, foreign direct investment, trade and renewable energy use with GDP growth in Pakistan using time series data ranging from 1985 to 2017. Stationarity of data was verified by using unit root tests including ADF and P-P, while an autoregressive distributed lag (ARDL) model was used to check the dynamic association amid prescribed variables with long- and short-run analysis. Furthermore, cointegrating regression analysis with FMOLS, DOLS and CCR was applied to validate the variables causality. Read More

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The Impact of the Risk Functional Form Assumptions on Maximum Acceptable Risk Measures.

Patient 2021 May 7. Epub 2021 May 7.

RTI Health Solutions, Belfast, UK.

Background: Discrete-choice experiments (DCEs) are increasingly conducted to quantify risk tolerance by computing maximum acceptable risk (MAR) for improvements in efficacy or other benefits gained from new medical treatments. To compute MARs from DCE data, respondents are asked to make choices under uncertainty between treatments. Specific treatment-related harms are included in the choice questions as probabilistic adverse events (AEs), and choice variation with the probability of these outcomes is assumed to indicate their effect on the expected utility of treatments. Read More

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Wired for insight-recent advances in Caenorhabditis elegans neural circuits.

Curr Opin Neurobiol 2021 May 3;69:159-169. Epub 2021 May 3.

Neurobiology Section, University of California San Diego, La Jolla, CA, 92093, USA; Kavli Institute of Brain and Mind, University of California San Diego, La Jolla, CA, 92093, USA. Electronic address:

The completion of Caenorhabditis elegans connectomics four decades ago has long guided mechanistic investigation of neuronal circuits. Recent technological advances in microscopy and computation programs have aided re-examination of this connectomics, expanding our knowledge by both uncovering previously unreported synaptic connections and also generating models for neural networks underlying behaviors. Combining molecular information from single cell transcriptomes with elegant tools for cell-specific manipulation has further enhanced the ability to precisely investigate individual neurons in behaving animals. Read More

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The incidence, risk factors and maternal and foetal outcomes of uterine rupture during different birth policy periods: an observational study in China.

BMC Pregnancy Childbirth 2021 May 5;21(1):360. Epub 2021 May 5.

National Office for Maternal and Child Health Surveillance of China, West China Second University Hospital, Sichuan University, No. 17 Ren Min Nan Lu, Chengdu City, Sichuan Province, 610041, P. R. China.

Background: Currently, there are no studies on changes in the incidence of uterine rupture or maternal and foetal outcomes in women with uterine rupture during different birth policy periods in China. Moreover, the results of association studies of maternal age, parity and previous caesarean section number with the risk of maternal and foetal outcomes in women with uterine rupture have not been consistent. This research aims to conduct and discuss the above two aspects. Read More

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Investigation of two cases of Mycobacterium chelonae infection in haemato-oncology patients using whole genome sequencing and a potential link to the hospital water supply.

J Hosp Infect 2021 May 1. Epub 2021 May 1.

Scottish Mycobacteria Reference Laboratory, Royal Infirmary of Edinburgh.

Background: Haemato-oncology patients are at increased risk of infection from atypical mycobacteria such as Mycobacterium chelonae which are commonly found in both domestic and hospital water systems.

Aims: To describe the investigation and control measures following two patient cases of M. chelonae and positive water samples in our hospital. Read More

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Emerging functions of piwi-interacting RNAs in diseases.

J Cell Mol Med 2021 May 4. Epub 2021 May 4.

Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.

PIWI-interacting RNAs (piRNAs) are recently discovered small non-coding RNAs consisting of 24-35 nucleotides, usually including a characteristic 5-terminal uridine and an adenosine at position 10. PIWI proteins can specifically bind to the unique structure of the 3' end of piRNAs. In the past, it was thought that piRNAs existed only in the reproductive system, but recently, it was reported that piRNAs are also expressed in several other human tissues with tissue specificity. Read More

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Complementary and alternative medicine in children with diffuse intrinsic pontine glioma-A SIOPE DIPG Network and Registry study.

Pediatr Blood Cancer 2021 May 4:e29061. Epub 2021 May 4.

Pediatric Oncology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Introduction: Diffuse intrinsic pontine glioma (DIPG) is a rare and aggressive childhood brainstem malignancy with a 2-year survival rate of <10%. This international survey study aims to evaluate the use of complementary and alternative medicine (CAM) in this patient population.

Methods: Parents and physicians of patients with DIPG were asked to participate in a retrospective online survey regarding CAM use during time of illness. Read More

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Sleep Studies in Children.

Indian Pediatr 2021 May 3. Epub 2021 May 3.

Pediatric Pulmonology and Sleep Medicine, Great Ormond Street Hospital for Children, London.

Sleep-related breathing disorders (SRBD), also referred to as sleep-disordered breathing (SDB), are common sleep disorders in children. They can be broadly divided between central and obstructive sleep-disordered breathing with or without associated hypoventilation. In most cases, SRBD are associated with adenotonsillar hypertrophy (obstructive SDB) which are classified as simple. Read More

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Sphingolipid lysosomal storage diseases: from bench to bedside.

Lipids Health Dis 2021 May 3;20(1):44. Epub 2021 May 3.

Department of Biology and Biochemistry, Birzeit University, P.O. Box 14, Ramallah, West Bank, 627, Palestine.

Johann Ludwig Wilhelm Thudicum described sphingolipids (SLs) in the late nineteenth century, but it was only in the past fifty years that SL research surged in importance and applicability. Currently, sphingolipids and their metabolism are hotly debated topics in various biochemical fields. Similar to other macromolecular reactions, SL metabolism has important implications in health and disease in most cells. Read More

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Integrating Option Grid Patient Decision Aids in the Epic Electronic Health Record: Case Study at 5 Health Systems.

J Med Internet Res 2021 May 3;23(5):e22766. Epub 2021 May 3.

Dartmouth College, Lebanon, NH, United States.

Background: Some researchers argue that the successful implementation of patient decision aids (PDAs) into clinical workflows depends on their integration into electronic health records (EHRs). Anecdotally, we know that EHR integration is a complex and time-consuming task; yet, the process has not been examined in detail. As part of an implementation project, we examined the work involved in integrating an encounter PDA for symptomatic uterine fibroids into Epic EHR systems. Read More

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Lung transplantation: candidate selection and timing of transplant.

Curr Opin Organ Transplant 2021 Jun;26(3):302-308

Emory University School of Medicine, Atlanta, Georgia, USA.

Purpose Of Review: Over the past two decades, lung transplant has become the mainstay of treatment for several end-stage lung diseases. As the field continues to evolve, the criteria for referral and listing have also changed. The last update to these guidelines was in 2014 and several studies since then have changed how patients are transplanted. Read More

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Occupational health nurses' personal attitudes toward smoking: A cross-sectional study.

J Occup Health 2021 Jan;63(1):e12221

COMWEL Incheon Hospital, Korea Workers' Compensation & Welfare Service, Incheon, Republic of Korea.

Objectives: This study aims to investigate if experience in smoking intervention training influences attitudes toward smoking, discuss the role of health management programs of small- and medium-sized enterprises, and analyze the current attitude of occupational health nurses regarding the hazards of smoking and responsibility to smokers to effectively facilitate smoking cessation support programs.

Methods: We conducted an anonymous self-administered cross-sectional survey of 108 nurses employed in occupational health services outsourcing specialized agency in Korea. We assessed the difference in attitude about smoking according to training experience in smoking interventions and perceived competence in counseling smokers using chi-square test and Fisher's exact test. Read More

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January 2021

Autophagy in Hepatic Steatosis: A Structured Review.

Front Cell Dev Biol 2021 15;9:657389. Epub 2021 Apr 15.

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.

Steatosis is the accumulation of neutral lipids in the cytoplasm. In the liver, it is associated with overeating and a sedentary lifestyle, but may also be a result of xenobiotic toxicity and genetics. Non-alcoholic fatty liver disease (NAFLD) defines an array of liver conditions varying from simple steatosis to inflammation and fibrosis. Read More

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Breast cancer: initial workup and staging with FDG PET/CT.

Clin Transl Imaging 2021 Apr 27:1-11. Epub 2021 Apr 27.

Department of Nuclear Medicine, Bordeaux University Hospital, Bordeaux, France.

Purpose: Precise staging is needed to plan optimal management in breast cancer. 18F-fluorodeoxyglucose positron emission tomography coupled with computed tomography (FDG-PET/CT) offers high sensitivity in detecting extra axillary lymph nodes and distant metastases. This review aims to clarify in which groups of patients staging with FDG-PET/CT would be beneficial and should be offered. Read More

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Gaze-Based Intention Estimation for Shared Autonomy in Pick-and-Place Tasks.

Front Neurorobot 2021 16;15:647930. Epub 2021 Apr 16.

Honda Research Institute Europe, Offenbach, Germany.

Shared autonomy aims at combining robotic and human control in the execution of remote, teleoperated tasks. This cooperative interaction cannot be brought about without the robot first recognizing the current human intention in a fast and reliable way so that a suitable assisting plan can be quickly instantiated and executed. Eye movements have long been known to be highly predictive of the cognitive agenda unfolding during manual tasks and constitute, hence, the earliest and most reliable behavioral cues for intention estimation. Read More

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Incidence, Histopathological Features and Differential Diagnosis of Cutaneous Graft Versus Host Disease in Allogeneic Bone Marrow Transplantation.

Sisli Etfal Hastan Tip Bul 2021 17;55(1):68-75. Epub 2021 Mar 17.

Department of Pathology, Acibadem Health Group, Istanbul, Turkey.

Objectives: Hematopoietic stem cell transplantation by allogeneic bone marrow transplantation is a method used in the treatment of various genetic, immunological disorders, hematologic and solid organ malignancies. Graft versus Host Disease is one of the major and fatal complications of allogeneic bone marrow transplantation. It is a systemic disease affecting five main areas: skin, gastrointestinal tract, liver, lung and hematopoietic system. Read More

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Binucleate Cells in Cytosmears: What do They Signify?

J Cytol 2021 Jan-Mar;38(1):38-43. Epub 2021 Feb 16.

Department of Pathology, Pondicherry Institute of Medical Sciences, Pondicherry, India.

Background: Although the classic Reed-Sternberg (RS) cell is considered a diagnostic of Hodgkin's disease, RS-like cells have been noted in various benign and malignant conditions. The presence of these cells can be a diagnostic challenge.

Aims: Our aim was to see if cells morphologically resembling or identical to RS cells occur in conditions other than Hodgkin lymphoma (HL) and what proportion of cases show binucleate cells in various benign and malignant conditions. Read More

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February 2021

Invited review: Characterization of new probiotics from dairy and nondairy products-Insights into acid tolerance, bile metabolism and tolerance, and adhesion capability.

J Dairy Sci 2021 Apr 29. Epub 2021 Apr 29.

Food and Nutritional Science, School of Biological Sciences, the University of Hong Kong, Pokfulam Road, Hong Kong 999077, P.R. China.

The selection of potential probiotic strains that possess the physiological capacity of performing successfully in the gastrointestinal tract (GIT) is a critical challenge. Probiotic microorganisms must tolerate the deleterious effects of various stresses to survive passage and function in the human GIT. Adhesion to the intestinal mucosa is also an important aspect. Read More

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Mirror of shame: Patients experiences of late-stage COPD. A qualitative study.

J Clin Nurs 2021 May 1. Epub 2021 May 1.

Faculty of Health Science, Institute of Nursing and Health Promotion, Oslo Metropolitan University, Oslo, Norway.

Aims And Objectives: This study aims to shed light on patients with late-stage COPD and their experiences of shame.

Background: Patients with COPD often experience shame for bringing the disease into their lives due to smoking. Knowledge about patients with COPD and their feelings of shame is crucial, but limited, however. Read More

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Representation, Interaction, Interpretation. Making sense of the context in clinical reasoning.

Med Educ 2021 May 1. Epub 2021 May 1.

Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden.

Background: All thinking occurs in some sort of context, rendering the relation between context and clinical reasoning a matter of significant interest. Context however has a notoriously vague and contested meaning and there is a profound disagreement between different research traditions studying clinical reasoning in how context is understood. Empirical evidence examining the impact (or not) of context on clinical reasoning cannot be interpreted without reference to the meaning ascribed to context. Read More

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Approaches for establishing and sustaining clinical academic partnerships: A discursive review.

J Clin Nurs 2021 Apr 30. Epub 2021 Apr 30.

Department of Nursing, Johns Hopkins University School of Nursing, Baltimore, MD, USA.

Aims And Objectives: To discuss the need for a formalised structure that bridges the clinical and academic realms with concrete recommendations for programme development.

Background: In the rapidly changing landscape of health care, nurses are challenged with the responsibility to engage in evidence-based practice, quality improvement and research projects. Clinical and academic partnerships play a vital role in fostering collaboration, mentorship and resources. Read More

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Statin intolerance: new data and further options for treatment.

Curr Opin Cardiol 2021 Apr 28. Epub 2021 Apr 28.

Clinical Emergency Hospital of Bucharest University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania Division of Endocrinology and Metabolism, First Department of Internal Medicine, Diabetes Center, AHEPA University Hospital, Thessaloniki, Greece Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy Camelia C. Diaconu and Florentina Furtunescu contributed equally to this article.

Purpose Of Review: Hypercholesterolemia is a major risk factor for cardiovascular diseases. Administration of statins represents the cornerstone of the prevention and treatment of cardiovascular disease, with demonstrated long-term safety and efficacy. This review aims to revisit statin intolerance mechanisms, as well as to discuss new data and therapeutic options. Read More

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Challenging Anatomies for TAVR-Bicuspid and Beyond.

Front Cardiovasc Med 2021 13;8:654554. Epub 2021 Apr 13.

Department of Internal Medicine III, Cardiology and Angiology, University Hospital Schleswig-Holstein, Kiel, Germany.

Transcatheter aortic valve replacement has emerged as the standard treatment for the majority of patients with symptomatic aortic stenosis. As transcatheter aortic valve replacement expands to patients across all risk groups, optimal patient selection strategies and device implantation techniques become increasingly important. A significant number of patients referred for transcatheter aortic valve replacement present with challenging anatomies and clinical indications that had been historically considered a contraindication for transcatheter aortic valve replacement. Read More

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Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical Significance.

Front Oncol 2021 13;11:579881. Epub 2021 Apr 13.

Department of Hematology and Oncology, International Cancer Center, Shenzhen Key Laboratory of Precision Medicine for Hematological Malignancies, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University Health Science Center, Shenzhen, China.

The occurrence of gene mutation is a major contributor to the initiation and propagation of acute myeloid leukemia (AML). Accumulating evidence suggests that genes encoding cohesin subunits have a high prevalence of mutations in AML, especially in the t(8;21) subtype. Therefore, it is important to understand how cohesin mutations contribute to leukemogenesis. Read More

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Institutional and Social Issues Surrounding Genetic Counselors in Japan: Current Challenges and Implications for the Global Community.

Front Genet 2021 13;12:646177. Epub 2021 Apr 13.

Department of Biomedical Ethics and Public Policy, Graduate School of Medicine, Osaka University, Suita, Japan.

In recent years, genetic counseling has started playing a major role in the field of genomic medicine. There are currently about 7,000 genetic counselors in more than 28 countries, with 267 certified genetic counselors in Japan alone (about 2 per million population, as of April 2020). While the rapid advancement of genomic medicine has expanded this field, the challenges genetic counselors face are also evolving. Read More

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Management of Return to School Following Brain Injury: An Evaluation Model.

Int J Educ Res 2021 ;108

University of Oregon, Eugene, 97403-5252, USA.

Traumatic brain injury (TBI) affects children's ability to succeed at school. Few educators have the necessary training and knowledge needed to adequately monitor and treat students with a TBI, despite schools regularly serving as the long-term service provider. In this article, we describe a model used in Oregon that implements best practices indicated by the extant literature, as well as our research protocol for evaluating this model. Read More

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January 2021

Nonsense-mediated RNA decay and its bipolar function in cancer.

Mol Cancer 2021 04 29;20(1):72. Epub 2021 Apr 29.

Departamento de Genética Humana, Instituto Nacional de Saúde Doutor Ricardo Jorge, 1649-016, Lisbon, Portugal.

Nonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature termination codons (PTCs). However, it was found that NMD also degrades a significant number of normal transcripts, thus arising as a mechanism of gene expression regulation. Based on these important functions, NMD regulates several biological processes and is involved in the pathophysiology of a plethora of human genetic diseases, including cancer. Read More

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Bereaved Informal Caregivers Rarely Recall a Relationship Between Transfusions and Hospice in Acute Myeloid Leukemia.

Am J Hosp Palliat Care 2021 Apr 29:10499091211013290. Epub 2021 Apr 29.

50826The Regenstrief Institute, Indianapolis, IN, USA.

Aims: The inability to prescribe blood transfusions is a potential barrier to timely hospice enrollment for patients with blood cancers. The benefits and harms of transfusions near the end of life (EOL), however, are poorly characterized and patients' preferences are unknown. We sought to characterize the recollections of bereaved caregivers about the relationships between transfusions and hospice enrollment decisions. Read More

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