336 results match your criteria aiming cumulative


Optimal individualization of patient-oriented ovarian stimulation in Japanese assisted reproductive technology clinics, a review for unique setting with advanced-age patients.

J Obstet Gynaecol Res 2022 Jan 13. Epub 2022 Jan 13.

Department of Obstetrics and Gynecology, Saitama Medical University, Saitama, Japan.

Ovarian stimulation is a key issue in assisted reproductive technology (ART) treatment. ART practice in Japan is unique with various types of ovarian stimulation protocols, which may contribute to lower pregnancy rates compared to other countries. This review aims to clarify optimal individualized ovarian stimulation for improving the pregnancy rate per one oocyte retrieval cycle in Japan. Read More

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January 2022

Evaluation on the phenotypic diversity of Calamansi (Citrus microcarpa) germplasm in Hainan island.

Sci Rep 2022 Jan 10;12(1):371. Epub 2022 Jan 10.

Key Laboratory of Genetics and Germplasm Innovation of Tropical Special Forest Trees and Ornamental Plants, Ministry of Education, Haikou, 570228, China.

Calamansi or Philippine lime (Citrofortunella macrocarpa) is an important crop for local economic in Hainan Island. There is no study about Calamansi germplasm evaluation and cultivar development. In this study, Calamansi data were collected from 151 of Calamansi seedling trees, and 37 phenotypic traits were analyzed to investigate their genetic diversities. Read More

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January 2022

The influences of ambient fine particulate matter constituents on plasma hormones, circulating TMAO levels and blood pressure: A panel study in China.

Environ Pollut 2022 Mar 27;296:118746. Epub 2021 Dec 27.

Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, PR China; Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, PR China; Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, 511436, PR China. Electronic address:

Considerable investigations have been carried out to address the relationship between ambient fine particulate matter (PM) and blood pressure (BP) in patients with hypertension. However, few studies have explored the influence of PM and its constituents on Trimethylamine N-oxide (TMAO), an established risk factor for hypertension and cardiovascular disease (CVD), particularly in severely air-polluted areas. To explore the potential impact of PM constituents on BP, plasma hormones, and TMAO, a panel study was conducted to investigate changes in BP, plasma hormones, and TMAO in response to ambient air pollution exposure in stage 1 hypertensive young adults. Read More

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Peripheral Infection after Traumatic Brain Injury Augments Excitability in the Perilesional Cortex and Dentate Gyrus.

Biomedicines 2021 Dec 19;9(12). Epub 2021 Dec 19.

A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.

Peripheral infections occur in up to 28% of patients with traumatic brain injury (TBI), which is a major etiology for structural epilepsies. We hypothesized that infection occurring after TBI acts as a "second hit" and facilitates post-traumatic epileptogenesis. Adult male Sprague-Dawley rats were subjected to lateral fluid-percussion injury or sham-operation. Read More

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December 2021

Effect of cropping systems and climate on soil physical characteristics, field crop emergence and yield: A dataset from a 19-year field experiment.

Data Brief 2021 Dec 16;39:107581. Epub 2021 Nov 16.

Agro-Impact, INRAE, Estrées-Mons, France.

A long-term field experiment was conducted from 1989 to 2007 in northern France in a loamy soil to assess the cumulative effects of cropping systems (CSs) on soil compaction, soil porosity, soil structure, crop emergence and yield. Three CSs, including different crop rotations and cultivations (early or late sowing and harvesting), were compared. CS I was the succession of spring pea/winter wheat/oilseed rape (flax from 2001)/winter wheat while CSs II and III were the succession of sugar beet/winter wheat/maize/winter wheat. Read More

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December 2021

Overview and Future Perspectives on Tumor-Targeted Positron Emission Tomography and Fluorescence Imaging of Pancreatic Cancer in the Era of Neoadjuvant Therapy.

Cancers (Basel) 2021 Dec 2;13(23). Epub 2021 Dec 2.

Department of Surgery, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

Background: Despite recent advances in the multimodal treatment of pancreatic ductal adenocarcinoma (PDAC), overall survival remains poor with a 5-year cumulative survival of approximately 10%. Neoadjuvant (chemo- and/or radio-) therapy is increasingly incorporated in treatment strategies for patients with (borderline) resectable and locally advanced disease. Neoadjuvant therapy aims to improve radical resection rates by reducing tumor mass and (partial) encasement of important vascular structures, as well as eradicating occult micrometastases. Read More

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December 2021

Relationships among adverse childhood experience patterns, psychological resilience, self-esteem and depressive symptoms in Chinese adolescents: A serial multiple mediation model.

Prev Med 2022 Jan 2;154:106902. Epub 2021 Dec 2.

Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No. 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, No. 81 Meishan Road, Hefei 230032, Anhui, China. Electronic address:

Adverse childhood experiences (ACEs) and adolescent depression are both prevalent social problems that can increase the risk of several negative health consequences throughout life. The original definition of ACEs misdirects the focus of intervention efforts for ACEs to only family dysfunction and parenting practices. We used a broader definition of ACEs and a latent class analysis (LCA) model to examine ACE patterns, aiming to overcome the shortcomings of cumulative and single adversity approaches based on the special social context of China. Read More

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January 2022

Population Pharmacokinetics of Melphalan in a Large Cohort of Autologous and Allogeneic Hematopoietic Cell Transplantation Recipients: Towards Individualized Dosing Regimens.

Clin Pharmacokinet 2021 Dec 2. Epub 2021 Dec 2.

Pediatric Hematopoeitic Cell Transplantation Program, Princess Maxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands.

Background And Objectives: High-dose melphalan is an integral part of conditioning chemotherapy prior to both autologous and allogeneic hematopoietic cell transplantation. While underexposure may lead to relapse, overexposure may lead to toxicities include mucositis, diarrhea, bone marrow suppression, and rarely sinusoidal obstruction syndrome. In this study, we describe the population pharmacokinetics of high-dose melphalan as a first step towards individualized dosing. Read More

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December 2021

Supplementation with subspecies EVC001 for mitigation of type 1 diabetes autoimmunity: the GPPAD-SINT1A randomised controlled trial protocol.

BMJ Open 2021 11 9;11(11):e052449. Epub 2021 Nov 9.

Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.

Introduction: The Global Platform for the Prevention of Autoimmune Diabetes-SINT1A Study is designed as a randomised, placebo-controlled, double-blind, multicentre, multinational, primary prevention study aiming to assess whether daily administration of from age 7 days to 6 weeks until age 12 months to children with elevated genetic risk for type 1 diabetes reduces the cumulative incidence of beta-cell autoantibodies in childhood.

Methods And Analysis: Infants aged 7 days to 6 weeks from Germany, Poland, Belgium, UK and Sweden are eligible for study participation if they have a >10.0% expected risk for developing multiple beta-cell autoantibodies by age 6 years as determined by genetic risk score or family history and HLA genotype. Read More

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November 2021

Global Health and Planetary Health: perspectives for a transition to a more sustainable world post COVID-19.

Cien Saude Colet 2021 Oct 1;26(10):4373-4382. Epub 2021 Sep 1.

Departamento de Saúde Ambiental, Faculdade de Saúde Pública, Universidade de São Paulo. Av. Dr. Arnaldo 715, Cerqueira César. 01246-904 São Paulo SP Brasil.

The manuscript discusses interfaces between academic and practical fields of Global Health and Planetary Health, shedding light on some critical perspectives of cumulative and synergistic causes of global crises, and effects on health and food security, on human rights, on migration, and on environment. Concepts of Global Health and Planetary Health and the path for the Sustainable Development Goals -SDG in the context of the Syndemy of Global Crisis, in particular the COVID-19 pandemic, are presented. COVID-19 lessons highlight challenges of infectious diseases and pandemics of the crisis of food insecurity, and of climate emergency. Read More

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October 2021

Soft tissue dimensional changes after alveolar ridge preservation using different sealing materials: a systematic review and network meta-analysis.

Clin Oral Investig 2021 Oct 20. Epub 2021 Oct 20.

Department of Biomedical, Surgical and Dental Sciences, Università Degli Studi Di Milano, Milan, Italy.

Background: Alveolar ridge preservation (ARP) is a proactive treatment option aiming at attenuating post-extraction hard and soft tissue dimensional changes. A high number of different types of biomaterials have been utilized during ARP to seal the socket, but their effectiveness in terms of soft tissue outcomes has rarely been investigated and compared in the literature.

Objective: To evaluate the efficacy of different types of membranes and graft materials in terms of soft tissue outcomes (keratinized tissue width changes, vertical buccal height, and horizontal changes) after ARP, and to assign relative rankings based on their performance. Read More

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October 2021

[Research status of bioweathering control of stone buildings].

Ying Yong Sheng Tai Xue Bao 2021 Aug;32(8):3023-3030

College of Eco-Environmental Engineering, Guizhou Minzu University, Guiyang 550025, China.

Stone buildings exposed to natural environment inevitably subject to various factors. Among which, biodeterioration caused by bacteria, fungi, algae, lichen, and moss is widespread. The long-term cumulative effect of biodeterioration will lead to irreversible changes in the aesthetic characteristics, physical and chemical properties of stone buildings. Read More

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Header biomechanics in youth and collegiate female soccer.

J Biomech 2021 11 2;128:110782. Epub 2021 Oct 2.

Department of Biomedical Engineering, Wake Forest School of Medicine, Winston-Salem, NC, USA; School of Biomedical Engineering and Sciences, Virginia Tech - Wake Forest University, Winston-Salem, NC, USA.

Concerns about the effects of intentional heading in soccer have led to regulatory restrictions on headers for youth players. However, there is limited data describing how header exposure varies across age levels, and few studies have attempted to compare head impact exposure across different levels of play with the same sensor. Additionally, little is known about the biomechanical response of the brain to header impacts. Read More

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November 2021

Evaluating the mitigation strategies of COVID-19 by the application of the CO emission data through high-resolution agent-based computational experiments.

Environ Res 2022 03 21;204(Pt B):112077. Epub 2021 Sep 21.

College of Systems Engineering, National University of Defense Technology (NUDT), 410073, 109 Deya Road, Kaifu District, Changsha City, Hunan province, China. Electronic address:

The negative consequences, such as healthy and environmental issues, brought by rapid urbanization and interactive human activities result in increasing social uncertainties, unreliable predictions, and poor management decisions. For instance, the Coronavirus Disease (COVID-19) occurred in 2019 has been plaguing many countries. Aiming at controlling the spread of COVID-19, countries around the world have adopted various mitigation and suppression strategies. Read More

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Improving sustainable hydrogen production from green waste: [FeFe]-hydrogenases quantitative gene expression RT-qPCR analysis in presence of autochthonous consortia.

Biotechnol Biofuels 2021 Sep 16;14(1):182. Epub 2021 Sep 16.

Department of Life Sciences and Systems Biology, University of Torino, Via Accademia Albertina 13, 10123, Torino, Italy.

Background: Bio-hydrogen production via dark fermentation of low-value waste is a potent and simple mean of recovering energy, maximising the harvesting of reducing equivalents to produce the cleanest fuel amongst renewables. Following several position papers from companies and public bodies, the hydrogen economy is regaining interest, especially in combination with circular economy and the environmental benefits of short local supply chains, aiming at zero net emission of greenhouse gases (GHG). The biomasses attracting the largest interest are agricultural and urban green wastes (pruning of trees, collected leaves, grass clippings from public parks and boulevards), which are usually employed in compost production, with some concerns over the GHG emission during the process. Read More

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September 2021

Binding Potassium to Improve Treatment With Renin-Angiotensin-Aldosterone System Inhibitors: Results From Multiple One-Stage Pairwise and Network Meta-Analyses of Clinical Trials.

Front Med (Lausanne) 2021 19;8:686729. Epub 2021 Aug 19.

Pharmacological Big Data Laboratory, University of Valladolid, Valladolid, Spain.

This manuscript presents findings from the first dichotomous data pooling analysis on clinical trials (CT) regarding the effectiveness of binding potassium. The results emanated from pairwise and network meta-analyses aiming evaluation of response to commercial potassium-binding polymers, that is, to achieve and maintain normal serum potassium ( = 1,722), and the association between this response and an optimal dosing of renin-angiotensin-aldosterone system inhibitors (RAASi) needing individuals affected by heart failure (HF) or resistant hypertension, who may be consuming other hyperkalemia-inducing drugs (HKID) (e.g. Read More

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Cost-effectiveness of adding a non-invasive acoustic rule-out test in the evaluation of patients with symptoms suggestive of coronary artery disease: rationale and design of the prospective, randomised, controlled, parallel-group multicenter FILTER-SCAD trial.

BMJ Open 2021 08 23;11(8):e049380. Epub 2021 Aug 23.

Department of Cardiology, Bispebjerg Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.

Introduction: Most patients with symptoms suggestive of chronic coronary syndrome (CCS) have no obstructive coronary artery disease (CAD) and better selection of patients to be referred for diagnostic tests is needed. The CAD-score is a non-invasive acoustic measure that, when added to pretest probability of CAD, has shown good rule-out capabilities. We aimed to test whether implementation of CAD-score in clinical practice reduces the use of diagnostic tests without increasing major adverse cardiac events (MACE) rates in patients with suspected CCS. Read More

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A framework for monitoring population immunity to SARS-CoV-2.

Ann Epidemiol 2021 11 21;63:75-78. Epub 2021 Aug 21.

School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA; School of Physics, Georgia Institute of Technology, Atlanta, GA. Electronic address:

In the effort to control SARS-CoV-2 transmission, public health agencies in the United States and globally are aiming to increase population immunity. Immunity through vaccination and acquired following recovery from natural infection are the two means to build up population immunity, with vaccination being the safe pathway. However, measuring the contribution to population immunity from vaccination or natural infection is non-trivial. Read More

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November 2021

Extended Stent Coverage Decreases Distal Aortic Segmental Enlargement After the Endovascular Repair of Acute Complicated Type B Aortic Dissection: A Multi-Center Retrospective Study of 814 Patients.

J Endovasc Ther 2022 Feb 16;29(1):96-108. Epub 2021 Aug 16.

Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Purpose: This study aimed to investigate the effect of distal aortic segmental enlargement (DASE) after thoracic endovascular aortic repair for complicated type B aortic dissection (cTBAD).

Materials And Methods: From March 2003 to October 2018, 814 patients with acute cTBAD from 5 medical centers were retrospectively identified. DASE is indicated as the enlargement of distal aortic segmental volume ≥1. Read More

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February 2022

Treatment and follow-up results of WHO grade II meningiomas.

J Clin Neurosci 2021 Sep 30;91:354-364. Epub 2021 Jul 30.

Acıbadem Mehmet Ali Aydınlar University, School of Medicine, Department of Neurosurgery, Istanbul, Turkey.

Meningiomas are the most common primary intracranial tumors. They have three pathologic grades. Surgical resection aiming Simpson I resection is the standard treatment for meningiomas. Read More

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September 2021

Wastewater monitoring as a supplementary surveillance tool for capturing SARS-COV-2 community spread. A case study in two Greek municipalities.

Environ Res 2021 09 24;200:111749. Epub 2021 Jul 24.

Laboratory of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, 22 Papakyriazi str, Larissa, Greece. Electronic address:

A pilot study was conducted from late October 2020 until mid-April 2021, aiming to examine the association between SARS-CoV-2 RNA concentrations in untreated wastewater and recorded COVID-19 cases in two Greek municipalities. A population of Random Forest and Linear Regression Machine Learning models was trained and evaluated incorporating the concentrations of SARS-CoV-2 RNA in 111 wastewater samples collected from the inlets of two Wastewater Treatment Plants, along with physicochemical parameters of the wastewater influent. The model's predictions were adequately associated with the 7-day cumulative cases with the correlation coefficients (after 5-fold cross validation) ranging from 0. Read More

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September 2021

Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update.

World J Clin Cases 2021 Jul;9(19):4890-4917

Department of Pathology, Akdeniz University Medical School, Antalya 07070, Turkey.

Hepatocellular carcinoma (HCC) is the most common type of cancer among primary malignant tumors of the liver and is a consequential cause of cancer-related deaths worldwide. In recent years, uncovering the molecular mechanisms involved in the development and behavior of this tumor has led to the identification of multiple potential treatment targets. Despite the vast amount of data on this topic, HCC remains a challenging tumor to treat due to its aggressive behavior and complex molecular profile. Read More

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The cumulative effect of multiple dimensions of lifestyle on risky drinking during the Covid-19 pandemic.

Prev Med 2021 09 7;150:106718. Epub 2021 Jul 7.

Institute of Scientific and Technological Communication and Information in Health (ICICT), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.

Lifestyle impacts morbidity and mortality worldwide. Herein, we evaluated the association of a multidimensional lifestyle measure and its domains (diet/nutrition, substance use, physical activity, social, stress management, sleep, environmental exposure) with risky drinking. Also, we analyzed the cumulative effect of unhealthy domains in the likelihood of presenting risky drinking. Read More

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September 2021

Endothelium Activation Markers in Severe Hospitalized COVID-19 Patients: Role in Mortality Risk Prediction.

TH Open 2021 Jul 4;5(3):e253-e263. Epub 2021 Jul 4.

Department of Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy.

 Endothelial damage and hypercoagulability are major players behind the hemostatic derangement of SARS-CoV-2 infection.  In this prospective study we assessed endothelial and inflammatory biomarkers in a cohort of COVID-19 patients, aiming to identify predictive factors of in-hospital mortality.  COVID-19 patients hospitalized in intensive care (ICU) and non-ICU units at 2 Bergamo (Italy) hospitals from March 23 to May 30, 2020, were enrolled. Read More

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Novel greenly synthesized titanium dioxide nanoparticles compared to liposomes in drug delivery: in vivo investigation on Ehrlich solid tumor model.

Heliyon 2021 Jun 21;7(6):e07370. Epub 2021 Jun 21.

Biophysics Branch, Physics Department, Faculty of Science, Zagazig University, 44519 Zagazig, Egypt.

Aims: In a previous work, a pure crystalline titanium dioxide nanoparticles (TiONPs) were synthesized by green synthesis technique using Aloe vera leaves extract as reducing agent. In this work, we are aiming to investigate the potential of the novel greenly synthesized TiONPs as a nano-drug delivery system for the anticancer drug, doxorubicin (Dox).

Main Methods: The cytotoxicity of the synthesized TiONPs was tested on two cell lines; normal human skin fibroblasts (HSF) and breast adenocarcinoma cells (MCF-7). Read More

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Suitability of superficial electron paramagnetic resonance dosimetry for in vivo measurement and verification of cumulative total doses during IMRT: A proof of principle.

Z Med Phys 2021 Nov 29;31(4):365-377. Epub 2021 Jun 29.

Klinik und Praxis fr Strahlentherapie am Klinikum Konstanz, Konstanz, Germany; Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Molecular Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Purpose: The present study investigates superficial in vivo dosimetry (IVD) by means of a previously proposed electron paramagnetic resonance (EPR) dosimetry system aiming at measuring and verifying total doses delivered by complex radiotherapy treatments. In view of novel regulatory requirements in Germany, differences between measured and planned total doses to the EPR dosimeters are analyzed and compared to reporting thresholds for significant occurrences.

Methods: EPR dosimeters, each consisting of one lithium formate monohydrate (LFM) and one polycrystalline l-alanine (ALA) pellet, were attached to the surface of an anthropomorphic head phantom. Read More

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November 2021

Low-Fat Dietary Modification and Risk of Ductal Carcinoma of the Breast in the Women's Health Initiative Dietary Modification Trial.

Cancer Epidemiol Biomarkers Prev 2021 09 29;30(9):1753-1756. Epub 2021 Jun 29.

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.

Background: Results of observational studies of the association between dietary fat and risk of invasive breast cancer have been inconsistent. In the Women's Health Initiative dietary modification (DM) randomized trial designed to lower fat intake, the intervention was not associated with a statistically significant reduction of overall breast cancer risk. However, the DM association with risk of ductal carcinoma (DCIS) of the breast, a putative breast cancer precursor, has not been reported. Read More

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September 2021

Continuous Complete Remission in Two Patients with Acute Lymphoblastic Leukemia and Severe Fungal Infection Following Short-Term, Dose-Reduced Chemotherapy.

Front Pharmacol 2021 2;12:599552. Epub 2021 Jun 2.

Department of Internal Medicine III, Hematology and Oncology, University Hospital of Regensburg, Regensburg, Germany.

Spontaneous remission in acute lymphoblastic leukemia (ALL) is a rare phenomenon, which typically involves a pattern of feverish or septic disease followed by quick but mostly transient remission. We report on two male patients (46-year-old (pt. 1) and 19-year-old (pt. Read More

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Indoor simulation test research on cumulative longitudinal displacement of rail based on force and displacement sensors data collection.

Sci Prog 2021 Apr-Jun;104(2):368504211023287

School of Civil Engineering, Central South University, Changsha, Hunan, China.

The train sometimes needs to brake frequently on the turnout, although the braking force does not exceed the limit resistance of fastener, cumulative displacement of rail occurs because of the long-term effect of the train brakes, thus, the relationship between the cumulative displacement of rail and the number of train braking actions should be explored. Aiming at the spring bar type III fastener, a 1:1 physical indoor simulation test was carried out, and an electromagnetic relay device was used to simulate the train load, force, and displacement sensors for data collection. Then a single load no more than the maximum resistance of fastener was applied to the rail end to explore the relationship between the number of loads and the rail cumulative deformation. Read More

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Reductions of migrant population reduces the number of COVID-19 epidemic: a case study in China.

Environ Sci Pollut Res Int 2021 Nov 11;28(41):58364-58374. Epub 2021 Jun 11.

Department of Biostatistics, School of Public Health, Peking University, No. 38, Xueyuan Road, Haidian District, Beijing City, 100191, China.

The novel coronavirus disease (COVID-19) broke out worldwide in 2020. The purpose of this paper was to find out the impact of migrant population on the epidemic, aiming to provide data support and suggestions for control measures in various epidemic areas. Generalized additive model was utilized to model the relationship between migrant population and the cumulative number of confirmed cases of COVID-19. Read More

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November 2021