175,310 results match your criteria aim review


Injectable Composite Systems Based on Microparticles in Hydrogels for Bioactive Cargo Controlled Delivery.

Gels 2021 Sep 18;7(3). Epub 2021 Sep 18.

CENIMAT/i3N, Departamento de Ciência dos Materiais, NOVA School of Science and Technology, 2829-516 Caparica, Portugal.

Engineering drug delivery systems (DDS) aim to release bioactive cargo to a specific site within the human body safely and efficiently. Hydrogels have been used as delivery matrices in different studies due to their biocompatibility, biodegradability, and versatility in biomedical purposes. Microparticles have also been used as drug delivery systems for similar reasons. Read More

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September 2021

Additive Manufacturing of Zirconia Ceramic and Its Application in Clinical Dentistry: A Review.

Dent J (Basel) 2021 Sep 6;9(9). Epub 2021 Sep 6.

College of Dentistry, Texas A&M University, Dallas, TX 75246, USA.

Additive manufacturing (AM) has many advantages and became a valid manufacturing technique for polymers and metals in dentistry. However, its application for dental ceramics is still in process. Among dental ceramics, zirconia is becoming popular and widely used in dentistry mainly due to its outstanding properties. Read More

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September 2021

Autotransplantation of the Third Molar: A Therapeutic Alternative to the Rehabilitation of a Missing Tooth: A Scoping Review.

Bioengineering (Basel) 2021 Sep 2;8(9). Epub 2021 Sep 2.

Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy.

Introduction: Tooth autotransplantation is the repositioning of an erupted, partially erupted, or non-erupted autologous tooth from one site to another within the same individual. Several factors influence the success rate of the autotransplant, such as the stage of root development, the morphology of the tooth, the surgical procedure selected, the extraoral time, the shape of the recipient socket, the vascularity of the recipient bed, and the vitality of the cells of the periodontal ligament. The aim of this scoping review was to provide the most up-to-date information and data on the clinical principles of the third-molar autograft and thus provide clinical considerations for its success. Read More

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September 2021

Recent Trends in Exhaled Breath Diagnosis Using an Artificial Olfactory System.

Biosensors (Basel) 2021 Sep 14;11(9). Epub 2021 Sep 14.

BIO-IT Foundry Technology Institute, Pusan National University, Busan 46241, Korea.

Artificial olfactory systems are needed in various fields that require real-time monitoring, such as healthcare. This review introduces cases of detection of specific volatile organic compounds (VOCs) in a patient's exhaled breath and discusses trends in disease diagnosis technology development using artificial olfactory technology that analyzes exhaled human breath. We briefly introduce algorithms that classify patterns of odors (VOC profiles) and describe artificial olfactory systems based on nanosensors. Read More

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September 2021

Diabetes Mellitus and COVID-19: Review Article.

Diabetes Metab Syndr 2021 Sep 4;15(6):102268. Epub 2021 Sep 4.

Chairman, Fortis-C-DOC Centre of Excellence for Diabetes, Metabolic Diseases, and Endocrinology, Chairman, National Diabetes, Obesity, And Cholesterol Foundation (N-DOC), President, Diabetes Foundation (India) (DFI), USA. Electronic address:

Background And Aims: We aim to cover most of the current evidence on the mutual effect of diabetes & COVID-19 infection on each other and the management of the COVID-19 patients with diabetes.

Methods: We utilized databases to review the current evidence related to diabetes mellitus and COVID-19.

Results: We discussed the most recent evidence of diabetes milieus and COVID-19 regarding risk factors, management, complications, and telemedicine. Read More

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September 2021

Combining histone deacetylase inhibitors (HDACis) with other therapies for cancer therapy.

Eur J Med Chem 2021 Sep 4;226:113825. Epub 2021 Sep 4.

Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Science, Health Science Center, Xi'an Jiaotong University, No.76 Yanta West Road, Xi'an, 710061, Shaanxi, People's Republic of China; Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Collaborative Innovation Center of Suzhou Nano Science & Technology, Soochow University, 199 Ren'ai Road, Suzhou, 215123, Jiangsu, PR China. Electronic address:

Histone deacetylases (HDACs) play an important role in regulating the expression of genes involved in tumorigenesis and tumor maintenance, and hence they have been considered as key targets in cancer therapy. As a novel category of antitumor agents, histone deacetylase inhibitors (HDACis) can induce cell cycle arrest, apoptosis, and differentiation in cancer cells, ultimately combating cancer. Although in the United States, the use of HDACis for the treatment of certain cancers has been approved, the therapeutic efficacy of HDACis as a single therapeutic agent in solid tumorshas been unsatisfactory and drug resistance may yet occur. Read More

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September 2021

Aspirin and growth, rupture of unruptured intracranial aneurysms: A systematic review and meta-analysis.

Clin Neurol Neurosurg 2021 Sep 17;209:106949. Epub 2021 Sep 17.

Department of Neurosurgery, Qinghai Provincial People's Hospital, Xining, Qinghai, China. Electronic address:

Objectives: Aspirin has been suggested as a potential therapeutic strategy to prevent the growth and rupture of unruptured intracranial aneurysms (UIAs), but there is still controversy. The aim of this systematic review and meta-analysis is to determine the association between aspirin use and growth, rupture of UIAs.

Methods: We performed a systematic literature search of electronic databases to identify cohort and case-control studies investigating the relationship between aspirin use and growth or rupture of UIAs. Read More

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September 2021

Radial artery or saphenous vein for coronary artery bypass grafitng.

Trends Cardiovasc Med 2021 Sep 22. Epub 2021 Sep 22.

Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA. Electronic address:

Coronary artery disease (CAD) is the most common cardiovascular disease worldwide, affecting over 18 million American adults. Coronary artery bypass grafting (CABG) is the standard of care for patients with left main or triple vessel CAD. Historically, the saphenous vein (SV) has been utilized to bypass the majority of the coronary vessels in patients undergoing CABG, but more recent data suggest that the use of the radial artery (RA), rather than the SV, is associated with improved cardiac outcomes and better survival. Read More

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September 2021

Catharanthus roseus (L.) G. Don: A review of its ethnobotany, phytochemistry, ethnopharmacology and toxicities.

J Ethnopharmacol 2021 Sep 22:114647. Epub 2021 Sep 22.

Department of Botany, Government Degree College Bahua Dehat, Fatehpur-212663 (affiliated to Professor Rajendra Singh (Rajju Bhaiya) University Prayagraj), Uttar, Pradesh, India.

Ethnopharmacological Relevance: Catharanthus roseus (L.) G. Don is a well known medicinal plant belonging to family Apocynaceae that have been traditionally used as medicine since ancient times. Read More

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September 2021

Mini Review: The Relationship between Energy Status and Adult Hippocampal Neurogenesis.

Neurosci Lett 2021 Sep 22:136261. Epub 2021 Sep 22.

East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA; Department of Kinesiology, East Carolina University, Greenville, North Carolina, USA; Human Performance Laboratory, College of Human Performance and Health, East Carolina University, Greenville, North Carolina, USA; Department of Physiology, East Carolina University, Greenville, North Carolina, USA. Electronic address:

The ability to generate new hippocampal neurons throughout adulthood and successfully integrate them into existing neural networks is critical to cognitive function, while disordered regulation of this process results in neurodegenerative or psychiatric disease. Consequently, identifying the molecular mechanisms promoting homeostatic hippocampal neurogenesis in adults is essential to understanding the etiologies of these disorders and developing therapeutic interventions. For example, recent evidence identifies a strong association between metabolic function and adult hippocampal neurogenesis. Read More

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September 2021

Improving process understanding in roll compaction.

J Pharm Sci 2021 Sep 22. Epub 2021 Sep 22.

Heinrich Heine University Duesseldorf, Institute of Pharmaceutics and Biopharmaceutics, Universitaetsstrasse 1, 40225 Duesseldorf, Germany. Electronic address:

Roll compaction/ dry granulation is gaining importance. Numerous papers have been published and many attempts to model the process are available in the meantime. Johanson published a model in 1965, which is the basis for many further modifications until today. Read More

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September 2021

Factors Associated with Return to Work After Heart Transplantation: A Systematic Review of the Literature.

Am J Med Sci 2021 Sep 22. Epub 2021 Sep 22.

Cardiology Service, Department of Internal Medicine, Fundación Valle del Lili, Cali, Columbia.

Background: Heart transplantation represents one of the last treatment options for advanced heart failure. Little is known about the factors associated with return to work in patients after heart transplantation. The aim of this study is to identify those factors. Read More

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September 2021

Efficacy of non-pharmacological interventions in patients with overactive bladder: A protocol for systematic review and network meta-analysis.

Nurs Open 2021 Sep 25. Epub 2021 Sep 25.

The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.

Background: Some meta-analyses have proved the superiority of non-pharmacological interventions in overactive bladder (OAB), but the best choice is still controversial.

Aim: To assess the most effective interventions in female with OAB.

Methods: Studies for relevant randomized controlled trials which compare different kinds of non-pharmacological interventions in females with OAB will be retrieved from 8 databases including PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure, Wanfang Database, VIP Database and China Biology Medicine disc, from inception to 1 January 2021. Read More

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September 2021

Prevention of Demineralization during Multi- bracketed Fixed Orthodontic Treatment: An Overview of Systematic Reviews.

Int J Paediatr Dent 2021 Sep 25. Epub 2021 Sep 25.

Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Hong Kong S.A.R, Hong Kong.

Background: Demineralization during multi-bracketed fixed orthodontic treatment is a well-known problem.

Aim: To systematically evaluate the evidence for the prevention of enamel demineralization during multi-bracketed fixed orthodontic treatment.

Design: Systematic reviews (with or without meta-analysis) that have appraised the primary studies on the prevention of demineralization during multi-bracketed fixed orthodontic treatment were searched systematically and included as per pre-defined eligibility criteria. Read More

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September 2021

Addressing current challenges in adult nursing: Describing a virtual consensus development project methodology.

Nurs Open 2021 Sep 25. Epub 2021 Sep 25.

Division of Nursing & Midwifery, Department of Health Sciences, University of Sheffield, Sheffield, UK.

Aim: This article describes the development and implementation of a virtual consensus development project to address current challenges in adult nursing care in the UK.

Design: This is a Consensus Development Project (CDP).

Methods: The five stages of this CDP were: develop questions (informed by PPI representatives and a documentary review), generate evidence reviews, recruit and orient the lay panel, host consensus seminars, and consult with panel members and stakeholders. Read More

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September 2021

A systematic review and meta-analysis of robotic-assisted transabdominal total mesorectal excision and transanal total mesorectal excision: which approach offers optimal short-term outcomes for mid-to-low rectal adenocarcinoma?

Tech Coloproctol 2021 Sep 25. Epub 2021 Sep 25.

Kings College Hospitals, Princess Royal University Hospital, Farnborough Common, London, BR6 8ND, Kent, UK.

Background: Resection of low rectal adenocarcinoma can be challenging in the narrow pelvis of male patients. Transanal total mesorectal excision (TaTME) appears to offer technical advantages for distal rectal tumours, and robotic-assisted transabdominal TME (rTME) was introduced in effort to improve operative precision and ergonomics. However, no study has comprehensively compared these approaches. Read More

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September 2021

Cerebral venous sinus thrombosis as a consequence of shunt hyperdrainage: a proposal of the pathophysiological mechanism and case report.

Childs Nerv Syst 2021 Sep 25. Epub 2021 Sep 25.

Centre for Neurology and Neurosurgery, Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil.

Background And Aim: Shunt dysfunction is a common event, especially in children who have this intervention performed early in life. The consequences of chronic shunt overdrainage can be multiple since the cerebral hydrodynamics is altered. A thrombotic event with consequent symptoms of intracranial hypertension is discussed in this article. Read More

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September 2021

Liquid biopsy: state of reproductive medicine and beyond.

Hum Reprod 2021 Sep 25. Epub 2021 Sep 25.

Department of Clinical Genetics, Maastricht University Medical Centre+, Maastricht, The Netherlands.

Liquid biopsy is the process of sampling and analyzing body fluids, which enables non-invasive monitoring of complex biological systems in vivo. Liquid biopsy has myriad applications in health and disease as a wide variety of components, ranging from circulating cells to cell-free nucleic acid molecules, can be analyzed. Here, we review different components of liquid biopsy, survey state-of-the-art, non-invasive methods for detecting those components, demonstrate their clinical applications and discuss ethical considerations. Read More

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September 2021

Azadirachta indica A. Juss (neem) against diabetes mellitus: a critical review on its phytochemistry, pharmacology, and toxicology.

J Pharm Pharmacol 2021 Sep 25. Epub 2021 Sep 25.

Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

Objective: We aim to provide a critical review focused on the various pharmacological activities of Azadirachta indica A. Juss related to diabetes management. We also emphasise on phytochemistry and toxicology of A. Read More

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September 2021

Exercise therapy for whiplash-associated disorders: a systematic review and meta-analysis.

Scand J Pain 2021 Sep 27. Epub 2021 Sep 27.

Department of Orofacial Pain and Jaw Function, Malmö University, Malmö, Sweden.

Objectives: Acute as well as chronic pain syndromes are common after whiplash trauma and exercise therapy is proposed as one possible intervention strategy. The aim of the present systematic review was to evaluate the effect of exercise therapy in patients with Whiplash-Associated Disorders for the improvement of neck pain and neck disability, compared with other therapeutic interventions, placebo interventions, no treatment, or waiting list.

Content: The review was registered in Prospero (CRD42017060356) and conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Read More

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September 2021

Use of Video Education Interventions to Increase Racial and Ethnic Diversity in Cancer Clinical Trials: A Systematic Review.

Worldviews Evid Based Nurs 2021 Sep 24. Epub 2021 Sep 24.

School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Background: Less than 5% of eligible adult cancer survivors participate in cancer clinical trials. Survivors identifying as Black, Indigenous, and people of color (BIPOC) are less likely to participate in clinical trials compared to those identifying as non-Hispanic White. Common barriers to BIPOC participation are lack of knowledge, lack of access, and mistrust. Read More

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September 2021

A case of annular atrophic lichen planus in a child and review of the literature.

Pediatr Dermatol 2021 Sep 24. Epub 2021 Sep 24.

Division of Pediatric Dermatology, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA.

Lichen planus (LP) is an inflammatory disease affecting both adults and children that may present with numerous rare morphologies. LP and its many subtypes can prove difficult to treat and often leave patients with dyspigmentation. Additionally, pruritus associated with LP can be distressing to patients. Read More

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September 2021

Vulvar vitiligo and lichen sclerosus in children: A clinical challenge.

Pediatr Dermatol 2021 Sep 24. Epub 2021 Sep 24.

Division of Dermatology - IRCSS Azienda Ospedaliero Universitaria di Bologna, Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Vulvar vitiligo (VV) and vulvar lichen sclerosus (VLS), both feature skin and mucosal hypo-/depigmentation. The aim of this study was to describe the clinical and dermoscopic features of VV and VLS in the pediatric population, providing diagnostic clues, and to define their association. We performed a systematic literature review of the clinical and dermoscopic features of pediatric VV and VLS. Read More

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September 2021

Comparison of 12 and 24-hours shift impacts on ICU nursing care, efficiency, safety, and work-life quality.

Int Nurs Rev 2021 Sep 25. Epub 2021 Sep 25.

Visiting Professor, Editor in Chief, International Nursing Review, Faculty of Nursing Chiang Mai, Chiang Mai University, Bangkok, Thailand.

Background: Nursing care quality is a central concern of health policy, and nurses' shift schedules affect the quality of care and their work-life status internationally. A lack of reliable information on the differences between 24- and 12-h shifts on care quality, nursing care quality, patient safety, and adverse and missed events warranted investigation in Cambodia.

Aim: We aimed to examine the impacts of 12-h shifts compared with 24-h shifts. Read More

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September 2021

Radiology Dictation Errors with COVID-19 Protective Equipment: Does Wearing a Surgical Mask Increase the Dictation Error Rate?

J Digit Imaging 2021 Sep 24. Epub 2021 Sep 24.

Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Our aim was to determine the effect of wearing a surgical mask on the number and type of dictation errors in unedited radiology reports. IRB review was waived for this prospective matched-pairs study in which no patient data was used. Model radiology reports (n = 40) simulated those typical for an academic medical center. Read More

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September 2021

Targeting of cancer cell death mechanisms by resveratrol: a review.

Apoptosis 2021 Sep 25. Epub 2021 Sep 25.

Medical Technology Research Center, Institute of Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Cancer cell death is the utmost aim in cancer therapy. Anti-cancer agents can induce apoptosis, mitotic catastrophe, senescence, or autophagy through the production of free radicals and induction of DNA damage. However, cancer cells can acquire some new properties to adapt to anti-cancer agents. Read More

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September 2021

Online Behavioral Parenting Interventions for Disruptive Behavioral Disorders: A PRISMA Based Systematic Review of Clinical Trials.

Child Psychiatry Hum Dev 2021 Sep 24. Epub 2021 Sep 24.

UTS: Family Child Behaviour Clinic, Discipline of Clinical Psychology, Graduate School of Health, University of Technology Sydney, Level 5 Building 20, 100 Broadway, Sydney, NSW, Australia.

Behavioral parenting interventions (BPIs) are efficacious, evidence-based interventions for disruptive behavioral disorders in children. Technological advances have seen online adaptations of BPIs further increase efficacy and expand program reach. This systematic review examined the treatment outcomes of online BPIs. Read More

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September 2021

Do panoramic radiographs offer improved diagnostic accuracy over clinical examination and other radiographic techniques in children?

Evid Based Dent 2021 Jan;22(3):110-111

Dean and Professor of Paediatric Dentistry, School of Clinical Dentistry, University of Sheffield, Sheffield, S10 2TA, UK.

Aim The aim of this study was to establish the diagnostic efficacy of panoramic radiographs in six clinical situations for paediatric patients: caries, acute dental infections, dental trauma, dental anomalies, developmental disorders and pathological conditions.Data sources The authors searched the following databases: Medline, Embase, the Cochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, the Database of Abstracts of Reviews of Effects and the Cochrane Health Technology Assessment database. Forward citation searches of included studies were carried out. Read More

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January 2021

What is the best mechanical device to clean the teeth in periodontal maintenance patients?

Authors:
Erfan Shamsoddin

Evid Based Dent 2021 Jan;22(3):91-93

National Institute for Medical Research Development, Tehran, Iran.

Aim This study evaluates the available clinical evidence with regards to the effectiveness of mechanical oral hygiene devices in patients who are in periodontal maintenance.Data sources A structured online search was conducted in PubMed/Medline, Cochrane Central Register of Controlled Trials (CENTRAL) and Embase. All the databases were explored from initiation to October 2019. Read More

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January 2021

Time course prevalence of post-COVID pain symptoms of musculoskeletal origin in patients who had survived to SARS-CoV-2 infection: a systematic review and meta-analysis.

Pain 2021 Sep 23. Epub 2021 Sep 23.

Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos (URJC), Madrid. Spain. Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark Department of Radiology, Rehabilitation and Physiotherapy, Universidad Complutense de Madrid, Madrid, Spain Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain.

Abstract: The aim of this review/meta-analysis is to synthesize the prevalence of post-COVID pain symptoms of musculoskeletal origin in hospitalized/non-hospitalized patients recovered from SARS-CoV-2 infection. MEDLINE, CINAHL, PubMed, EMBASE, and Web of Science databases, as well as medRxiv and bioRxiv preprint servers were searched up to May 1, 2021. Studies or preprints reporting data on post-COVID pain symptoms such as myalgias, arthralgias, or chest pain after SARS-CoV-2 infection and collected by personal, telephonic, or electronical interview were included. Read More

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September 2021