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Long-term Kidney Function and Survival in Recipients of Allografts from Living Kidney Donors with Hypertension: A National Cohort Study.

Transpl Int 2021 Jun 15. Epub 2021 Jun 15.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore.

Allografts from living kidney donors with hypertension may carry subclinical kidney disease from the donor to recipient and thus lead to adverse recipient outcomes. We examined eGFR trajectories and all-cause allograft failure in recipients from donors with vs. without hypertension, using mixed-linear and Cox regression models stratified by donor age. Read More

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Thiazolidinediones and Glucagon-like Peptide-1 Receptor Agonists and the Risk of Nonalcoholic Fatty Liver Disease: A Cohort Study.

Hepatology 2021 Jun 15. Epub 2021 Jun 15.

CARIM School for Cardiovascular Disease, Maastricht University, Maastricht, the Netherlands.

Thiazolidinediones (TZDs) and glucagon-like peptide-1 (GLP-1) receptor agonists are potential pharmacological treatment options for patients at risk of nonalcoholic fatty liver disease (NAFLD). Therefore, we examined the association between the risk of NAFLD and the use of thiazolidinediones and GLP-1 receptor agonists compared with the use of sulfonylureas (SUs) and insulins. Additionally, we calculated the incidence of hepatocellular carcinoma (HCC) in users of TZDs and GLP-1 receptor agonists. Read More

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Long-term Continuity of Antipsychotic Treatment for Schizophrenia: A Nationwide Study.

Schizophr Bull 2021 Jun 15. Epub 2021 Jun 15.

Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, Kuopio, Finland.

Schizophrenia often requires long-term treatment with antipsychotic medication. This study aims to measure the continuity of antipsychotic treatment over the course of illness in schizophrenia, as well as factors involved in the interruption of treatment. For this, we followed up a national cohort of first-episode psychosis patients in Finland for up to 18 years. Read More

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2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) catalytic mutant mice (TiparpH532A) exhibit increased sensitivity to TCDD-induced hepatotoxicity and lethality.

Toxicol Sci 2021 Jun 15. Epub 2021 Jun 15.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada.

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-ADP-ribose polymerase (TIPARP/PARP7), an aryl hydrocarbon receptor (AHR) target gene and mono-ADP-ribosyltransferase, acts as part of a negative feedback loop to repress AHR signaling. This process is prevented by a single H532A mutation in TIPARP that destroys its catalytic activity. We hypothesized that the loss of TIPARP catalytic activity would increase sensitivity to TCDD-induced toxicity in vivo. Read More

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Outcomes of SARS-CoV-2 Infection in Patients with Chronic Liver Disease and Cirrhosis: a N3C Study.

medRxiv 2021 Jun 7. Epub 2021 Jun 7.

Background And Aims: In patients with chronic liver diseases (CLD) with or without cirrhosis, existing data on the risk of adverse outcomes with SARS-CoV-2 infection have been mixed or have limited generalizability. We used the National COVID Cohort Collaborative (N3C) Data Enclave, a harmonized electronic health record (EHR) dataset of 5.9 million nationally-representative, diverse, and gender-balanced patients, to describe outcomes in patients with CLD and cirrhosis with SARS-CoV-2. Read More

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People Living with HIV Easily lose their Immune Response to SARS-CoV-2: Result From A Cohort of COVID-19 Cases in Wuhan, China.

Res Sq 2021 Jun 7. Epub 2021 Jun 7.

Background To date, whether the immune response for SARS-CoV-2 infection among people living with HIV(PLWH) is different from HIV-naïve individuals is still not clear. Methods In this cohort study, COVID-19 patients admitted to hospital in Wuhan between January 15 and April 1, 2020, were enrolled. Patients were categorized into PLWH and HIV-naïve group. Read More

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Roles of Aryl-hydrocarbon Receptor in metabolism and proliferative behaviors of Bone Marrow MSCs: Implications for targeted therapy.

Curr Top Med Chem 2021 Jun 11. Epub 2021 Jun 11.

Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

Background: Mesenchymal stromal cells (MSCs) due to convenient isolation and ex vivo expansion, multipotent differentiation, and migrating capacity into the inflammation sites and tumor microenvironments are interesting candidates in precise medicine. MSCs, as an important component of bone marrow microenvironment, can regulate hematopoiesis and immunity via direct contact or secretion of adhesion factors and hematopoietic chemokines. Recent evidence showed that aryl-hydrocarbon receptor (AHR) signal pathway plays a crucial role in hematopoiesis and immunity. Read More

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Anti-asthmatic effects of tannic acid from Chinese natural gall nuts in a mouse model of allergic asthma.

Int Immunopharmacol 2021 Jun 11;98:107847. Epub 2021 Jun 11.

Department of Biochemistry, ICMR-National Institute for Research in Environmental Health, Bhopal, Madhya Pradesh, India. Electronic address:

Asthma is a chronic inflammatory disease of the airways, which is characterized by infiltration of inflammatory cells, airway hyperresponsiveness (AHR), and airway remodeling. This study aimed to explore the role and mechanism of tannic acid (TA), a naturally occurring plant-derived polyphenol, in murine asthma model. BALB/c mice were given ovalbumin (OVA) to establish an allergic asthma model. Read More

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After the initial fracture in postmenopausal women, where do subsequent fractures occur?

EClinicalMedicine 2021 May 5;35:100826. Epub 2021 May 5.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States.

Background: The locations of subsequent fractures after initial fracture in postmenopausal women are poorly characterized.

Methods: We conducted a prospective analysis of subsequent fractures after initial fracture in Women's Health Initiative (1993-2018) participants who provided follow-up (mean 15.4 years, SD 6. Read More

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Impact of Bacterial Metabolites on Gut Barrier Function and Host Immunity: A Focus on Bacterial Metabolism and Its Relevance for Intestinal Inflammation.

Front Immunol 2021 26;12:658354. Epub 2021 May 26.

Laboratory of Innate Immunity, Program of Immunology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.

The diverse and dynamic microbial community of the human gastrointestinal tract plays a vital role in health, with gut microbiota supporting the development and function of the gut immune barrier. Crosstalk between microbiota-gut epithelium and the gut immune system determine the individual health status, and any crosstalk disturbance may lead to chronic intestinal conditions, such as inflammatory bowel diseases (IBD) and celiac disease. Microbiota-derived metabolites are crucial mediators of host-microbial interactions. Read More

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The Association Between Cholecystectomy and the Risk for Fracture: A Nationwide Population-Based Cohort Study in Korea.

Front Endocrinol (Lausanne) 2021 27;12:657488. Epub 2021 May 27.

Department of Internal Medicine and Seoul National University Bundang Hospital, Seongnam, South Korea.

Objectives: To evaluate the risk of fracture in individuals with a history of cholecystectomy in Korean population.

Methods: Individuals (n = 143,667) aged ≥ 40 y who underwent cholecystectomy between 2010 and 2015 and the controls (n = 255,522), matched by age and sex, were identified from the database of the Korean National Health Insurance Services. The adjusted hazard ratio (aHR) and 95% confidence interval (CI) of fracture were estimated following cholecystectomy, and a Cox regression analysis was performed. Read More

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Oral Administration of Brain Protein Combined With Probiotics Induces Immune Tolerance Through the Tryptophan Pathway.

Front Mol Neurosci 2021 28;14:634631. Epub 2021 May 28.

Tianjin Neurosurgical Institute, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China.

Excessive inflammation leads to secondary immune damage after traumatic brain injury (TBI). The intestinal mucosa is a key component of immune tolerance due to gut-brain axis regulation, but the curative effect is not optimal. Intestinal dysfunction impairs the establishment of immune tolerance in patients with TBI. Read More

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The oncologic safety of left colectomy with modified complete mesocolic excision for distal transverse colon cancer: Comparison with descending colon cancer.

Eur J Surg Oncol 2021 Jun 6. Epub 2021 Jun 6.

Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea.

Background: The optimal surgical approach for distal transverse colon cancer has not been well established. This study aimed to evaluate the oncologic safety of left colectomy with a modified complete mesocolic excision for distal transverse colon cancer as compared with descending colon cancer.

Material And Methods: This study involved 383 patients who underwent left colectomy with modified complete mesocolic excision for non-metastatic distal transverse and splenic flexure colon (transverse group, N = 110) and descending colon cancer (descending group, N = 237) from 3 institutions. Read More

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Functional characterization of the transcription factors AhR and ARNT in Nilaparvata lugens.

Pestic Biochem Physiol 2021 Jul 14;176:104875. Epub 2021 May 14.

Hubei Insect Resources Utilization and Sustainable Pest Management Key Laboratory, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China. Electronic address:

In the present study, the aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (ARNT) of Nilaparvata lugens were cloned and identified. The NlAhR and NlARNT expression levels significantly increased after imidacloprid, etofenprox and isoprocarb treatments. Knockdowns of NlAhR and NlARNT increased the susceptibility of N. Read More

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HDAC4 induces the development of asthma by increasing Slug-upregulated CXCL12 expression through KLF5 deacetylation.

J Transl Med 2021 Jun 12;19(1):258. Epub 2021 Jun 12.

School of Health, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong, People's Republic of China.

Background: Asthma is a frequently occurring respiratory disease with an increasing incidence around the world. Airway inflammation and remodeling are important contributors to the occurrence of asthma. We conducted this study aiming at exploring the effect of Histone deacetylase 4 (HDAC4)-mediated Kruppel-like factor 5 (KLF5)/Slug/CXC chemokine ligand-12 (CXCL12) axis on the development of asthma in regulation of airway inflammation and remodeling. Read More

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A retrospective cohort study of medication dispensing at pharmacies: Administration matters!

Drug Alcohol Depend 2021 May 29;225:108792. Epub 2021 May 29.

Norwegian Centre for Addiction Research (SERAF), University of Oslo, Bygg 45, Ullevål sykehus, Kirkeveien 166, 0450, Oslo, Norway. Electronic address:

Background: Opioid agonist treatment (OAT) for opioid use disorders may be delivered at treatment clinics or dispensed from pharmacies, however the type of delivery may be associated with different risks and benefits. The aim of the study was to investigate whether dispensing of methadone or buprenorphine at pharmacies during treatment for opioid use disorders was associated with adverse outcomes.

Methods: Retrospective cohort study using a national, linked, population-level data set from Denmark. Read More

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Risk of psoriasis according to body mass index: a retrospective cohort analysis.

J Am Acad Dermatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra / Northwell, New Hyde Park, NY, USA. Electronic address:

Background: Psoriasis has been linked to obesity, although there is limited data on the incidence of psoriasis according to body mass index.

Objective: To compare incidence of psoriasis among patients stratified by BMI category (normal or underweight, overweight, obese-class 1, obese-class 2/3).

Methods: Retrospective cohort analysis of a demographically heterogeneous sample of over 1. Read More

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Statin therapy for patients with aortic stenosis who underwent transcatheter aortic valve implantation: a report from a Japanese multicentre registry.

BMJ Open 2021 06 11;11(6):e044319. Epub 2021 Jun 11.

Department of Cardiology, Keio University School of Medicine, Shinjuku-ku, Japan.

Objective: Data on statin for patients with aortic stenosis (AS) who underwent transcatheter aortic valve implantation (TAVI) are limited. The present study aimed to evaluate the impact of statin on midterm mortality of TAVI patients.

Design: Observational study. Read More

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Prenatal Antidepressant Use and the Implication of Hypertensive Disorders during Pregnancy.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

School of Pharmacy, College of Pharmacy, Taipei Medical University. Electronic address:

Background: Evidence regarding prenatal antidepressant use and the development of hypertensive disorders during pregnancy is inconsistent. Previous studies have reported that antidepressant use during pregnancy increases the risk of gestational hypertension and preeclampsia, but the results of these studies are potentially confounded by important methodologic limitations. Furthermore, it remains unknown whether a higher cumulative dose of antidepressant increases the risk of hypertensive disorders of pregnancy. Read More

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Association between abdominal fat and mortality in patients undergoing cardiovascular surgery.

Ann Thorac Surg 2021 Jun 8. Epub 2021 Jun 8.

Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea. Electronic address:

Background: Obesity is associated with reduced postoperative mortality in patients undergoing cardiovascular surgery. However, body mass index cannot differentiate abdominal fat composition. This study evaluated the relationships between total abdominal, subcutaneous, and visceral fat composition and postoperative mortality in East Asian patients undergoing cardiovascular surgery. Read More

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Evolving trends in risk profiles and outcomes in older adults undergoing kidney re-transplantation.

Transplantation 2021 Jun 2. Epub 2021 Jun 2.

1 Division of Nephrology, Department of Medicine, McGill University Health Centre, Montreal, Quebec 2 Research Institute of the McGill University Health Centre, Montreal, Quebec 3 Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 4 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Background: In older adults (≥65) access to and outcomes following kidney transplantation (KT) have improved over the past three decades. It is unknown if there were parallel trends in re-KT. We characterized the trends, changing landscape, and outcomes of re-KT in older adults. Read More

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Survival of stainless steel crowns and composite resin restorations in molars affected by Molar-Incisor Hypomineralization (MIH).

Int J Paediatr Dent 2021 Jun 11. Epub 2021 Jun 11.

Department of Morphology, Genetics, Orthodontics and Pediatric Dentistry, São Paulo State University (Unesp), Araraquara School of Dentistry, Araraquara, São Paulo, Brazil.

Background: Currently, there is no consensus on the superiority of any material for the restorative treatment of molars affected by Molar-Incisor Hypomineralization (MIH).

Aim: To evaluate the survival of restorations with stainless steel crown (SSC) or composite resin (CR) in first permanent molars affected by MIH for 24 months.

Design: In this retrospective cohort study, 61 CR and 54 SSC restorations performed on molars affected by MIH of patients, aged between 7 and 10, that were treated and overseen at a university dental clinic in the period of 2017-2020 were evaluated. Read More

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Trends in Venous Thromboembolism Anticoagulation in Patients Hospitalized With COVID-19.

JAMA Netw Open 2021 06 1;4(6):e2111788. Epub 2021 Jun 1.

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor.

Importance: Venous thromboembolism (VTE) is a common complication of COVID-19. It is not well understood how hospitals have managed VTE prevention and the effect of prevention strategies on mortality.

Objective: To characterize frequency, variation across hospitals, and change over time in VTE prophylaxis and treatment-dose anticoagulation in patients hospitalized for COVID-19, as well as the association of anticoagulation strategies with in-hospital and 60-day mortality. Read More

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Comparison of Clinical Features and Outcomes between Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma in the United States.

Hepatology 2021 Jun 11. Epub 2021 Jun 11.

Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Background & Aims: Intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC) are the most common primary liver cancers. Differences in their clinical features and outcomes have not been investigated in a large-scale study. We aim to investigate the differences in clinical features and outcomes between iCCA and HCC. Read More

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Correlation of medial longitudinal arch morphology with body characteristics and locomotive function in community-dwelling older women: A cross-sectional study.

J Orthop Surg (Hong Kong) 2021 May-Aug;29(2):23094990211015504

School of Rehabilitation, Osaka Kawasaki Rehabilitation University, Osaka, Japan.

Purpose: This cross-sectional study aimed to investigate the effects of foot arch deformities on physical characteristics, muscular strength, and motor function in older women depending on the presence or absence of pain.

Methods: Overall, 145 community-dwelling women aged 65 to 90 years were included in this study. We measured the foot arch height ratio (AHR, dorsal height/truncated foot length) and classified participants with AHR values above, below, or within 1. Read More

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Surgery and the Subtype of Inflammatory Bowel Disease Impact the Risk of Venous Thromboembolism After Hospital Discharge.

Dig Dis Sci 2021 Jun 10. Epub 2021 Jun 10.

CHEO Inflammatory Bowel Disease Centre, Division of Gastroenterology Hepatology and Nutrition, Children's Hospital of Eastern Ontario, Ottawa, Canada.

Background: Surgery for inflammatory bowel disease (IBD) is associated with an increased risk of venous thromboembolism (VTE) during hospitalization. It is unclear whether this association persists after hospital discharge.

Aims: We assessed the association between surgery and VTE following hospital discharge in IBD. Read More

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A multicenter prospective randomized controlled trial of cardiac resynchronization therapy guided by invasive dP/dt.

Heart Rhythm O2 2021 Feb 22;2(1):19-27. Epub 2021 Jan 22.

Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.

Background: No periprocedural metric has demonstrated improved cardiac resynchronization therapy (CRT) outcomes in a multicenter setting.

Objective: We sought to determine if left ventricular (LV) lead placement targeted to the coronary sinus (CS) branch generating the best acute hemodynamic response (AHR) results in improved outcomes at 6 months.

Methods: In this multicenter randomized controlled trial, patients were randomized to guided CRT or conventional CRT. Read More

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February 2021

Evaluating multisite pacing strategies in cardiac resynchronization therapy in the preclinical setting.

Heart Rhythm O2 2020 Jun 15;1(2):111-119. Epub 2020 Jun 15.

Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.

Background: Multisite pacing strategies that improve response to cardiac resynchronization therapy (CRT) have been proposed. Current available options are pacing 2 electrodes in a multipolar lead in a single vein (multipoint pacing [MPP]) and pacing using 2 leads in separate veins (multizone pacing [MZP]).

Objective: The purpose of this study was to compare in a systematic manner the acute hemodynamic response (AHR) and electrophysiological effects of MPP and MZP and compare them with conventional biventricular pacing (BiVP). Read More

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Stroke care and case fatality in people with and without schizophrenia: a retrospective cohort study.

BMJ Open 2021 06 10;11(6):e044766. Epub 2021 Jun 10.

Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Background: Schizophrenia is associated with an increased risk of death following stroke; however, the magnitude and underlying reasons for this are not well understood.

Objective: To determine the association between schizophrenia and stroke case fatality, adjusting for baseline characteristics, stroke severity and processes of care.

Design: Retrospective cohort study used linked clinical and administrative databases. Read More

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Sex difference of mortality by age and body mass index in gastric cancer.

Dig Liver Dis 2021 Jun 7. Epub 2021 Jun 7.

Surgery, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea.

Mortality difference by age, sex, body mass index (BMI) in gastric cancer (GC) has been controversial. We evaluated sex-specific mortality by age and BMI. A total of 5961 patients diagnosed with GC from 2005 to 2013 in a single tertiary center were included and were followed until December 2017. Read More

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