308 results match your criteria ahi derived

Accelerometry-derived respiratory index estimating apnea-hypopnea index for sleep apnea screening.

Comput Methods Programs Biomed 2021 May 31;207:106209. Epub 2021 May 31.

Grenoble Alpes University, CNRS, CHU Grenoble Alpes, Grenoble INP, TIMC, Grenoble, France. Electronic address:

Background And Objective: Sleep Apnea Syndrome (SAS) is a multimorbid chronic disease with individual and societal deleterious consequences. Polysomnography (PSG) is the multi-parametric reference diagnostic tool that allows a manual quantification of the apnea-hypopnea index (AHI) to assess SAS severity. The burden of SAS is affecting nearly one billion people worldwide explaining that SAS remains largely under-diagnosed and undertreated. Read More

View Article and Full-Text PDF

Role of PSA Kinetics in Hormone-refractory Prostate Cancer.

J Coll Physicians Surg Pak 2021 Jun;30(6):673-678

Department of Urology, Erciyes University, Faculty of Medicine, Kayseri, Turkey.

Objective: To demonstrate the predictive effect of PSA derivatives and time markers that is prostate-specific antigen (PSA) doubling time (PSADT) and PSA velocity (PSAV) on survival in men with hormone-refractory prostate cancer (HRPCa).

Study Design: Descriptive, analytical study.

Place And Duration Of Study:  Department of Urology, Erciyes University, Faculty of Medicine, Kayseri, Turkey, between 2012 and 2020. Read More

View Article and Full-Text PDF

Influence of obstructive sleep apnea on auditory event-related potentials.

Sleep Breath 2021 Jun 5. Epub 2021 Jun 5.

Department of Physical Therapy, Speech-Language Pathology and Audiology, and Occupational Therapy, Faculty of Medicine (FMUSP), University of São Paulo, Rua Cipotânea, 51, São Paulo, CEP: 05360-160, Brazil.

Purpose: To evaluate the influence of obstructive sleep apnea (OSA) on the P300 response of auditory event-related potentials (ERPs) and to correlate the electrophysiological findings with OSA severity.

Methods: Patients with no OSA and mild, moderate, and severe OSA according to polysomnography (PSG) with normal hearing and no comorbidities were studied. Individuals with a body mass index (BMI) ≥ 40 kg/m, hypertension, diabetes, dyslipidemia, the use of chronic medications, and a risk of hearing loss were excluded. Read More

View Article and Full-Text PDF

Aerodynamics Analysis of the Impact of Nasal Surgery on Patients with Obstructive Sleep Apnea and Nasal Obstruction.

ORL J Otorhinolaryngol Relat Spec 2021 May 31:1-8. Epub 2021 May 31.

Department of Otolaryngology-Head & Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Objective: The purpose of this study was to evaluate the effects of nasal surgery on airflow characteristics in patients with obstructive sleep apnea (OSA) by comparing the alterations of airflow characteristics within the nasal and palatopharyngeal cavities.

Methods: Thirty patients with OSA and nasal obstruction who underwent nasal surgery were enrolled. A pre- and postoperative 3-dimensional model was constructed, and alterations of airflow characteristics were assessed using the method of computational fluid dynamics. Read More

View Article and Full-Text PDF

Beyond the AHI-pulse wave analysis during sleep for recognition of cardiovascular risk in sleep apnea patients.

J Sleep Res 2021 May 25:e13364. Epub 2021 May 25.

Center for Sleep and Vigilance Disorders, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.

Recent evidence supports the use of pulse wave analysis during sleep for assessing functional aspects of the cardiovascular system. The current study compared the influence of pulse wave and sleep study-derived parameters on cardiovascular risk assessment. In a multi-centric study design, 358 sleep apnea patients (age 55 ± 13 years, 64% male, body mass index 30 ± 6 kg m , apnea-hypopnea index 13 [5-26] events per hr) underwent a standard overnight sleep recording. Read More

View Article and Full-Text PDF

Sleep apnoea and incident malignancy in type 2 diabetes.

ERJ Open Res 2021 Apr 4;7(2). Epub 2021 May 4.

Dept of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.

Background: Sleep apnoea and type 2 diabetes (T2D) have been linked to malignancy. The aim of the present study was to evaluate the association between sleep apnoea and incidence of malignancy in patients with T2D.

Methods: The DIACORE (DIAbetes COhoRtE) study is a prospective, population-based cohort study in T2D patients. Read More

View Article and Full-Text PDF

Estimation of Apnea-Hypopnea Index using Deep Learning on 3D Craniofacial Scans.

IEEE J Biomed Health Inform 2021 May 7;PP. Epub 2021 May 7.

Obstructive sleep apnea (OSA) is characterized by decreased breathing events that occur through the night, with severity reported as the apnea-hypopnea index (AHI), which is associated with certain craniofacial features. In this study, we used data from 1366 patients collected as part of Stanford Technology Analytics and Genomics in Sleep (STAGES) across 11 US and Canadian sleep clinics and analyzed 3D craniofacial scans with the goal of predicting AHI, as measured using gold standard nocturnal polysomnography (PSG). First, the algorithm detects pre-specified landmarks on mesh objects and aligns scans in 3D space. Read More

View Article and Full-Text PDF

Endothelial dysfunction in obstructive sleep apnea patients.

Sleep Breath 2021 May 7. Epub 2021 May 7.

Department of Cardiac and Vascular Diseases, John Paul 2Nd Hospital, Jagiellonian University Medical College, Prądnicka Str 80, 31-202, Kraków, Poland.

Purpose: Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for cardiovascular diseases. The aim of the study was to assess the influence of OSAS on endothelial dysfunction and thrombosis biomarkers and to evaluate the effect of treatment with continuous positive airway pressure (CPAP) on biomarker levels.

Methods: NT-proBNP, sICAM-1, endothelin-1, von Willebrand factor, D-dimers, and thrombin-antithrombin complex (TAT) were measured in 50 patients diagnosed with moderate-to-severe OSAS. Read More

View Article and Full-Text PDF

A New Virulent Race of Wheat Stripe Rust Pathogen (Puccinia striiformis f. sp. tritici) on the Resistance Gene Yr5 in Turkey.

Plant Dis 2021 Apr 29. Epub 2021 Apr 29.

Akdeniz University, 37502, Field Crops, Akdeniz University Faculty of Agriculture Dept. of Field Crops, Antalya, Antalya, Konyaaltı, Turkey, 07058;

The gene Yr5 in wheat has generally been known to confer resistance to Puccinia striiformis f. sp. tritici races worldwide. Read More

View Article and Full-Text PDF

Compared to Individuals with Mild to Moderate Obstructive Sleep Apnea (OSA), Individuals with Severe OSA Had Higher BMI and Respiratory-Disturbance Scores.

Life (Basel) 2021 Apr 21;11(5). Epub 2021 Apr 21.

Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah 67146, Iran.

Objective: Individuals with obstructive sleep apnea (OSA) are at increased risk to suffer from further somatic and sleep-related complaints. To assess OSA, demographic, anthropometric, and subjective/objective sleep parameters are taken into consideration, but often separately. Here, we entered demographic, anthropometric, subjective, and objective sleep- and breathing-related dimensions in one model. Read More

View Article and Full-Text PDF

Comparing respiratory polygraphy with pulse transit time analysis versus overnight polysomnography in the diagnosis of obstructive sleep apnoea in children.

Sleep Med 2021 May 1;81:457-462. Epub 2021 Mar 1.

FHKAM(Otolaryngology), Department of Otolaryngology, Tuen Mun Hospital, Hong Kong.

Objective: Obstructive sleep apnea syndrome in children is associated with significant morbidity. Polysomnography is the main diagnostic tool but is time consuming and requires skilled manpower to supervise the patient overnight and hence long referral to diagnosis time. However, there are limitations and underestimation of the apnoea hyponea index (AHI) with alternative home sleep apnoea testing (HSAT), such as type 3 respiratory polygraphy (RP). Read More

View Article and Full-Text PDF

The predictive value of Holter monitoring in the risk of obstructive sleep apnea.

J Thorac Dis 2021 Mar;13(3):1872-1881

Department of Sleep Center, Department of Pulmonary and Critical Care Medicine, Guangdong Provincial People's Hospital/Guangdong Academy of Medical Sciences/Guangdong Provincial Geriatrics Institute/Medical College, South China University of Technology, Guangzhou, China.

Background: Patients with obstructive sleep apnea (OSA) often present with cardiovascular symptoms. Holter monitors were reported to predict sleep apnea, though were rarely used in everyday clinical practice. In this study, by comparing Holter monitoring to polysomnography (PSG), we try to find out an operable way for clinicians to use Holter to predict OSA risk. Read More

View Article and Full-Text PDF

Impact of obstructive sleep apnea on cardiometabolic health in a random sample of older adults in rural South Africa: building the case for the treatment of sleep disorders in under-resourced settings.

J Clin Sleep Med 2021 Mar 9. Epub 2021 Mar 9.

Wits Sleep Laboratory, Brain Function Research Group, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.

Study Objectives: The association between obstructive sleep apnea (OSA) and increased cardiometabolic risk (CMR) has been well documented in higher-income countries. However, OSA and its association with CMR have not yet been investigated, based on objective measures, in Southern Africa. We measured polysomnography (PSG)-derived sleep characteristics, OSA prevalence and its association with cardiometabolic diseases in a rural, low-income, aging African-ancestry sample in South Africa. Read More

View Article and Full-Text PDF

Subclinical left ventricular systolic dysfunction detected in obstructive sleep apnea with automated function imaging and its association with nocturnal hypoxia.

Sleep Breath 2021 Mar 7. Epub 2021 Mar 7.

Sleep Medicine Center, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, 100029, China.

Background: Early detection of left ventricular (LV) dysfunction is crucial in obstructive sleep apnea (OSA) due to its close relationship with cardiovascular diseases. Global longitudinal strain (GLS) derived from automated function imaging (AFI) can precisely assess global longitudinal function. The aim of this study was to determine if LV GLS was reduced in patients with OSA and a normal LV ejection fraction (LVEF) and to assess any associated determinants. Read More

View Article and Full-Text PDF

Sleep-Dependent Memory in Older People With and Without MCI: The Relevance of Sleep Microarchitecture, OSA, Hippocampal Subfields, and Episodic Memory.

Cereb Cortex 2021 May;31(6):2993-3005

School of Psychology, University of Sydney, Sydney, New South Wales, 2000, Australia.

This study aimed to determine if, relative to cognitively healthy controls, sleep-dependent memory consolidation (SDMC) is diminished in mild cognitive impairment (MCI), a group at high risk of conversion to dementia. We also sought to determine whether SDMC is associated with sleep characteristics, daytime episodic memory, and hippocampal integrity. Participants with MCI (n = 43) and controls (n = 20) underwent clinical and neuropsychological profiling. Read More

View Article and Full-Text PDF

Obstructive Sleep Apnea, Glucose Tolerance, and β-Cell Function in Adults With Prediabetes or Untreated Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study.

Diabetes Care 2021 Apr 5;44(4):993-1001. Epub 2021 Feb 5.

University of Chicago, Chicago, IL.

Objective: Obstructive sleep apnea (OSA) is associated with insulin resistance and has been described as a risk factor for type 2 diabetes. Whether OSA adversely impacts pancreatic islet β-cell function remains unclear. We aimed to investigate the association of OSA and short sleep duration with β-cell function in overweight/obese adults with prediabetes or recently diagnosed, treatment-naive type 2 diabetes. Read More

View Article and Full-Text PDF

Automated Apnea-Hypopnea Index from Oximetry and Spectral Analysis of Cardiopulmonary Coupling.

Ann Am Thorac Soc 2021 05;18(5):876-883

Division of Pulmonary and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

The increased prevalence of obstructive sleep apnea (OSA) coincides with a severe shortage of sleep physicians. There is a need for widescale home-sleep-testing devices with accurate automated scoring to accelerate access to treatment. To examine the accuracy of an automated apnea-index (AHI) derived from spectral analysis of cardiopulmonary coupling (CPC) extracted from electrocardiograms, combined with oximetry signals, in relation to polysomnograms (PSGs). Read More

View Article and Full-Text PDF

Sleep apnea detection from ECG using variational mode decomposition.

Biomed Phys Eng Express 2020 01 20;6(1):015026. Epub 2020 Jan 20.

Dept. of Electronics & Communication Engineering, National Institute of Technology Rourkela, Rourkela-769008, India.

Sleep apnea is a pervasive breathing problem during night sleep, and its repetitive occurrence causes various health problems. Polysomnography is commonly used for apnea screening which is an expensive, time-consuming, and complex process. In this paper, a simple but efficient technique based on the variational mode decomposition (VMD) for automated detection of sleep apnea from single-lead ECG is proposed. Read More

View Article and Full-Text PDF
January 2020

Relationship between the mitochondria-derived peptide MOTS-c and insulin resistance in obstructive sleep apnea.

Sleep Breath 2021 Jun 4;25(2):861-866. Epub 2021 Jan 4.

Department of Chest Diseases, Necip Fazıl City Hospital, Kahramanmaras, Turkey.

Purpose: The co-occurrence of obstructive sleep apnea (OSA) and obesity are common. Mitochondrial open reading frame of the 12S rRNA-c (MOTS-C) is one of the newly identified mitochondrial derivative peptides that play a role in the regulation of metabolic homeostasis. We aimed to examine the serum levels of MOTS-C to help understand the role of the disease in the pathophysiology, thereby investigating whether it can contribute to the appropriate treatment. Read More

View Article and Full-Text PDF

Watch-PAT is Useful in the Diagnosis of Sleep Apnea in Patients with Atrial Fibrillation.

Nat Sci Sleep 2020 3;12:1115-1121. Epub 2020 Dec 3.

Technion Faculty of Medicine, Sleep Laboratory, Carmel Medical Center, Haifa, Israel.

Background: Early diagnosis and treatment of sleep apnea in patients with atrial fibrillation (AF) is critical. The WatchPAT (WP) device was shown to be accurate for the diagnosis of sleep apnea; however, studies using the WatchPAT device have thus far excluded patients with arrhythmias due to the potential effect of arrhythmias on the peripheral arterial tonometry (PAT) amplitude and pulse rate changes.

Purpose: To examine the accuracy of the WP in detecting sleep apnea in patients with AF. Read More

View Article and Full-Text PDF
December 2020

Non-REM Apnea and Hypopnea Duration Varies across Population Groups and Physiologic Traits.

Am J Respir Crit Care Med 2021 May;203(9):1173-1182

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts.

Symptoms and morbidities associated with obstructive sleep apnea (OSA) vary across individuals and are not predicted by the apnea-hypopnea index (AHI). Respiratory event duration is a heritable trait associated with mortality that may further characterize OSA. We evaluated how hypopnea and apnea durations in non-REM (NREM) sleep vary across demographic groups and quantified their associations with physiological traits (loop gain, arousal threshold, circulatory delay, and pharyngeal collapsibility). Read More

View Article and Full-Text PDF

Validation of an Overnight Wireless High-Resolution Oximeter plus Cloud-Based Algorithm for the Diagnosis of Obstructive Sleep Apnea.

Clinics (Sao Paulo) 2020 27;75:e2414. Epub 2020 Nov 27.

Laboratorio do Sono, Divisao de Pneumologia, Instituto do Coraçao (InCor), Hospital das Clinicas (HCFMUSP), Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: Obstructive sleep apnea (OSA) is a common but largely underdiagnosed condition. This study aimed to test the hypothesis that the oxygen desaturation index (ODI) obtained using a wireless high-resolution oximeter with a built-in accelerometer linked to a smartphone with automated cloud analysis, Overnight Digital Monitoring (ODM), is a reliable method for the diagnosis of OSA.

Methods: Consecutive patients referred to the sleep laboratory with suspected OSA underwent in-laboratory polysomnography (PSG) and simultaneous ODM. Read More

View Article and Full-Text PDF
December 2020

Associations of OSA and Nocturnal Hypoxemia with Strength and Body Composition in Community Dwelling Middle Aged and Older Men.

Nat Sci Sleep 2020 10;12:959-968. Epub 2020 Nov 10.

The Health Observatory, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.

Purpose: Reduced hand grip strength (HGS) is associated with poorer health in chronic conditions, yet there has been little research examining the association with hand grip strength and obstructive sleep apnea (OSA). Further, these studies have not examined, nor adjusted, for muscle mass. The aim of this study was to determine associations between OSA indices, HGS, muscle mass, and fat mass. Read More

View Article and Full-Text PDF
November 2020

Sexual function and depression in polycystic ovary syndrome: Is it associated with inflammation and neuromodulators?

Neuropeptides 2020 Dec 23;84:102099. Epub 2020 Oct 23.

Department of Biochemistry, Yozgat Bozok University, Faculty of Medicine, Yozgat, Turkey.

Numerous studies have been carried out on depression and sexual dysfunction concomitant with polycystic ovary syndrome (PCOS). Increasing evidence has revealed the importance of inflammation in the etiology of PCOS. In addition, it has been known that some neuromodulators affect depression and sexual function. Read More

View Article and Full-Text PDF
December 2020

Prolonged Circulation Time Is Associated With Mortality Among Older Men With Sleep-Disordered Breathing.

Chest 2021 Apr 16;159(4):1610-1620. Epub 2020 Oct 16.

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Background: Conventional metrics to evaluate sleep-disordered breathing (SDB) have many limitations, including their inability to identify subclinical markers of cardiovascular (CV) dysfunction.

Research Question: Does sleep study-derived circulation time (Ct) predict mortality, independent of CV risks and SDB severity?

Study Design And Methods: We derived average lung to finger Ct (LFCt) from sleep studies in older men enrolled in the multicenter Osteoporotic Fractures in Men (MrOS) Sleep study. LFCt was defined as the average time between end of scored respiratory events and nadir oxygen desaturations associated with those events. Read More

View Article and Full-Text PDF

Estimation of respiration rate and sleeping position using a wearable accelerometer.

Annu Int Conf IEEE Eng Med Biol Soc 2020 07;2020:4668-4671

Wearable inertial sensors offer the possibility to monitor sleeping position and respiration rate during sleep, enabling a comfortable and low-cost method to remotely monitor patients. Novel methods to estimate respiration rate and position during sleep using accelerometer data are presented, with algorithm performance examined for two sensor locations, and accelerometer-derived respiration rate compared across sleeping positions. Eleven participants (9 male; aged: 47. Read More

View Article and Full-Text PDF

Is Cumulative Time of Oxygen Desaturation a Better Predictor of Cardiovascular Mortality than Apnoea Hypopnoea Index?

Annu Int Conf IEEE Eng Med Biol Soc 2020 07;2020:2788-2791

In this paper, we explored the link between sleep apnoea and cardiovascular disease (CVD) using a time-series statistical measure of sleep apnoea-related oxygen desaturation. We compared the performance of a hypoxic measure derived from the polysomnogram with the Apnoea Hypopnoea Index (AHI) in predicting CVD mortality in patients of the Sleep Heart Health Study.We estimated the relative cumulative time of SpO below 90% (T90) using pulse oximetry signals from polysomnogram recordings as the hypoxic measure of desaturation patterns. Read More

View Article and Full-Text PDF

A CPAP data-based algorithm for automatic early prediction of therapy adherence.

Sleep Breath 2021 Jun 25;25(2):957-962. Epub 2020 Sep 25.

Department of Respiratory and Sleep Medicine, University Hospital of Angers, INSERM Unit 1063, University of Angers, Angers, France.

Objective: Adherence is a critical issue in the treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP). Approximately 40% of patients treated with CPAP are at risk of discontinuation or insufficient use (< 4 h/night). Assuming that the first few days on CPAP are critical for continued treatment, we tested the predictive value at day 14 (D14) of the Philips Adherence Profiler™ (AP) algorithm for adherence at 3 months (D90). Read More

View Article and Full-Text PDF

Night-to-night variability in respiratory parameters in children and adolescents examined for obstructive sleep apnea.

Int J Pediatr Otorhinolaryngol 2020 Oct 8;137:110206. Epub 2020 Jul 8.

Dept. of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Lykkebækvej 1, 4600, Køge, Denmark; Dept. of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark. Electronic address:

Introduction: The diagnosis of obstructive sleep apnea (OSA) is routinely based on just a single night's sleep examination. The night-to-night variability in children and adolescents has previously been investigated using type 4 sleep monitors or PSG. However, there is a lack of studies investigating the night-to-night variability when using type 3 sleep monitors. Read More

View Article and Full-Text PDF
October 2020

Determination of equation for estimating continuous positive airway pressure in patients with obstructive sleep apnea for the Indian population.

Lung India 2020 Sep-Oct;37(5):411-414

Department of Pulmonology, KIMS Hospital, Secunderabad, Telangana, India.

Background: Continuous positive airway pressure (CPAP) is the treatment of obstructive sleep apnea (OSA). The CPAP pressure is generally estimated by manual titration or an auto CPAP device. An alternative method involves the use of the predictive equation. Read More

View Article and Full-Text PDF
September 2020