J Clin Neurophysiol 2020 Dec 15;Publish Ahead of Print. Epub 2020 Dec 15.
Department of Neurology, Emory University and Emory Epilepsy Center, Atlanta, Georgia, U.S.A.; Departments of Pediatrics and Neurology. Atlanta, Georgia, U.S.A. Department of Neurosurgery, Emory University, Atlanta, Georgia, U.S.A.; and Emory Neuromodulation Technology Innovation Center, Emory University and Georgia Institute of Technology, Atlanta, Georgia, U.S.A.
Purpose: Corticocortical evoked potentials (CCEPs) resulting from single pulse electrical stimulation are increasingly used to understand seizure networks, as well as normal brain connectivity. However, we observed that when using depth electrodes, traditional measures of CCEPs amplitude using a referential montage can be falsely localizing, often to white matter.
Methods: We pooled 27 linear electrode arrays targeting the amygdala, hippocampus, or cingulate cortex from eight participants. Read More