468,399 results match your criteria aging


Effects of Aging on Hemodynamic Kinetics in Different Intensities of Dynamic Exercise.

Int J Sports Med 2021 Jun 22. Epub 2021 Jun 22.

Department of Physiotherapy, UFSCar, Sao Carlos, Brazil.

Healthy aging hemodynamics is known to exhibit a time-dependent loss of function. We aimed at verifying whether older men would have a slowed cardiac output and stroke volume dynamics in response to the onset ("on") and on recovery ("off") of exercise in comparison to young men. Twenty healthy active men (10 young and 10 older) were recruited. Read More

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An individually adjusted endurance test reveals differences in physical fitness between young and old Beagles.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2021 Jun 22;49(3):165-172. Epub 2021 Jun 22.

Clinic for Small Animals, University of Veterinary Medicine, Foundation.

Objective: Aim was to establish an individually adapted endurance test for dogs on a treadmill, which takes the individual's physical condition into account. To check the applicability of the test, two age groups of clinically healthy beagles were examined.

Methods: A total of 10 clinically healthy Beagles were enrolled and divided in a younger (1-3 years, n = 5) and older group (> 8 years, n = 5). Read More

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High S100A9 cell density predicts a poor prognosis in hepatocellular carcinoma patients after curative resection.

Aging (Albany NY) 2021 Jun 22;13. Epub 2021 Jun 22.

MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.

S100A9 is differentially expressed in various cell types and is associated with the development, progression and metastasis of various cancers. However, the expression, distribution, and clinical significance of S100A9 in hepatocellular carcinoma (HCC) remain unclear. In the present study, The Cancer Genome Atlas (TCGA) database was used to examine gene expression in HCC; we found that expression was associated with HCC prognosis. Read More

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Immunological discrepancy in aged mice facilitates skin allograft survival.

Aging (Albany NY) 2021 Jun 22;13. Epub 2021 Jun 22.

Division of Liver and Transplantation Surgery, Department of General Surgery, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan, Taiwan.

More and more aged people are undergoing organ transplantation. Understanding aging effects on immunity will be helpful for post-transplantation care and adjustment of immunosuppressants for aged recipients. A mouse model, using C3H mice as donors and aged/young C57BL/10J mice as recipients, was employed to study aging effects on immunity. Read More

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Deoxyribonuclease 1-like 3 may be a potential prognostic biomarker associated with immune infiltration in colon cancer.

Aging (Albany NY) 2021 Jun 22;13. Epub 2021 Jun 22.

Department of Laboratory Medicine, Guangdong Second Provincial General Hospital, Guangzhou 510317, China.

Colon adenocarcinoma (COAD) is a common cancer of the digestive system. It's high morbidity and mortality make it one of the leading causes of cancer deaths. In this study, we studied the microenvironment of colon cancer to find new diagnostic markers and immunotherapy targets for colon cancer. Read More

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Associations of Social Network Characteristics With Gait Speed in Older Women From Physical Activity Community Groups.

J Aging Phys Act 2021 Jun 21:1-8. Epub 2021 Jun 21.

The identification of social network factors associated with gait speed may offer different perspectives for improving community and clinical interventions for older adults. The objective of this study was to explore the associations of the social network of friends with gait speed. This was a cross-sectional study conducted in a sample of 128 older adult women recruited in community groups of physical activity. Read More

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Does Interrupting Prolonged Sitting With 10- or 20-Min Standing Attenuate Postprandial Glycemia and Blood Pressure in Middle-Aged and Older Adults With Type 2 Diabetes?

J Aging Phys Act 2021 Jun 21:1-8. Epub 2021 Jun 21.

We carried out three types of 2-hr experimental sessions with middle-aged and older adults with Type 2 diabetes in order to examine the acute effect of interrupting prolonged sitting with varying periods of standing on postprandial glycemia and blood pressure (BP): (a) prolonged sitting after breakfast; (b) standing for 10 min, 30 min after breakfast; and (c) standing for 20 min, 30 min after breakfast. Glucose and BP were assessed before and after breakfast. A generalized linear model revealed no significant differences for the incremental area under the curve of glucose between standing for 10 min, 30 min after breakfast, versus prolonged sitting after breakfast (β = -4. Read More

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Feasibility and Acceptability of Home-Based Exercise Snacking and Tai Chi Snacking Delivered Remotely to Self-Isolating Older Adults During COVID-19.

J Aging Phys Act 2021 Jun 21:1-11. Epub 2021 Jun 21.

The purpose of this study was to examine the feasibility and acceptability of remotely delivered, home-based exercise programs on physical function and well-being in self-isolating older adults during the COVID-19 pandemic. In a four-arm randomized controlled trial, 63 participants (aged 65 years and older) were allocated to one of three home-based daily (2 × 10-min) exercise interventions (exercise snacking, tai chi snacking, and combination) or control (UK National Health Service Web pages). Functional assessments were conducted via video call at baseline and 4-week follow-up. Read More

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Translation of the poly(GR) frame in C9ORF72-ALS/FTD is regulated by cis-elements involved in alternative splicing.

Neurobiol Aging 2021 May 8;105:327-332. Epub 2021 May 8.

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

GGGGCC (GC) repeat expansion in the first intron of C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia, two devastating age-dependent neurodegenerative disorders. Both sense and antisense repeat RNAs can be translated into 5 different dipeptide repeat proteins, such as poly(GR), which is toxic in various cellular and animal models. However, it remains unknown how poly(GR) is synthesized in patient neurons. Read More

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Molecular follow-up of first-line treatment by osimertinib in lung cancer: Importance of using appropriate tools for detecting EGFR resistance mutation C797S.

Cancer Genet 2021 Jun 10;256-257:158-161. Epub 2021 Jun 10.

Laboratory of Solid Tumor Genetics, University Hospital of Nice-Côte d'Azur University, Nice, France; Laboratory of Solid Tumor Genetics, Institute for Research on Cancer and Aging of Nice (IRCAN), CNRS UMR 7284/INSERM U1081, Nice, France. Electronic address:

The C797S mutation encoded by EGFR exon 20 is classically observed as a tertiary event in EGFR-mutant non-small-cell lung carcinoma (NSCLC) primarily treated by first generation tyrosine kinase inhibitors (TKI) and secondarily treated by third-generation TKI, such as osimertinib, if the EGFR-T790M resistance mutation is detected. Recently, significant prolonged progression free survival has been observed following first-line osimertinib, in EGFR-mutant NSLC. While mechanisms of molecular resistance to first-generation TKI have been well studied, little is known about resistance induced by primary third-generation TKI treatments. Read More

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Synthesis, characterization, CO mineralization in air, and thermal decomposition of nano- CHMgO·4HO powder.

J Environ Manage 2021 Jun 19;295:113095. Epub 2021 Jun 19.

Entropic Interface Group, Engineering Product Development, Singapore University of Technology and Design, 8 Somapah Road, 487372, Singapore. Electronic address:

Effective solutions for efficient carbon dioxide (CO) capture in air at room temperature are in high demand due to the major impacts CO has on global climatic changes. Solid adsorbents materials for CO capture received great attention over the past years, among them, magnesium-based sorbents have been identified as a promising solution for CO capture at intermediate temperatures. This study reports for the first time (1) the synthesis of monoclinic magnesium malate tetrahydrate by combining electrospinning and aging processes, and (2) its room temperature CO adsorption and mineralization in air. Read More

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Blood Mitochondrial DNA Copy Number: What Are We Counting?

Authors:
Martin Picard

Mitochondrion 2021 Jun 19. Epub 2021 Jun 19.

Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York NY, USA; Department of Neurology, Merritt Center, Columbia Translational Neuroscience Initiative, Columbia University Irving Medical Center, New York NY, USA; New York State Psychiatric Institute, New York NY, USA. Electronic address:

There is growing scientific interest to develop scalable biological measures that capture mitochondrial (dys)function. Mitochondria have their own genome, the mitochondrial DNA (mtDNA), and it has been proposed that the number of mtDNA copies per cell (mtDNA copy number; mtDNAcn) reflects mitochondrial health. The common availability of stored DNA material or existing DNA sequencing data, especially from blood and other easy-to-collect samples, has made its quantification a popular approach in clinical and epidemiological studies. Read More

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Poor Odor Identification Predicts Mortality Risk in Older Adults Without Neurodegenerative Diseases: The Shanghai Aging Study.

J Am Med Dir Assoc 2021 Jun 19. Epub 2021 Jun 19.

Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

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Vision, Eye Disease, and the Onset of Balance Problems: The Canadian Longitudinal Study on Aging: Vision and Balance Problems.

Am J Ophthalmol 2021 Jun 19. Epub 2021 Jun 19.

School of Epidemiology and Public Health, University of Ottawa, Ottawa; University of Ottawa Eye Institute, Ottawa; Ottawa Hospital Research Institute, Ottawa; Canada. Electronic address:

Purpose: To understand the relationship between visual impairment, self-reported eye disease, and the onset of balance problems.

Design: Population-based prospective cohort study METHODS: : Baseline and 3-year follow-up data were used from the Canadian Longitudinal Study on Aging. The Comprehensive Cohort included 30,097 adults ages 45-85 years old recruited from 11 sites across 7 provinces. Read More

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The community-based LIVE WELL Initiative: Improving the lives of older adults.

J Prev Interv Community 2021 Jun 22:1-20. Epub 2021 Jun 22.

Area Agency on Aging, United Way of Tarrant County, Fort Worth, Texas, USA.

A collaborative partnership among community-based organizations (CBOs) could strengthen local services and enhance the capacity of a community to provide services as well as meet the diverse needs of older adults. The United Way of Tarrant County developed the LIVE WELL Initiative, partnering with six CBOs to provide nine evidence-based or evidence-informed health interventions to improve the health and lower healthcare costs of vulnerable individuals at risk for poor health. The nine programs include specific target areas, such as falls prevention, chronic disease self-management, medication management, and diabetes screening and education. Read More

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Age-related changes in metabolites in young donor livers and old recipient sera after liver transplantation from young to old rats.

Aging Cell 2021 Jun 22:e13425. Epub 2021 Jun 22.

Department of Geriatrics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Liver ageing not only damages liver function but also harms systemic metabolism. To better understand the mechanisms underlying liver ageing, we transplanted the livers of young rats to young and old rats and performed untargeted metabolomics to detect changes in the metabolites in the liver tissues and sera. A total of 153 metabolites in the livers and 83 metabolites in the sera were different between the old and young rats that did not undergo liver transplantation; among these metabolites, 7 different metabolites were observed in both the livers and sera. Read More

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Application of a dual mechanistic approach to support bilastine dose selection for older adults.

CPT Pharmacometrics Syst Pharmacol 2021 Jun 22. Epub 2021 Jun 22.

Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, University of Florida, USA.

The objective of this study was to evaluate bilastine dosing recommendations in older adults and overcome the limitation of insufficient data from phase I studies in this underrepresented population. This was achieved by integrating bilastine physicochemical, in vitro and in vivo data in young adults and the effect of aging in the pharmacology by means of two alternative approaches: a physiologically-based pharmacokinetic (PBPK) model and a semi-mechanistic population pharmacokinetic (Senescence) model. Intestinal apical efflux and basolateral influx transporters were needed in the PBPK model to capture the observations from young adults after single IV (10mg) and PO (20 mg) doses, supporting the hypothesis of involvement of gut transporters on secretion. Read More

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Visuospatial Dysfunction is Associated with Posterior Distribution of White Matter Damage in Non-Demented Cerebral Amyloid Angiopathy.

Eur J Neurol 2021 Jun 22. Epub 2021 Jun 22.

Department of Neurology, National Centre for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Background And Purpose: Cerebral amyloid angiopathy (CAA) is a well-recognized contributor to cognitive decline in the elderly. The posterior cortical predilection of CAA pathology would cause visuospatial dysfunction, which are still underexplored. We aimed to investigate whether the visuospatial dysfunction in CAA is associated with the posterior distribution of small vessel disease (SVD) imaging markers. Read More

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To study the Effect of Acute Infrared Radiation-Induced Alterations in Human skin at Cellular and Molecular level Using In-vivo Confocal Raman Spectroscopy.

Photodermatol Photoimmunol Photomed 2021 Jun 22. Epub 2021 Jun 22.

College of Engineering, Biomedical Engineering Department, Imam Abdulrahman Bin Faisal University Dammam, Saudi Arabia.

Background: Solar radiations are classified in terms of wavelengths, including visible light, infrared, and ultraviolet. Infrared radiation (IR) account the largest proportion of solar radiations that causes oxidative stress-induced aging of human skin. This study investigates the biochemical changes in proteins, lipids, and DNA associated with acute exposure to IR radiations. Read More

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Protective Role of DHEAS in Age-related Changes in Bone Mass and Fracture Risk: A Mendelian Randomization Study.

J Clin Endocrinol Metab 2021 Jun 22. Epub 2021 Jun 22.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Purpose: Dehydroepiandrosterone sulfate (DHEAS) from the adrenal cortex substantially decreases with age, which may accelerate osteoporosis. However, the association of DHEAS with bone mineral density (BMD) and fracture is inconclusive. We conducted a Mendelian randomization (MR) analysis to investigate the role of DHEAS in age-related changes in BMD and fracture risk. Read More

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Comparison of Various Time-Related Modifications of Ultraviolet Photofunctionalization on SLA-Treated Titanium Surfaces.

Int J Oral Maxillofac Implants 2021 Jun 22. Epub 2021 Jun 22.

Purpose: The purpose of this study was to compare changes in the physicochemical and biologic characteristics of titanium surfaces through short-term re-hydrophobization for 24 hours and ultraviolet (UV) re-irradiation for 24 hours.

Materials And Methods: Photofunctionalization was performed with four 15-W bactericidal lamps at an intensity of 5.0 mW/cm (wavelength = 254 ± 20 nm) on sandblasted, large-grit, acid-etched (SLA)-treated titanium surfaces, which were stored in a sterilized sealed container for 8 weeks to allow enough biologic aging. Read More

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Sexual dimorphism of the mandibular conformational changes in aging human adults: A multislice computed tomographic study by geometric morphometrics.

PLoS One 2021 22;16(6):e0253564. Epub 2021 Jun 22.

Laboratoire d'Anthropobiologie AMIS, UMR 5288 CNRS, Université Paul Sabatier, Toulouse, France.

The aging process has an impact on mandibular bone morphology and can therefore affect shape sexual dimorphism. Understanding the effect of senescence on mandibular shape changes is particularly important to correctly estimate the sex of an individual and predict age-related conformational modifications. The purpose of this study was to assess age-related changes in mandibular shape and sexual dimorphism. Read More

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A549 in-silico 1.0: A first computational model to simulate cell cycle dependent ion current modulation in the human lung adenocarcinoma.

PLoS Comput Biol 2021 Jun 22;17(6):e1009091. Epub 2021 Jun 22.

Institute of Health Care Engineering with European Testing Center for Medical Devices, Graz University of Technology, Graz, Austria.

Lung cancer is still a leading cause of death worldwide. In recent years, knowledge has been obtained of the mechanisms modulating ion channel kinetics and thus of cell bioelectric properties, which is promising for oncological biomarkers and targets. The complex interplay of channel expression and its consequences on malignant processes, however, is still insufficiently understood. Read More

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Searching for female reproductive aging and longevity biomarkers.

Aging (Albany NY) 2021 Jun 22;13. Epub 2021 Jun 22.

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov, Moscow 117997, Russia.

Female reproductive aging is, in a way, a biological phenomenon that develops along canonical molecular pathways; however, it has particular features. Recent studies revealed complexity of the interconnections between reproductive aging and aging of other systems, and even suggested a cause-effect uncertainty between them. It was also shown that reproductive aging can impact aging processes in an organism at the level of cells, tissues, organs, and systems. Read More

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Diagnostic accuracy of high -value diffusion weighted imaging for patients with prostate cancer: a diagnostic comprehensive analysis.

Aging (Albany NY) 2021 Jun 22;13. Epub 2021 Jun 22.

Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China.

We performed a meta-analysis to assess the diagnostic accuracy of high -value diffusion-weighted imaging for patients with prostate cancer. A comprehensive literature search of the PubMed, Excerpta Medica Database, Cochrane Library, China National Knowledge Infrastructure, China Biology Medicine disc, and Wanfang databases from January 1, 1995, to April 30, 2021, was conducted. The quality of the retrieved papers was assessed using the Quality Assessment of Diagnostic Accuracy Studies 2. Read More

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miRNAs generated from Meg3-Mirg locus are downregulated during aging.

Aging (Albany NY) 2021 Jun 22;13. Epub 2021 Jun 22.

Laboratory of Stem Cell Biology, Institute of Cellular Biology and Pathology “Nicolae Simionescu", Bucharest 050568, Romania.

Aging determines a multilevel functional decline and increases the risk for cardiovascular pathologies. MicroRNAs are recognized as fine tuners of all cellular functions, being involved in various cardiac diseases. The heart is one of the most affected organs in aged individuals, however little is known about the extent and robustness to which miRNA profiles are modulated in cardiac cells during aging. Read More

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Canadian Older Adults' Perceptions of Transitioning from Driver to Non-Driver.

Occup Ther Health Care 2021 Jun 22:1-21. Epub 2021 Jun 22.

Centre for Research on Safe Driving, Lakehead University, Thunder Bay, Canada.

Ceasing driving is associated with many negative outcomes. We examined the perceived impact of driving cessation among current older drivers. Transcripts from 92 interviews with participants from several locations across Canada were analyzed using inductive thematic analysis. Read More

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The relationship between alcohol intake and falls hospitalization: Results from the EPIC-Norfolk.

Geriatr Gerontol Int 2021 Jun 22. Epub 2021 Jun 22.

Ageing Clinical & Experimental Research (ACER) Team, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.

Aim: To evaluate the relationship between habitual alcohol consumption and the risk of falls hospitalization.

Methods: The EPIC-Norfolk is a prospective population-based cohort study in Norfolk, UK. In total, 25 637 community dwelling adults aged 40-79 years were recruited. Read More

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A double-blind randomized controlled trial combining cognitive training (CoRe) and neurostimulation (tDCS) in the early stages of cognitive impairment.

Aging Clin Exp Res 2021 Jun 22. Epub 2021 Jun 22.

IRCCS Mondino Foundation, Via Mondino 2, Pavia, Italy.

Background: The prevalence of neurodegenerative diseases is expected to increase over the next years, therefore, new methods able to prevent and delay cognitive decline are needed.

Aims: To evaluate the effectiveness of a combined treatment protocol associating a computerized cognitive training (CoRe) with anodal transcranial direct current stimulation (tDCS).

Methods: In this randomized controlled trial, 33 patients in the early stage of cognitive impairment were assigned to the experimental group (CoRE + real tDCS) or control group (CoRE + sham tDCS). Read More

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Effect of exergaming on wellbeing of residents in a nursing home: a single blinded intervention study.

Aging Clin Exp Res 2021 Jun 22. Epub 2021 Jun 22.

Department of Public Health and Primary Care, KU Leuven, Kapucijnenvoer 33, 7001, 3000, Leuven, Belgium.

Introduction: To improve the quality of life in nursing homes, meaningful activities and social contact are indispensable. Exergames can play a role addressing these needs.

Methods: In a randomized single blinded controlled intervention study, we investigated the effect of playing exergames on general wellbeing, fun and on social interaction. Read More

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