Mitochondrion 2021 Jun 19. Epub 2021 Jun 19.
Department of Psychiatry, Division of Behavioral Medicine, Columbia University Irving Medical Center, New York NY, USA; Department of Neurology, Merritt Center, Columbia Translational Neuroscience Initiative, Columbia University Irving Medical Center, New York NY, USA; New York State Psychiatric Institute, New York NY, USA. Electronic address:
There is growing scientific interest to develop scalable biological measures that capture mitochondrial (dys)function. Mitochondria have their own genome, the mitochondrial DNA (mtDNA), and it has been proposed that the number of mtDNA copies per cell (mtDNA copy number; mtDNAcn) reflects mitochondrial health. The common availability of stored DNA material or existing DNA sequencing data, especially from blood and other easy-to-collect samples, has made its quantification a popular approach in clinical and epidemiological studies. Read More