8,385,274 results match your criteria agesmaterial methods

Diagnostic accuracy of stroke volume variation for predicting fluid responsiveness in children undergoing cardiac surgery: a systematic review and meta-analysis.

Paediatr Anaesth 2021 Apr 21. Epub 2021 Apr 21.

Department of Intensive Care Unit, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Dong Lake District, Nanchang, 330000, Jiangxi Province, China.

Background: Stroke volume variation (SVV) appears to be reliable for predicting fluid responsiveness (FR) in adults and its predictive value in paediatric patients has been recently reported. However, its predictive value in children undergoing cardiac surgery is unclear.

Methods: A review and meta-analysis were performed on the diagnostic utility of SVV for predicting FR in children undergoing cardiac surgery. Read More

View Article and Full-Text PDF

Erastin synergizes with cisplatin via ferroptosis to inhibit ovarian cancer growth in vitro and in vivo.

J Obstet Gynaecol Res 2021 Apr 21. Epub 2021 Apr 21.

Department of Gynecology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, China.

Aim: Cisplatin-based chemotherapy is the first-line treatment for ovarian cancer. However, acquired resistance to cisplatin treatment or serious side effects often occurs in ovarian cancer, and thus, there is an urgent need for effective and combined therapies to overcome such obstacles. In the present study, we aimed to uncover synergistic effects between erastin and cisplatin (CDDP) in inhibiting ovarian cancer cell growth by inducing ferroptosis in vitro and in vivo. Read More

View Article and Full-Text PDF

[Delegation and the Efficient Use of Medical Personnel - Ideas During Times of Physician Shortage].

Zentralbl Chir 2021 Apr 21. Epub 2021 Apr 21.

Abteilung für Unfall-Hand und Wiederherstellungschirurgie, Universitätsklinikum des Saarlandes, Homburg/Saar, Deutschland.

Background: Patient care is a cost intensive process and an important fraction of these costs is the salary of medical staff. Efficient use, especially in times of physician shortage, should thus be of great importance to hospital management. We aim to calculate the costs and resulting saving potential from delegation of tasks, that are performed by medical personnel, but could in principle be delegated. Read More

View Article and Full-Text PDF

Surgical Outcomes of Non-Small Cell Lung Cancer in Single-Zone N2 in the Aortopulmonary Zone.

Thorac Cardiovasc Surg 2021 Apr 21. Epub 2021 Apr 21.

Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, Seoul, Korea.

Objectives:  We evaluate the surgical outcome of clinically single-zone N2 lung cancer limited to aortopulmonary zone (AP zone; lymph node #5 or #6).

Patients And Methods:  We performed a retrospective analysis of patients with non-small cell lung cancer, in whom mediastinal lymph node metastasis was confined to AP zone.

Results:  A total of 84 patients who underwent upfront surgery were included in final analysis. Read More

View Article and Full-Text PDF

Heater-Cooler Devices and Risk of Contamination during Cardiac Surgery.

Thorac Cardiovasc Surg 2021 Apr 21. Epub 2021 Apr 21.

Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich-Schiller University of Jena, Jena, Germany.

Background:  Heater-cooler devices (HCD) have been implicated in a cardiosurgical contamination scenario causing prosthetic valve endocarditis.

Aim:  We characterized contamination of new HCDs and assessed the risk of intraoperative microorganism transmission from the HCD to the operating field.

Methods:  We initially acquired four new FlexTherm and then four new Maquet HCU40 HCDs and assessed occurrence and speed of microbial contamination (including mycobacteria) assessing swab and water samples from the device. Read More

View Article and Full-Text PDF

How to Improve Information Technology to Support Healthcare to Address the COVID-19 Pandemic: an International Survey with Health Informatics Experts.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Daphne Cockwell School of Nursing, Ryerson University, Toronto, Canada.

Objectives: To identify the ways in which healthcare information and communication technologies can be improved to address the challenges raised by the COVID-19 pandemic.

Methods: The study population included health informatics experts who had been involved with the planning, development and deployment of healthcare information and communication technologies in healthcare settings in response to the challenges presented by the COVID-19 pandemic. Data were collected via an online survey. Read More

View Article and Full-Text PDF

Primary Care Informatics Response to Covid-19 Pandemic: Adaptation, Progress, and Lessons from Four Countries with High ICT Development.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Nuffield Department of Primary Care Health Sciences, University of Oxford, UK.

Objective: Internationally, primary care practice had to transform in response to the COVID pandemic. Informatics issues included access, privacy, and security, as well as patient concerns of equity, safety, quality, and trust. This paper describes progress and lessons learned. Read More

View Article and Full-Text PDF

Using Open Source, Open Data, and Civic Technology to Address the COVID-19 Pandemic and Infodemic.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Objectives: The emerging COVID-19 pandemic has caused one of the world's worst health disasters compounded by social confusion with misinformation, the so-called "Infodemic". In this paper, we discuss how open technology approaches - including data sharing, visualization, and tooling - can address the COVID-19 pandemic and infodemic.

Methods: In response to the call for participation in the 2020 International Medical Informatics Association (IMIA) Yearbook theme issue on Medical Informatics and the Pandemic, the IMIA Open Source Working Group surveyed recent works related to the use of Free/Libre/Open Source Software (FLOSS) for this pandemic. Read More

View Article and Full-Text PDF

Trials and Tribulations: mHealth Clinical Trials in the COVID-19 Pandemic.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Graduate School of Biomedical Engineering, The University of New South Wales, Sydney, Australia.

Introduction: Mobile phone-based interventions in cardiovascular disease are growing in popularity. A randomised control trial (RCT) for a novel smartphone app-based model of care, named TeleClinical Care - Cardiac (TCC-Cardiac), commenced in February 2019, targeted at patients being discharged after care for an acute coronary syndrome or episode of decompensated heart failure. The app was paired to a digital sphygmomanometer, weighing scale and a wearable fitness band, all loaned to the patient, and allowed clinicians to respond to abnormal readings. Read More

View Article and Full-Text PDF

Role of Participatory Health Informatics in Detecting and Managing Pandemics: Literature Review.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Institute for Medical Informatics, Bern University of Applied Sciences, Bern, Switzerland.

Objectives: Using participatory health informatics (PHI) to detect disease outbreaks or learn about pandemics has gained interest in recent years. However, the role of PHI in understanding and managing pandemics, citizens' role in this context, and which methods are relevant for collecting and processing data are still unclear, as is which types of data are relevant. This paper aims to clarify these issues and explore the role of PHI in managing and detecting pandemics. Read More

View Article and Full-Text PDF

Enhancing Safety During a Pandemic Using Virtual Care Remote Monitoring Technologies and UML Modeling.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Division of Clinical Informatics, Harvard School of Medicine, Harvard University, United States of America.

Objectives: This paper describes a methodology for gathering requirements and early design of remote monitoring technology (RMT) for enhancing patient safety during pandemics using virtual care technologies. As pandemics such as COrona VIrus Disease (COVID-19) progress there is an increasing need for effective virtual care and RMT to support patient care while they are at home.

Methods: The authors describe their work in conducting literature reviews by searching PubMed. Read More

View Article and Full-Text PDF

Telehealth and the COVID-19 Pandemic: International Perspectives and a Health Systems Framework for Telehealth Implementation to Support Critical Response.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Sri Sathya Sai Central Trust, Puttaparthi, India.

Objectives: Telehealth implementation is a complex systems-based endeavour. This paper compares telehealth responses to (COrona VIrus Disease 2019) COVID-19 across ten countries to identify lessons learned about the complexity of telehealth during critical response such as in response to a global pandemic. Our overall objective is to develop a health systems-based framework for telehealth implementation to support critical response. Read More

View Article and Full-Text PDF

Investigating the Scientific 'Infodemic' Phenomenon Related to the COVID-19 Pandemic.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Department of Medical Informatics, Amsterdam University Medical Center - University of Amsterdam, Amsterdam Public Health research institute, Amsterdam, The Netherlands.

Objectives: The study aims at understanding the structural characteristics and content features of COVID-19 literature and public health data from the perspective of the 'Language and Meaning in Biomedicine' Working Group (LaMB WG) of IMIA. The LaMB WG has interest in conceptual characteristics, transparency, comparability, and reusability of medical information, both in science and practice.

Methods: A set of methods were used (i) investigating the overall speed and dynamics of COVID-19 publications; (ii) characterizing the concepts of COVID-19 (text mining, visualizing a semantic map of related concepts); (iii) assessing (re)usability and combinability of data sets and paper collections (as textual data sets), and checking if information is Findable, Accessible, Interoperable, and Reusable (FAIR). Read More

View Article and Full-Text PDF

Digital Health during COVID-19: Informatics Dialogue with the World Health Organization.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

eHealth Development Association, Amman, Jordan.

Background: On December 16, 2020 representatives of the International Medical Informatics Association (IMIA), a Non-Governmental Organization in official relations with the World Health Organization (WHO), along with its International Academy for Health Sciences Informatics (IAHSI), held an open dialogue with WHO Director General (WHO DG) Tedros Adhanom Ghebreyesus about the opportunities and challenges of digital health during the COVID-19 global pandemic.

Objectives: The aim of this paper is to report the outcomes of the dialogue and discussions with more than 200 participants representing different civil society organizations (CSOs).

Methods: The dialogue was held in form of a webinar. Read More

View Article and Full-Text PDF

Drawing Reproducible Conclusions from Observational Clinical Data with OHDSI.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Observational Health Data Sciences and Informatics, New York, New York, USA.

Objective: The current observational research literature shows extensive publication bias and contradiction. The Observational Health Data Sciences and Informatics (OHDSI) initiative seeks to improve research reproducibility through open science.

Methods: OHDSI has created an international federated data source of electronic health records and administrative claims that covers nearly 10% of the world's population. Read More

View Article and Full-Text PDF

Managing Pandemics with Health Informatics: Successes and Challenges.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Clinical Informatics Center, UT Southwestern, Medical Center, Dallas, TX, USA.

Introduction: The novel COVID-19 pandemic struck the world unprepared. This keynote outlines challenges and successes using data to inform providers, government officials, hospitals, and patients in a pandemic.

Methods: The authors outline the data required to manage a novel pandemic including their potential uses by governments, public health organizations, and individuals. Read More

View Article and Full-Text PDF

Pandemics: Historically Slow "Learning Curve" Leading to Biomedical Informatics and Vaccine Breakthroughs.

Yearb Med Inform 2021 Apr 21. Epub 2021 Apr 21.

Department of Computer Science, Rutgers University, USA.

Background: The worldwide tragedy of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic vividly demonstrates just how inadequate mitigation and control of the spread of infectious diseases can be when faced with a new microorganism with unknown pathogenic effects. Responses by governments in charge of public health, and all other involved organizations, have proved largely wanting. Data infrastructure and the information and communication systems needed to deal with the pandemic have likewise not been up to the task. Read More

View Article and Full-Text PDF

Multidisciplinary Sprint Program Achieved Specialty-Specific EHR Optimization in 20 Clinics.

Appl Clin Inform 2021 Mar 21;12(2):329-339. Epub 2021 Apr 21.

University of Colorado Health Medical Group and University of Colorado Health, Aurora, Colorado, United States.

Objective:  The objective of the study was to highlight and analyze the outcomes of software configuration requests received from Sprint, a comprehensive, clinic-centered electronic health record (EHR) optimization program.

Methods:  A retrospective review of 1,254 Sprint workbook requests identified (1) the responsible EHR team, (2) the clinical efficiency gained from the request, and (3) the EHR intervention conducted.

Results:  Requests were received from 407 clinicians and 538 staff over 31 weeks of Sprint. Read More

View Article and Full-Text PDF

Data Quality of Chemotherapy-Induced Nausea and Vomiting Documentation.

Appl Clin Inform 2021 Mar 21;12(2):320-328. Epub 2021 Apr 21.

School of Nursing, Columbia University, New York, New York, United States.

Objective:  The objective of the study was to characterize the completeness and concordance of the electronic health record (EHR) documentation of cancer symptoms among multidisciplinary health care professionals.

Methods:  We examined the EHRs of children, adolescents, and young adults who received highly emetogenic chemotherapy and characterized the completeness and concordance of chemotherapy-induced nausea and vomiting (CINV) documentation by clinician type and by the International Classification of Diseases 10th Revision (ICD-10) coding choice.

Results:  The EHRs of 127 patients, comprising 870 patient notes, were abstracted and reviewed. Read More

View Article and Full-Text PDF

[Preventive Check-ups and Routine Vaccinations in Pre-school Children - An Analysis of Mutual Participation Behaviour, Taking into Account Living Conditions].

Heribert Stich

Gesundheitswesen 2021 Apr 21. Epub 2021 Apr 21.

Landratsamt Landshut, Abteilung 7 Gesundheitsamt.

Aim Of The Study: Preventive screenings and vaccinations are essential health protecting measures in childhood, but no quantitative data on mutual distribution patterns of acceptance are available. The aim of the study was the quantification of distribution patterns and the identification of associations between preventive check-ups and defined routine vaccinations for children starting school, taking into account the social environment.

Methods: The 2015 school entrance health checks included documented preventive screenings and routine vaccinations on a city-wide basis. Read More

View Article and Full-Text PDF

[The Impact of Parenthood, Support, and Short-Term Contracts on Work-Family Conflict of Female and Male Residents' Career].

Gesundheitswesen 2021 Apr 21. Epub 2021 Apr 21.

Institut für Biochemie und Molekulare Zellbiologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.

Background: Work factors and work-family interference play an important role in physicians leaving clinical practice.

Objectives: The purpose of this study was to examine residents' work-family conflict and family-work conflict in association with parental status, perceived support, and short-term contracts.

Material And Methods: Data acquisition was carried out within the multi-centric and prospective "KarMed" study in Germany at the end of the postgraduate training in 2016 (N=433). Read More

View Article and Full-Text PDF

The Influence of Using Different Types of Scan Bodies on the Transfer Accuracy of Implant Position: An In Vitro Study.

Int J Prosthodont 2021 Mar-Apr;34(2):254-260

Purpose: To assess the absolute linear distances of three different intraoral scan bodies (ISBs) using an intraoral scanner compared to a conventional impression in a common clinical model setup with a gap and a free-end situation in the maxilla.

Materials And Methods: An implant master model with a reference cube was digitized using x-ray computed tomography and served as the reference file. Digital impressions (TRIOS, 3Shape) were taken using three different ISB manufacturers: NT Trading, Kulzer, and Medentika (n = 10 per group). Read More

View Article and Full-Text PDF

Esthetic Outcomes of Implant-Supported Single Crowns Related to Abutment Type and Material: A Systematic Review.

Int J Prosthodont 2021 Mar-Apr;34(2):229-249

Purpose: To systematically review the influence of abutment material and configuration on the soft tissue esthetic outcomes of implant-supported single crowns (iSCs) after 3 years.

Materials And Methods: An electronic search on MEDLINE (PubMed) from January 2000 to July 2019 was conducted for clinical trials with no language restrictions. The focus question was: In partially edentulous patients with iSCs, does the abutment material (metal vs ceramic) or the configuration (standardized vs customized) have an effect on the soft tissue esthetic outcomes? Randomized controlled trials, controlled clinical trials, and prospective or retrospective case series with at least 10 patients and a minimum of 3 years of follow-up were included. Read More

View Article and Full-Text PDF

Effect of Different Light-Curing Modes on Bond Strength of Ceramic Laminate Veneers.

Int J Prosthodont 2021 Mar-Apr;34(2):221-228

Purpose: To investigate whether high-level irradiance and short light exposure times with light-emitting diode (LED) curing units could provide bond strength comparable to halogen lights for ceramic laminate veneers (CLVs).

Materials And Methods: A total of 160 extracted human maxillary central incisors were prepared to receive CLVs (lithium disilicate) in shades A1 and A3.5. Read More

View Article and Full-Text PDF

Comparison Between Accuracy of Posts Fabricated Using a Digital CAD/CAM Technique and a Conventional Direct Technique.

Int J Prosthodont 2021 Mar-Apr;34(2):212-220

Purpose: To compare the accuracy of posts fabricated using a conventional direct technique with casting to the accuracy of posts fabricated using a fully digital protocol with CAD/CAM technology and selective laser melting.

Materials And Methods: Ten extracted permanent maxillary incisors were endodontically treated and prepared for a post. For each tooth, two metal posts were fabricated, one by casting (Group C) and one by a fully digital protocol (Group D). Read More

View Article and Full-Text PDF

Color Stability and Mechanical Properties of Two Commonly Used Silicone Elastomers with e-Skin and Reality Coloring Systems.

Int J Prosthodont 2021 Mar-Apr;34(2):204-211

Purpose: To evaluate the color stability and mechanical properties of two commonly used maxillofacial silicone elastomers after addition of pigments and opacifiers and before and after artificial aging.

Materials And Methods: This study evaluated two maxillofacial silicone elastomers: A-2000 and M511. Two different pigment and opacifier systems (e-Skin and Reality Series) were used with the elastomers. Read More

View Article and Full-Text PDF

Medium- and Long-Term Survival Rates of Implant-Supported Single and Partial Restorations at a Maximum Follow-up of 12 Years: A Retrospective Study.

Int J Prosthodont 2021 Mar-Apr;34(2):183-191

Purpose: To present medium- and long-term biologic outcomes of implant-supported single-tooth restorations and fixed partial dentures and to analyze their correlations with prosthesis and patient characteristics.

Materials And Methods: The records of patients treated with implant-supported fixed restorations between 2004 and 2019 reporting the presence or absence of peri-implantitis and/or implant failure were analyzed. The cumulative survival rate (%) over time was calculated, as well as the cumulative prevalence of units free of peri-implantitis. Read More

View Article and Full-Text PDF

Effects of Different Therapeutic Modalities on the Clicking Sound and Quantitative Assessment of the Vertical and Lateral Mandibular Movements of Patients with Internal Derangements of the Temporomandibular Joint.

Int J Prosthodont 2021 Mar-Apr;34(2):173-182

Purpose: To compare the efficacy of low-dose laser therapy to that of conservative treatment using two different occlusal splints (stabilization and anterior repositioning splints) in patients with internal derangements of the temporomandibular joint (TMJ).

Materials And Methods: The study population consisted of patients with disc displacement with reduction diagnosed according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) Axis I and Axis II. In addition, disc displacement with reduction was confirmed in all patients using TMJ ultrasonography. Read More

View Article and Full-Text PDF

Translucent Zirconium Dioxide and Lithium Disilicate: A 3-Year Follow-up of a Prospective, Practice-Based Randomized Controlled Trial on Posterior Monolithic Crowns.

Int J Prosthodont 2021 Mar-Apr;34(2):163-172

Purpose: To systematically evaluate and compare the clinical performance of lithium disilicate (LDS)- and zirconium dioxide (ZrO)-based ceramic monolithic crowns in the posterior dentition.

Materials And Methods: Treatment was administered by two experienced general dental practitioners in two public dental health care clinics. Forty-four patients received 60 crowns randomized to be either LDS or ZrO and cemented with resin cement. Read More

View Article and Full-Text PDF