765,472 results match your criteria agents patients


[Bowel resections for Crohn's disease: developments over the last three decades].

Z Gastroenterol 2021 Jun 23. Epub 2021 Jun 23.

Department of Surgery, Universitätsklinikum Regensburg, Regensburg, Germany.

Background: The present observational study demonstrates developments of surgery in Crohn's disease patients undergoing bowel resection at two tertiary referral centers during the recent 3 decades.

Methods: Consecutive patients undergoing intestinal resections were included. Exclusion criteria were: resection for malignancy, mere stoma formation and closure, bowel resections for other reasons than Crohn's disease, abdomino-perineal resections for anal fistula. Read More

View Article and Full-Text PDF

Are other tick-borne infections overlooked in patients investigated for Lyme neuroborreliosis? A large retrospective study from South-eastern Sweden.

Ticks Tick Borne Dis 2021 Jun 4;12(5):101759. Epub 2021 Jun 4.

Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linköping University, Linköping, Sweden; Department of Infectious Diseases, Region Östergötland County, Linköping/Norrköping, Sweden.

In Europe, the hard tick Ixodes ricinus is considered the most important vector of human zoonotic diseases. Human pathogenic agents spread by I. ricinus in Sweden include Borrelia burgdorferi sensu lato (s. Read More

View Article and Full-Text PDF

Prevalence of and risk factors for extended-spectrum beta-lactamase genes carriership in a population-based cohort of middle-aged and elderly.

Int J Antimicrob Agents 2021 Jun 20:106388. Epub 2021 Jun 20.

Department of Epidemiology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus MC University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands; Inspectorate of Health Care, PO Box 2518, 6401 DA Heerlen, The Netherlands. Electronic address:

Introduction: The increasing worldwide resistance to beta-lactam antibiotics is an alarming development. We studied fecal carriership of TEM, SHV, CTX-M and CMY in a community-dwelling population of middle-aged and elderly individuals.

Patients And Methods: Feces was obtained from individuals of the Rotterdam Study. Read More

View Article and Full-Text PDF

Audit of empirical antibiotic therapy for sepsis and the impact of early multidisciplinary consultation on patient outcomes.

Int J Antimicrob Agents 2021 Jun 20:106379. Epub 2021 Jun 20.

Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

Objectives: To perform an audit of empirical antibiotic therapy (EAT) of sepsis at the emergency department and to analyse the impact of an antimicrobial stewardship (AMS) programme on process and patient outcomes.

Patients And Methods: A prospective single centre cohort study including patients with SOFA score ≥2 from whom blood cultures were taken, was conducted between February 2019 and April 2020. EAT assessment was done using eight applicable quality indicators for responsible antibiotic use in inpatients (IQIs). Read More

View Article and Full-Text PDF

Luspatercept as a therapy for myelodysplastic syndromes with ring sideroblasts.

Expert Rev Hematol 2021 Jun 23. Epub 2021 Jun 23.

Department of Hematology, Oncology and Clinical Immunology, University Hospital Düsseldorf, Düsseldorf, Germany.

Introduction: Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic stem cell diseases characterized by cell dysplasia, ineffective hematopoiesis and risk of transformation to acute myeloid leukemia (AML). The median age of 75 years at diagnosis is associated with the presence of comorbidities, which preclude intensive therapies like allogeneic hematopoietic stem cell transplantation in most MDS patients. Risk stratification using the (Revised) International Prognostic Scoring System (IPSS/IPSS-R) is necessary to plan individualized treatment. Read More

View Article and Full-Text PDF

Only SF3B1 mutation involving K700E independently predicts overall survival in myelodysplastic syndromes.

Cancer 2021 Jun 23. Epub 2021 Jun 23.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: SF3B1 mutations (SF3B1 ) in myelodysplastic syndromes (MDS) frequently involve codon K700E and have a favorable prognosis. The prognostic effect of non-K700E SF3B1 is uncertain.

Methods: The authors analyzed the clinicopathological features and outcomes of a single-institution series of 94 treatment-naive SF3B1 MDS patients (18%) and 415 treatment-naive SF3B1 MDS patients and explored the differences between K700E and non-K700E SF3B1 MDS. Read More

View Article and Full-Text PDF

Effect of medication withdrawal on pain in Parkinson's disease patients - an observational study based on a sample of patients without antiparkinsonian medications.

Rev Assoc Med Bras (1992) 2021 Jan;67(1):125-130

Instituto de Assistência Médica do Servidor Público Estadual, Programa de Pós-Graduação em Ciências da Saúde - São Paulo (SP), Brasil.

Objectives: To assess the effect of withdrawal of the antiparkinsonian drug regimen administration on patients with PD and its relation to pain.

Methods: The sample included 22 men and 12 women who were candidates for neurosurgery to control motor signs and symptoms treated with L-dopa as a drug, alone or in combination with others (Cholinergic Antagonists; Dopamine Agents). All of them were examined at two different moments, with and without medication, and analyzed for painful symptoms. Read More

View Article and Full-Text PDF
January 2021

Episode of Hepatitis C viral infection in the people of Swat, Pakistan.

Braz J Biol 2021 21;82:e243283. Epub 2021 Jun 21.

Center for Animal Sciences & Fisheries, University of Swat, Swat, Pakistan.

Infectious agents cause serious diseases in humans worldwide and are responsible for the high rate of morbidity and mortality. The prevalence and epidemiology of infectious disease (HCV) in the hospital visited patients referred by the physicians through the initial findings and their associated risk factors were studied in Swat. The data of 174 infected patients were collected during the period of 2015 to 2017 from two clinical laboratories of Tehsil Matta Swat. Read More

View Article and Full-Text PDF

Hyperbaric hyperoxemia as a risk factor for ventilator-acquired pneumonia?

PLoS One 2021 23;16(6):e0253198. Epub 2021 Jun 23.

Intensive Care Unit and Hyperbaric Center, Lille University Hospital, Lille, France.

Objectives: Ventilator-acquired pneumonia (VAP) is the leading cause of serious associated infections in Intensive Care Units (ICU) and is associated with significant morbidity. The use of hyperbaric oxygen therapy (HBOT) in patients on mechanical ventilation may increase exposure to certain risk factors such as hyperoxemia and the need for multiple transfers. The aim of our study was to assess the relationship between HBOT and VAP. Read More

View Article and Full-Text PDF

Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.

PLoS Negl Trop Dis 2021 Jun 23;15(6):e0009554. Epub 2021 Jun 23.

Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.

Schistosomiasis is second only to malaria as the most devastating parasitic disease in the world. It is caused by the helminths Schistosoma mansoni (S. mansoni), S. Read More

View Article and Full-Text PDF

CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents.

PLoS One 2021 23;16(6):e0251079. Epub 2021 Jun 23.

Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Platinum sensitivity is an important prognostic factor in patients with ovarian cancer. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a core member of the nucleosome remodeling and deacetylase complex, which functions as a chromatin remodeler. Emerging evidence indicates that CHD4 could be a potential therapeutic target for cancer therapy. Read More

View Article and Full-Text PDF

Evolution of the Antimicrobial resistance of Bacteria causing Urinary Tract Infections.

Comb Chem High Throughput Screen 2021 Jun 22. Epub 2021 Jun 22.

Basic Science Department, College of Medicine, Hawler Medical University, Erbil, Kurdistan Region. Iraq.

Background: The bacteria, Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae), are the main reasons for urinary tract infections (UTIs). Read More

View Article and Full-Text PDF

[Targeted therapies and high blood pressure].

Rev Prat 2021 Feb;71(2):212-215

"Service de cardiologie, hôpital Saint-Antoine, AP-HP, Sorbonne-Université, unité de cardio-oncologie et groupe de recherche clinique en cardio-oncologie, Sorbonne-Université, Paris, France".

"Targeted therapies and hypertension The recent advent of molecular targeted agents represents an important improvement in the management of cancer patients. The administration of therapies targeting the vascular endothelial growth factor or its receptor could be associated with side effects including cardiovascular complications (hypertension, heart Failure, QT interval prolongation). Hypertension due to molecular targeted agents is considered as a class effect, which can affect nearly 90% of treated patients; its management is most often based on the introduction of anti-hypertensive treatment and more rarely on dose drug reduction. Read More

View Article and Full-Text PDF
February 2021

[Renal failure and renal symptoms associated with molecular targeted therapies in oncology].

Rev Prat 2021 Feb;71(2):198-205

"Université Paris Est-Créteil, Inserm, Institut Mondor de recherche biomédicale, Créteil, France".

"Targeted therapies and pathophysiological mechanisms of proteinuria Targeted therapy represents a promising therapeutic approach for patients with diverse cancers and has enabled significant development in medical oncology. This new class of anticancer drugs includes antibodies, fusion-proteins and receptor tyrosine kinase inhibitors among others. Depending on their molecular targeting, side effects can affect multiple organs, especially the kidney. Read More

View Article and Full-Text PDF
February 2021

[Epidemiology and risk factors for kidney damage during chemotherapy].

Rev Prat 2021 Feb;71(2):190-192

"Département de néphrologie, APHP Sorbonne Université, groupe hospitalier La Pitié-Salpêtrière- Charles-Foix, Paris, France".

Epidemiology and risk factors for kidney damage during chemotherapy Cancer and kindey are closely related with 12 to 25% of cancer patients exhibiting chronic kidney disease. During cancer treatment, almost one third of the patients, whatever their baseline glomerular filtration rate will experience acute renal failure. Therefore, it is critical to precisely estimate renal functions, adapt drug dosage to glomerular filtration rate, and prevent chemotherapy induced renal toxicity. Read More

View Article and Full-Text PDF
February 2021

Thrombopoietin Receptor Agonists (TPO-RAs): Drug Class Considerations for Pharmacists.

Drugs 2021 Jun 23. Epub 2021 Jun 23.

Division of Hematology and Medical Oncology, and Oncology Clinical Pharmacist, OHSU Hospital and Clinics, Portland, OR, USA.

The thrombopoietin receptor agonists (TPO-RAs) romiplostim, eltrombopag, avatrombopag, and lusutrombopag carry unique US Food and Drug Administration (US FDA)- and European Medicines Agency (EMA)-approved indications and may be used to increase platelet counts in a variety of conditions. Current indications for available TPO-RAs include treatment of chronic immune thrombocytopenia (ITP) in cases of insufficient response to prior treatment (avatrombopag, eltrombopag, romiplostim), management of thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo a procedure (avatrombopag, lusutrombopag), management of severe aplastic anemia (eltrombopag), and management of thrombocytopenia associated with interferon-based therapy for hepatitis C (eltrombopag). Across current indications, pharmacists can assist in stabilizing platelet counts and help to reduce large undulations commonly seen when starting, stopping, or transitioning between these agents. Read More

View Article and Full-Text PDF

Management of tandem occlusions in patients who receive rtPA.

J Thromb Thrombolysis 2021 Jun 23. Epub 2021 Jun 23.

Department of Neurological Surgery, The Ohio State University Wexner Medical Center, 410 W 10th Ave, Columbus, OH, 43210, USA.

Background: Tandem occlusions exist in 17-32% of large vessel occlusion (LVO) strokes. A significant concern is bleeding when carotid stenting is performed in tandem with thrombectomy due the administration of antiplatelet agents such as glycoprotein IIb/IIIa inhibitors (GP2b3aI) after receiving rtPA, but data are limited in this setting.

Methods: A mutlicenter, retrospective chart review was conducted at two comprehensive stroke centers to assess the safety and efficacy of using GP2b3aI to facilitate carotid stent placement simultaneously with endovascular thrombectomy in patients who have received rtPA. Read More

View Article and Full-Text PDF

Favorable response to second-line atezolizumab and bevacizumab following progression on nivolumab in advanced hepatocellular carcinoma: A case report demonstrating that anti-VEGF therapy overcomes resistance to checkpoint inhibition.

Medicine (Baltimore) 2021 Jun;100(25):e26471

Division of Hematology and Medical Oncology.

Rationale: Advanced hepatocellular carcinoma (HCC) remains a deadly disease in part due to decades of limited therapeutic options. With recent advances in our understanding of the tumor biology, several promising treatment strategies involving targeted and immunotherapies have emerged. However, enhancing their modest efficacy in HCC and other gastrointestinal malignancies is essential to improving survival. Read More

View Article and Full-Text PDF

The Impact of Cefazolin Shortage on Surgical Site Infection Following Spine Surgery in Japan.

Spine (Phila Pa 1976) 2021 Jul;46(14):923-930

Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo Hospital, Tokyo, Japan.

Study Design: Retrospective study using prospectively collected data.

Objective: This study aimed to investigate the effect of alternative antimicrobial prophylaxis agents on surgical site infections (SSIs) after spine surgery.

Summary Of Background Data: Although the use of alternative antimicrobial prophylaxis agents might have a negative effect on SSI prevention, their association with SSI risk in spine surgery remains unclear. Read More

View Article and Full-Text PDF

Therapy in elderly IBD patients.

Minerva Gastroenterol (Torino) 2021 Jun 23. Epub 2021 Jun 23.

Department of Surgery, Oncology, and Gastroenterology, Azienda ospedale - Università di Padova, Padua, Italy -

Introduction: Appropriate treatment is critical in elderly inflammatory bowel disease (IBD) subjects since they are at higher risk of complications such as infections, malignancies and mortality.

Evidence Acquisition: We conducted an extensive PUBMED search for guidelines, systematic reviews and primary studies to perform a critical analysis of the existing literature on the efficacy and safety of conventional and biological therapies for elderly IBD patients.

Evidence Synthesis: Due to the exclusion of elderly population from clinical trials, most evidences comes from real-life studies. Read More

View Article and Full-Text PDF

Etiological prevalence and antifungal sensitivity patterns of dermatophytosis in India - A multicentric study.

Indian J Dermatol Venereol Leprol 2021 Jun 7:1-7. Epub 2021 Jun 7.

Calcutta Skin Institute, 169, Scheme 6 M, C I T Road, Kankurgachi, Kolkata, West Bengal, India.

Background: The prevalence of dermatophytes varies with season, geographical area, socio-economic factors and effective management strategies.

Aims: The aim of the study was to assess the prevalence of pathogenic dermatophytes, clinical types of dermatophyte fungal infection, and in vitro antifungal drug susceptibility testing against dermatophytes.

Methods: Three hundred and ninety five patients with dermatophytosis were enrolled from five cities (Mumbai, Delhi, Lucknow, Kolkata and Hyderabad) across India. Read More

View Article and Full-Text PDF

BACTERIAL INFECTION CAUSES OF PREGNANCY LOSS AND PREMATURE BIRTH IN THE WOMEN IN UKRAINE.

Wiad Lek 2021 ;74(6):1355-1359

SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE.

Objective: The aim: To find out whether or not the presence of pregnancy loss and preterm birth was associated with the history of healthcare-associated infection (HAI) of women reproductive tract.

Patients And Methods: Materials and methods: We performed a retrospective cohort study was based on surveillance data. This study included 1,027 fertile women aged 21-50 years admitted to 8 hospitals from 2017-2019 with complaints to pregnancy loss or preterm birth. Read More

View Article and Full-Text PDF

A Phase II Study of the Efficacy and Safety of Chloroquine in Combination With Taxanes in the Treatment of Patients With Advanced or Metastatic Anthracycline-refractory Breast Cancer.

Clin Breast Cancer 2021 Jun 5;21(3):199-204. Epub 2020 Oct 5.

Houston Methodist Cancer Center, Houston, TX; Houston Methodist Research Institute, Houston, TX. Electronic address:

Introduction: Chemotherapy eliminates most of the cancer cells except those with potential for self-renewal and tumor initiation, called cancer stem cells (CSCs). Chloroquine, through bioinformatics, was found to be a potential agent to target CSCs. We designed a phase II trial to test the efficacy and safety of chloroquine in combination with taxane or taxane-like chemotherapy agents in patients with advanced or metastatic breast cancer who are refractory to anthracycline-based chemotherapy. Read More

View Article and Full-Text PDF

Effect of Low Dose Haloperidol and Quetiapine on QTc Interval in Hospitalized Elderly Patients With Delirium.

J Pharm Pract 2021 Jun 23:8971900211025148. Epub 2021 Jun 23.

Department of Clinical Health Professions, 4131St. John's University, Queens, NY, USA.

View Article and Full-Text PDF

Establishment of an immune-related gene prognostic model for head and neck tumors.

J Biol Regul Homeost Agents 2021 Jun 23;35(3). Epub 2021 Jun 23.

Department of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

This study aimed to screen the key immune-related genes (IRGs) in head and neck squamous cell carcinoma (HNSC) and construct the IRGs-related prognostic model to predict the overall survival (OS) of patients with HNSC. The RNA-seq data and clinical data were downloaded from The Cancer Genome Atlas database, and IRGs were obtained from the Immunology Database and Analysis Portal. Differentially expressed genes (DEGs) between HNSC and normal samples were identified, followed by integration with IRGs to screen differentially expressed IRGs. Read More

View Article and Full-Text PDF

microRNA-29b mediates Th17/Treg imbalance in chronic obstructive pulmonary disease by targeting IL-22.

J Biol Regul Homeost Agents 2021 Jun 23;35(3). Epub 2021 Jun 23.

Department of Respiratory Medicine, Hangzhou Third Hospital, Hangzhou, Zhejiang, P.R. China.

Chronic obstructive pulmonary disease (COPD) represents a chronic inflammatory disorder of the airways induced mainly by cigarette smoking. In the current study, cigarette smoke extract (CSE) was used to develop an in vitro COPD model using human bronchial epithelium (HBE) cells to expound the possible role of microRNA-29b (miR-29b) in COPD. Firstly, miR-29b and interleukin (IL)-22 expression was assessed in serum of 20 healthy non-smokers, 20 healthy smokers and 20 COPD patients as well as CSE-treated HBE cells. Read More

View Article and Full-Text PDF

Effect of Interleukin-17 gene on glomerular ultrastructure and podocyte injury in adriamycin nephropathy rat models.

J Biol Regul Homeost Agents 2021 Jun 23;35(3). Epub 2021 Jun 23.

Kidney Disease and Dialysis Center, Shaanxi Provincial People's Hospital, Xian, Shaanxi, China.

The aim of this study was to investigate the mechanism of interleukin-17 (IL-17) gene in renal tissues of rats suffering from adriamycin (ADM) nephropathy and its effect on the expression level of characteristic proteins, such as Podocalyxin and Nephrin, in podocytes. Sprague-Dawley (SD) rats were randomly divided into a control group (treated with normal saline) and an ADM group (treated with adriamycin). ADM model rats were transfected with lentivirus and divided into a transfection group (transfected with recombinant plasmid IL-17-shRNA) and a negative control group (transfected with plasmid shNC). Read More

View Article and Full-Text PDF

Engineered cyclotides with potent broad in vitro and in vivo antimicrobial activity.

Chemistry 2021 Jun 22. Epub 2021 Jun 22.

University of Southern California, School of Pharmacy, UNITED STATES.

The search for novel antimicrobial agents to combat microbial pathogens is intensifying in response to bioterrorism and rapid drug resistance development to current antibiotic therapeutics. Respiratory failure and septicemia are the leading causes of mortality among hospitalized patients. Here, we report the development of a novel engineered cyclotide with effective broad-spectrum antibacterial activity against several ESKAPE bacterial strains and clinical isolates. Read More

View Article and Full-Text PDF

Lower incidence of COVID-19 in patients with inflammatory bowel disease treated with non-gut selective biologic therapy.

J Gastroenterol Hepatol 2021 Jun 23. Epub 2021 Jun 23.

Gastroenterology Unit, ASST Fatebenefratelli-Sacco, L. Sacco University Hospital, Department of Biochemical and Clinical Sciences, University of Milan, Milan, Italy.

Background And Aim: Since the outbreak of COVID-19, concerns have been raised as to whether IBD patients under biologic therapy may be more susceptible to the disease. This study aimed to determine the incidence and outcomes of COVID-19 in a large cohort of IBD patients on biologic therapy.

Methods: This observational retrospective multicenter study collected data about COVID-19 in IBD patients on biologic therapy in Italy, between February and May 2020. Read More

View Article and Full-Text PDF

Preventing Infectious Complications of Immunomodulation in COVID-19 in Foreign-Born Patients.

J Immigr Minor Health 2021 Jun 22. Epub 2021 Jun 22.

Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.

Immunomodulating therapies for COVID-19 may carry risks of reactivating latent infections in foreign-born people. We conducted a rapid review of infection-related complications of immunomodulatory therapies for COVID-19. We convened a committee of specialists to formulate a screening and management strategy for latent infections in our setting. Read More

View Article and Full-Text PDF