J Inorg Biochem 2021 Apr 22;220:111467. Epub 2021 Apr 22.
Department of Chemistry "Ugo Schiff", University of Florence, via della Lastruccia 3, 50019 Sesto Fiorentino, Italy.
The antimicrobial potential of two ruthenium(II) polypyridyl complexes, [Ru(phen)L1] and [Ru(phen)L2] (phen = 1,10-phenanthroline) containing the 4,4'-(2,5,8,11,14-pentaaza)-2,2'-bipyridilophane (L1) and the 4,4'-bis-[methylen-(1,4,7,10-tetraazacyclododecane)]-2,2' bipyridine (L2) units, is herein investigated. These peculiar polyamine frameworks afford the formation of highly charged species in solution, influence the DNA-binding and cleavage properties of compounds, but they do not undermine their singlet oxygen sensitizing capacities, thus making these complexes attractive O generators in aqueous solution. L1 and L2 also permit to stably host Fenton -active Cu ion/s, leading to the formation of mixed Ru/Cu forms capable to further strengthen the oxidative damages to biological targets. Read More