2,997 results match your criteria ageing protects

Antidiabetic E4orf1 protein prevents hepatic steatosis and reduces markers of aging-related cellular damage in high fat fed older mice.

BMJ Open Diabetes Res Care 2021 May;9(1)

Department of Nutritional Sciences, Texas Tech University, Lubbock, Texas, USA

Introduction: Older age is associated with greater prevalence of hyperinsulinemia, type 2 diabetes, and fatty liver disease. These metabolic conditions and aging are bidirectionally linked to mitochondrial dysfunction and telomere attrition. Although effectively addressing these conditions is important for influencing the health and the lifespan, it is particularly challenging in older age. Read More

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The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy.

Aging (Albany NY) 2021 May 2;13. Epub 2021 May 2.

Department of Surgery, Basic Science Division, The Pritzker School of Medicine, University of Chicago, IL 60637, Chicago.

Sirtuins have been shown to regulate the aging process. We have previously demonstrated that Sirt6 blocks the pressure overload-induced cardiac hypertrophy in mice. Here, we show that Sirt6 can also mitigate aging-induced cardiomyocyte senescence and cardiac hypertrophy. Read More

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PINK1/Parkin-mediated mitophagy inhibits warangalone-induced mitochondrial apoptosis in breast cancer cells.

Aging (Albany NY) 2021 Apr 30;13. Epub 2021 Apr 30.

Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.

Breast cancer is the most common malignancy in women all around the world, especially in many countries in Asia. However, antitumor drugs with unique curative effects and low toxic side-effects have not been found yet. Warangalone is an isoflavone extracted from the fruit, and is reported to possess anti-inflammatory and anti-cancer activity. Read More

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Integrated Action of Autophagy and Adipose Tissue Triglyceride Lipase Ameliorates Diet-Induced Hepatic Steatosis in Liver-Specific PLIN2 Knockout Mice.

Cells 2021 Apr 25;10(5). Epub 2021 Apr 25.

Obesity and Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.

An imbalance in the storage and breakdown of hepatic lipid droplet (LD) triglyceride (TAG) leads to hepatic steatosis, a defining feature of non-alcoholic fatty liver disease (NAFLD). The two primary cellular pathways regulating hepatic TAG catabolism are lipolysis, initiated by adipose triglyceride lipase (ATGL), and lipophagy. Each of these processes requires access to the LD surface to initiate LD TAG catabolism. Read More

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Cisd2 Protects the Liver from Oxidative Stress and Ameliorates Western Diet-Induced Nonalcoholic Fatty Liver Disease.

Antioxidants (Basel) 2021 Apr 3;10(4). Epub 2021 Apr 3.

Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.

Nonalcoholic fatty liver disease (NAFLD) and its more severe form, nonalcoholic steatohepatitis (NASH), are the most common chronic liver diseases worldwide. However, drugs to treat NAFLD and NASH are an unmet clinical need. This study sought to provide evidence that Cisd2 is a molecular target for the development of treatments targeting NAFLD and NASH. Read More

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Shikimic acid protects skin cells from UV-induced senescence through activation of the NAD+-dependent deacetylase SIRT1.

Aging (Albany NY) 2021 04 26;13. Epub 2021 Apr 26.

Chromatin Biology Laboratory, Josep Carreras Leukaemia Research Institute (IJC), Ctra de Can Ruti, Camí de les Escoles s/n, Barcelona 08916, Badalona, Spain.

UV radiation is one of the main contributors to skin photoaging by promoting the accumulation of cellular senescence, which in turn induces a proinflammatory and tissue-degrading state that favors skin aging. The members of the sirtuin family of NAD-dependent enzymes play an anti-senescence role and their activation suggests a promising approach for preventing UV-induced senescence in the treatment of skin aging. A two-step screening designed to identify compounds able to protect cells from UV-induced senescence through sirtuin activation identified shikimic acid (SA), a metabolic intermediate in many organisms, as a bona-fide candidate. Read More

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Overexpression of microRNA-202-3p in bone marrow mesenchymal stem cells improves cerebral ischemia-reperfusion injury by promoting angiogenesis and inhibiting inflammation.

Aging (Albany NY) 2021 Apr 23;13. Epub 2021 Apr 23.

Department of Rehabilitation, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.

Background: Cerebral ischemia-reperfusion injury (CIRI) can cause brain tissue inflammation, neuronal degeneration, and apoptosis. There is increasing evidence that microRNAs (miRNA) exert neuroprotective effects by regulating the inflammatory process during cerebral ischemia-reperfusion injury. Additionally, it is increasingly acknowledged that neuroinflammation is regulated by Toll-like receptor 4 (TLR4). Read More

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Divergent Regulation of Alveolar Type 2 Cell and Fibroblast Apoptosis by Plasminogen Activator Inhibitor 1 in Lung Fibrosis.

Am J Pathol 2021 Apr 20. Epub 2021 Apr 20.

Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address:

Increased apoptosis sensitivity of alveolar type 2 (ATII) cells and increased apoptosis resistance of (myo)fibroblasts, the apoptosis paradox, is believed to contribute importantly to the pathogenesis of idiopathic pulmonary fibrosis (IPF). The mechanism underlying the apoptosis paradox in IPF lungs, however, is unclear. Aging is the greatest risk factor for IPF. Read More

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HOTAIR/miR-17-5p Axis is Involved in the Propofol-Mediated Cardioprotection Against Ischemia/Reperfusion Injury.

Clin Interv Aging 2021 15;16:621-632. Epub 2021 Apr 15.

Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, People's Republic of China.

Background: Propofol (PPF) ameliorates ischemia/reperfusion (I/R) injury in multiple organs by reducing apoptosis and release of pro-inflammatory cytokines. This study aims to explore the mechanism of PPF in attenuating myocardial ischemia-reperfusion injury (MIRI).

Materials And Methods: Rat MIRI model was established, and PPF pre-treatment was performed 10 min before I/R. Read More

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Coenzyme Q10 supplement rescues postovulatory oocyte aging by regulating SIRT4 expression.

Curr Mol Pharmacol 2021 Apr 19. Epub 2021 Apr 19.

College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China.

Background: High-quality of the oocyte is crucial for embryo development and the success of human assisted reproduction. The postovulatory aged oocytes lose the developmental competence with mitochondrial dysfunction and oxidative stress. Coenzyme Q10 (CoQ10) is widely distributed in the membranes of cells, and has an important role in the mitochondrial respiration chain, against oxidative stress and modulation of gene expression. Read More

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Mitochondrial quality control protects photoreceptors against oxidative stress in the HO-induced models of retinal degeneration diseases.

Cell Death Dis 2021 Apr 20;12(5):413. Epub 2021 Apr 20.

Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.

Retinal degeneration diseases (RDDs) are common and devastating eye diseases characterized by the degeneration of photoreceptors, which are highly associated with oxidative stress. Previous studies reported that mitochondrial dysfunction is associated with various neurodegenerative diseases. However, the role of mitochondrial proteostasis mainly regulated by mitophagy and mitochondrial unfolded protein response (mtUPR) in RDDs is unclear. Read More

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Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson's disease models.

Aging (Albany NY) 2021 Apr 20;13. Epub 2021 Apr 20.

Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Mounting evidence suggests that mitochondrial dysfunction and impaired mitophagy lead to Parkinson's disease (PD). Quercetin, one of the most abundant polyphenolic flavonoids, displays many health-promoting biological effects in many diseases. We explored the neuroprotective effect of quercetin in the 6-hydroxydopamine (6-OHDA)-lesioned rat model of PD and in 6-OHDA-treated PC12 cells. Read More

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Selenomethionine protects hematopoietic stem/progenitor cells against cobalt nanoparticles by stimulating antioxidant actions and DNA repair functions.

Aging (Albany NY) 2021 Apr 19;13. Epub 2021 Apr 19.

Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.

Hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) can differentiate into all blood lineages to maintain hematopoiesis, wound healing, and immune functions. Recently, cobalt-chromium alloy casting implants have been used extensively in total hip replacements; however, cobalt nanoparticles (CoNPs) released from the alloy were toxic to HSCs and HPCs. We aimed to investigate the mechanism underlying the toxic effect of CoNPs on HSCs/HPCs and to determine the protective effect of selenomethionine (SeMet) against CoNPs and . Read More

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Qigong exercise enhances cognitive functions in the elderly via an interleukin-6-hippocampus pathway: a randomized active-controlled trial.

Brain Behav Immun 2021 Apr 16. Epub 2021 Apr 16.

State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong; Laboratory of Neuropsychology and Human Neuroscience, The University of Hong Kong, Hong Kong; Institute of Clinical Neuropsychology, The University of Hong Kong, Hong Kong. Electronic address:

Background: Evidence has suggested that exercise protects against cognitive decline in aging, but the recent lockdown measures associated with the COVID-19 pandemic have limited the opportunity for outdoor exercise. Herein we tested the effects of an indoor exercise, Qigong, on neurocognitive functioning as well as its potential neuro-immune pathway.

Methods: We conducted a 12-week randomized active-controlled trial with two study arms in cognitively healthy older people. Read More

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MicroRNA-532-5p protects against cerebral ischemia-reperfusion injury by directly targeting CXCL1.

Aging (Albany NY) 2021 Apr 18;13. Epub 2021 Apr 18.

Department of Central Laboratory, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng 224001, Jiangsu, China.

We investigated the function of microRNA (miR)-532-5p in cerebral ischemia-reperfusion injury (CI/RI) and the underlying mechanisms using oxygen-glucose deprivation and reperfusion (OGD/R)-treated SH-SY5Y cells and middle cerebral artery occlusion (MCAO) model rats. MiR-532-5p levels were significantly downregulated in OGD/R-treated SH-SY5Y cells and the brain tissues of MCAO model rats. MiR-532-5p overexpression significantly reduced apoptosis, reactive oxygen species (ROS), and inflammation in the OGD/R-induced SH-SY5Y cells. Read More

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The role of the aqueous extract Polypodium leucotomos in photoprotection.

Photochem Photobiol Sci 2020 Jun 27;19(6):831-843. Epub 2020 Oct 27.

Medicine and Medical Specialties Department, Alcala University, Madrid, Spain.

Solar radiation in the ultraviolet (UV), visible (VIS), and infrared (IR) ranges produces different biological effects in humans. Most of these, particularly those derived from ultraviolet radiation (UVR) are harmful to the skin, and include cutaneous aging and increased risk of cutaneous diseases, particularly skin cancer. Pharmacological photoprotection is mostly topical, but it can also be systemic. Read More

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eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction.

Cell Rep 2021 Apr;35(2):108941

Institute for Biology/Genetics, Freie Universität Berlin, Berlin 14195, Germany; NeuroCure Cluster of Excellence, Charité Universitätmedizin Berlin, Berlin 10117, Germany. Electronic address:

Mitochondrial function declines during brain aging and is suspected to play a key role in age-induced cognitive decline and neurodegeneration. Supplementing levels of spermidine, a body-endogenous metabolite, has been shown to promote mitochondrial respiration and delay aspects of brain aging. Spermidine serves as the amino-butyl group donor for the synthesis of hypusine (N-[4-amino-2-hydroxybutyl]-lysine) at a specific lysine residue of the eukaryotic translation initiation factor 5A (eIF5A). Read More

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Triiodothyronine (T3) enhances lifespan and protects against oxidative stress via activation of Klotho in Caenorhabditis elegans.

Biogerontology 2021 Apr 13. Epub 2021 Apr 13.

Department of Biochemistry and Molecular Biology, Pondicherry University, Pondicherry, 605 014, India.

Age predisposes individuals to significant diseases, and the biological processes contributing to aging are currently under intense investigation. Klotho is an anti-aging protein with multifaceted roles and is an essential component of the endocrine fibroblast growth factor. In Caenorhabditis elegans (C. Read More

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Constitutive activation of ERK1/2 signaling protects against myocardial ischemia via inhibition of mitochondrial fragmentation in the aging heart.

Ann Transl Med 2021 Mar;9(6):479

Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Background: Studies have shown that the ability of the myocardium to tolerate ischemia becomes significantly compromised with age. During ischemia, several endogenous protective signals are activated to protect the heart from injury, among which extracellular-signal regulated kinase (ERK) 1/2 signaling has been established as playing a pivotal role. However, in aging hearts, the activation of ERK1/2 is compromised. Read More

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Inhibition of long non-coding RNA HOXA11-AS against neuroinflammation in Parkinson's disease model via targeting miR-124-3p mediated FSTL1/NF-κB axis.

Aging (Albany NY) 2021 Apr 4;13. Epub 2021 Apr 4.

Department of Neurology, Kaifeng Central Hospital, Kaifeng 475000, Henan, China.

Background: Studies have revealed that lncRNA HOXA11-AS contributes to regulating inflammation, while the role of HOXA11-AS in Parkinson's disease (PD) remains unclear.

Methods: Both and PD models were induced. Gain- or loss-assays of HOXA11-AS and miR-124-3p were conducted. Read More

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Targets identified from exercised heart: killing multiple birds with one stone.

NPJ Regen Med 2021 Apr 9;6(1):23. Epub 2021 Apr 9.

Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.

Cardiovascular diseases (CVDs) are a major cause of mortality worldwide, which are mainly driven by factors such as aging, sedentary lifestyle, and excess alcohol use. Exercise targets several molecules and protects hearts against many of these physiological and pathological stimuli. Accordingly, it is widely recognized as an effective therapeutic strategy for CVD. Read More

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"We Are Doing These Things So That People Will Not Laugh at Us": Caregivers' Attitudes About Dementia and Caregiving in Nigeria.

Qual Health Res 2021 Apr 9:10497323211004105. Epub 2021 Apr 9.

Manchester Metropolitan University, Manchester, United Kingdom.

Some Nigerians, in their effort to make sense of dementia symptoms, use descriptions that may stigmatize people with dementia and their families. This qualitative descriptive study focused on the everyday understanding of dementia and the impact of stigma on the caregiving experiences of informal female Nigerian dementia caregivers. Semi-structured interviews were conducted with a purposive sample of 12 adult informal female caregivers in Nigeria and analyzed for themes. Read More

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Periostin loss-of-function protects mice from post-traumatic and age-related osteoarthritis.

Arthritis Res Ther 2021 04 8;23(1):104. Epub 2021 Apr 8.

Department of Orthopaedic Surgery, Washington University School of Medicine at Barnes-Jewish Hospital MS 8233, 425 South Euclid Avenue, St. Louis, MO, 63110, USA.

Background: Elevated levels of periostin (Postn) in the cartilage and bone are associated with osteoarthritis (OA). However, it remains unknown whether Postn loss-of-function can delay or prevent the development of OA. In this study, we sought to better understand the role of Postn in OA development and assessed the functional impact of Postn deficiency on post-traumatic and age-related OA in mice. Read More

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Sedentary Behaviour among Urban Civil Servants in Eastern Part of Southern Nations, Nationalities and Peoples' Region, Ethiopia.

Biomed Res Int 2021 22;2021:8847107. Epub 2021 Mar 22.

Department of Sports Science, College of Natural and Computational Sciences, Dilla University, Ethiopia.

Background: Active lifestyle is a determining factor for functional and clinical health that protects and maintains both physical and mental health of an individual, whereas sedentary lifestyle is a contrary vital cause for higher premature mortality, heart disease, diabetics, and poorer quality of life. This study is aimed at determining the amount of time spent on sedentary activity and identifying sedentary behaviours frequently practiced by civil servants in Southern Ethiopia in 2015.

Methods: It was a cross-sectional study which employed both qualitative and quantitative approach. Read More

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Carminic acid supplementation protects against fructose-induced kidney injury mainly through suppressing inflammation and oxidative stress via improving Nrf-2 signaling.

Aging (Albany NY) 2021 Apr 4;13(7):10326-10353. Epub 2021 Apr 4.

Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, PR China.

Excessive fructose (Fru) intake has become an increased risk for chronic kidney disease progression. Despite extensive researches that have been performed to develop effective treatments against Fru-induced renal injury, the outcome has achieved limited success. In this study, we attempted to explore whether carminic acid (CA) could influence the progression of Fru-induced kidney injury, and the underlying molecular mechanism. Read More

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protects the rat brain function from traumatic brain injury by inhibiting autophagy via mammalian targeting of rapamycin.

Aging (Albany NY) 2021 04 4;13. Epub 2021 Apr 4.

Department of Intensive Care Unit, The First Affiliated Rehabilitation Hospital of Zhejiang Chinese Medical University, The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China.

Traumatic brain injury (TBI) remains one of the leading causes of death and disability worldwide. Our previous studies have found that traditional Chinese medicine, () can reduce cerebral hemorrhage in rats with TBI. Yet, the exact mechanism still remains unclear. Read More

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Maternal high sugar and fat diet benefits offspring brain function via targeting on the gut-brain axis.

Aging (Albany NY) 2021 Mar 26;13(7):10240-10274. Epub 2021 Mar 26.

State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, Guangdong, China.

A recent study showed that a gestational high fat diet protects 3xTg-AD offspring from memory impairments, synaptic dysfunction, and brain pathology. However, it is unknown whether this diet exerts the same effects on normal mice or on other functions, and if so, how. In the present study, mother mice were pre-fed a high sugar and high fat (HSHF) diet for 1 month and then fertilized; the HSHF diet was continued until birth and then mother mice were returned to a standard diet. Read More

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FAM134B-mediated endoplasmic reticulum autophagy protects against sepsis myocardial injury in mice.

Aging (Albany NY) 2021 Mar 26;13. Epub 2021 Mar 26.

Intensive Care Unit, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR China.

Reticulophagy regulator 1 (RETEG1, also known as FAM134B) plays a crucial role in endoplasmic reticulum autophagy. We aimed to explore the effect of FAM134B-mediated endoplasmic reticulum autophagy in sepsis myocardial injury in mice. Sepsis myocardial injury mice were established via cecal ligation and puncture procedures. Read More

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Silencing long non-coding RNA MIAT ameliorates myocardial dysfunction induced by myocardial infarction MIAT/miR-10a-5p/EGR2 axis.

Aging (Albany NY) 2021 Mar 26;13. Epub 2021 Mar 26.

Department of Neurology, Tangshan People’s Hospital, Tangshan 063001, P.R. China.

Long non-coding RNA (lncRNA) myocardial infarction-associated transcript (MIAT) has been widely-demonstrated to function as diagnostic markers for acute myocardial infarction (MI). This study was designed to explore the modulatory role of MIAT and its underlying molecular mechanism in MI. Firstly, MI mouse model was developed ligation of the descending branch of the left coronary artery, and cell model was established through exposure to hypoxic conditions Online prediction indicated that MIAT could bind to microRNA-10a-5p (miR-10a-5p), while miR-10a-5p was highlighted to bind to early growth response gene-2 (EGR2). Read More

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Nicotinamide Supplementation Improves Oocyte Quality and Offspring Development by Modulating Mitochondrial Function in an Aged Model.

Antioxidants (Basel) 2021 Mar 26;10(4). Epub 2021 Mar 26.

Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Korea.

Aging is associated with a decline in the quality of biological functions. Among the aging processes, reproductive aging is a critical process because of its intergenerational effects. However, the mechanisms underlying reproductive aging remain largely unknown. Read More

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