733,649 results match your criteria aged three


A prospective cohort study of ambient air pollution exposure and risk of uterine leiomyomata.

Hum Reprod 2021 May 13. Epub 2021 May 13.

Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Study Question: To what extent are ambient concentrations of particulate matter <2.5 microns (PM2.5), nitrogen dioxide (NO2) and ozone (O3) associated with risk of self-reported physician-diagnosed uterine leiomyomata (UL)?

Summary Answer: In this large prospective cohort study of Black women, ambient concentrations of O3, but not PM2. Read More

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The effect of the use of copper carbonate and copper nanoparticles in the diet of rats on the level of β-amyloid and acetylcholinesterase in selected organs.

J Trace Elem Med Biol 2021 May 8;67:126777. Epub 2021 May 8.

Department of Biochemistry and Toxicology, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, 20-950, Lublin, Poland.

Background: Copper has an important role in nervous system function, as a cofactor of many enzymes and in the synthesis of neurotransmitters. Both the dose and the chemical form of copper can determine the impact of this element on metabolism, the neurological system and the immune system.

Aims: The aim of the study was to determine whether and in what form the addition of copper changes the level of amyloid beta and acetylcholinesterase level in selected rat tissues. Read More

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The combined effect of behavioural risk factors on disability in aging adults from the Canadian longitudinal study on aging.

Prev Med 2021 May 10:106609. Epub 2021 May 10.

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; Labarge Centre for Mobility in Aging, McMaster University, Hamilton, Ontario, Canada; McMaster Institute for Research on Aging, McMaster University, Hamilton, Ontario, Canada.

The objective of this study was to explore how behavioural risk factors (smoking, physical activity, and nutrition) cluster together and assess how clusters of behavioural risk factors are associated with functional disability by age and sex at the individual and population level. We used currently available baseline cross-sectional data from the Canadian Longitudinal Study on Aging (CLSA). The CLSA is a national, population-based longitudinal study established to understand and examine health of an aging population. Read More

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Prevalence, incidence and mortality of delirium in patients with COVID-19: A systematic review and meta-analysis.

Age Ageing 2021 May 12. Epub 2021 May 12.

College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: Attention should be paid to delirium in COVID-19 patients, especially older people, since advanced age poses increased risk of both delirium and COVID-19-related death.

Objective: This study aims to summarize the evidence on prevalence, incidence and mortality of delirium in COVID-19 patients.

Methods: We conducted a comprehensive literature search on Pubmed and Embase from inception to December 1, 2020. Read More

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Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development.

PLoS One 2021 13;16(5):e0251598. Epub 2021 May 13.

Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.

Background: Many studies investigating pubertal development use Tanner staging to assess maturation. Endocrine markers in urine and saliva may provide an objective, sensitive, and non-invasive method for assessing development.

Objective: Our objective was to examine whether changes in endocrine levels can indicate the onset of pubertal development prior to changes in self-rated Tanner stage. Read More

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Does perioperative respiratory event increase length of hospital stay and hospital cost in pediatric ambulatory surgery?

PLoS One 2021 13;16(5):e0251433. Epub 2021 May 13.

Department of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

Objective: We examined the consequences of perioperative respiratory event (PRE) in terms of hospitalization and hospital cost in children who underwent ambulatory surgery.

Methods: This subgroup analysis of a prospective cohort study (ClinicalTrials.gov: NCT02036021) was conducted in children aged between 1 month and 14 years who underwent ambulatory surgery between November 2012 and December 2013. Read More

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Psychometric properties of the Dutch-Flemish PROMIS pediatric item banks Anxiety and Depressive Symptoms in a general population.

Qual Life Res 2021 May 13. Epub 2021 May 13.

Department of Public and Occupational Health, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, De Boelelaan 1117, Amsterdam, The Netherlands.

Purpose: This study aims to validate the Dutch-Flemish PROMIS pediatric item banks v2.0 Anxiety and Depressive Symptoms, the short forms 8a, and computerized adaptive tests (CATs) in a general Dutch population and to provide reference data.

Methods: Participants (N = 2,893, aged 8-18), recruited by two internet survey providers, completed both item banks. Read More

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Severe abrupt (thunderclap) non-traumatic headache at the pediatric emergency department - a retrospective study.

Cephalalgia 2021 May 13:3331024211014612. Epub 2021 May 13.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Adult abrupt severe non-traumatic headache (thunderclap) is often related to serious underlying etiologies such as subarachnoid hemorrhage. However, data are sparse regarding thunderclap headache in the pediatric population.

Objective: The aim of the study was to evaluate the prevalence, characteristics and causes of thunderclap headache in the pediatric and adolescent population, aged 6-18 years, presenting to a pediatric emergency department. Read More

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Early childhood circumcision in Australia: Trends over 20 years and interrupted time series analysis.

ANZ J Surg 2021 May 12. Epub 2021 May 12.

Department of Surgery, Austin Health, Heidelberg, Victoria, Australia.

Background: Male circumcision is one of the most common surgical procedures performed in the Australian private sector. This study examines the trends in childhood circumcision throughout the early 21st century.

Methods: Circumcisions performed between 2000 and 2019 amongst preschool-aged Australian boys (0-4 years) were obtained from the Medicare Benefits Schedule. Read More

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Expectations, experiences, perceptions of oral and maxillofacial surgery residents to training in Nigeria.

Eur J Dent Educ 2021 May 12. Epub 2021 May 12.

Department of Oral and Maxillofacial Surgery, Obafemi Awolowo University/Teaching Hospital, Ile Ife, Nigeria.

Purpose: How surgical residents fare during their training could enhance job satisfaction and fulfillment post training. But there is paucity of literature on the experiences of oral and maxillofacial surgery (OMS) trainees during residency training. The aim of this study was to report the expectations, experiences and perceptions of OMS residents towards training in Nigeria. Read More

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Relationship among clinical characteristics, morphological culprit plaque features, and long-term prognosis in patients with acute coronary syndrome.

Int J Cardiovasc Imaging 2021 May 12. Epub 2021 May 12.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Culprit lesions of acute coronary syndrome (ACS) could be classified as plaque rupture (PR), erosion, or calcified nodule (CN). We aimed to determine the relationship among clinical characteristics, morphological plaque features, and long-term prognosis in ACS. Patients with ACS, who underwent pre-intervention optical coherence tomography between April 2013 and July 2018 were retrospectively enrolled, and classified into the three groups based on the culprit lesion morphology. Read More

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Knowing How to Fold 'em: Paper Folding across Early Childhood.

J Mot Learn Dev 2018 Jun;6(1):147-166

University of Wisconsin-Madison.

Folding paper is a seemingly simple act that requires planning, bimanual coordination, and manual strength and control to produce specific forces. Although paper folding has been used as an assessment tool and as a way to promote spatial skills, this study represents the first attempt to document when paper folding emerges across early childhood. Seventy-seven children (ages 18 months to 7 years) and an adult reference group (24 college-aged adults) completed three pre-specified folds on a single piece of paper. Read More

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Prognostic Utility of the Combination of Platelet Count with Neutrophil-to-Lymphocyte Ratio in Aged Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention.

Emerg Med Int 2021 23;2021:4023472. Epub 2021 Apr 23.

Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Method: This was a study recording 637 patients who were diagnosed with acute myocardial infarction. Our patients were grouped according to the combination of platelet count and neutrophil-to-lymphocyte ratio. The prognostic role of the combination of platelet count and neutrophil-to-lymphocyte ratio on mortality was assessed by the univariate and multivariate Cox regression analysis. Read More

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Intestinal Helminth Infections and Associated Risk Factors among School-Aged Children of Bamendjou Community, West Region of Cameroon.

J Parasitol Res 2021 23;2021:6665586. Epub 2021 Apr 23.

Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 067, Dschang, Cameroon.

Background: Infection with intestinal nematodes is of major public health concern worldwide, and school-age children and pregnant women are the principal victims. The present study was undertaken to provide baseline information on the status of gastrointestinal nematodes among school-age children in Bamendjou. . Read More

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Efficacy of high-intensity interval training compared with moderate-intensity continuous training on maximal aerobic potency in dogs: Trial protocol for a randomised controlled clinical study.

Vet Rec Open 2021 Dec 2;8(1):e4. Epub 2021 May 2.

Biogenesis Research Group Facultad de Ciencias Agrarias Universidad de Antioquia Medellín Antioquia Colombia.

Background: High-intensity interval training (HIIT) is a more efficient method to improve exercise capacity than moderate-intensity continuous training (MICT) because of its greater physiological stimulus.

Objective: The aim of this protocol is to evaluate the efficacy of HIIT on maximal aerobic potency in dogs as compared to MICT.

Methods: This protocol is for a randomised, blinded controlled clinical trial, with three parallel groups for the purpose of demonstrating superiority. Read More

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December 2021

Progressive Reduction of Iconic Gestures Contributes to School-Aged Children's Increased Word Production.

Front Psychol 2021 26;12:651725. Epub 2021 Apr 26.

Psycholinguistics, Faculty of Arts and Humanities, Paderborn University, Paderborn, Germany.

The economic principle of communication, according to which successful communication can be reached by least effort, has been studied for verbal communication. With respect to nonverbal behavior, it implies that forms of iconic gestures change over the course of communication and become reduced in the sense of less pronounced. These changes and their effects on learning are currently unexplored in relevant literature. Read More

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Early Adverse Stress and Depressive and Bipolar Disorders: A Systematic Review and Meta-Analysis of Treatment Interventions.

Front Psychiatry 2021 26;12:650706. Epub 2021 Apr 26.

Psicomedica, Clinical and Research Group, Santiago, Chile.

A significant proportion of adults with depressive or bipolar disorders exposed to early adverse stressors do not adequately respond to standard treatments. This review aimed at synthesizing the evidence on the effectiveness of treatment interventions for depressive or bipolar disorders in adult individuals (aged 18 years or more) exposed to adverse stress early in life. Systematic review and meta-analysis including experimental and quasi-experimental published studies indexed in CINAHL, EMBASE, PubMed, and Web of Science databases and/or in reference lists. Read More

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Effects of Different Training Interventions on Heart Rate Variability and Cardiovascular Health and Risk Factors in Young and Middle-Aged Adults: A Systematic Review.

Front Physiol 2021 23;12:657274. Epub 2021 Apr 23.

Department of Sport Science, Faculty of Humanities, Otto von Guericke University, Magdeburg, Germany.

Heart rate variability (HRV), the beat-to-beat variation of adjacent heartbeats, is an indicator of the function of the autonomic nervous system (ANS). Increased HRV reflects well-functioning of autonomic control mechanism and cardiovascular health. The aim of this systematic review is to provide a systematic overview of the effects of different physical training modalities on resting HRV and cardiovascular health and risk factors (i. Read More

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Primary Pancreatic Lymphoma: Recommendations for Diagnosis and Management.

J Blood Med 2021 5;12:257-267. Epub 2021 May 5.

Hematology and Bone Marrow Transplant Unit, Department of Medicine, University of Verona, Verona, Italy.

Background: Primary pancreatic lymphoma (PPL) is a rare disease representing 0.1% of all malignant lymphomas, which lacks well-defined diagnostic and therapeutic protocols. We conducted a systematic review to analyze demographic, diagnostic and therapeutic features of PPL. Read More

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Prevalence and Causes of Visual Impairment and Blindness in Three Ecological Regions of Nepal.

Nepal J Ophthalmol 2021 Jan;13(25):4-12

Tilganga Institute of Ophthalmology, Kathmandu, Nepal.

Introduction: Visual impairment and blindness are significant public health issues worldwide. The objective of this study was to estimate the prevalence and causes of moderate to severe visual impairment (MSVI) and blindness in people aged 15 years and above across three ecological regions of Nepal.

Materials And Methods: A comparative cross-sectional study was conducted in one district in each of the three ecological regions of Nepal. Read More

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January 2021

Public health impact of delaying second dose of BNT162b2 or mRNA-1273 covid-19 vaccine: simulation agent based modeling study.

BMJ 2021 05 12;373:n1087. Epub 2021 May 12.

Department of Medicine, Mayo Clinic, Rochester, MN, USA

Objective: To estimate population health outcomes with delayed second dose versus standard schedule of SARS-CoV-2 mRNA vaccination.

Design: Simulation agent based modeling study.

Setting: Simulated population based on real world US county. Read More

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Association between extremely high high-density lipoprotein-cholesterol and hypertensive retinopathy: results of a cross-sectional study from Kanagawa Investigation of Total Checkup Data from the National Database-6 (KITCHEN-6).

BMJ Open 2021 May 11;11(5):e043677. Epub 2021 May 11.

School of Nutrition and Dietetics, Faculty of Health and Social Services, Kanagawa University of Human Services, Yokosuka, Kanagawa, Japan.

Objectives: Doubt has been cast on the atheroprotective effect of very high high-density lipoprotein cholesterol (HDL-C). Hypertensive retinopathy (HR) is caused by persistent systemic hypertension. Therefore, we aimed to investigate the association between extremely high HDL-C (EH-HDL) and HR. Read More

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The role of correlated factors based on Pender health promotion model in brushing behavior in the 13-16 years old students of Guilan, Iran.

Ital J Pediatr 2021 May 12;47(1):111. Epub 2021 May 12.

Health Promotion Research Center, Zahedan University of Medical Science, Zahedan, Iran.

Background: Tooth decay is one of the diseases that is closely related to people's behaviors and it can have adverse effects on their performance and their success in the future. Brushing twice a day is the simplest and most effective way to reduce tooth decay. The study aim was to determining the roles of correlational factors based on the Pender's health promotion model in brushing behavior of ninth grade students at urban public schools of Guilan province during the academic year 2019. Read More

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Implementing a digital health model of care in Australian youth mental health services: protocol for impact evaluation.

BMC Health Serv Res 2021 May 12;21(1):452. Epub 2021 May 12.

The University of Sydney, Brain and Mind Centre, 94 Mallett St, Camperdown, Sydney, NSW, 2050, Australia.

Background: The World Economic Forum has recently highlighted substantial problems in mental health service provision and called for the rapid deployment of smarter, digitally-enhanced health services as a means to facilitate effective care coordination and address issues of demand. In mental health, the biggest enabler of digital solutions is the implementation of an effective model of care that is facilitated by integrated health information technologies (HITs); the latter ensuring the solution is easily accessible, scalable and sustainable. The University of Sydney's Brain and Mind Centre (BMC) has developed an innovative digital health solution - delivered through the Youth Mental Health and Technology Program - which incorporates two components: 1) a highly personalised and measurement-based (data-driven) model of youth mental health care; and 2) an industrial grade HIT registered on the Australian Register of Therapeutic Goods. Read More

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BEFRIENding for Depression, Anxiety and Social support in older adults living in Australian residential aged care facilities (BEFRIENDAS): randomised controlled trial protocol.

BMC Geriatr 2021 May 12;21(1):305. Epub 2021 May 12.

Aged Care Division, National Ageing Research Institute, Poplar Road, Parkville, 3052, Australia.

Background: This protocol describes an ongoing study of the impact of befriending on depression, anxiety and loneliness in older people living in residential aged care facilities in Australia. While systematic reviews of befriending have indicated positive benefits of befriending for people in a range of ages and settings, there have been no randomised controlled trials (RCTs) of befriending for older people living in residential aged care with depression and no studies of the cost effectiveness of befriending in residential aged care facilities (RACFs) in Australia.

Methods And Analysis: We are conducting a single blind pragmatic RCT comparing two groups of older people living in RACFs, one receiving an intervention consisting of weekly befriending for 4 months from a trained volunteer and the other receiving treatment as usual. Read More

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Development of a complex intervention to improve mobility and participation of older people with vertigo, dizziness and balance disorders in primary care: a mixed methods study.

BMC Fam Pract 2021 May 12;22(1):89. Epub 2021 May 12.

Faculty for Applied Health and Social Sciences, Development and Technology Transfer, Cen-Tre for Research, Rosenheim Technical University of Applied Sciences, Hochschulstraße 1, 83024, Rosenheim, Germany.

Background: Vertigo, dizziness and balance disorders (VDB) are common in older people and cause restrictions in mobility and social participation. Due to a multifactorial aetiology, health care is often overutilised, but many patients are also treated insufficiently in primary care. The purpose of this study was to develop a care pathway as a complex intervention to improve mobility and participation in older people with VDB in primary care. Read More

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Psychiatric and cognitive characteristics of older adults admitted to a Video-EEG monitoring (VEM) unit.

Epilepsy Behav 2021 May 9;120:107987. Epub 2021 May 9.

Department of Medicine (RMH), The University of Melbourne, Australia; Department of Neurology, Royal Melbourne Hospital, Parkville, Australia; Melbourne School of Psychological Sciences, The University of Melbourne, Australia.

Objective: To compare the clinical, psychiatric, and cognitive characteristics of older with younger patients presenting to a video-EEG monitoring (VEM) unit.

Method: This was a retrospective case-control study involving patients admitted for VEM over a two-year period (from April 2018 to April 2020) at two comprehensive epilepsy units. Patients were categorized into an older (≥60 years) and a younger (<60 years) group. Read More

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Impaired glucose-1,6-biphosphate production due to bi-allelic PGM2L1 mutations is associated with a neurodevelopmental disorder.

Am J Hum Genet 2021 May 5. Epub 2021 May 5.

de Duve Institute, UCLouvain, 1200 Brussels, Belgium. Electronic address:

We describe a genetic syndrome due to PGM2L1 deficiency. PGM2 and PGM2L1 make hexose-bisphosphates, like glucose-1,6-bisphosphate, which are indispensable cofactors for sugar phosphomutases. These enzymes form the hexose-1-phosphates crucial for NDP-sugars synthesis and ensuing glycosylation reactions. Read More

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Differences in risk perception, knowledge and protective behaviour regarding COVID-19 by education level among women and men in Germany. Results from the COVID-19 Snapshot Monitoring (COSMO) study.

PLoS One 2021 12;16(5):e0251694. Epub 2021 May 12.

Robert Koch Institute, Berlin, Germany.

The main strategy for combatting SARS-CoV-2 infections in 2020 consisted of behavioural regulations including contact reduction, maintaining distance, hand hygiene, and mask wearing. COVID-19-related risk perception and knowledge may influence protective behaviour, and education could be an important determinant. The current study investigated differences by education level in risk perception, knowledge and protective behaviour regarding COVID-19 in Germany, exploring the development of the pandemic over time. Read More

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Social mobility and healthy behaviours from a gender perspective in the Spanish multicase-control study (MCC-Spain).

PLoS One 2021 12;16(5):e0251447. Epub 2021 May 12.

Cancer and Public Health Area, Foundation for the Promotion of the Research in Healthcare and Biomedicine (FISABIO-Salud Pública), Valencia, Valencian Community, Spain.

There is evidence for the influence of socioeconomic status (SES) on healthy behaviours but the effect of social mobility (SM) is not yet well known. This study aims to analyse the influence of origin and destination SES (O-SES and D-SES) and SM on healthy behaviours and co-occurrence, from an integrated gender and age perspective. Data were obtained from the controls of MCC-Spain between 2008-2013 (3,606 participants). Read More

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