2,948 results match your criteria aged 50-60


Discrimination of vascular aging using the arterial pulse spectrum and machine-learning analysis.

Microvasc Res 2021 Sep 8;139:104240. Epub 2021 Sep 8.

Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, 23561 New Taipei City, Taiwan; Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan.

Aging contributes to the progression of vascular dysfunction and is a major nonreversible risk factor for cardiovascular disease. The aim of this study was to determine the effectiveness of using arterial pulse-wave measurements, frequency-domain pulse analysis, and machine-learning analysis in distinguishing vascular aging. Radial pulse signals were measured noninvasively for 3 min in 280 subjects aged 40-80 years. Read More

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September 2021

Characteristics of Corneal Subbasal Nerves in Different Age Groups: An in vivo Confocal Microscopic Analysis.

Clin Ophthalmol 2021 24;15:3563-3572. Epub 2021 Aug 24.

Research Division, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailanda.

Purpose: To determine the normative characteristics of corneal subbasal nerves in different age groups using laser scanning in vivo confocal microscopy (IVCM).

Patients And Methods: This descriptive observational study recruited healthy subjects (aged 20-60 years) from Siriraj Health-Screening Center. Excluded were individuals who had abnormal ocular symptoms, previous ocular surgery, a history of any diseases related to systemic and/or corneal neuropathy, or abnormal corneal sensitivity. Read More

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Model-based assessment of SARS-CoV-2 Delta variant transmission dynamics within partially vaccinated K-12 school populations.

medRxiv 2021 Aug 23. Epub 2021 Aug 23.

Background: We examined school reopening policies amidst rising transmission of the highly transmissible Delta variant, accounting for vaccination among individuals aged 12 years and older, with the goal of characterizing risk to students and teachers under various within-school non-pharmaceutical interventions (NPIs) combined with specific vaccination coverage levels.

Methods: We developed an individual-based transmission model to simulate transmission of the Delta variant of SARS-CoV-2 among a synthetic population, representative of Bay Area cities. We parameterized the model using community contact rates from vaccinated households ascertained from a household survey of Bay Area families with children conducted between February - April, 2021. Read More

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The Aging Kidney-As Influenced by Heavy Metal Exposure and Selenium Supplementation.

Biomolecules 2021 07 22;11(8). Epub 2021 Jul 22.

Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria, 09042 Monserrato-Cagliari, Italy.

The aging process in the kidneys has been well studied. It is known that the glomerular filtration rate (GFR) declines with age in subjects older than 50-60 years. However, there is still insufficient knowledge regarding the response of the aged kidney to environmental toxicants such as mercury, cadmium, and lead. Read More

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Distribution of diabetic retinopathy in diabetes mellitus patients and its association rules with other eye diseases.

Sci Rep 2021 Aug 20;11(1):16993. Epub 2021 Aug 20.

Henan Eye Institute, Henan Eye Hospital, and Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou City, 450000, China.

The study aims to explore the distribution characteristics and influencing factors of diabetic retinopathy (DR) in diabetes mellitus (DM) patients and association rules of eye diseases in these patients. Data were obtained from 1284 DM patients at Henan Provincial People's Hospital. Association rules were employed to calculate the probability of the common occurrence of eye-related diseases in DM patients. Read More

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Overall Volume Trends in Esophageal Cancer Surgery Results From the Dutch Upper Gastrointestinal Cancer Audit.

Ann Surg 2021 09;274(3):449-458

Department of Surgery, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, the Netherlands.

Objective: In the pursuit of quality improvement, this study aimed to investigate volume-outcome trends in oncologic esophagectomy in the Netherlands.

Summary Of Background Data: Concentration of Dutch esophageal cancer care was dictated by introducing an institutional minimum of 20 resections/yr.

Methods: This nationwide cohort study included all esophagectomy patients registered in the Dutch Upper Gastrointestinal Cancer Audit in 2016-2019 from hospitals currently still performing esophagectomies. Read More

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September 2021

Correlation between Abdominal Wall Subcutaneous Fat Thickness and Heart Weight in Southern Chinese Population.

Fa Yi Xue Za Zhi 2021 Jun;37(3):351-357

Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

Abstract: Objective To study the correlation between the abdominal wall subcutaneous fat thickness and heart weight, so as to provide reference for prediction methods of normal range of heart weight that is suitable for autopsy in China. Methods The forensic pathology autopsy cases accepted by Center for Medicolegal Expertise of Sun Yat-sen University from 1998 to 2017 were collected. Then the exclusion criteria were determined, and according to them the total case group was selected, and the 6 disease groups and the normal group were further selected from the total case group. Read More

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Resistance training improves nerve conduction and arterial stiffness in older adults with diabetic distal symmetrical polyneuropathy: A randomized controlled trial.

Exp Gerontol 2021 10 17;153:111481. Epub 2021 Jul 17.

Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, UK; Water Research Group, North West University, Potchefstroom, South Africa.

Diabetes is the main cause of peripheral neuropathy where older patients are at increased risk of diabetic distal symmetrical polyneuropathy (DSPN) due to age-related nerve degeneration and vascular changes. The aim of the study was to investigate the effect of resistance training on nerve conduction, measures of neuropathy and arterial stiffness in older patients with DSPN. In a randomized controlled trial, thirty-four older adults with type-2 diabetes and peripheral neuropathy were enrolled and randomly assigned to experimental and control groups. Read More

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October 2021

Economic and health impacts of introducing Helicobacter pylori eradication strategy into national gastric cancer policy in Japan: A cost-effectiveness analysis.

Helicobacter 2021 Oct 18;26(5):e12837. Epub 2021 Jul 18.

Advanced Research Promotion Center, Health Sciences University of Hokkaido, Ishikari gun, Japan.

Background: Helicobacter pylori (H. pylori) eradication reduces gastric cancer risk. Since 2013, a population-wide H. Read More

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October 2021

Risk of colorectal adenomas and cancer in monoallelic carriers of MUTYH pathogenic variants: a single-centre experience.

Int J Colorectal Dis 2021 Oct 9;36(10):2199-2204. Epub 2021 Jul 9.

Polyposis Registry, St Mark's Hospital, Harrow, UK.

Purpose: The carrier frequency of MUTYH pathogenic variants in the population may be as high as one in 45. Some studies have found an increased risk of colorectal cancer (CRC) in monoallelic carriers of MUTYH pathogenic variants, but the role of early surveillance colonoscopy is not conclusive. This study aimed to assess the outcomes of colonoscopy surveillance in MUTYH carriers. Read More

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October 2021

Early integrated palliative care for haematology cancer patients-the impact on symptom burden in Hong Kong.

Ann Palliat Med 2021 06;10(6):6316-6324

Palliative Medical Unit, Grantham Hospital, Hong Kong, China.

Background: Evidence showed that early palliative care could have many benefits in clinical outcomes for patients living with advanced medical illnesses. In fact, most of these studies have not involved patients with advanced haematologic cancer (HC), which are known to be associated with significant physical and psychological symptoms. In Hong Kong, an Early Integrated Palliative Care (EIPC) collaboration involving both Heamatology unit of Queen Mary Hospital (QMH) and the Palliative Medical Unit of Grantham Hospital (GH) has been started since early 2018 as a better way to improve the service gap. Read More

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Lifetime risks of hip fracture in patients with type 2 diabetic: Taiwan Diabetes Study.

Osteoporos Int 2021 Jul 6. Epub 2021 Jul 6.

Department of Public Health, College of Public Health, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist, Taichung City, 406040, Taiwan, Republic of China.

This study is to estimate the lifetime risks of hip fracture in Chinese patients with type 2 diabetes.

Introduction: The lifetime risks of hip fracture have not been reported across the age spectrum in male adults and female adults with type 2 diabetes.

Methods: A retrospective cohort study was conducted on 25275 men and 27953 women with type 2 diabetes aged 30-100 years old and participated in the National Diabetes Case Management Program in 2002-2004 in Taiwan. Read More

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Description of call handling in emergency medical dispatch centres in Scandinavia: recognition of out-of-hospital cardiac arrests and dispatcher-assisted CPR.

Scand J Trauma Resusc Emerg Med 2021 Jun 30;29(1):88. Epub 2021 Jun 30.

Copenhagen Emergency Medical Services, University of Copenhagen, Copenhagen, Denmark.

Background: The European resuscitation council have highlighted emergency medical dispatch centres as an important key player for early recognition of Out-of-Hospital Cardiac Arrest (OHCA) and in providing dispatcher assisted cardiopulmonary resuscitation (CPR) before arrival of emergency medical services. Early recognition is associated with increased bystander CPR and improved survival rates. The aim of this study is to describe OHCA call handling in emergency medical dispatch centres in Copenhagen (Denmark), Stockholm (Sweden) and Oslo (Norway) with focus on sensitivity of recognition of OHCA, provision of dispatcher-assisted CPR and time intervals when CPR is initiated during the emergency call (NO-CPR), and to describe OHCA call handling when CPR is initiated prior to the emergency call (CPR). Read More

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Thermal treatment enhances the α-glucosidase inhibitory activity of bitter melon (Momordica charantia) by increasing the free form of phenolic compounds and the contents of Maillard reaction products.

J Food Sci 2021 Jul 19;86(7):3109-3121. Epub 2021 Jun 19.

Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan.

Inhibition of α-glucosidase can slow carbohydrate metabolism, which is known as an effective strategy for diabetes treatment. The aim of this study is to evaluate the effect of thermal treatment (50, 60, and 70℃) for 15 days on the α-glucosidase inhibitory activity of bitter melon. The results show that the bitter melon heated at 70℃ for 12 days had the best α-glucosidase inhibitory effect. Read More

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Mild to moderate osteoarthritis is not considered a contraindication to arthroscopic treatment of symptomatic femoroacetabular impingement: results of an international survey.

Knee Surg Sports Traumatol Arthrosc 2021 Jun 18. Epub 2021 Jun 18.

Fowler Kennedy Sport Medicine Clinic, 3M Centre, Western University, London, ON, N6A 3K7, Canada.

Purpose: Hip arthroscopy offers a minimally invasive approach for the treatment of femoroacetabular impingement (FAI). Although osteoarthritis (OA) is a known negative prognostic factor for arthroscopy, it is unclear if patients with FAI and concomitant mild to moderate OA benefit from hip preservation surgery. The goal of this study was to evaluate current practice patterns among surgeons experienced in FAI management in the treatment of patients between 40 and 60 years of age with symptomatic FAI and concomitant OA of varying severity. Read More

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Depression predicts emotion acceptance beliefs in early adolescence: A longitudinal investigation.

Br J Clin Psychol 2021 Jun 2. Epub 2021 Jun 2.

School of Psychology, University of Sydney, New South Wales, Australia.

Objectives: Adolescence is a time period which confers significant risk for the development of psychopathology. There is increasing consensus within the literature that beliefs about one's emotional experience are important and may present a unique risk factor during this time period. However, to date, there has been no longitudinal examination of the relationship between depression and specific beliefs regarding the acceptability of experiencing and expressing emotion in young people. Read More

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Cervical testing beyond the screening target age - A register-based cohort study from Finland.

Gynecol Oncol 2021 Aug 30;162(2):315-321. Epub 2021 May 30.

Mass Screening Registry, Finnish Cancer Registry, Helsinki, Finland.

Objective: It has been proposed that cervical cancer screening should be continued in women with previous abnormal results or irregular attendance. We examined the coverage and factors that might influence cervical testing beyond the age range of the organized cervical screening programme in Finland. The national programme invites women in every five years least until the age of 60. Read More

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Prediction of One Repetition Maximum Using Reference Minimum Velocity Threshold Values in Young and Middle-Aged Resistance-Trained Males.

Behav Sci (Basel) 2021 May 7;11(5). Epub 2021 May 7.

Department of Sport and Exercise Sciences, University of Chester, Chester CH1 4BJ, UK.

Background: This study determined the accuracy of different velocity-based methods when predicting one-repetition maximum (1RM) in young and middle-aged resistance-trained males.

Methods: Two days after maximal strength testing, 20 young (age 21.0 ± 1. Read More

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The differential demographic pattern of coronavirus disease 2019 fatality outside Hubei and from six hospitals in Hubei, China: a descriptive analysis.

BMC Infect Dis 2021 May 26;21(1):481. Epub 2021 May 26.

State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China.

Background: The coronavirus disease 2019 (COVID-19) epidemic has been largely controlled in China, to the point where case fatality rate (CFR) data can be comprehensively evaluated.

Methods: Data on confirmed patients, with a final outcome reported as of 29 March 2020, were obtained from official websites and other internet sources. The hospitalized CFR (HCFR) was estimated, epidemiological features described, and risk factors for a fatal outcome identified. Read More

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Exoskeleton-assisted walking improves pulmonary function and walking parameters among individuals with spinal cord injury: a randomized controlled pilot study.

J Neuroeng Rehabil 2021 05 24;18(1):86. Epub 2021 May 24.

Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.

Background: Exoskeleton-assisted walking (EAW) is expected to improve the gait of spinal cord injury (SCI) individuals. However, few studies reported the changes of pulmonary function (PF) parameters after EAW trainings. Hence, we aimed to explore the effect of EAW on PF parameters, 6-min walk test (6MWT) and lower extremity motor score (LEMS) in individuals with SCI and to compare those with conventional trainings. Read More

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[Hashimoto Encephalopathy].

Brain Nerve 2021 May;73(5):544-551

Faculty of Nursing and Social Welfare Sciences, Fukui Prefectural University.

Hashimoto encephalopathy (HE) has been recognized as a new clinical disease based on an autoimmune mechanism associated with Hashimoto's thyroiditis. HE is successfully treated with steroids. In 2005, we discovered serum autoantibodies against the NH-terminal of α-enolase (NAE) as a highly specific diagnostic biomarker for HE. Read More

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Public health impact of delaying second dose of BNT162b2 or mRNA-1273 covid-19 vaccine: simulation agent based modeling study.

BMJ 2021 05 12;373:n1087. Epub 2021 May 12.

Department of Medicine, Mayo Clinic, Rochester, MN, USA

Objective: To estimate population health outcomes with delayed second dose versus standard schedule of SARS-CoV-2 mRNA vaccination.

Design: Simulation agent based modeling study.

Setting: Simulated population based on real world US county. Read More

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Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles.

Diabetes 2021 08 10;70(8):1816-1825. Epub 2021 May 10.

Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.

The pathogenesis of type 2 diabetes (T2D) might change with increasing age. Here, we used a stratification based on age of diagnosis to gain insight into the genetics and causal risk factors of T2D across different age-groups. We performed genome-wide association studies (GWAS) on T2D and T2D subgroups based on age of diagnosis (<50, 50-60, 60-70, and >70 years) (total of 24,986 cases). Read More

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Effects of Screenings in Reducing Colorectal Cancer Incidence and Mortality Differ by Polygenic Risk Scores.

Clin Transl Gastroenterol 2021 05 6;12(5):e00344. Epub 2021 May 6.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Introduction: Colorectal cancer (CRC) screening reduces CRC incidence and mortality. However, it is unclear whether the reduction in CRC risk may differ by genetic susceptibility.

Methods: We evaluated this question in a cohort of 304,740 participants of European descent aged 50 years and older. Read More

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The association of estimated cardiorespiratory fitness with COVID-19 incidence and mortality: A cohort study.

PLoS One 2021 5;16(5):e0250508. Epub 2021 May 5.

Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Background: It has been suggested that cardiorespiratory fitness (CRF) may be used to identify those at greatest risk for severe COVID-19 illness. However, no study to date has examined the association between CRF and COVID-19. The objectives of this study were to determine whether CRF is independently associated with testing positive with or dying from COVID-19. Read More

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Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Follicular Differentiation.

Int J Mol Sci 2021 Apr 30;22(9). Epub 2021 Apr 30.

Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.

Neoplasms derived from follicular tissue are extremely rare. Clinically, they are reported as non-symptomatic, slow-growing nodules. These lesions are mainly benign, but the malignant type can occur. Read More

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Association of sleep duration in middle and old age with incidence of dementia.

Nat Commun 2021 04 20;12(1):2289. Epub 2021 Apr 20.

Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France.

Sleep dysregulation is a feature of dementia but it remains unclear whether sleep duration prior to old age is associated with dementia incidence. Using data from 7959 participants of the Whitehall II study, we examined the association between sleep duration and incidence of dementia (521 diagnosed cases) using a 25-year follow-up. Here we report higher dementia risk associated with a sleep duration of six hours or less at age 50 and 60, compared with a normal (7 h) sleep duration, although this was imprecisely estimated for sleep duration at age 70 (hazard ratios (HR) 1. Read More

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Sulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary intervention with whole foods and amino acid supplements.

J Transl Med 2021 04 15;19(1):153. Epub 2021 Apr 15.

Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Sognsvannveien 9, 0372, Oslo, Norway.

Background: Dietary sulfur amino acid (SAA) restriction is an established animal model for increasing lifespan and improving metabolic health. Data from human studies are limited. In the study outlined in this protocol, we will evaluate if dietary SAA restriction can reduce body weight and improve resting energy expenditure (REE) and parameters related to metabolic health. Read More

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Association between Anti-inflammatory Drug and Dementia in Patients with Gout: A Nationwide, Population-Based Nested Case-Control Study.

Int J Med Sci 2021 10;18(9):2042-2050. Epub 2021 Mar 10.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

The interaction between hyperuricemia and the cognitive system is still under debate, with studies presenting somewhat conflicting results. This study aimed to investigate the risk of dementia in patients with gout who are administered anti-inflammatory drug treatment. Gouty arthritis patients aged 50 years and older, who received at least one of the background therapy drugs (colchicine, corticosteroids, or nonsteroidal anti-inflammatory drugs for 6 months), were divided into the following groups and compared: patients who had dementia over a period of 5 years (n = 2,292) and matched patients without dementia (n = 2,292). Read More

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