88 results match your criteria age-based prenatal


Sonographic growth curves versus neonatal birthweight growth curves for the identification of fetal growth restriction.

J Matern Fetal Neonatal Med 2020 Dec 1:1-8. Epub 2020 Dec 1.

Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, affiliated with the Hebrew University Hadassah Medical School, Jerusalem, Israel.

Objective: Fetal growth restriction is suspected when the estimated fetal weight is <10th percentile for gestational age. Using a regional sonographic estimated fetal weight growth curve to diagnose fetal growth restriction has no known benefits; however, the traditional approach of using birthweight curves is misleading, since a large proportion of preterm births arise from pathological pregnancies. Our aim was to compare the diagnostic accuracies of sonographic versus birthweight curves in diagnosing fetal growth restriction. Read More

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December 2020

A Race Against Time-Changing the Natural History of CRIM Negative Infantile Pompe Disease.

Front Immunol 2020 4;11:1929. Epub 2020 Sep 4.

Duke University Medical Center, Durham, NC, United States.

We report the clinical course of the first prenatally diagnosed cross-reactive immunologic material (CRIM)-negative infantile Pompe disease (IPD) patient [homozygous for c.2560C>T (p.Arg854X) variant in the gene] to undergo prophylactic immune tolerance induction (ITI) and enzyme replacement therapy (ERT) within the first 2 days of life. Read More

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September 2020

Early termination of pregnancy: differences in gestational age estimation using last menstrual period and ultrasound in Mexico.

Reprod Health 2020 Jun 9;17(1):89. Epub 2020 Jun 9.

Department of Obstetrics and Gynecology and School of Public Health Portland, Oregon Health & Science University, Mail code UHN-50, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA.

Background: Gestational age estimation is key to the provision of abortion, to ensure safety and successful termination of pregnancy. We compared gestational age based on reported last menstrual period and ultrasonography among a large sample of women in Mexico City's public first trimester abortion program, Interrupcion Legal de Embarazo (ILE).

Methods: We conducted a retrospective study of 43,219 clinical records of women seeking abortion services in the public abortion program from 2007 to 2015. Read More

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Non-invasive prediction of fetal growth restriction by whole-genome promoter profiling of maternal plasma DNA: a nested case-control study.

BJOG 2021 Jan 2;128(2):458-466. Epub 2020 Jun 2.

Department of Obstetrics and Gynaecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Objective: To predict fetal growth restriction (FGR) by whole-genome promoter profiling of maternal plasma.

Design: Nested case-control study.

Setting: Hospital-based. Read More

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January 2021

Neurodevelopment of children exposed intra-uterus by Zika virus: A case series.

PLoS One 2020 28;15(2):e0229434. Epub 2020 Feb 28.

Instituto Fernandes Figueira-Fiocruz, Rio de Janeiro, Brazil.

The main goal of this manuscript was to investigate the neurodevelopment of children exposed by Zika virus in the intrauterine period who are asymptomatic at birth. Newborns with documented Zika virus exposure during the intrauterine period who were asymptomatic at birth were followed in the first two years of life for neurodevelopment using Bayley III test. Children were classified as having normal or delayed neurodevelopment for age based on most recent Bayley III evaluation results. Read More

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Abortion for fetal indications: Timing of prenatal diagnosis and abortion for structural and genetic abnormalities.

Contraception 2020 05 13;101(5):293-295. Epub 2020 Feb 13.

Weill Cornell Medical College, 525 East 68th Street, Room J130, New York, NY 10065, United States. Electronic address:

Objective: To compare diagnoses in patients undergoing abortion for fetal indications at 15-0/7 to 21-6/7 vs. ≥22-0/7 weeks' gestation.

Study Design: This retrospective cohort study included women undergoing abortion at ≥15-0/7 weeks' gestation for fetal indications from 2012 to 2018 at our institution. Read More

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Neurodevelopmental Abnormalities in Children With In Utero Zika Virus Exposure Without Congenital Zika Syndrome.

JAMA Pediatr 2020 03;174(3):269-276

BIOMELAB, Barranquilla, Colombia.

Importance: The number of children who were born to mothers with Zika virus (ZIKV) infection during pregnancy but who did not have apparent disability at birth is large, warranting the study of the risk for neurodevelopmental impairment in this population without congenital Zika syndrome (CZS).

Objective: To investigate whether infants without CZS but who were exposed to ZIKV in utero have normal neurodevelopmental outcomes until 18 months of age.

Design, Setting, And Participants: This cohort study prospectively enrolled a group of pregnant women with ZIKV in Atlántico Department, Colombia, and in Washington, DC. Read More

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Cell-free DNA fetal fraction in twin gestations in single-nucleotide polymorphism-based noninvasive prenatal screening.

Prenat Diagn 2020 01 21;40(2):179-184. Epub 2019 Nov 21.

Department of Genetics and Genome Sciences, UConn Health, Farmington, CT.

Objectives: The performance of noninvasive prenatal screening (NIPS) for fetal aneuploidy in twin pregnancies is dependent on the amount of placentally derived cell-free DNA, the "fetal fraction (FF)," present in maternal plasma. We report FF values in monozygotic (MZ) and dizygotic (DZ) pregnancies.

Methods: We reviewed FF in pregnancies at 10 to 20 completed weeks gestational age based on single-nucleotide polymorphism (SNP)-based NIPS where zygosity was routinely established in twin pregnancies. Read More

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January 2020

Guideline No. 388-Determination of Gestational Age by Ultrasound.

J Obstet Gynaecol Can 2019 Oct;41(10):1497-1507

Vancouver, BC. Electronic address:

Objective: To assist clinicians in assigning gestational age based on ultrasound biometry.

Outcomes: To determine whether ultrasound dating provides more accurate gestational age assessment than menstrual dating with or without the use of ultrasound. To provide maternity health care providers and researchers with evidence-based guidelines for the assignment of gestational age. Read More

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October 2019

Updating fetal foot length to gestational age references: a chart review of abortion cases from 2012 to 2014.

Contraception 2020 01 11;101(1):10-13. Epub 2019 Jul 11.

Department of Obstetrics, Gynecology & Women's Health, University of Hawaii, 1319 Punahou St, Ste 801, Honolulu HI, 96826, Honolulu, HI.

Objectives: We sought to develop an updated fetal foot length-to-gestational week reference range from patient-reported last menstrual period (LMP), ultrasound, and best-estimate for gestational age based on American College of Obstetricians and Gynecologists' (ACOG) pregnancy dating guidelines. Subsequently, we aimed to determine the impact, if any, of race/ethnicity on our findings and compare our measurements to commonly referenced ranges.

Methods: We performed a chart review of 610 dilation and evacuation records with gestational ages 14 weeks 0 days to 21 weeks 6 days from October 2012 to December 2014 in Honolulu, Hawaii. Read More

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January 2020

[Exploration of the process of prenatal screening and diagnosis for women with advanced maternal age based on results of 351 cases of fetal chromosomal abnormalities].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2019 Jun;36(6):538-542

Prenatal Diagnosis Center, Bejing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China. Email:

Objective: To explore the suitable process for prenatal screening and diagnosis for women with advanced maternal age.

Methods: From January 2014 to November 2017, the indications and distributions of prenatal diagnosis for women with advanced maternal age only or accompanying with positive maternal serum test screening and non-invasive prenatal testing (NIPT), abnormal fetal ultrasound, one harboring chromosomal abnormalities or anomalous reproductive history were analyzed. The rate of fetal chromosomal abnormalities was compared between different groups. Read More

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An Age-Based Framework for Evaluating Genome-Scale Sequencing Results in Newborn Screening.

J Pediatr 2019 06 7;209:68-76. Epub 2019 Mar 7.

Department of Genetics, UNC Chapel Hill, Chapel Hill, NC. Electronic address:

Objective: To assess the performance of a standardized, age-based metric for scoring clinical actionability to evaluate conditions for inclusion in newborn screening and compare it with the results from other contemporary methods.

Study Design: The North Carolina Newborn Exome Sequencing for Universal Screening study developed an age-based, semiquantitative metric to assess the clinical actionability of gene-disease pairs and classify them with respect to age of onset or timing of interventions. This categorization was compared with the gold standard Recommended Uniform Screening Panel and other methods to evaluate gene-disease pairs for newborn genomic sequencing. Read More

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Temporal trends, patterns, and predictors of preterm birth in California from 2007 to 2016, based on the obstetric estimate of gestational age.

Matern Health Neonatol Perinatol 2018 12;4:25. Epub 2018 Dec 12.

2School of Agriculture and Food Sciences, Faculty of Science, The University of Queensland, Brisbane, QLD 4072 Australia.

Background: Preterm birth (PTB) is associated with increased infant mortality, and neurodevelopmental abnormalities among survivors. The aim of this study is to investigate temporal trends, patterns, and predictors of PTB in California from 2007 to 2016, based on the obstetric estimate of gestational age (OA).

Methods: A retrospective cohort study evaluated 435,280 PTBs from the 5,137,376 resident live births (8. Read More

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December 2018

Factors affecting complete and timely childhood immunization coverage in Sindh, Pakistan; A secondary analysis of cross-sectional survey data.

PLoS One 2018 31;13(10):e0206766. Epub 2018 Oct 31.

Global Health Unit, Department of Health Sciences, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.

Background: Pakistan has a high burden of newborn mortality, which would be significantly preventable through appropriate routine immunization. The purpose of this study was to measure the basic timely childhood immunization coverage and to identify determinants of factors influencing childhood immunization coverage in Sindh, Pakistan.

Methods: Data from Maternal and Child Health Program Indicator Survey 2013-2014 which was conducted in Sindh province of Pakistan was used. Read More

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Fetal Medicine Foundation reference ranges for umbilical artery and middle cerebral artery pulsatility index and cerebroplacental ratio.

Ultrasound Obstet Gynecol 2019 Apr 13;53(4):465-472. Epub 2019 Feb 13.

Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.

Objectives: To develop gestational age-based reference ranges for the pulsatility index in the umbilical artery (UA-PI) and fetal middle cerebral artery (MCA-PI) and the cerebroplacental ratio (MCA-PI/UA-PI), and to examine the maternal characteristics and medical history that affect these measurements.

Methods: This was a cross-sectional study of 72 387 pregnancies undergoing routine ultrasound examination at 20 + 0 to 22 + 6 weeks' gestation (n = 3712), 31 + 0 to 33 + 6 weeks (n = 29 035), 35 + 0 to 36 + 6 weeks (n = 37 252) or 41 + 0 to 41 + 6 weeks (n = 2388). For the purpose of this study, we included data for only one of the second- or third-trimester visits. Read More

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Use of Electronic Health Record Integration for Down Syndrome Guidelines.

Pediatrics 2018 09;142(3)

Down Syndrome Program, Division of Medical Genetics, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts; and.

Objectives: Established guidelines from the American Academy of Pediatrics for the care of patients with Down syndrome are often not followed. Our goal was to integrate aspects of the guidelines into the electronic health record (EHR) to improve guideline adherence throughout a child's life span.

Methods: Two methods of EHR integration with age-based logic were created and implemented in June 2016: (1) a best-practice advisory that prompts an order for referral to genetics; and (2) a health maintenance record that tracks completion of complete blood cell count and/or hemoglobin testing, thyrotropin testing, echocardiogram, and sleep study. Read More

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September 2018

Recent trends, risk factors, and disparities in low birth weight in California, 2005-2014: a retrospective study.

Matern Health Neonatol Perinatol 2018 8;4:15. Epub 2018 Aug 8.

3School of Agriculture and Food Sciences, Faculty of Science, The University of Queensland, Brisbane, Qld 4072 Australia.

Background: Low birth weight (LBW) is a leading risk factor for infant morbidity and mortality in the United States. There are large disparities in the prevalence of LBW by race and ethnicity, especially between African American and White women. Despite extensive research, the practice of clinical and public health, and policies devoted to reducing the number of LBW infants, the prevalence of LBW has remained unacceptably and consistently high. Read More

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Evaluating parents' decisions about next-generation sequencing for their child in the NC NEXUS (North Carolina Newborn Exome Sequencing for Universal Screening) study: a randomized controlled trial protocol.

Trials 2018 Jun 28;19(1):344. Epub 2018 Jun 28.

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Background: Using next-generation sequencing (NGS) in newborn screening (NBS) could expand the number of genetic conditions detected pre-symptomatically, simultaneously challenging current precedents, raising ethical concerns, and extending the role of parental decision-making in NBS. The NC NEXUS (Newborn Exome Sequencing for Universal Screening) study seeks to assess the technical possibilities and limitations of NGS-NBS, devise and evaluate a framework to convey various types of genetic information, and develop best practices for incorporating NGS-NBS into clinical care. The study is enrolling both a healthy cohort and a cohort diagnosed with known disorders identified through recent routine NBS. Read More

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Identifying Fetal Growth Disorders Using Ultrasonography in Women With Diabetes.

J Ultrasound Med 2018 May 31;37(5):1103-1108. Epub 2017 Oct 31.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Objectives: We evaluated the ability of third-trimester ultrasonography (US) to diagnose disorders of fetal growth among women with diabetes mellitus.

Methods: This work was a retrospective cohort study of women with diabetes who delivered term singleton neonates at a single academic medical center and who had a US examination within 5 weeks of delivery. We characterized the sensitivity, specificity, positive predictive value, and negative predictive value of US to detect large-for-gestational age (LGA) and small-for-gestational age (SGA) infants. Read More

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The Estimation of Gestational Age at Birth in Database Studies.

Epidemiology 2017 11;28(6):854-862

From the aCenter for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada; bDepartment of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada; cDepartment of Pediatrics, McGill University, Montreal, QC, Canada; and dDepartment of Medicine, McGill University, Montreal, QC, Canada.

Background: Studies on the safety of prenatal medication use require valid estimation of the pregnancy duration. However, gestational age is often incompletely recorded in administrative and clinical databases. Our objective was to compare different approaches to estimating the pregnancy duration. Read More

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November 2017

Age-based differences in the predictive accuracy of a one-size-fits-all risk-cutoff value in prenatal integrated screening for Down syndrome.

Prenat Diagn 2017 Sep 25;37(9):894-898. Epub 2017 Jul 25.

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.

Objective: The objective of this study is to assess variation in detection and false positive rates and adverse pregnancy outcomes across different age groups when a one-size-fits-all risk-cutoff value, such as 1/270, is used in integrated screening for Down syndrome.

Method: A Monte Carlo simulation was utilized to estimate the detection and false positive rates as well as adverse pregnancy outcomes.

Results: Using a one-size-fits-all risk-cutoff value, such as 1/270, can result in considerably high variations in detection and false positive rates across maternal ages and lead to a higher than the minimum possible total number of adverse outcomes. Read More

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September 2017

Age-Based Reproductive Healthcare Stereotype Threat (HCST) as a Stressor Affecting Prenatal Mental Health in Pregnant Women of Advanced Maternal Age: Measurement, Process, Outcomes, and Interactions with Ethnicity/Race, SES, and Other Social Identities.

Curr Epidemiol Rep 2017 Jun 30;4(2):133-144. Epub 2017 May 30.

University of Southern California.

Purpose Of Review: Reproductive health, and pregnancy more specifically, is the first critical link between generations. Beginning with this first critical link, pregnancy acts as a domino, affecting the expression of genes and determining the lifespan mental and physical health and reproductive potential of offspring and, likely, of subsequent generations. Given the powerful intergenerational domino that is pregnancy, the development of innovative models to enhance reproductive health and outcomes is an invaluable public health investment. Read More

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Dichorionic twin trajectories: the NICHD Fetal Growth Studies.

Am J Obstet Gynecol 2016 08 30;215(2):221.e1-221.e16. Epub 2016 Apr 30.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, MD.

Background: Systematic evaluation and estimation of growth trajectories in twins require ultrasound measurements across gestation that are performed in controlled clinical settings. Currently, there are few such data for contemporary populations. There is also controversy about whether twin fetal growth should be evaluated with the use of the same benchmarks as singleton growth. Read More

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Influence of medically assisted reproduction techniques on crown-rump length and biochemical markers of trisomy 21 in the first trimester of pregnancy.

Fertil Steril 2016 Feb 19;105(2):410-6. Epub 2015 Nov 19.

Gynecology-obstetrics department, Centre Médico-Chirurgical et d'Obstétrique (CMCO), Schiltigheim, France.

Objective: To determine whether there is a difference between the known gestational age in pregnancies conceived after IVF and the estimated gestational age based on the crown-rump length (CRL) measurement during the first trimester.

Design: We retrospectively (between 2007 and 2012) studied a cohort of 6,739 patients who underwent ultrasonography between 11 and 13+6 weeks of amenorrhea.

Setting: Hospital. Read More

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February 2016

Effectiveness of a normative nutrition intervention (diet, physical activity and breastfeeding) on maternal nutrition and offspring growth: the Chilean maternal and infant nutrition cohort study (CHiMINCs).

BMC Pregnancy Childbirth 2015 Aug 18;15:175. Epub 2015 Aug 18.

Institute of Nutrition and Food Technology (INTA), University of Chile, Avenida El Líbano 5524, Macul, Santiago, Chile.

Background: Maternal obesity before and during pregnancy predicts maternal and infant risks of obesity and its associated metabolic conditions. Dietary and physical activity recommendations during pregnancy as well as weight monitoring are currently available in the Chilean primary health care system. However some of these recommendations are not updated and most of them are poorly implemented. Read More

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Association between prenatal exposure to polybrominated diphenyl ethers and young children's neurodevelopment in China.

Environ Res 2015 Oct 29;142:104-11. Epub 2015 Jun 29.

MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

The use of polybrominated diphenyl ethers (PBDEs) has been dramatically increasing over the last two decades in China. Animal studies suggest that prenatal exposure to PBDEs may result in neurodevelopmental deficits. Two hundred thirty-two participating mothers were recruited from a prospective birth cohort in rural northern China between September 2010 and February 2012. Read More

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October 2015

Factors associated with the differential in actual gestational age and gestational age predicted from transrectal ultrasonography in pregnant dairy cows.

Theriogenology 2015 Aug 28;84(3):358-64. Epub 2015 Mar 28.

Animal & Grassland Research and Innovation Centre, Teagasc, Moorepark, County Cork, Ireland. Electronic address:

The objective of the study was to determine (1) how gestational age predicted using transrectal ultrasonography related to actual gestational age derived as the number of days from the most recent artificial insemination date, (2) what factors, if any, were associated with the differential between the two measures, and (3) the association between this differential in gestational age and the likelihood of subsequent pregnancy loss, stillbirth, or calving dystocia. The data set contained 7340 ultrasound records from 6805 Holstein Friesian dairy cows in 175 herds. Ultrasonography assessment underestimated gestational age relative to days since last service by 0. Read More

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Determining gestational age based on information from the Birth in Brazil study.

Cad Saude Publica 2014 Aug;30 Suppl 1:S1-12

Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.

This study aimed at assessing the validity of different measures for estimating gestational age and to propose the creation of an algorithm for gestational age at birth estimates for the Birth in Brazil survey--a study conducted in 2011-2012 with 23,940 postpartum women. We used early ultrasound imaging, performed between 7-20 weeks of gestation, as the reference method. All analyses were performed stratifying by payment of maternity care (public or private). Read More

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Determination of gestational age by ultrasound.

J Obstet Gynaecol Can 2014 Feb;36(2):171-181

Vancouver BC.

Objective: To assist clinicians in assigning gestational age based on ultrasound biometry.

Outcomes: To determine whether ultrasound dating provides more accurate gestational age assessment than menstrual dating with or without the use of ultrasound. To provide maternity health care providers and researchers with evidence-based guidelines for the assignment of gestational age. Read More

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February 2014