195 results match your criteria age unremitting

Professional Quality of Life in intensive care medicine: The 2018 Faculty of Intensive Care Medicine Workforce survey.

J Intensive Care Soc 2020 Nov 23;21(4):299-304. Epub 2019 Sep 23.

Cardiff Critical Care, Cardiff and Vale University Health Board, Cardiff, UK.

Background: Critical care is widely perceived, both within and outside of the speciality, as unremitting and emotionally burdensome. There is a perception of a higher risk to medical staff of burnout than other specialities. Critical care also has considerable emotional and professional rewards. Read More

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November 2020

New Daily Persistent Headache in a Pediatric Population.

J Child Neurol 2021 May 28:8830738211004514. Epub 2021 May 28.

Children's National Hospital, Washington, DC, USA.

Introduction: New daily persistent headache (NDPH) is a primary headache disorder characterized by an intractable, daily, and unremitting headache lasting for at least 3 months. Currently, there are limited studies in the pediatric population describing the characteristics of NDPH.

Objective: The objective of the current study is to describe the characteristics of NDPH in pediatric patients presenting to a headache program at a tertiary referral center. Read More

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The incisional hernia epidemic: evaluation of outcomes, recurrence, and expenses using the healthcare cost and utilization project (HCUP) datasets.

Hernia 2021 Apr 9. Epub 2021 Apr 9.

Division of Plastic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.

Background: Incisional hernias (IH) following abdominal surgery persist as morbid, costly, and multi-disciplinary surgical challenges. Using longitudinal, multi-state, administrative claims data (HCUP State Inpatient Databases (SID)); (HCUP State Ambulatory Surgery and Services Databases (SASD)), we aimed to characterize the epidemiology, outcomes, recurrence, and costs of IH.

Study Design: 529,108 patients undergoing abdominal surgery in 2010 across six specialties (colorectal, general/bariatric, hepatobiliary, obstetrics/gynecology, urology, and vascular) were identified within inpatient and ambulatory databases for Florida (FL), Iowa (IA), Nebraska (NE), New York (NY), and Utah (UT). Read More

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Better outcome of COVID-19 positive kidney transplant recipients during the unremitting stage with optimized anticoagulation and immunosuppression.

Clin Transplant 2021 06 12;35(6):e14297. Epub 2021 May 12.

Chest Department, Zagazig University, Zagaziz, Egypt.

Introduction: COVID-19 is an ongoing pandemic with high morbidity and mortality and with a reported high risk of severe disease in kidney transplant recipients (KTR).

Aim: We aimed to report the largest number of COVID-19-positive cases in KTR in a single center and to discuss their demographics, management, and evolution.

Methods: We enrolled all the two thousand KTR followed up in our center in Kuwait and collected the data of all COVID-19-positive KTR (104) from the start of the outbreak till the end of July 2020 and have reported the clinical features, management details, and both patient and graft outcomes. Read More

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Efficacy in deceptive vocal exaggeration of human body size.

Nat Commun 2021 02 12;12(1):968. Epub 2021 Feb 12.

Equipe de Neuro-Ethologie Sensorielle (ENES), Centre de Recherche en Neurosciences de Lyon (CRNL), CNRS, INSERM, University of Lyon/Saint-Étienne, Saint-Étienne, France.

How can deceptive communication signals exist in an evolutionarily stable signalling system? To resolve this age-old honest signalling paradox, researchers must first establish whether deception benefits deceivers. However, while vocal exaggeration is widespread in the animal kingdom and assumably adaptive, its effectiveness in biasing listeners has not been established. Here, we show that human listeners can detect deceptive vocal signals produced by vocalisers who volitionally shift their voice frequencies to exaggerate or attenuate their perceived size. Read More

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February 2021

One-stage oblique lateral corridor antibiotic-cement reconstruction for Candida spondylodiscitis in patients with major comorbidities: Preliminary experience.

Neurochirurgie 2021 Apr 12;67(2):157-164. Epub 2021 Jan 12.

Division of Orthopedics, Centre Hospitalier de l'Université de Montréal (CHUM), University of Montreal, 1051 Sanguinet Street, Montreal, QC H2X 3E4 Canada.

Fungal spondylodiscitis is rare (0.5%-1.6% of spondylodiscitis) and mainly caused by Candida albicans. Read More

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Multiscale Regulation of the Intervertebral Disc: Achievements in Experimental, In Silico, and Regenerative Research.

Int J Mol Sci 2021 Jan 12;22(2). Epub 2021 Jan 12.

BCN MedTech, Department of Information and Communication Technologies, Universitat Pompeu Fabra, 08018 Barcelona, Spain.

Intervertebral disc (IVD) degeneration is a major risk factor of low back pain. It is defined by a progressive loss of the IVD structure and functionality, leading to severe impairments with restricted treatment options due to the highly demanding mechanical exposure of the IVD. Degenerative changes in the IVD usually increase with age but at an accelerated rate in some individuals. Read More

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January 2021

Emergency hysterectomy in a tertiary care hospital: indications, surgical outcomes and challenges: a 2-year retrospective descriptive cross-sectional study.

Pan Afr Med J 2020 1;37:106. Epub 2020 Oct 1.

Directorate of Obstetrics and Gynaecology, Komfo Anokye Teaching Hospital, Kumasi, Ghana.

Introduction: emergency hysterectomy (EH) remains a life-saving procedure in cases of life-threatening obstetric hemorrhage and other gynaecological emergencies. We aim to determine the indications, surgical outcomes and challenges of EH in our tertiary centre.

Methods: an ethically approved retrospective descriptive cross-sectional study on all EHs performed at a tertiary hospital during the period of 1 January 2018 to 31 December 2019 was conducted. Read More

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January 2021

Thoracic endovascular aortic repair for symptomatic penetrating aortic ulcers and intramural hematomas is associated with poor outcomes.

J Vasc Surg 2020 Dec 16. Epub 2020 Dec 16.

Division of Vascular and Endovascular Surgery, Department of Surgery, NYU Langone Health, New York, NY. Electronic address:

Background: The natural history of penetrating aortic ulcers (PAUs) and intramural hematomas (IMHs) of the aorta has not been well described. Although repair is warranted for rupture, unremitting chest pain, or growth, no threshold has been established for treating those found incidentally. Thoracic endovascular aortic repair (TEVAR) offers an attractive approach for treating these pathologic entities. Read More

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December 2020

The Importance of Eosinopenia for Predicting Treatment Response in Patients with Cholangitis.

J Coll Physicians Surg Pak 2020 Nov;30(11):1143-1148

Department of Gastroenterology, Sakarya University Research and Education Hospital, Sakarya, Turkey.

Objective: To compare recovery of eosinopenia, C-reactive protein (CRP) and procalcitonin levels in predicting the response to treatment in patients with cholangitis.

Study Design: Descriptive, analytical study.

Place And Duration Of Study: Department of Gastroenterology, Sakarya Training and Research Hospital, Turkey between September 2018 and February 2019. Read More

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November 2020

Endogenous glucocorticoids may serve as biomarkers for migraine chronification.

Ther Adv Chronic Dis 2020 21;11:2040622320939793. Epub 2020 Jul 21.

Department of Neurology and Neurological Sciences, Division of Headache, Stanford University School of Medicine, Stanford, CA, USA.

Aims: The aims of this study were to: (a) identify differences in serum and cerebrospinal fluid (CSF) glucocorticoids among episodic migraine (EM) and chronic migraine (CM) patients compared with controls; (b) determine longitudinal changes in serum glucocorticoids in CM patients; and (c) determine migraine-related clinical features contributing to glucocorticoid levels.

Methods: Serum and CSF levels of cortisol and corticosterone were measured using liquid chromatography-mass spectrometry among adult patients with EM, CM, and controls. Serum and CSF samples were collected from 26 and four participants in each group, respectively. Read More

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Interventional Management of Refractory Trigeminal Neuropathic Pain: A Prospective Audit of a Novel Management Pathway in 70 Patients.

Pain Physician 2020 09;23(5):E525-E534

University Hospitals of Leicester NHS Trust, Leicester, UK.

Background: Trigeminal neuropathic pain (TNP) can present as a constant, unremitting unilateral facial pain. Current management is based on expert recommendation that includes pharmacologic agents and psychological therapy. However, treatment success with pharmacologic management is poor. Read More

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September 2020

Hyperplasia and accelerated hypertrophy of marrow adipocytes with knee immobilization were sustained despite remobilization.

J Appl Physiol (1985) 2020 10 27;129(4):701-708. Epub 2020 Aug 27.

Department of Biology, Faculty of Science, University of Ottawa, Ontario, Canada.

Skeletal disuse can cause an accumulation of bone marrow adipose tissue (MAT) characterized by a combination of marrow adipocyte hyperplasia and/or hypertrophy. The malleability of MAT accumulation and of the hyperplasia and hypertrophy upon remobilization is unknown. In this study, we showed extensive hyperplasia and accelerated hypertrophy of bone marrow adipocytes in the proximal tibia epiphysis of rat knees immobilized for durations between 1 and 32 wk. Read More

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October 2020

The course of depression in late life: a longitudinal perspective.

Epidemiol Psychiatr Sci 2020 Jul 29;29:e147. Epub 2020 Jul 29.

Centre for Biomedical Research in Mental Health (CIBERSAM), Spain.

Depression in old age deserves special attention in view of the fact of progressive population ageing, because of the way in which depression and risk factors interact in this period of life and the particularly negative impact of late-life depression on health and quality of life. This editorial aims to provide some insight into longitudinal aspects of depression in old age. Depression may follow varying trajectories (e. Read More

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Clinical Use of Short-Course and Low-Dose Corticosteroids in Patients With Non-severe COVID-19 During Pneumonia Progression.

Front Public Health 2020 3;8:355. Epub 2020 Jul 3.

Nanjing Infectious Disease Center, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China.

The emerging coronavirus disease 2019 (COVID-19) has become a serious public health concern with a high number of fatalities. It is unclear whether corticosteroids could be a candidate for an early intervention strategy for patients with COVID-19. In this retrospective cohort study, we analyzed data from 28 corticosteroid-treated patients with non-severe but advanced COVID-19, in which short-course and low-dose corticosteroids were administered because of unremitting or worsening clinical conditions during hospitalization. Read More

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[Clinical Features of Nosocomial Infections in Agranulocytosis Patients with Hematological Malignancies and Analysis of Risk Factors].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Apr;28(2):669-676

Department of Hematology, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China,E-mail: [email protected] 163.com.

Objective: To explore the clinical features and risk factors for nosocomial infections in agranulocytosis patients with hematological malignancies so as to provide basis for clinical prevention and treatment of nosocomial infections.

Methods: The clinical data of 725 patients with agranulocytosis in the First Hospital of Lanzhou University from May 2015 to May 2018 were retrospectively analyzed, including sex, age, primary disease, treatment stage, agranulocytosis degree, agranulocytosis duration, nosocomial infection, infectous site, average length of stay and average days of infection. Univariate analysis (Chi-square test) and multivariate analysis (non-conditional Logistic regression models) were used to analyze the risk factors of nosocomial infection. Read More

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The Epidemiology of Epilepsy.

Ettore Beghi

Neuroepidemiology 2020 18;54(2):185-191. Epub 2019 Dec 18.

Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy,

Epilepsy is a chronic disease of the brain characterized by an enduring (i.e., persisting) predisposition to generate seizures, unprovoked by any immediate central nervous system insult, and by the neurobiologic, cognitive, psychological, and social consequences of seizure recurrences. Read More

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February 2021

Stability of clinically relevant depression symptoms in old-age across 11 cohorts: a multi-state study.

Acta Psychiatr Scand 2019 12 20;140(6):541-551. Epub 2019 Oct 20.

Centre for Biomedical Research in Mental Health (CIBERSAM), Madrid, Spain.

Aims: To study the temporal dynamics of depression symptom episodes in old-age and the related influence of risk factors.

Methods: Data from 41 362 old adults (54.61% women; mean age = 75. Read More

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December 2019

McCune-Albright Syndrome With Unremitting Hyperthyroidism at Early Age: Management Perspective for Early Thyroidectomy.

Glob Pediatr Health 2019 9;6:2333794X19875153. Epub 2019 Sep 9.

Baylor College of Medicine, Houston, TX, USA.

. McCune-Albright syndrome (MAS) is characterized by hyperpigmented macules, endocrinopathies, and fibrous dysplasia. Hyperthyroidism is the second most common endocrinopathy in MAS and its management is challenging, particularly among infants and toddlers. Read More

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September 2019

Revision of a Medial UKA to a Kinematic Aligned TKA: Comparison of Operative Complexity, Postoperative Alignment, and Outcome Scores to a Primary TKA.

J Knee Surg 2021 Mar 9;34(4):406-414. Epub 2019 Sep 9.

Department of Orthopaedic Surgery, University of California, Davis, Sacramento, California.

Revision of a medial unicompartmental knee arthroplasty (UKA) to a mechanically aligned total knee arthroplasty (MA TKA) is inferior to a primary TKA; however, revision with kinematic alignment (KA) has not been well studied. The present study determined whether patients revised with KA had a higher use of revision components, different postoperative alignment, and different clinical outcome scores from patients with a primary KA TKA. From 2006 to 2017, all patients suitable for a revision of a failed medial UKA to a TKA and a primary TKA were treated with KA. Read More

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Development of homeothermic endothermy is delayed in high-altitude native deer mice (Peromyscus maniculatus).

Proc Biol Sci 2019 07 24;286(1907):20190841. Epub 2019 Jul 24.

Department of Biology, McMaster University, Hamilton, Ontario, Canada L8S 4K1.

Altricial mammals begin to independently thermoregulate during the first few weeks of postnatal development. In wild rodent populations, this is also a time of high mortality (50-95%), making the physiological systems that mature during this period potential targets for selection. High altitude (HA) is a particularly challenging environment for small endotherms owing to unremitting low O and ambient temperatures. Read More

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Experiences of racism among Aboriginal and Torres Strait Islander adults living in the Australian state of Victoria: a cross-sectional population-based study.

BMC Public Health 2019 Mar 14;19(1):309. Epub 2019 Mar 14.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Rd, Melbourne, Victoria, 3004, Australia.

Background: Racism is a key determinant of the health of Indigenous Australians that may explain the unremitting gap in health and socioeconomic outcomes between Indigenous and non-Indigenous Australians. We quantified the population-based prevalence of experiences of racism of Indigenous adults in the Australian state of Victoria and investigated whether this was independent of social determinants and lifestyle risk factors.

Methods: We combined data from the 2011, 2012 and 2014 Victorian Population Health Surveys to obtain a sample size of 33,833 Victorian adults, including 387 Indigenous adults. Read More

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Severe and enduring anorexia nervosa: Can risk of persisting illness be identified, and prevented, in young patients?

Int J Eat Disord 2019 04 14;52(4):478-480. Epub 2019 Jan 14.

Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.

Objective: Long-term outcome studies of anorexia nervosa (AN) have demonstrated that up to 20% of cases will follow an unremitting course despite many attempts at symptom-based treatments. The objectives of this study are to identify in a younger age group with AN whether persistent illness can be identified early and prevented.

Methods: An extensive literature review of such studies published in Pubmed was conducted. Read More

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A standardized rat burr hole defect model to study maxillofacial bone regeneration.

Acta Biomater 2019 03 31;86:450-464. Epub 2018 Dec 31.

Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University and Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China. Electronic address:

With high incidence rate and unique regeneration features, maxillofacial burr hole bone defects require a specially designed bone defect animal model for the evaluation of related bone regenerative approaches. Although some burr hole defect models have been developed in long bones or calvarial bones, the mandible has unique tissue development origins and regenerative environments. This suggests that the defect model should be prepared in the maxillofacial bone area. Read More

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Epilepsy in classic Rett syndrome: Course and characteristics in adult age.

Epilepsy Res 2018 09 23;145:134-139. Epub 2018 Jun 23.

Department of Neurology and Clinical Neurophysiology, St. Olav's University Hospital, P.O. Box 3250, Torgarden, 7006, Trondheim, Norway; Department of Neuroscience, Norwegian University of Science and Technology, 7491, Trondheim, Norway. Electronic address:

Purpose: Rett syndrome (RTT) is a neurodevelopmental disorder that almost exclusively affects females. Epilepsy is a major clinical feature, but its long-term course in RTT has not been sufficiently explored. This study addresses the development of the epilepsy in adults with RTT. Read More

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September 2018

Neonatal Presentation of Unremitting Inflammatory Bowel Disease.

Iran J Med Sci 2018 May;43(3):328-331

Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. Read More

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Clinical Characteristics and Prognosis of Severe Anti-N-methyl-D-aspartate Receptor Encephalitis Patients.

Neurocrit Care 2018 10;29(2):264-272

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.

Background And Purpose: Data concerning the characteristics and duration of the critical manifestations, treatment response, and long-term outcomes of severe anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis patients compared to those of non-severe patients are limited. This observational study was performed to explore the clinical characteristics and long-term outcomes of severe anti-NMDAR encephalitis patients.

Methods: According to their characteristics on admission to the neurology intensive care unit, patients with anti-NMDAR encephalitis were divided into a severe group and a non-severe group. Read More

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October 2018

Clinical heterogeneity of mitochondrial NAD kinase deficiency caused by a NADK2 start loss variant.

Am J Med Genet A 2018 03 1;176(3):692-698. Epub 2018 Feb 1.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.

Mitochondrial NAD kinase deficiency (NADK2D, OMIM #615787) is a rare autosomal recessive disorder of NADPH biosynthesis that can cause hyperlysinemia and dienoyl-CoA reductase deficiency (DECRD, OMIM #616034). NADK2 deficiency has been reported in only three unrelated patients. Two had severe, unremitting disease; one died at 4 months and the other at 5 years of age. Read More

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Early-onset epileptic encephalopathy with de novo SCN8A mutation.

Epilepsy Res 2018 01 28;139:9-13. Epub 2017 Oct 28.

Department of Pediatrics, Second Xiangya Hospital, Central South University, 139 Mid Renmin Road, Furong District, Changsha City, Hunan Province 410011, China. Electronic address:

Early-onset epileptic encephalopathies (EOEEs) are clinically and genetically heterogeneous disorders characterized by intractable seizures and unremitting interictal paroxysmal epileptiform activity. Consequently, these syndromes impair neurodevelopment during the first year of life. Currently, the etiology of these disorders is largely unknown. Read More

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January 2018