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Psychophysical predictors of experimental muscle pain intensity following fatiguing calf exercise.

PLoS One 2021 30;16(7):e0253945. Epub 2021 Jul 30.

Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.

Musculoskeletal pain affects approximately 20% of the population worldwide and represents one of the leading causes of global disability. As yet, precise mechanisms underlying the development of musculoskeletal pain and transition to chronicity remain unclear, though individual factors such as sleep quality, physical activity, affective state, pain catastrophizing and psychophysical pain sensitivity have all been suggested to be involved. This study aimed to investigate whether factors at baseline could predict musculoskeletal pain intensity to an experimental delayed onset of muscle soreness (DOMS) pain model. Read More

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Jumping into a Healthier Future: Trampolining for Increasing Physical Activity in Children.

Sports Med Open 2021 Jul 30;7(1):53. Epub 2021 Jul 30.

School of Clinical and Applied Sciences, Leeds Beckett University, Leeds, Great Britain.

Objectives: Physical activity in children and adolescents has positive effects on cardiopulmonary function in this age group as well as later in life. As poor cardiopulmonary function is associated with higher mortality and morbidity, increasing physical activity especially in children needs to become a priority. Trampoline jumping is widely appreciated in children. Read More

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Olfaction in patients with Parkinson's disease: a new threshold test analysis through turning points trajectories.

J Neural Transm (Vienna) 2021 Jul 30. Epub 2021 Jul 30.

Section of Neurology, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Piazzale Scuro 10, 37134, Verona, Italy.

Olfactory deficit is a widely documented non-motor symptom in Parkinson's disease (PD). Abnormal turning points trajectories through olfactory threshold testing have been recently reported in patients with olfactory dysfunction, who seem to adapt faster to olfactory stimuli, but data on PD patients are lacking. The aim of this study is to perform olfactory threshold test and explore the turning points trajectories in PD patients in comparison to normal controls. Read More

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App-Tailoring Requirements to Increase Stress Management Competencies Within Families: Cross-sectional Survey Study.

J Med Internet Res 2021 Jul 30;23(7):e26376. Epub 2021 Jul 30.

Department of Movement Science, Faculty of Psychology and Human Movement, University of Hamburg, Hamburg, Germany.

Background: Families experiencing high levels of psychological distress are considered a particularly vulnerable population for adverse effects on mental and physical health. Moreover, highly stressed individuals engage less in mental health promoting activities and show low stress management competencies. App-based stress interventions seem promising for the treatment and prevention of stress outcomes and might be a low-threshold solution. Read More

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Individual physiological and mitochondrial responses during 12 weeks of intensified exercise.

Physiol Rep 2021 Aug;9(15):e14962

Institute for Health and Sport (iHeS), Victoria University, Melbourne, Australia.

Aim: Observed effects of exercise are highly variable between individuals, and subject-by-training interaction (i.e., individual response variability) is often not estimated. Read More

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Assessing measurement invariance in the EORTC QLQ-C30.

Qual Life Res 2021 Jul 29. Epub 2021 Jul 29.

Department of Methodology and Statistics, Tilburg School of Social and Behavioral Sciences, Tilburg University, Tilburg, The Netherlands.

Purpose: We aimed to investigate measurement invariance (MI) in the European Organisation for research and treatment of cancer quality of life questionnaire core 30 (EORTC QLQ-C30) in a heterogeneous sample of patients with cancer.

Methods: Data from 12 studies within the PROFILES registry were used for secondary analyses (n = 7007). We tested MI by successive restrictions on thresholds, loadings, and intercepts across subgroups based on primary cancer sites, age, sex, time since diagnosis, and life stage, using multigroup confirmatory factor analysis (MGCFA) for ordered categorical measures. Read More

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Patterns of hearing changes in women and men from denarians to nonagenarians.

Lancet Reg Health West Pac 2021 Apr 24;9:100131. Epub 2021 Mar 24.

Department of Otolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjuku, Tokyo 160-8582, Japan.

Background: Hearing loss needs to be diagnosed and treated early, especially in older individuals, since presbycusis potentially increases the risk of depression and dementia. However, standard data on hearing thresholds across the life-span in Japanese individuals are lacking.

Methods: In a retrospective consecutive sample of 10681 native-Japanese speakers (37. Read More

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Evaluating Baseline and Sensitised Heat Nociception in Adult .

Bio Protoc 2021 Jul 5;11(13):e4079. Epub 2021 Jul 5.

Dr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre, Centenary Institute, and School of Life and Environmental Sciences, The University of Sydney, Camperdown NSW 2006, Australia.

Chronic pain is a complex disease that affects a large proportion of the population. With little to no effective treatments currently available for patients, this malady presents a large burden to society. has been previously used to describe conserved molecular components of nociception in larvae and adults. Read More

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Discriminating between IgG4-related orbital disease and other causes of orbital inflammation with intra voxel incoherent motion (IVIM) MR imaging at 3T.

Diagn Interv Imaging 2021 Jul 26. Epub 2021 Jul 26.

Department of Neuroradiology, Fondation Adolphe de Rothschild Hospital, 75019 Paris, France.

Purpose: The purpose of this prospective study was to determine the capabilities of intravoxel incoherent motion (IVIM) MRI at 3 Tesla in discriminating between IgG4-related orbital disease (IgG4-ROD) and other causes of orbital inflammation.

Materials And Methods: Main selection criteria for the patients enrolled in this prospective study were age over 18 years and histopathologicaly proven orbital inflammatory lesion. MRI examinations were performed prior to surgery and treatment in all patients with suspected orbital inflammation. Read More

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Factors predicting clinical outcomes from 494 vitrified oocyte donation cycles at a UK-regulated egg bank.

Reprod Biomed Online 2021 May 24. Epub 2021 May 24.

London Egg Bank, London Women's Clinic, 113-115 Harley Street, London W1G 6AP, UK. Electronic address:

Research Question: Do donor age, AMH, AFC, BMI and reproductive history predict response to ovarian stimulation? Do donor and recipient clinical markers and embryology parameters predict recipient pregnancy and live birth?

Design: Retrospective cohort study of 494 altruistic oocyte donors aged 18-35 years; 340 were matched to 559 recipients. Predictors of donor total oocyte yield and total mature oocyte yield were identified. Total and mature oocyte number were compared according to stratified donor AMH and age. Read More

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Baseline extended zone retinal vascular calibers associate with sensory nerve abnormalities in adolescents with type 1 diabetes: a prospective longitudinal study.

Diabet Med 2021 Jul 29:e14662. Epub 2021 Jul 29.

The Children's Hospital at Westmead, Sydney, Australia.

Objective: The relationship between retinal vascular calibers (RVCs) and diabetic neuropathy is unclear. We investigated associations between RVCs and sensory nerve abnormality in adolescents with type 1 diabetes.

Research Design And Methods: In a prospective longitudinal study of 889 adolescents with type 1 diabetes with baseline mean (±SD) age 14. Read More

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Breast Cancer Screening Among Childhood Cancer Survivors Treated Without Chest Radiation: Clinical Benefits and Cost-Effectiveness.

J Natl Cancer Inst 2021 Jul 29. Epub 2021 Jul 29.

Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA.

Background: Early initiation of breast cancer screening is recommended for high-risk women, including survivors of childhood cancer treated with chest radiation. Recent studies suggest that female survivors of childhood leukemia or sarcoma treated without chest radiation are also at elevated early onset breast cancer risk. However, the potential clinical benefits and cost-effectiveness of early breast cancer screening among these women are uncertain. Read More

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A systematic review of temporomandibular disorder diagnostic methods.

Cranio 2021 Jul 29:1-13. Epub 2021 Jul 29.

Department of Health Sciences (GIDFYS), Miguel de Cervantes European University, Valladolid, Spain.

: To compile the screening tools used to study temporomandibular disorders (TMD), classify and analyze their potential application in the field of physiotherapy. All gathered data included randomized clinical trials on humans over 18 years of age pulled from three databases up to November 2019. Nineteen articles were retained, in which the subjects included 1095 women and 385 men. Read More

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Lower seroprevalence for SARS-CoV-2-specific antibodies among kidney transplant recipients compared to the general population in the city of Sao Paulo, Brazil.

Transpl Infect Dis 2021 Jul 29. Epub 2021 Jul 29.

Transplant Division, Hospital do Rim, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

Background: Kidney transplant recipients have higher COVID-19 associated mortality compared to the general population. However, as only symptomatic patients seek medical attention, the current level of exposure, the main sources of acquisition and the behavior of humoral immunity over time are poorly understood.

Methods: This cross-sectional prospective single-center study recruited kidney transplant recipients of any age living in Sao Paulo. Read More

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Ethnicity, Comorbid Medical Conditions, and SARS-CoV-2 Test Cycle Thresholds in the Veteran Population.

J Racial Ethn Health Disparities 2021 Jul 28. Epub 2021 Jul 28.

Department of Pathology and Laboratory Medicine, Corporal Michael J Crescenz Veteran Affairs Medical Center (CMCVAMC), 3900 Woodland Ave, Philadelphia, PA, 19104, USA.

Background And Aims: It has been documented that African Americans have been significantly affected by COVID-19 infection due to systemic societal factors, which may lead to increases in comorbid medical history and subsequently vulnerability to having higher viral loads as measured by the cycle threshold/number (CT/CN) values by reverse transcriptase polymerase chain reaction (RT-PCR). Differences in CT/CN values by ethnicity and comorbid medical history could play an important role in public health research, particularly in elucidating the reasons for differential public health outcomes by ethnicity, as viral loads are known to correlate with disease severity. However, there is a gap in the literature regarding CT/CN values by ethnicity and comorbid medical history. Read More

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Diagnostic accuracy of screening tools for chronic obstructive pulmonary disease in primary health care: Rapid evidence synthesis.

J Family Med Prim Care 2021 Jun 2;10(6):2184-2194. Epub 2021 Jul 2.

The George Institute for Global Health, New Delhi, India.

Background: Chronic obstructive pulmonary disease (COPD) contributed significantly to burden of diseases in India, with missed, incorrect, and delayed diagnosis in primary care. We conducted a rapid evidence synthesis, to summarize the evidence on accuracy of the screening tests for COPD in primary health care on request form State Health Resource Centre, Chhattisgarh.

Methods: Considering the rapid nature of decision making, our approach was to first search for existing systematic reviews. Read More

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Age Influences Loss Aversion Through Effects on Posterior Cingulate Cortical Thickness.

Front Neurosci 2021 12;15:673106. Epub 2021 Jul 12.

Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United States.

Decision-making strategies shift during normal aging and can profoundly affect wellbeing. Although overweighing losses compared to gains, termed "loss aversion," plays an important role in choice selection, the age trajectory of this effect and how it may be influenced by associated changes in brain structure remain unclear. We therefore investigated the relationship between age and loss aversion, and tested for its mediation by cortical thinning in brain regions that are susceptible to age-related declines and are implicated in loss aversion - the insular, orbitofrontal, and anterior and posterior cingulate cortices. Read More

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Association of Proportional Recovery After Stroke With Health-Related Quality of Life.

Stroke 2021 Jul 29:STROKEAHA120033672. Epub 2021 Jul 29.

Department of Neurology, The University of Chicago, IL (S.P.).

Background And Purpose: No data exists on whether proportional recovery (PR) is associated with health-related quality of life (HRQOL) domains. We evaluated whether PR was associated with domain-specific HRQOL scores at 3 months after ischemic stroke.

Methods: This prospective cohort study enrolled patients with ischemic stroke between January 2017 and June 2018. Read More

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Automated Adaptive Wideband Acoustic Reflex Threshold Estimation in Normal-hearing Adults.

Ear Hear 2021 Jul 26. Epub 2021 Jul 26.

Hearing & Balance Research Program James H. Quillen VA Medical Center, Mountain Home, Tennessee Department of Audiology & Speech Language Pathology, East Tennessee State University, Johnson City, Tennessee VA Portland Health Care System, National Center for Rehabilitative Auditory Research, Portland, Oregon Department of Otolaryngology, Head and Neck Surgery, Oregon Health & Science University, Portland, Oregon Boys Town National Research Hospital, Omaha, Nebraska Neuroscience and Cognitive Science Program, Hearing and Speech Sciences Department, University of Maryland, College Park, Maryland.

Acoustic stapedius reflex threshold (ART) tests are included in a standard clinical acoustic immittance test battery as an objective cross-check with behavioral results and to help identify site of lesion. In traditional clinical test batteries, middle-ear admittance of a 226 Hz probe is estimated using ear-canal measurements in the presence of a reflex-activating stimulus. In the wideband (WB) acoustic immittance ART test used in this study, the pure-tone probe is replaced by a WB probe stimulus and changes in absorbed power are estimated using ear-canal measurements in the presence of the activator. Read More

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Objective and Subjective Outcomes in Patients with Hearing Aids: A Cross-Sectional, Comparative, Associational Study.

Audiol Neurootol 2021 Jul 28:1-9. Epub 2021 Jul 28.

Hearing Center/Hearing and Speech Laboratory, Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.

Introduction: Outcome assessment for hearing aids (HAs) is an essential part of HA fitting and validation. There is no consensus about the best or standard approach for evaluating HA outcomes. And, the relationship between objective and subjective measures is ambiguous. Read More

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Magnocellular visual function in developmental dyslexia: deficit in frequency-doubling perimetry and ocular motor skills.

Arq Bras Oftalmol 2021 Jul 14. Epub 2021 Jul 14.

Laboratory of Applied Research in Neuroscience of Vision, Hospital de Olhos de Minas Gerais-Dr. Ricardo Guimarães, Belo Horizonte, MG, Brazil.

Purpose: This study aimed to verify if patients with developmental dyslexia present deficits coherent with visual magnocellular dysfunction.

Methods: Participants with confirmed diagnosis of developmental dyslexia (n=62; age range=8-25 years; mean age=13.8 years, standard deviation=3. Read More

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Effects of Alternating Unilateral vs. Bilateral Resistance Training on Sprint and Endurance Cycling Performance in Trained Endurance Athletes: A 3-Armed, Randomized, Controlled, Pilot Trial.

J Strength Cond Res 2021 Jul 26. Epub 2021 Jul 26.

The German Research Center for Elite Sport Cologne, German Sport University Cologne, Cologne, Germany; Department of Preventative and Rehabilitative Sports and Performance Medicine, Institute of Cardiology and Sport Medicine, German Sport University Cologne, Cologne, Germany; Department of Intervention Research in Exercise Training, Institute of Exercise Training and Sport Informatics, German Sport University Cologne, Cologne, Germany; Department of Molecular and Cellular Sports Medicine, Institute of Cardiology and Sports Medicine, German Sport University Cologne, Cologne, Germany; and Institute of Interdisciplinary Exercise Science and Sports Medicine, Medical School Hamburg, Hamburg, Germany.

Abstract: Ji, S, Donath, L, and Wahl, P. Effects of alternating unilateral vs. bilateral resistance training on sprint and endurance cycling performance in trained endurance athletes: A 3-armed, randomized, controlled, pilot trial. Read More

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Characteristics of hearing loss in elderly outpatients over 60 years of age: an annual cross-sectional study.

Acta Otolaryngol 2021 Jul 28:1-6. Epub 2021 Jul 28.

College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital; National Clinical Research Center for Otolaryngologic Diseases; Key Lab of Hearing Science, Ministry of Education; Beijing Key Lab of Hearing Impairment for Prevention and Treatment, Beijing, China.

Background: The prevention and treatment of presbycusis becomes a serious health challenge and socio-economic problem.

Objectives: We performed a cross-sectional analysis of the audiometry results of all elderly patients who visited our department throughout the year of 2018.

Material And Methods: A total of 5520 people aged 60 and over were included and divided into three groups: young-old group (60-74 years old), old-old group (75-89 years old), and longevous group (over 90 years old). Read More

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Systematic review and meta-analysis of Sniffin Sticks Test performance in Parkinson's disease patients in different countries.

Eur Arch Otorhinolaryngol 2021 Jul 28. Epub 2021 Jul 28.

Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.

Introduction: Olfaction impairment occurs in about 90% of patients with Parkinson's disease. The Sniffin Sticks Test is a widely used instrument to measure olfactory performance and is divided into three subtests that assess olfactory threshold, discrimination and identification. However, cultural and socioeconomic differences can influence test performance. Read More

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Evaluation of Physiological Parameters on Discomfort Glare Thresholds Using LUMIZ 100 Tool.

Transl Vis Sci Technol 2021 Jul;10(8):28

Department of Optics and Optometry and Vision Sciences, University of Valencia, Burjassot, Spain.

Purpose: To assess the links between discomfort glare sensitivity and physiological factors such as eye biometry, refraction, skin phototype, age, and gender among a large sample of healthy human subjects.

Methods: A total of 489 participants who were 20 to 70 years old (241 men, 248 women) underwent discomfort glare threshold measurements via the LUMIZ 100. Eye biometry and optical quality were measured using a Zeiss IOLMaster 700 biometer and i. Read More

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Association Between NEDD4L Variation and the Genetic Risk of Acute Appendicitis: A Multi-institutional Genome-Wide Association Study.

JAMA Surg 2021 Jul 28. Epub 2021 Jul 28.

Department of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts.

Importance: The familial aspect of acute appendicitis (AA) has been proposed, but its hereditary basis remains undetermined.

Objective: To identify genomic variants associated with AA.

Design, Setting, And Participants: This genome-wide association study, conducted from June 21, 2019, to February 4, 2020, used a multi-institutional biobank to retrospectively identify patients with AA across 8 single-nucleotide variation (SNV) genotyping batches. Read More

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An exploration of the impact of COVID-19 on mental health in South Africa.

Psychol Health Med 2021 Jul 28:1-11. Epub 2021 Jul 28.

School of Public Health, University of the Western Cape, Cape Town, South Africa.

In response to the COVID-19 pandemic, South Africa implemented a strict stay-at-home order. The mental health effects of the pandemic and related containment measures are minimally documented in this region. This study examines the association between COVID-19 related stressors and mental health during a strict stay-at-home order in South Africa. Read More

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Axillary Nodal Metastases in Invasive Lobular Carcinoma Versus Invasive Ductal Carcinoma: Comparison of Node Detection and Morphology by Ultrasound.

AJR Am J Roentgenol 2021 Jul 28. Epub 2021 Jul 28.

The University of Texas MD Anderson Cancer Center, Department of Breast Imaging, 1515 Holcombe Blvd, Unit 1350, Houston, Texas 77030.

Invasive lobular carcinoma is more subtle on imaging compared with invasive ductal carcinoma; nodal metastases may also differ on imaging between these. To determine whether invasive lobular carcinoma and invasive ductal carcinoma differ in the detection rate by ultrasound (US) of metastatic axillary nodes and in metastatic nodes' US characteristics. This retrospective study included 695 women (median age 53 years) with breast cancer in a total of 723 breasts (76 lobular, 586 ductal, 61 mixed), with biopsy-proven axillary nodal metastases and who underwent pretreatment US. Read More

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An overview of pain in Parkinson's disease.

Clin Park Relat Disord 2020 28;2:1-8. Epub 2019 Nov 28.

Department of Neurology, National Taiwan University, College of Medicine, Taipei, Taiwan.

Pain is a common non-motor symptom of Parkinson's disease (PD) and the prevalence of pain among PD patients varies because of the disease stage, co-morbidities, and evaluating tools. Risk factors for pain in PD include an early age of onset, long disease duration, motor complications, concomitant depressive symptoms, female gender, and associated medical conditions. In patients with PD, pain can be classified as musculoskeletal pain, chronic body pain (central or visceral), fluctuation-related pain, nocturnal pain, orofacial pain, pain with discolouration/oedema/swelling, and radicular/neuropathic pain; musculoskeletal pain as the most common type. Read More

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November 2019

Pharmacokinetics and safety of liposomal bupivacaine after local infiltration in healthy Chinese adults: a phase 1 study.

BMC Anesthesiol 2021 Jul 27;21(1):197. Epub 2021 Jul 27.

Pacira BioSciences, Inc., 5 Sylvan Way, Parsippany-Troy Hills, NJ, USA.

Background: Liposomal bupivacaine (LB) is a long-acting formulation of bupivacaine. The safety and efficacy of LB has been demonstrated across surgical procedures. However, pharmacokinetic (PK) parameters and safety of LB in the Chinese population have not been assessed. Read More

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