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Second trimester prediction of gestational diabetes: maternal analytes as an additional screening tool.

J Perinat Med 2021 Jul 27. Epub 2021 Jul 27.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Hawaii, Honolulu, HI, USA.

Objectives: Early diagnosis of gestational diabetes can lead to greater optimization of glucose control. We evaluated associations between maternal serum analytes (alpha-fetoprotein [AFP], free beta-human chorionic gonadotropin [beta-hCG], inhibin, and estriol) and the development of gestational diabetes mellitus (GDM).

Methods: This retrospective cohort study identified single-ton pregnancies with available second trimester serum analytes between 2009 and 2017. Read More

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Outcomes after Acute Peritoneal Dialysis for Critical Cardiorenal Syndrome Type 1.

Cardiorenal Med 2021 Jul 27:1-9. Epub 2021 Jul 27.

Department of Medicine, Maharat Nakhon Ratchasima Hospital, Nakhonratchasima, Thailand.

Introduction: The aim of the study was to demonstrate the outcomes of peritoneal dialysis (PD) in critically ill cardiorenal syndrome type 1 (CRS1).

Methods: A cohort of 147 patients with CRS1 who received PD from 2011 to 2019 in a referral hospital in Thailand was analyzed. The primary outcome was 30-day in-hospital mortality. Read More

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Vision Impairment and Adverse Health Conditions in Congolese Older People: A Population-Based Study.

Gerontology 2021 Jul 27:1-10. Epub 2021 Jul 27.

INSERM, IRD, U1094 Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, University of Limoges, Limoges, France.

Introduction: In sub-Saharan Africa, many older people experience vision impairment (VI) and its adverse health outcomes. In this study, we examined separately the association between VI and each adverse health conditions (cognitive disorders, vision-related quality of life [VRQoL], and daily functioning interference [DFI]) among Congolese older people. We also explored whether VI had a significant effect on VRQoL components in our population. Read More

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The Risk Factors and Clinical Outcomes Associated with Acute Kidney Injury in Patients with COVID-19: Data from a Large Cohort in Iran.

Kidney Blood Press Res 2021 Jul 27:1-9. Epub 2021 Jul 27.

Department of Nephrology Diseases, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Kidney involvement, ranging from mild hematuria and proteinuria to acute kidney injury (AKI) in patients with coronavirus disease-2019 (COVID-19), is a recent finding with various incidence rates reported among hospitalized patients with COVID-19. Given the various AKI rates and their associated risk factors, lack of AKI recovery in the majority of patients hospitalized with COVID-19, and limited data regarding AKI in patients with COVID-19 in Iran, we aim to investigate the potential risk factors for AKI development and its incidence in patients hospitalized with COVID-19.

Methods: In this retrospective cohort study, we enrolled adult patients referred to the Sina Hospital, Iran, from February 20 to May 14, 2020, with either a positive PCR test or a highly susceptible chest computed tomography features consistent with COVID-19 diagnosis. Read More

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Sarcopenia Is Associated with Mortality in Adults: A Systematic Review and Meta-Analysis.

Gerontology 2021 Jul 27:1-16. Epub 2021 Jul 27.

Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.

Background: Sarcopenia can predispose individuals to falls, fractures, hospitalization, and mortality. The prevalence of sarcopenia depends on the population studied and the definition used for the diagnosis.

Objective: This systematic review and meta-analysis aimed to investigate the association between sarcopenia and mortality and if it is dependent on the population and sarcopenia definition. Read More

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Nephrologist Interventions to Avoid Kidney Replacement Therapy in Acute Kidney Injury.

Kidney Blood Press Res 2021 Jul 27:1-10. Epub 2021 Jul 27.

Nephrology Service, Civil Hospital of Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico.

Background: Based on the pathophysiology of acute kidney injury (AKI), it is plausible that certain early interventions by the nephrologist could influence its trajectory. In this study, we investigated the impact of 5 early nephrology interventions on starting kidney replacement therapy (KRT), AKI progression, and death.

Methods: In a prospective cohort at the Hospital Civil of Guadalajara, we followed up for 10 days AKI patients in whom a nephrology consultation was requested. Read More

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The Association between Glomerular Diameter and Secondary Focal Segmental Glomerulosclerosis in Chronic Kidney Disease.

Kidney Blood Press Res 2021 Jul 27:1-8. Epub 2021 Jul 27.

Department of Cardiovascular Medicine, Nephrology and Neurology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

Introduction: When nephron loss occurs, the glomerular filtration rate (GFR) is suggested to be maintained by glomerular hypertrophy, but excessive hypertrophy can rather lead to the formation of focal segmental glomerulosclerosis (FSGS), thereby causing progressive kidney damage. However, it is not clear how much glomerular hypertrophy leads to the formation of FSGS. We examined the association between glomerular diameter and FSGS lesions in chronic kidney disease (CKD) patients. Read More

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Longitudinal associations with alcohol consumption during the first COVID-19 lockdown: Associations with mood, drinking motives, context of drinking, and mental health.

Drug Alcohol Depend 2021 Jul 21;226:108913. Epub 2021 Jul 21.

Department of Psychology, Institute of Population Health, University of Liverpool, United Kingdom; Liverpool Centre for Alcohol Research, United Kingdom.

Background: Coronavirus (COVID-19) resulted in lockdown measures in the UK, which has impacted alcohol use. Alcohol is often used as a coping mechanism and there are public health concerns regarding excessive consumption due to the pandemic. We aimed to longitudinally assess drinking behaviors, and associated factors, during the first UK government-mandated lockdown. Read More

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Beyond internalizing and externalizing symptoms: The association between body disconnection and the symptoms of Internet gaming disorder.

Addict Behav 2021 Jul 7;123:107043. Epub 2021 Jul 7.

Faculty of Human and Social Sciences, UKE - Kore University of Enna, Enna, Italy.

As the vast majority of online videogames imply the immersion into an alternative reality where a virtual body is also involved, the current cross-sectional study aims to investigate the contribution of low body awareness (i.e. low attention to sensory cues indicating bodily state) and body dissociation (i. Read More

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Hair and nails as noninvasive bioindicators of human exposure to chlorinated paraffins: Contamination patterns and potential influencing factors.

Sci Total Environ 2021 Jul 23;798:149257. Epub 2021 Jul 23.

Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality, Jinan University, Guangzhou 511443, China. Electronic address:

Most of the studies on short- and medium-chain chlorinated paraffins (SCCPs and MCCPs) in human tissues have focused on human milk and blood. However, little is known about the occurrence of CPs in human hair and nails. In this study, SCCPs and MCCPs were analyzed in 62 pairs of human hair and nails from North China. Read More

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Nursing informatics competences of Finnish registered nurses after national educational initiatives: A cross-sectional study.

Nurse Educ Today 2021 Jul 20;106:105060. Epub 2021 Jul 20.

Finnish Institute for Health and Welfare, P.O. Box 30, FI-00271 Helsinki, Finland. Electronic address:

Background: Nursing informatics competences (ie. knowledge and skills in electronic and structured documentation) have become a necessary prerequisite for nurses to carry out their professional roles. Therefore, there is a global need to integrate nursing informatics into nursing curricula. Read More

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Cognition in children and young adults with myoclonus dystonia - A case control study.

Parkinsonism Relat Disord 2021 Jul 21;89:162-166. Epub 2021 Jul 21.

Department of Neurology, University of Groningen, University Medical Center Groningen, the Netherlands; Expertise Center Movement Disorders Groningen, University Medical Center Groningen (UMCG), Groningen, the Netherlands. Electronic address:

Introduction: In adult patients with myoclonus dystonia (MD), cognitive deficits regarding information processing speed and executive functioning have been demonstrated, but it is unclear whether cognition is also affected in young MD patients. The present study investigates cognition in young MD patients and the role of an SGCE mutation.

Methods: In this case control study 20 young MD patients (9 children (5. Read More

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On the prevention and treatment of Alzheimer's disease: Control the promoters and look beyond the brain.

Med Hypotheses 2021 Jul 19;154:110645. Epub 2021 Jul 19.

Harvard Medical School Multi-Campus Geriatric Fellowship, Boston, Massachusetts, USA. Electronic address:

Alzheimer's disease (AD) is a progressive incurable neurodegenerative disease of the brain afflicting a third of the population aged 85 and older. Pathologic hallmarks include extracellular plaques of amyloid-beta (Aß), intraneuronal neurofibrillary tangles of hyperphosphorylated tau protein, synaptic destruction, neuronal death, and brain atrophy. Neuroinflammation, mediated by microglia, is a central component of the disease, and is intricately connected with peripheral inflammation. Read More

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Age adjusted normative data for Video Head Impulse Test in healthy subjects.

Am J Otolaryngol 2021 Jul 23;42(6):103160. Epub 2021 Jul 23.

Otolaryngology and Head and Neck Surgery Division, School of Medicine and University Hospital "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.

Purpose: This study aims to assess the effect of age in vestibulo-ocular reflex (VOR) gain measured by Video Head Impulse Test (VHIT) and to present normative data of VOR gain, median gain at 40, 60, 80 and 0-100 ms, and gain asymmetry according to decades of life in healthy subjects.

Material And Methods: A total of 132 subjects with no previous history of vestibular disorders were enrolled to assess VOR gain by employing VHIT. The test was performed in the X-axis evaluating both horizontal semicircular canals (HSC). Read More

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INR and COVID-19 severity and mortality: A systematic review with meta-analysis and meta-regression.

Adv Med Sci 2021 Jul 21;66(2):372-380. Epub 2021 Jul 21.

Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, Australia; Department of Clinical Pharmacology, Flinders Medical Centre, Southern Adelaide Local Health Network, Adelaide, Australia. Electronic address:

Objectives: D-dimer elevations, suggesting a pro-thrombotic state and coagulopathy, predict adverse outcomes in coronavirus disease 2019 (COVID-19). However, the clinical significance of other coagulation markers, particularly the international normalized ratio (INR), is not well established. We conducted a systematic review and meta-analysis of the INR in COVID-19. Read More

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Evolution of physical activity and body weight changes in breast cancer survivors five years after diagnosis - VICAN 2 & 5 French national surveys.

Breast 2021 Jul 20;59:248-255. Epub 2021 Jul 20.

Aix Marseille Univ, INSERM, IRD, SESSTIM, Economics & Social Sciences Applied to Health & Analysis of Medical Information, CANBIOS Team Labelled League Against Cancer, 232 Bd Sainte Marguerite, 13273, Marseille Cedex, 9, France; APHM, BIOSTIC, Hop Timone, 264 Rue Saint-Pierre, 13005, Marseille, France. Electronic address:

Background: Regular physical activity (PA) and healthy body weight have proven benefits on survival in breast cancer (BC) survivors. We aimed to define predictors of long-term PA and weight gain in a representative sample of BC survivors.

Methods: Data were analysed from 723 women with BC who participated in both the 2012 and 2015 French National VICAN surveys. Read More

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Online sexual harassment and depression in Chilean adolescents: Variations based on gender and age of the offenders.

Child Abuse Negl 2021 Jul 24;120:105219. Epub 2021 Jul 24.

School of Health in Social Sciences, University of Edinburgh, UK.

Background: Online sexual harassment in adolescence is associated with depressive symptoms. There is, however, a dearth of research investigating variability of symptom profiles in this population in relation to offender gender and age.

Objective: To identify the proportion of adolescents reporting online harassment by different types of offenders and compare their levels of depression. Read More

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Effects of immunosuppression on the efficacy of vaccination against Mycoplasma gallisepticum infection in chickens.

Vet Microbiol 2021 Jul 12;260:109182. Epub 2021 Jul 12.

Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Immunosuppression can increase the susceptibility of chickens to other disease-causing pathogens and interfere with the efficacy of vaccination against those pathogens. Chicken anaemia virus (CAV) and infectious bursal disease virus (IBDV) are common causes of immunosuppression in chickens. Immunosuppression was induced by experimental infection with either CAV or IBDV to assess the effect of immunosuppression on the efficacy of vaccination with Mycoplasma gallisepticum strain ts-304 against infection with virulent M. Read More

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Psychiatric morbidity adult transgender people in Iran.

J Psychiatr Res 2021 Jul 22;142:33-39. Epub 2021 Jul 22.

Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Psychiatric morbidity among transgender and gender diverse people is thought to be to an important extent related to socio-cultural intolerance, but such morbidity has been understudied in non-western socio-political contexts. This study aims to report the psychiatric profiles of clients who are seeking gender-affirming treatment in a gender clinic in Iran. All transgender people who were consecutively referred to the Mashhad University of Medical Sciences in Mashhad, Iran, between February 2015 and December 2016 were investigated. Read More

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Experiential avoidance is associated with medical and mental health diagnoses in a national sample of deployed Gulf War veterans.

J Psychiatr Res 2021 Jul 22;142:17-24. Epub 2021 Jul 22.

Durham VA Health Care System, 508 Fulton Street, Durham, NC, 27705, USA; VA Mid-Atlantic Mental Illness Research, Education and Clinical Center, 3022 Croasdaile Dr., Durham, NC, 27705, USA; Duke University School of Medicine Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, DUMC 3625, Durham, NC, 27710, USA. Electronic address:

A substantial minority of deployed Gulf War veterans developed posttraumatic stress disorder (PTSD), depression, and several chronic illnesses. Although military combat and exposure to certain nuclear, biological, and chemical agents (NBCs) increase risk for post-deployment health problems, they do not fully explain many Gulf War veteran health diagnoses and are not viable treatment targets. Experiential avoidance (EA; one's unwillingness to remain in contact with unpleasant internal experiences) is a modifiable psychosocial risk factor associated with PTSD and depression in veterans as well as pain and gastrointestinal diseases in the general population. Read More

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Comorbidity in Stroke-Survivors: Prevalence and Associations with Functional Outcomes and Health.

J Stroke Cerebrovasc Dis 2021 Jul 24;30(10):106000. Epub 2021 Jul 24.

University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Objectives: The purpose of this study was to evaluate the prevalence and impact of stroke-related comorbidity in a community-based sample of stroke survivors. We sought to find out which types of comorbidity that were most important with respect to the patients' functional outcomes and general health.

Materials And Methods: All stroke survivors (n = 330) living in a medium-sized Swedish municipality were included. Read More

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Association of phthalate exposure with autistic traits in children.

Environ Int 2021 Jul 24;157:106775. Epub 2021 Jul 24.

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Background: Phthalates are synthetic chemicals with endocrine-disrupting properties. They are reportedly associated with various neurotoxic outcomes. Studies on exposure to phthalates and children's autistic traits have shown inconsistent results with respect to sex and susceptible time periods. Read More

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Intensive clinical trauma treatment for children and adolescents with mild intellectual disability or borderline intellectual functioning: A pilot study.

Res Dev Disabil 2021 Jul 24;117:104030. Epub 2021 Jul 24.

Trajectum, Zwolle, the Netherlands; Behavioural Science Institute, Radboud University, Nijmegen, the Netherlands.

Background: Children and adolescents with mild intellectual disability (MID) or borderline intellectual functioning (BIF) are at increased risk for posttraumatic stress disorder (PTSD) or trauma-related symptoms due to adverse childhood experiences (ACEs). Weekly provided treatment sessions and/or outpatient treatment may not be effective enough.

Aims: Investigate feasibility, safety and potential effectiveness of an intensive clinical trauma treatment in children and adolescents with MID-BIF and trauma-related symptoms as a result of ACEs or PTSD. Read More

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Chronic subdural hematoma-induced parkinsonism: A systematic review.

Clin Neurol Neurosurg 2021 Jul 21;208:106826. Epub 2021 Jul 21.

Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

Background: Chronic subdural hematoma (CSDH) is one of the most common neurosurgical cases, especially in elderly individuals. Secondary parkinsonism due to CSDH is a rare entity. The mechanism of parkinsonism symptoms in chronic subdural hematoma has been suggested to include direct mechanical compression of the basal ganglia due to hematoma or indirectly through brain structure changes due to space lesions and vascular disorders. Read More

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Postoperative oral dysfunction following oral cancer resection and reconstruction: A preliminary cross-sectional study.

Oral Oncol 2021 Jul 24;121:105468. Epub 2021 Jul 24.

Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.

Objectives: Oral cancer treatment reportedly causes decreased oral function, but few studies have examined the effects of oral cancer treatment on oral function in depth. This study aimed to comprehensively evaluate the oral function after treatment and classify the conditions related to oral dysfunction in patients with oral cancer.

Materials And Methods: We recruited participants, collected their background data, and evaluated their oral function from September 2019 to March 2021. Read More

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Comparison of Surgical Outcomes Between Staged and Simultaneous Decompression of Discontinuous Thoracic Ossification of the Ligamentum Flavum: A Retrospective Study.

World Neurosurg 2021 Jul 24. Epub 2021 Jul 24.

Department of Orthopaedics, Peking University Third Hospital, No. 49 Huayuanbei Rd, Haidian District, Beijing 100191, China.

Background: Discontinuous thoracic ossification of the ligamentum flavum (TOLF) is diagnosed according to the number and distribution of involved segments seen on magnetic resonance images. When TOLF causes thoracic myelopathy, surgical intervention for these lesions becomes unavoidable. However, there are few reports on the outcomes of surgery for discontinuous TOLF. Read More

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Global sagittal balance of spine in asymptomatic controls: A systematic review and meta-analysis.

World Neurosurg 2021 Jul 24. Epub 2021 Jul 24.

Mental Health Research Group, Health Metrics Research Centre, Iranian Institute for Health Sciences Research, ACECR, Tehran, Iran.

Objective: The purpose of this study was to assess the global sagittal balance of spine (GSBS) in asymptomatic controls.

Methods: PubMed, Scopus, Cochrane library, and Web of Science searched up to July 2020. Studies were screened for the GSB parameters including T1 pelvic angle (TPA), spinosacral angle (SSA), sagittal vertical axis (SVA), C7/ sacrofemoral distance ratio (Barrey index), odontoid hip axis (OD-HA) and Full Balance Index (FBI) as measured in asymptomatic participants. Read More

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Flexion contracture can be relieved by concurrent notchplasty in medial open wedge high tibial osteotomy.

Orthop Traumatol Surg Res 2021 Jul 24:103020. Epub 2021 Jul 24.

Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background: Given that medial open wedge high tibial osteotomy (OWHTO) not only delays the progression of osteoarthritis but also alleviates the resulting pain, surgical outcomes would be improved if limited ROM can also be managed. In this regard, the effect of concurrent notchplasty on flexion contracture has not been evaluated.

Hypothesis: (1) Concurrent notchplasty in OWHTO would relieve flexion contracture regardless of the severity of osteoarthritis and this effect would be maintained over time, and (2) concurrent notchplasty would not cause any added complications compared to the same procedure without notchplasty. Read More

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Effect of physical activity and BMI SDS on bone metabolism in children and adolescents.

Bone 2021 Jul 24:116131. Epub 2021 Jul 24.

Department of Pediatric Surgery, University Hospital Leipzig, Leipzig, Germany. Electronic address:

Objective: Children with obesity are known to have reduced bone density and are at a higher risk for fractures. This may be caused by decreased physical activity or a metabolic phenomenon. In this study, we evaluated associations of physical activity with bone metabolism in children and adolescents with and without obesity. Read More

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