225,045 results match your criteria age neonatal


Factors Associated With Neonatal Pneumonia and its Mortality in India: A Systematic Review and Meta-Analysis.

Indian Pediatr 2021 Nov;58(11):1059-1061

Department of Statistics, Public Health Evidence South Asia (PHESA), Manipal Academy of Higher Education, Manipal, Karnataka. Correspondence to: Dr Bhumika T Venkatesh, Room no. 35, Public Health Evidence South Asia (PHESA), Prasanna School of Public Health, Manipal Academy of Higher Education, Madhav Nagar, Manipal, Karnataka.

Background: Neonatal pneumonia remains a significant contributor to infant mortality in India and responsible for increased prevalence of infant deaths globally.

Objective: To identify risk factors associated with neonatal pneumonia and its mortality in India.

Study Design: A systematic review was conducted including both analytic study designs and descriptive study designs, which reported a quantitative analysis of factors associated with all the three types of pneumonia among neonates. Read More

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November 2021

Predictors of Mortality in Neonatal Pneumonia: An INCLEN Childhood Pneumonia Study.

Indian Pediatr 2021 Nov;58(11):1040-1045

Department of Neonatology, Niloufer Hospital and Osmania Medical College, Hyderabad, Telangana.

Background: Neonatal pneumonia contributes significantly to mortality due to pneumonia in the under-five age group, but the predictors of mortality are largely unknown.

Objectives: To evaluate the clinical and microbiological characteristics and other risk factors that predict mortality in neonates admitted with pneumonia in tertiary care centres.

Study Design: Prospective observational cohort study. Read More

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November 2021

Clinical characteristics, growth patterns, and long-term diabetes complications of 24 patients with neonatal diabetes mellitus: a single center experience.

Pediatr Diabetes 2021 Nov 27. Epub 2021 Nov 27.

The Jesse Z. and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva.

Objectives: Neonatal diabetes mellitus (NDM) is a rare form of monogenic diabetes, diagnosed before age 6 months. We aimed to describe the clinical characteristics, molecular genetics, and long-term follow-up of NDM patients from a single pediatric endocrine center in Israel.

Methods: Retrospective study (1975-2020) of all patients diagnosed with diabetes before 6 months of age, who tested negative for pancreatic autoantibodies. Read More

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November 2021

Retrospective comparison of pregnancy outcomes of fresh and frozen-warmed single blastocyst transfer: a 5-year single-center experience.

J Assist Reprod Genet 2021 Nov 26. Epub 2021 Nov 26.

Division of Gynecology and Reproductive Medicine, Department of Gynecology, Fertility Center, Humanitas Research Hospital, IRCCS, Via Manzoni 56, 20089, Rozzano, Milan, Italy.

Purpose: To assess whether live birth rates (LBR) and maternal/neonatal complications differed following single fresh and frozen-warmed blastocyst transfer.

Methods: The present retrospective observational study analyzed 4,613 single embryo transfers (SET) (646 fresh and 3,967 frozen) from January 1, 2014, to December 31, 2018. Fresh embryo transfer at blastocyst stage was considered according to the age of the patient and her prognosis. Read More

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November 2021

Testing positive pressure delivered from commercial and WHO-style pediatric bubble CPAP devices.

BMC Pediatr 2021 Nov 27;21(1):524. Epub 2021 Nov 27.

Division of Emergency Medicine, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, TX, USA.

Background/aim: Low-cost commercial bCPAP devices have been deployed in resource-limited settings to treat neonatal respiratory failure. The use of these devices has increased access to pediatric respiratory support for infants. However, constrained resources may result in substitution of recommended consumables and/or use in older age groups. Read More

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November 2021

Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study.

BMC Pregnancy Childbirth 2021 Nov 27;21(1):793. Epub 2021 Nov 27.

Key Laboratory of Reproductive Genetics (Ministry of Education), Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China.

Background: Parental body mass index (BMI) is associated with pregnancy outcomes. But the effect of parental prepregnancy BMI on offspring conceived via in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), especially the birth defect, remains to be determined. This study aimed to investigate the associations of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles. Read More

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November 2021

Energy Expenditure, Protein Oxidation and Body Composition in a Cohort of Very Low Birth Weight Infants.

Nutrients 2021 Nov 6;13(11). Epub 2021 Nov 6.

Neonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

The nutritional management of preterm infants is a critical point of care, especially because of the increased risk of developing extrauterine growth restriction (EUGR), which is associated with worsened health outcomes. Energy requirements in preterm infants are simply estimated, so the measurement of resting energy expenditure (REE) should be a key point in the nutritional evaluation of preterm infants. Although predictive formulae are available, it is well known that they are imprecise. Read More

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November 2021

Early Enteral Feeding Improves Tolerance of Parenteral Nutrition in Preterm Newborns.

Nutrients 2021 Oct 29;13(11). Epub 2021 Oct 29.

Department of Maternal and Child Health, Policlinico Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy.

(1) Background: The tolerance of preterm newborns for the high nutritional intakes given by parenteral nutrition (PN) is still debated because of the risk of metabolic complications. Despite enteral nutrition (EN) being the preferred route of nutrition, an exclusive enteral feeding is not always possible, as in preterm newborns, the gut is immature and less tolerant of EN. We aimed to study the impact of a minimal enteral feeding (MEF) on the possible early metabolic complications of PN in a cohort of preterms with gestational age at birth GA ≤ 29 + 6/7 weeks of postmenstrual age. Read More

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October 2021

Milk Formula Diet Alters Bacterial and Host Protein Profile in Comparison to Human Milk Diet in Neonatal Piglet Model.

Nutrients 2021 Oct 22;13(11). Epub 2021 Oct 22.

USDA-ARS, Arkansas Children's Nutrition Center, Little Rock, AR 72202, USA.

The metaproteome profiling of cecal contents collected from neonatal piglets fed pasteurized human milk (HM) or a dairy-based infant formula (MF) from postnatal day (PND) 2 to 21 were assessed. At PND 21, a subset of piglets from each group ( = 11/group) were euthanized, and cecal contents were collected for further metaproteome analysis. Cecal microbiota composition showed predominantly more Firmicutes phyla and family in the lumen of cecum of HM-fed piglets in comparison to the MF-fed group. Read More

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October 2021

Fetal Surveillance in Pregnancies with Myasthenia Gravis.

Medicina (Kaunas) 2021 Nov 20;57(11). Epub 2021 Nov 20.

Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Myasthenia gravis (MG) is an autoimmune condition, that commonly impacts adult women of reproductive age. Myasthenia gravis in pregnancy is rare, but the incidence is higher in different geographical areas. Pregnancies in mothers with MG can have an unfortunate outcome. Read More

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November 2021

Maternal-Fetal Outcomes in Women with Endometriosis and Shared Pathogenic Mechanisms.

Medicina (Kaunas) 2021 Nov 17;57(11). Epub 2021 Nov 17.

Department of Obstetrics and Gynecology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.

The connection between endometriosis and pregnancy outcomes is trending among the research topics. Until recently, endometriosis and its painful symptomatology were considered to be alleviated by pregnancy. However, these beliefs have shifted, as emerging literature has demonstrated the role of this condition in affecting pregnancy evolution. Read More

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November 2021

Analysis of Maternal and Neonatal Complications in a Group of Patients with Gestational Diabetes Mellitus.

Medicina (Kaunas) 2021 Oct 28;57(11). Epub 2021 Oct 28.

Department of Diabetes Nutrition and Metabolic Diseases, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

: Gestational diabetes mellitus (GDM) represents one of the most common complications during pregnancy, being associated with numerous maternal and neonatal complications. The study aimed to analyze maternal and neonatal complications associated with GDM. The risk factors of GDM and of the maternal and neonatal complications were studied in order to prevent their occurrence. Read More

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October 2021

Lactate Predicts Neurological Outcomes after Perinatal Asphyxia in Post-Hypothermia Era: A Prospective Cohort Study.

Life (Basel) 2021 Nov 5;11(11). Epub 2021 Nov 5.

Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City 70403, Taiwan.

Background: Neonatal hypoxic-ischemic encephalopathy (HIE) is the most common cause of mortality and neurological disability in infancy after perinatal asphyxia. Reliable biomarkers to predict neurological outcomes of neonates after perinatal asphyxia are still not accessible in clinical practice.

Methods: A prospective cohort study enrolled neonates with perinatal asphyxia. Read More

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November 2021

Maternal Perinatal Characteristics in Patients with Severe Preeclampsia: A Case-Control Nested Cohort Study.

Int J Environ Res Public Health 2021 Nov 10;18(22). Epub 2021 Nov 10.

Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain.

Preeclampsia is one of the most worrisome complications during pregnancy, affecting approximately 1 out of 20 women worldwide. Preeclampsia is mainly characterized by a sustained hypertension, proteinuria, also involving a significant organ dysfunction. Moreover, 25% of the cases could be classified as severe preeclampsia (SP), a serious condition that could be life-threatening for both the mother and fetus. Read More

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November 2021

Oxidative Stress and Respiratory Diseases in Preterm Newborns.

Int J Mol Sci 2021 Nov 19;22(22). Epub 2021 Nov 19.

Neonatal and Pediatric Intensive Care Unit, Department of Human Pathology of the Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.

Premature infants are exposed to increased generation of reactive oxygen species, and on the other hand, they have a deficient antioxidant defense system. Oxidative insult is a salient part of lung injury that begins as acute inflammatory injury in respiratory distress disease and then evolves into chronic and structural scarring leading to bronchopulmonary dysplasia. Oxidative stress is also involved in the pathogenesis of pulmonary hypertension in newborns through the modulation of the vascular tone and the response to pulmonary vasodilators, with consequent decrease in the density of the pulmonary vessels and thickening of the pulmonary arteriolar walls. Read More

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November 2021

The Emerging Role of Presepsin (P-SEP) in the Diagnosis of Sepsis in the Critically Ill Infant: A Literature Review.

Int J Mol Sci 2021 Nov 10;22(22). Epub 2021 Nov 10.

Neonatal Intensive Care Unit (NICU), Medical and Surgical Department of the Fetus-Newborn-Infant, "Bambino Gesù" Children's Hospital IRCCS, 00165 Rome, Italy.

Sepsis causes high rates of morbidity and mortality in NICUs. The estimated incidence varies between 5 and 170 per 1000 births, depending on the social context. In very low birth-weight neonates, the level of mortality increases with the duration of hospitalization, reaching 36% among infants aged 8-14 days and 52% among infants aged 15-28 days. Read More

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November 2021

Early Biomarkers and Hearing Impairments in Patients with Neonatal Hypoxic-Ischemic Encephalopathy.

Diagnostics (Basel) 2021 Nov 6;11(11). Epub 2021 Nov 6.

Department of Pediatrics, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.

Identifying biomarkers for hearing impairments (HIs) in patients with neonatal hypoxic-ischemic encephalopathy (HIE), to initialize early hearing habilitation, is crucial. Seventy-eight neonates with HIE were divided into the following two groups: those with HIs and those without HIs. We compared those patients with 11,837 newborns without HIE, and analyzed the risk factors of HIs among neonatal HIE. Read More

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November 2021

The Value of Posterior Cervical Angle as a Predictor of Vaginal Delivery: A Preliminary Study.

Diagnostics (Basel) 2021 Oct 25;11(11). Epub 2021 Oct 25.

Department of Obstetrics and Gynecology, Korea University School of Medicine, Seoul 02841, Korea.

Accurate prediction of failure to progress and rapid decision making regarding the mode of delivery can improve pregnancy outcomes. We examined the value of sonographic cervical markers in the prediction of successful vaginal delivery beyond 34 weeks of gestation. A retrospective chart review was carried out. Read More

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October 2021

Long-Term Outcomes after Neonatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia: A Longitudinal, Prospective, Multicenter Case-Control Study in Children without Overt Brain Damage.

Children (Basel) 2021 Nov 22;8(11). Epub 2021 Nov 22.

Department of General Psychology, University of Padova, 35131 Padova, Italy.

Background: Data on long-term outcomes in the era before therapeutic hypothermia (TH) showed a higher incidence of cognitive problems. Since the introduction of TH, data on its results are limited.

Methods: Our sample population consisted of 40 children with a history of hypoxic-ischemic encephalopathy (HIE) treated with TH, with an average age of 6. Read More

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November 2021

High Mortality among Premature Neonates with Positive Blood Culture Neonatal Sepsis in a Tertiary Hospital, Tanzania: A Call for Action.

Children (Basel) 2021 Nov 11;8(11). Epub 2021 Nov 11.

Department of Microbiology and Immunology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza 1464, Tanzania.

Well-documented vital signs are key in the prediction of sepsis in low- and middle-income countries. We determined prevalence, associated factors, and outcomes of positive blood culture sepsis in premature neonates at Bugando Medical Centre Mwanza, Tanzania. Temperature, oxygen saturation, heart rate, respiratory rate, and random blood glucose were repeatedly recorded at admission, 8 h, and 24 h in all 250 neonates enrolled. Read More

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November 2021

Cardiovascular Intervention in Neonates Using an Umbilical Vein Approach.

Children (Basel) 2021 Nov 5;8(11). Epub 2021 Nov 5.

Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng-Kung University, Tainan 704302, Taiwan.

Cardiovascular catheterization has been applied in infant treatment for several decades. To date, considerable research attention has been paid to cardiovascular catheterization in small neonates. However, peripheral vascular routes of catheterization are possible obstacles for interventionists. Read More

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November 2021

Impact of a "Brain Protection Bundle" in Reducing Severe Intraventricular Hemorrhage in Preterm Infants <30 Weeks GA: A Retrospective Single Centre Study.

Children (Basel) 2021 Oct 31;8(11). Epub 2021 Oct 31.

Department of Paediatrics, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.

Background: despite advances in perinatal care, periventricular/intraventricular hemorrhage (IVH) continues to remain high in neonatal intensive care units (NICUs) worldwide. Studies have demonstrated the benefits of implementing interventions during the antenatal period, stabilization after birth (golden hour management) and postnatally in the first 72 h to reduce the incidence of IVH.

Objective: to compare the incidence of severe intraventricular hemorrhage (IVH ≥ Grade III) before and after implementation of a "brain protection bundle" in preterm infants <30 weeks GA. Read More

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October 2021

Neuropsychological Development and New Criteria for Extrauterine Growth Restriction in Very Low-Birth-Weight Children.

Children (Basel) 2021 Oct 23;8(11). Epub 2021 Oct 23.

Hospital Universitario Central de Asturias, Universidad de Oviedo, 33003 Oviedo, Spain.

Background: Controversy between short-term neonatal growth of very low birth-weight preterm (VLBW) and neurodevelopment may be affected by criteria changes of extrauterine growth restriction (EUGR).

Objective: to determine if new EUGR criteria imply modifications in the relationship between old criteria and results of neuropsychological tests in preterm children.

Patients And Methods: 87 VLBW at 5-7 years of age were studied. Read More

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October 2021

Neurologic Sequelae Associated with Hypertensive Disorders of Pregnancy.

Authors:
Mark S Scher

Children (Basel) 2021 Oct 20;8(11). Epub 2021 Oct 20.

Pediatrics and Neurology, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

Hypertensive disorders of pregnancy (HDP) contribute to adverse gene-environment interactions prior to conception and continue throughout pregnancy. Embryonic/fetal brain disorders occur from interactions between genetic susceptibilities interacting with acquired diseases or conditions affecting the maternal/placental fetal (MPF) triad. Trimester-specific pathophysiological mechanisms, such as maternal immune activation and ischemic placental syndrome, contribute to adverse peripartum, neonatal and childhood outcomes. Read More

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October 2021

Analysis of Selected Risk Factors Depending on the Type of Cerebral Palsy.

Brain Sci 2021 Oct 30;11(11). Epub 2021 Oct 30.

Department of Pediatric Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-752 Katowice, Poland.

Cerebral palsy (CP) is not a defined, separate disease classification, but a set of etiologically diverse symptoms that change with the child's age. According to the up-to-date definition, CP is a group of permanent but not unchanging disorders of movement and/or posture and motor function, which are due to a nonprogressive interference, lesion, or abnormality of the developing/immature brain. CP is one of the most frequent causes of motor disability in children. Read More

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October 2021

Performance of Scoring Systems in Predicting Clinical Outcomes in Patients with Bacteremia of : A 9-Year Hospital-Based Study.

Biology (Basel) 2021 Oct 21;10(11). Epub 2021 Oct 21.

Department of Pathology and Laboratory, Taipei Veterans General Hospital, Taoyuan Branch, Taoyuan 330, Taiwan.

Background: (LM) is a facultative anaerobe, Gram-positive bacillus which is widely distributed in nature, and can be separated from soil, water, and rotten vegetables. Immunocompetent people are less likely to suffer from LM infection or may only show gastrointestinal symptoms. However, immunocompromised elderly people, pregnant women, and newborns may develop life-threatening invasive infections. Read More

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October 2021

Long-term health and neurodevelopment in children after antenatal exposure to low-dose aspirin for the prevention of preeclampsia and fetal growth restriction: A systematic review of randomized controlled trials.

Eur J Obstet Gynecol Reprod Biol 2021 Nov 11;267:213-220. Epub 2021 Nov 11.

Amsterdam UMC, University of Amsterdam, Department of Obstetrics and Gynecology, Amsterdam Reproduction & Development Research Institute, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands.

Objective: To evaluate the long-term effects of antenatal aspirin exposure on child health and neurodevelopmental outcome beyond the perinatal period.

Study Design: PubMed, Embase.com, the Cochrane Library and Web of Science were systematically searched from inception through 5 November 2020. Read More

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November 2021

Ontogeny of the human fetal, neonatal, and infantile basioccipital bone: traditional and extended eigenshape geometric morphometric analysis.

Anat Rec (Hoboken) 2021 Nov 25. Epub 2021 Nov 25.

Department of Biological Sciences, West Liberty University, West Liberty, WV, USA.

The basioccipital bone is an essential developmental component to the occipital bone, occipital condyles, foramen magnum, clivus, and cranial base. The basioccipital bone joins each exoccipital bone with a basiexoccipital synchondrosis and the basisphenoid / sphenoid bone with a sphenooccipital synchondrosis. The basioccipital is found intermediate to the petrous temporal bones and forms the bilateral petrooccipital / petroclival fissures otherwise known as the petrooccipital complex. Read More

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November 2021

Population-based study found that placental histology predicted adverse outcomes in extremely premature neonates in Norway.

Acta Paediatr 2021 Nov 26. Epub 2021 Nov 26.

Department of Clinical Medicine, University of Bergen, Norway.

Aim: We evaluated the role of placental pathology in predicting adverse outcomes for neonates born extremely preterm (EPT) before 28 weeks of gestation.

Methods: This was a prospective observational study of 123 extremely preterm singletons born in a hospital in western Norway and the placentas were classified according to the Amsterdam criteria. The associations between histologic chorioamnionitis (HCA), by the presence or absence of a fetal inflammatory response (FIR+ or FIR-), maternal vascular malperfusion (MVM) as a whole and adverse neonatal outcomes were evaluated by logistic regression analyses. Read More

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November 2021

Obstetric consequences of a false positive diagnosis of large for gestational age fetus.

Int J Gynaecol Obstet 2021 Nov 26. Epub 2021 Nov 26.

Division of Obstetrics and Gynecology, ASST Spedali Civili, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Objective: To compare delivery outcomes between true positive (TP) and false positive (FP) LGA, appropriate for gestational age (AGA) and false negative LGA (FN LGA) fetuses.

Methods: Retrospective cohort study of singleton pregnancies at risk for macrosomia without contraindication to vaginal delivery, receiving an ultrasound scan at 34-37 weeks.

Results: 430 pregnancies were included: 155 TP LGA, 87 FP LGA and 177 AGA and 11 FN LGA newborns. Read More

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November 2021