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Enhancing the cardiovascular protective effects of a healthy dietary pattern with wolfberry (Lycium barbarum): A randomized controlled trial.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore, Singapore.

Background: The consumption of wolfberry (Lycium barbarum), a rich source of carotenoids and bioactive polysaccharides, may serve as a potential dietary strategy for cardiovascular disease (CVD) risk management although limited studies examined its effects as whole fruits.

Objectives: To investigate the impact of wolfberry consumption as part of a healthy dietary pattern on vascular health-related outcomes and classical CVD risk factors in middle-aged and older adults in Singapore.

Methods: This is a 16-week, parallel design, randomized controlled trial. Read More

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Georgian Med News 2021 Mar(312):119-125

Tbilisi State Medical University, Georgia.

Uterine leiomyomas decrease the quality of life by causing significant morbidity among women of reproductive age. Histologically various types of leiomyoma's can be differentiated. We have analysed the histopathological, proliferation, apoptotic and hormonal profile in different types of leiomyomas. Read More

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Georgian Med News 2021 Mar(312):92-99

Tbilisi State Medical University.

Different studies indicate that cancer stem cells (CSCs) play an important role in the progression and therapy resistance in different cancer types. The aim of our study was to analyse the distribution of CSCs in different thyroid lesions, in reproductive, menopausal and post-menopausal women. Study included altogether 200 formalin-fixed and paraffin-embedded tissue material, with the diagnosis of NIFTP, Hashimoto's thyroiditis, papillary thyroid carcinoma (PTC) and PTC and Hashimoto's thyroiditis co-occurred cases. Read More

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Georgian Med News 2021 Mar(312):88-92

Tbilisi State Medical University, Department of Paediatric Neurology, Georgia.

Epilepsy is one of the most common neurological disorder affecting up to 1% of the world population. It is a heterogeneous disorder and includes genetic, structural, metabolic causes, sometimes reason is unknown. In recent 20 years inflammation has been considered as a possible etiologic factor in angiogenesis and epileptogenesis in experimental models but there is still lack of evidence if inflammation could be seen in clinical cases of children with different forms of epilepsy. Read More

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Georgian Med News 2021 Mar(312):52-56

NJSC "Medical University of Karaganda", Kazakhstan.

The new cardiovascular events development remains the main factors limiting its long-term effectiveness despite technological progress and the widespread use of percutaneous coronary intervention (PCI). Objective - to assess the effect of clinical and genetic factors on the development of complication after percutaneous coronary intervention with double antiplatelet therapy (DAT). Case-control. Read More

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Y Ivashchuk

Georgian Med News 2021 Mar(312):46-52

State Institution "Zaporozhye Medical Academy of Postgraduate Education" of the Ministry of Health of Ukraine.

Objective - to determine the features of the daily profile of blood pressure (BP), blood lipid spectrum, features of left ventricular remodeling in patients with hypertension in combination with RA and to evaluate the effectiveness of using medium doses of rosuvastatin to correct dyslipidemia in this group of patients. 70 patients aged 40-65 years were examined (average - M±m - 54.88±0. Read More

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Georgian Med News 2021 Mar(312):42-46

Bogomolets National Medical University, Institute of Postgraduate Education, Department of Dentistry, Kyiv, Ukraine.

In recent years, according to the WHO, more than 1,9 billion people over the age of 18 are overweight, of whom more than 650 million are obese, with an annual trend. Studies in recent decades have shown that obese young people with generalized periodontitis have abnormalities in protein, fat and carbohydrate metabolism, which contributes to the early destruction of the periodontal tissue complex and rapid tooth loss. The aim of our study was to examine changes in serum leptin and adiponectin in patients with generalized periodontitis on the background of obesity. Read More

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Incidence and risk factors associated with the development of epilepsy in patients with intracranial alveolar echinococcosis.

Epilepsy Res 2021 Apr 27;174:106643. Epub 2021 Apr 27.

Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, Sichuan, 610041, People's Republic of China. Electronic address:

Parasitic infection remains a critical health problem in Ganzi Tibetan Autonomous Prefecture of China. The association of epilepsy and intracranial alveolar echinococcosis (IAE) is still largely unclear. This study primarily aimed to assess both the incidence and possible risk factors of epilepsy in patients with IAE. Read More

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Plasma NfL, clinical subtypes and motor progression in Parkinson's disease.

Parkinsonism Relat Disord 2021 Apr 27;87:41-47. Epub 2021 Apr 27.

Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Introduction: neurofilament light chain (NfL) levels have been proposed as reliable biomarkers of neurodegeneration in Parkinson's disease (PD) but the relationship between plasma NfL, clinical subtypes of PD and motor progression is still debated.

Methods: plasma NfL concentration was measured in 45 healthy controls and consecutive 92 PD patients who underwent an extensive motor and non-motor assessment at baseline and after 2 years of follow-up. PD malignant phenotype was defined as the combination of at least two out of cognitive impairment, orthostatic hypotension and REM sleep behavior disorder. Read More

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Shorter outpatient wait-times for buprenorphine are associated with linkage to care post-hospital discharge.

Drug Alcohol Depend 2021 Apr 20;224:108703. Epub 2021 Apr 20.

Department of Medicine, Boston University School of Medicine, 801 Massachusetts Ave, Boston, MA, 02118, USA.

Background: Inpatient addiction consult services (ACS) lower barriers to accessing medications for opioid use disorder (MOUD), however not every patient recommended for MOUD links to outpatient care. We hypothesized that fewer days between discharge date and outpatient appointment date was associated with improved linkage to buprenorphine treatment among patients evaluated by an ACS.

Methods: We extracted appointment and demographic data from electronic medical records and conducted retrospective chart review of adults diagnosed with opioid use disorder (OUD) evaluated by an ACS in Boston, MA between July 2015 and August 2017. Read More

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Vestibular disorders in children: A retrospective analysis of vestibular function test findings.

Int J Pediatr Otorhinolaryngol 2021 Apr 29;146:110751. Epub 2021 Apr 29.

Acibadem Maslak Hospital ENT Department, Istanbul, Turkey.

Objective: This study was designed to describe the most common vestibular disorders in children and their associated findings on vestibular function testing.

Method: Data from 203 children with a mean age of 11.16 ± 3. Read More

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Postnatal outcome of prenatally-detected "simple" renal cysts: Are they really simple?

Early Hum Dev 2021 May 4;157:105382. Epub 2021 May 4.

Department of Paediatric Surgery and Urology, Chelsea and Westminster Hospital NHS Foundation Trust, 369 Fulham Road, London SW10 9NH, UK; Centre for Fetal Care, Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, Du Cane Road, London W12 0HS, UK. Electronic address:

Background: The majority of simple renal cysts diagnosed postnatally are asymptomatic and rarely require treatment unless they become symptomatic or complex. We hypothesised that prenatally-detected simple renal cysts would have a similar harmless outcome.

Aims: To establish the natural history and postnatal outcome of prenatally-diagnosed simple renal cysts. Read More

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Iatrogenic Ureteral Injury and Prophylactic Stent Use in Veterans Undergoing Colorectal.

J Surg Res 2021 May 5;265:272-277. Epub 2021 May 5.

Michael and Marian Ilitch Department of Surgery, Wayne State University School of Medicine / Detroit Medical Center, Detroit, Michigan; John D. Dingell VA Medical Center, Detroit, Michigan. Electronic address:

Introduction: Iatrogenic ureteral injury (IUI) is an uncommon complication in colorectal surgery. Prophylactic ureteral stenting (PUS) gained acceptance to aid in intraoperative identification of the ureter. Despite its use, the benefit of pus to avoid IUI remains debatable. Read More

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Clinicopathological characteristics and outcomes in embryonal tumor with multilayered rosettes: A decade long experience from a tertiary care centre in North India.

Ann Diagn Pathol 2021 Apr 19;53:151745. Epub 2021 Apr 19.

Departments of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Embryonal tumor with multilayered rosettes (ETMR) are a heterogenous group clinically, pathologically and topographically. Due to limited cases, data regarding its molecular genetics, pathology and prognostic factors is evolving. We retrospectively analysed our cohort of ETMR over last decade in order to study their clinicopathological characteristics and outcome. Read More

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Association of Early White Blood Cell Trend with Outcomes in Aneurysmal Subarachnoid Hemorrhage.

World Neurosurg 2021 May 5. Epub 2021 May 5.

Department of Neurology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI.

Background: An increasing white blood cell (WBC) count in early course of aneurysmal subarachnoid hemorrhage (SAH) can indicate a systemic inflammatory state triggered by the initial insult. We sought to determine the significance of the early WBC trend as a potential predictor of outcomes.

Methods: We analyzed a cohort of consecutive patients with aneurysmal SAH. Read More

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Single-Position Prone Lateral Interbody Fusion Improves Segmental Lordosis in Lumbar Spondylolisthesis.

World Neurosurg 2021 May 5. Epub 2021 May 5.

Department of Neurosurgery, Barrow Neurological Institute, Phoenix, Arizona. Electronic address:

Objective: Single-position surgery in the prone position is a novel technique for lateral interbody fusion with pedicle screw fixation. We performed a radiographic comparison of patients treated for spondylolisthesis using the prone lateral (PL) transpsoas approach to those treated with the traditional dual-position (DP) strategy (lateral decubitus then prone).

Methods: 30 consecutive patients with spondylolisthesis treated using PL (N=15) were compared to patients treated using DP surgery (N=15). Read More

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Comparison of clinical outcomes after transforaminal interbody fusion using cortical bone trajectory versus percutaneous pedicle screw fixation.

World Neurosurg 2021 May 5. Epub 2021 May 5.

Department of Orthopaedic Surgery, Hyogo College of Medicine, Mukogawa-cho 1-1, Nishinomiya, Hyogo 663-8501, Japan.

Objective: The study aim was to compare clinical outcomes between patients undergoing transforaminal interbody fusion (TLIF) using percutaneous pedicle screw (PPS) and cortical bone trajectory (CBT) by a single surgeon.

Methods: This was a retrospective matched-cohort study of 77 patients (mean age: 71.7 years, 56% female) who underwent TLIF using CBT or PPS. Read More

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Clinical characteristics and outcome of bacteremia caused by Enterobacter cloacae and Klebsiella aerogenes: more similarities than differences.

J Glob Antimicrob Resist 2021 May 5. Epub 2021 May 5.

Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Infectious Diseases Research Group, Institute of Biomedicine of Seville (IBiS), University of Seville/CSIC/ Virgen del Rocío University Hospital, Seville, Spain.

Introduction: The genus Enterobacter is a common cause of nosocomial infections. Historically, the most frequent Enterobacter species were those of the Enterobacter cloacae complex and Enterobacter aerogenes. In 2019, E. Read More

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Prognostic value of preoperative psoas muscle index as a measure of nutritional status in patients with esophageal cancer receiving neoadjuvant therapy.

Nutrition 2021 Mar 6;90:111232. Epub 2021 Mar 6.

First Department of Surgery, Faculty of Medicine University of Yamanashi, Yamanashi, Japan.

Objectives: It has been reported that preoperative nutritional status in some gastrointestinal cancers has a significant effect on postoperative prognosis. However, there are few reports on esophageal cancer, especially for esophageal cancer patients who have undergone neoadjuvant therapy and surgery. Psoas muscle index (PMI) is widely known as an index for assessing preoperative nutritional status, and has recently been reported for its prognostic value in many malignancies. Read More

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Xiao-Xu-Ming decoction prevented hemorrhagic transformation induced by acute hyperglycemia through inhibiting AGE-RAGE-mediated neuroinflammation.

Pharmacol Res 2021 May 5:105650. Epub 2021 May 5.

College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, 280 Waihuan East Road, Panyu District, Guangdong 510006, P.R. China; Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, P.R. China. Electronic address:

Stroke is one of the leading causes of death worldwide. Hemorrhagic transformation (HT) is a common serious complication of ischemic stroke (IS) and is related to poor prognosis. Hyperglycemia after stroke is associated with the occurrence of HT and seriously affects the clinical treatment of stroke. Read More

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Effects of a combination of Mass and Dutch variant as an inactivated vaccine against variant 2 avian infectious bronchitis virus challenge.

Microb Pathog 2021 May 5:104937. Epub 2021 May 5.

Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

The present study aimed to evaluate the effects of inactivated vaccines combining Mass and Dutch variants as vaccine boosters after H120 priming on inhibiting variant 2 viral load in the kidneys (as the target organ) and reducing fecal shedding. Ciliostasis score and antibody response were investigated as well. A total of 150 specific-pathogen-free (SPF) chicken were divided into six groups. Read More

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The Incidence of Hip Arthroscopy in Patients with Femoroacetabular Impingement Syndrome and Labral Pathology Increased by 85% Between 2011 and 2018 in the United States.

Arthroscopy 2021 May 5. Epub 2021 May 5.

Cedars Sinai-Kerlan Jobe Institute.

Purpose: The purpose of this study was to investigate the incidence of hip arthroscopy in patients with labral pathology in the United States from the year 2011-2018 using a large national database.

Methods: Patients who underwent hip arthroscopy from 2011-2018 were identified using CPT (Current Procedural Terminology) codes in the PearlDiver Patients Records Database (Colorado Springs, CO), which is a national database of orthopedic insurance records, including Medicare patients. The incidence of surgeries, age, gender, and geographical location (by region) were all recorded. Read More

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Plasma adrenomedullin level and year-by-year variability of body mass index in the general population.

Peptides 2021 May 5:170567. Epub 2021 May 5.

Frontier Science Research Center, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, 889-1692, Japan.

Plasma levels of the hypotensive peptides of adrenomedullin and atrial and B-type natriuretic peptides (AM, ANP, BNP) are possible biomarkers for cardiovascular diseases. Increased variability of body mass index (BMI) over a certain period of time has been reported to be associated with cardiovascular morbidity or mortality. The aim of this study is to examine clinical significance of those hypotensive peptides as biomarkers by analyzing the relationship between plasma levels of the peptides and year-by-year variability of BMI in the general population without overt cardiovascular diseases. Read More

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Pancreatic cyst fluid glucose in differentiating mucinous from nonmucinous pancreatic cysts: a systematic review and meta-analysis.

Gastrointest Endosc 2021 May 5. Epub 2021 May 5.

Division of Gastroenterology and Hepatology, University of New Mexico, Albuquerque, NM, USA. Electronic address:

Background And Aims: Recently, low levels of intracystic glucose acquired via EUS-guided pancreatic cyst fluid sampling have been shown to help to differentiate mucinous from nonmucinous cystic neoplasms. The aim of this study was to perform a systematic review and meta-analysis to evaluate the diagnostic characteristics of pancreatic cyst fluid glucose compared with carcinoembryonic antigen (CEA) for pancreatic cystic lesions.

Methods: Individualized searches were developed in accordance with PRISMA and MOOSE guidelines and meta-analysis analyzed according to Cochrane Diagnostic Test Accuracy working group methodology. Read More

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One-and-one-half Ventricle Repair: Role for Restricting Antegrade Pulmonary Blood Flow.

Ann Thorac Surg 2021 May 5. Epub 2021 May 5.

Harvard Medical School, Boston, MA; Department of Cardiovascular Surgery, Boston Children's Hospital, Boston, MA. Electronic address:

Background: In patients with hypoplastic sub-pulmonary ventricles, the one-and-one-half ventricle (1.5V) repair is an alternative to the Fontan. However, 1. Read More

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Is Outpatient Management of Mandibular Fractures Associated With Inflammatory Complications? An ACS-NSQIP Study.

J Oral Maxillofac Surg 2021 Mar 26. Epub 2021 Mar 26.

Assistant Professor, Oral & Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA. Electronic address:

Purpose: Timing of mandibular fracture repair has long been debated. The purpose of the present study was to assess the incidence of postoperative inflammatory complications (POICs) following open repair of mandibular fractures managed non-urgently in the outpatient setting versus urgently in the inpatient setting.

Methods: The authors utilized the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database to enroll a sample of patients with mandibular fractures who underwent open repair. Read More

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Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data.

Lancet 2021 May 5. Epub 2021 May 5.

Public Health Services, Israel Ministry of Health, Jerusalem, Israel. Electronic address:

Background: Following the emergency use authorisation of the Pfizer-BioNTech mRNA COVID-19 vaccine BNT162b2 (international non-proprietary name tozinameran) in Israel, the Ministry of Health (MoH) launched a campaign to immunise the 6·5 million residents of Israel aged 16 years and older. We estimated the real-world effectiveness of two doses of BNT162b2 against a range of SARS-CoV-2 outcomes and to evaluate the nationwide public-health impact following the widespread introduction of the vaccine.

Methods: We used national surveillance data from the first 4 months of the nationwide vaccination campaign to ascertain incident cases of laboratory-confirmed SARS-CoV-2 infections and outcomes, as well as vaccine uptake in residents of Israel aged 16 years and older. Read More

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The formulation and efficacy of topical in treating Melasma: a randomized double-blind, placebo-controlled trial.

J Complement Integr Med 2021 May 10. Epub 2021 May 10.

Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Objectives: An acquired melanin-related hyperpigmentation that occurs in sun exposure areas is Melasma which presents as gray-brown ridges and macules with prominent margins on the skin. The aim of this assay was to assess the formulation and efficacy of topical among Melasma patients.

Methods: This study was a 30 days double-blind, randomized clinical trial in Melasma with a placebo group. Read More

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Risk stratification in men with a negative prostate biopsy: An interim analysis of a prospective cohort study.

BJU Int 2021 May 8. Epub 2021 May 8.

Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Objective: To investigate if a risk score for prostate cancer (PC) lifetime risk can be used to optimize triaging of patients with a negative prostate biopsy, but under sustained suspicion of PC.

Methods And Patients: In this prospective clinical study, we included, and risk scored patients who had a cancer-negative transrectal ultrasound guided (TRUS) prostate biopsy, but elevated prostate specific antigen (PSA), a suspicious prostate digital rectal examination and/or a positive family history (FH) of PC. The risk score estimated individual lifetime risk of PC, based on a polygenic risk score (33 single nucleotide polymorphisms), age, and FH of PC. Read More

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Association between nutrition delivery, modified Nutrition Risk in Critically Ill score, and 28-day mortality.

Nutr Clin Pract 2021 May 8. Epub 2021 May 8.

Division of Biostatistics, National Institute of Nutrition, Hyderabad, Telangana, India.

Background: Nutrition delivery, is a key component in the management of critical illness. Traditional scoring systems are inadequate in the intensive care unit (ICU), as patients are sedated. Our study examines the associations between calorie and protein adequacy, 28-day mortality, and modified Nutrition Risk in Critically Ill (mNUTRIC) score and identify at-risk ICU patients who may benefit more from nutrition intervention. Read More

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